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المؤلفون: Seal JT, Atkinson SJ, Bamborough P, Bassil A, Chung CW, Foley J; Cancer Epigenetics Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Gordon L, Grandi P; IVIVT Cellzome, Platform Technology and Science, GlaxoSmithKline, Meyerhofstr. 1, 69117 Heidelberg, Germany., Gray JRJ, Harrison LA, Kruger RG; Cancer Epigenetics Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Matteo JJ; Cancer Epigenetics Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., McCabe MT; Cancer Epigenetics Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Messenger C, Mitchell D, Phillipou A, Preston A, Prinjha RK, Rianjongdee F, Rioja I, Taylor S, Wall ID, Watson RJ, Woolven JM, Wyce A; Cancer Epigenetics Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Zhang XP; Cancer Epigenetics Research Unit, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States., Demont EH

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Aug 12; Vol. 64 (15), pp. 10772-10805. Date of Electronic Publication: 2021 Jul 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Furans/*pharmacology , Proteins/*antagonists & inhibitors , Pyrazoles/*pharmacology, Dose-Response Relationship, Drug ; Furans/chemistry ; Humans ; Molecular Structure ; Proteins/metabolism ; Pyrazoles/chemistry ; Structure-Activity Relationship

المؤلفون: Wyce A; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Matteo JJ; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Foley SW; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Felitsky DJ; Target Sciences, GlaxoSmithKline, Upper Merion, PA, USA., Rajapurkar SR; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Zhang XP; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Musso MC; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Korenchuk S; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Karpinich NO; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Keenan KM; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Stern M; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Mathew LK; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., McHugh CF; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., McCabe MT; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Tummino PJ; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA.; Janssen Pharmaceuticals, Spring House, Montgomery, PA, USA., Kruger RG; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Carpenter C; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA., Barbash O; Cancer Epigenetics DPU, Oncology R&D, GlaxoSmithKline, Collegeville, PA, USA. olena.x.barbash@gsk.com.

المصدر: Oncogenesis [Oncogenesis] 2018 Apr 20; Vol. 7 (4), pp. 35. Date of Electronic Publication: 2018 Apr 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101580004 Publication Model: Electronic Cited Medium: Print ISSN: 2157-9024 (Print) Linking ISSN: 21579024 NLM ISO Abbreviation: Oncogenesis Subsets: PubMed not MEDLINE

المؤلفون: Murrills RJ; Department of Osteoporosis and Frailty, Women's Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania, USA. murrills@aol.com, Fukayama S, Boschelli F, Matteo JJ, Owens J, Golas JM, Patel D, Lane G, Liu YB, Carter L, Jussif J, Spaulding V, Wang YD, Boschelli DH, McKew JC, Li XJ, Lockhead S, Milligan C, Kharode YP, Diesl V, Bai Y, Follettie M, Bex FJ, Komm B, Bodine PV

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2012 Mar; Vol. 340 (3), pp. 676-87. Date of Electronic Publication: 2011 Dec 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Osteogenesis/*drug effects , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins c-abl/*antagonists & inhibitors , src-Family Kinases/*antagonists & inhibitors, Amino Acid Sequence ; Animals ; Cell Differentiation ; Gene Expression Profiling ; Humans ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteoclasts/cytology ; Osteoclasts/drug effects

المؤلفون: Lebarbenchon C; Southeastern Cooperative Wildlife Disease Study, Department of Population Health, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA. cleb@uga.edu, Sreevatsan S, Ramakrishnan MA, Poulson R, Goekjian V, Di Matteo JJ, Wilcox B, Stallknecht DE

المصدر: Journal of wildlife diseases [J Wildl Dis] 2010 Oct; Vol. 46 (4), pp. 1284-9.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wildlife Disease Association Country of Publication: United States NLM ID: 0244160 Publication Model: Print Cited Medium: Internet ISSN: 1943-3700 (Electronic) Linking ISSN: 00903558 NLM ISO Abbreviation: J Wildl Dis Subsets: MEDLINE

مواضيع طبية MeSH: Influenza A virus*/genetics, Influenza in Birds/*epidemiology, Animals ; Animals, Wild/virology ; Birds ; Cloaca/virology ; Female ; Male ; Minnesota/epidemiology

المؤلفون: Murrills RJ; Department of Osteoporosis and Frailty, Women's Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA. murrills@aol.com, Matteo JJ, Bhat BM, Coleburn VE, Allen KM, Chen W, Damagnez V, Bhat RA, Bex FJ, Bodine PV

المصدر: Journal of cellular biochemistry [J Cell Biochem] 2009 Dec 01; Vol. 108 (5), pp. 1066-75.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8205768 Publication Model: Print Cited Medium: Internet ISSN: 1097-4644 (Electronic) Linking ISSN: 07302312 NLM ISO Abbreviation: J Cell Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Intercellular Signaling Peptides and Proteins/*metabolism , LDL-Receptor Related Proteins/*metabolism , Molecular Chaperones/*metabolism , Receptors, Cell Surface/*metabolism , Receptors, LDL/*metabolism, Amino Acid Substitution ; Binding Sites ; Biological Assay ; Bone and Bones/metabolism ; Cell Line ; Humans ; LDL-Receptor Related Proteins/chemistry ; LDL-Receptor Related Proteins/genetics ; Low Density Lipoprotein Receptor-Related Protein-5 ; Low Density Lipoprotein Receptor-Related Protein-6 ; Molecular Chaperones/genetics ; Mutation ; Protein Binding ; Protein Interaction Domains and Motifs ; Receptors, Cell Surface/genetics

المؤلفون: Pelletier JC; Chemical Sciences, Drug Safety & Metabolism, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA. Pelletj@wyeth.com, Lundquist JT 4th, Gilbert AM, Alon N, Bex FJ, Bhat BM, Bursavich MG, Coleburn VE, Felix LA, Green DM, Green P, Hauze DB, Kharode YP, Lam HS, Lockhead SR, Magolda RL, Matteo JJ, Mehlmann JF, Milligan C, Murrills RJ, Pirrello J, Selim S, Sharp MC, Unwalla RJ, Vera MD, Wrobel JE, Yaworsky P, Bodine PV

المصدر: Journal of medicinal chemistry [J Med Chem] 2009 Nov 26; Vol. 52 (22), pp. 6962-5.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Osteogenesis/*drug effects , Piperidines/*pharmacology , Pyrimidines/*pharmacology , Wnt Proteins/*agonists , beta Catenin/*agonists, Animals ; Catalytic Domain ; Cell Line, Tumor ; Glycogen Synthase Kinase 3/antagonists & inhibitors ; Glycogen Synthase Kinase 3/chemistry ; Glycogen Synthase Kinase 3 beta ; Humans ; Mice ; Models, Molecular ; Piperidines/administration & dosage ; Piperidines/pharmacokinetics ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacokinetics ; Rats ; Signal Transduction/drug effects ; Wnt Proteins/metabolism ; beta Catenin/metabolism

المؤلفون: Liu PQ; Sangamo BioSciences, Inc., Richmond, CA 94804, USA., Tan S, Mendel MC, Murrills RJ, Bhat BM, Schlag B, Samuel R, Matteo JJ, de la Rosa R, Howes K, Reik A, Case CC, Bex FJ, Young K, Gregory PD

المصدر: Journal of biomolecular screening [J Biomol Screen] 2005 Jun; Vol. 10 (4), pp. 304-13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print Cited Medium: Print ISSN: 1087-0571 (Print) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation* , Protein Engineering* , Zinc Fingers*, Transcription Factors/*physiology, Amino Acid Sequence ; Base Sequence ; Cell Line ; DNA Primers ; Humans ; Molecular Sequence Data ; RNA, Messenger/genetics ; Receptor, Parathyroid Hormone, Type 1/chemistry ; Receptor, Parathyroid Hormone, Type 1/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Transcription Factors/chemistry