المؤلفون: Matheson, CJ, Coxon, CR, Bayliss, R, Boxall, K, Carbain, B, Fry, AM, Hardcastle, IR, Harnor, SJ, Mas-Droux, C, Newell, DR, Richards, MW, Sivaprakasam, M, Turner, D, Griffin, RJ, Golding, BT, Cano, C

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::50079741394e01f4bd1b1137f16bfc2a
https://eprints.whiterose.ac.uk/160431/19/d0md00074d.pdf

المؤلفون: Coxon, CR, Wong, C, Bayliss, RWA, Boxall, K, Carr, KH, Fry, AM, Hardcastle, IR, Matheson, CJ, Newell, DR, Sivaprakasam, M, Thomas, H, Turner, D, Yeoh, S, Wang, LZ, Griffin, RJ, Golding, BT, Cano, C

المصدر: Oncotarget

مصطلحات موضوعية: Nek2, Structure-Activity Relationship, Magnetic Resonance Spectroscopy, Cell Line, Tumor, Drug Design, cancer, Humans, NIMA-Related Kinases, Antineoplastic Agents, structure-guided design, small molecule inhibitors, Research Paper

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2a81c9e348a99e3a06a93c16991f5ec9

المؤلفون: Warfield BM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO 80045, United States., Casalvieri KA; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO 80045, United States., Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO 80045, United States., Backos DS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO 80045, United States., Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO 80045, United States.

المصدر: Data in brief [Data Brief] 2021 Sep 25; Vol. 38, pp. 107433. Date of Electronic Publication: 2021 Sep 25 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101654995 Publication Model: eCollection Cited Medium: Internet ISSN: 2352-3409 (Electronic) Linking ISSN: 23523409 NLM ISO Abbreviation: Data Brief Subsets: PubMed not MEDLINE

المؤلفون: Warfield BM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States., Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States., McArthur DG; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States., Backos DS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States., Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, Colorado 80045, United States.

المصدر: ACS chemical neuroscience [ACS Chem Neurosci] 2021 Sep 15; Vol. 12 (18), pp. 3477-3486. Date of Electronic Publication: 2021 Sep 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Glioblastoma*/drug therapy , Thymidine Phosphorylase*, Cell Line ; Humans ; Temozolomide/pharmacology ; Uracil

المؤلفون: Casalvieri KA; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Warfield BM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Backos DS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA. Electronic address: philip.reigan@cuanschutz.edu.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jul 01; Vol. 41, pp. 116220. Date of Electronic Publication: 2021 May 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*pharmacology , Purines/*chemistry , Purines/*pharmacology , Pyrimidines/*chemistry , Pyrimidines/*pharmacology , Pyrroles/*chemistry , Pyrroles/*pharmacology , Ribosomal Protein S6 Kinases, 90-kDa/*antagonists & inhibitors, Catalytic Domain ; Cell Line ; Cell Survival/drug effects ; Enzyme Inhibitors/chemistry ; Humans ; Models, Molecular ; Protein Binding ; Protein Conformation

المؤلفون: Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Casalvieri KA; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Backos DS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Minhajuddin M; Division of Hematology, University of Colorado Anschutz Medical Campus, 12700 E 19th Avenue, Aurora, CO, 80045, USA., Jordan CT; Division of Hematology, University of Colorado Anschutz Medical Campus, 12700 E 19th Avenue, Aurora, CO, 80045, USA., Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA. Electronic address: philip.reigan@cuanschutz.edu.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2020 Jul 01; Vol. 197, pp. 112316. Date of Electronic Publication: 2020 Apr 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: AMP-Activated Protein Kinases/*metabolism , Antineoplastic Agents/*pharmacology , Oxindoles/*pharmacology , Protein Kinase Inhibitors/*pharmacology, AMP-Activated Protein Kinases/chemistry ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Cell Survival/drug effects ; Drug Screening Assays, Antitumor ; Humans ; K562 Cells ; Molecular Docking Simulation ; Oxindoles/chemical synthesis ; Oxindoles/metabolism ; Protein Binding ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/metabolism

المؤلفون: Casalvieri KA; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO 80045, USA., Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO 80045, USA., Backos DS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO 80045, USA., Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO 80045, USA. Electronic address: philip.reigan@cuanschutz.edu.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Mar 01; Vol. 28 (5), pp. 115303. Date of Electronic Publication: 2020 Jan 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Protein Kinase Inhibitors/*pharmacology , Pteridines/*pharmacology , Ribosomal Protein S6 Kinases, 90-kDa/*antagonists & inhibitors, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pteridines/chemical synthesis ; Pteridines/chemistry ; Ribosomal Protein S6 Kinases, 90-kDa/metabolism ; Structure-Activity Relationship

المؤلفون: Casalvieri KA; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Backos DS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA.

المصدر: Data in brief [Data Brief] 2020 Feb 28; Vol. 29, pp. 105347. Date of Electronic Publication: 2020 Feb 28 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101654995 Publication Model: eCollection Cited Medium: Internet ISSN: 2352-3409 (Electronic) Linking ISSN: 23523409 NLM ISO Abbreviation: Data Brief Subsets: PubMed not MEDLINE

المؤلفون: Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Casalvieri KA; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Backos DS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA., Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA.

المصدر: ChemMedChem [ChemMedChem] 2018 Aug 20; Vol. 13 (16), pp. 1681-1694. Date of Electronic Publication: 2018 Jul 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Cell Cycle Proteins/*antagonists & inhibitors , Nuclear Proteins/*antagonists & inhibitors , Protein Kinase Inhibitors/*pharmacology , Protein-Tyrosine Kinases/*antagonists & inhibitors , Pyrazoles/*pharmacology , Pyrimidines/*pharmacology , Pyrimidinones/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/toxicity ; Binding Sites ; CDC2 Protein Kinase/chemistry ; CDC2 Protein Kinase/metabolism ; Cell Cycle Proteins/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Enzyme Assays ; Humans ; Molecular Structure ; Nuclear Proteins/chemistry ; Phosphorylation/drug effects ; Protein Binding ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/toxicity ; Protein-Tyrosine Kinases/chemistry ; Pyrazoles/chemical synthesis ; Pyrazoles/metabolism ; Pyrazoles/toxicity ; Pyrimidines/chemical synthesis ; Pyrimidines/metabolism ; Pyrimidines/toxicity ; Pyrimidinones/chemical synthesis ; Pyrimidinones/metabolism ; Pyrimidinones/toxicity ; Structure-Activity Relationship

المؤلفون: Casalvieri KA; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, V20-2102, Aurora, CO 80045, USA., Matheson CJ; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, V20-2102, Aurora, CO 80045, USA., Backos DS; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, V20-2102, Aurora, CO 80045, USA., Reigan P; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, V20-2102, Aurora, CO 80045, USA. Electronic address: philipreigan@ucdenver.edu.

المصدر: Trends in cancer [Trends Cancer] 2017 Apr; Vol. 3 (4), pp. 302-312. Date of Electronic Publication: 2017 Apr 03.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101665956 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-8025 (Electronic) Linking ISSN: 24058025 NLM ISO Abbreviation: Trends Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms/*genetics , Protein Isoforms/*genetics , Ribosomal Protein S6 Kinases, 90-kDa/*genetics, Humans ; Signal Transduction