نتائج البحث - "Matteo Zini"

المساهمون: Di Marco, A., Gonzalez Paz, O., Fini, I., Vignone, D., Cellucci, A., Battista, M. R., Auciello, G., Orsatti, L., Zini, M., Monteagudo, E., Khetarpal, V., Rose, M., Dominguez, C., Herbst, T., Toledo-Sherman, L., Summa, V., Munoz-Sanjuan, I.

المصدر: Molecular Pharmaceutics. 16:2069-2082

مصطلحات موضوعية: Swine, Pharmaceutical Science, 02 engineering and technology, Pharmacology, efflux transporter, 030226 pharmacology & pharmacy, brain penetration, Rats, Sprague-Dawley, 0302 clinical medicine, Drug Discovery, Electric Impedance, Coculture Technique, Cells, Cultured, Cerebral Cortex, Endothelial Cell, Tight junction, Tight Junction, Drug discovery, Chemistry, Huntington's disease, Biological activity, 021001 nanoscience & nanotechnology, Huntington Disease, medicine.anatomical_structure, Blood-Brain Barrier, Molecular Medicine, Central Nervous System Agent, CNS, Astrocyte, 0210 nano-technology, ATP-Binding Cassette Transporter, Central nervous system, Blood–brain barrier, Models, Biological, Permeability, Tight Junctions, Capillary Permeability, 03 medical and health sciences, In vivo, Huntingtin Protein, medicine, Animals, Solute Carrier Protein, Solute Carrier Proteins, Animal, Endothelial Cells, medicine.disease, Coculture Techniques, Rats, Astrocytes, transport, Rat, ATP-Binding Cassette Transporters, Central Nervous System Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cfdbc702df6685a64c4f15855675c2
https://doi.org/10.1021/acs.molpharmaceut.9b00042

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6

An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer

المؤلفون: Paolo Rovero, Alfredo Paio, Annunziata D’Ercole, Matteo Zini, Francesca Nuti, L. Pacini, Anna Maria Papini, Arianna Ribecai, Giuseppina Sabatino

المصدر: Organic process research & development 25 (2021): 2754–2771. doi:10.1021/acs.oprd.1c00368
info:cnr-pdr/source/autori:D'Ercole, Annunziata; Pacini, Lorenzo; Sabatino, Giuseppina; Zini, Matteo; Nuti, Francesca; Ribecai, Arianna; Paio, Alfredo; Rovero, Paolo; Papini, Anna Maria/titolo:An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer/doi:10.1021%2Facs.oprd.1c00368/rivista:Organic process research & development/anno:2021/pagina_da:2754/pagina_a:2771/intervallo_pagine:2754–2771/volume:25

مصطلحات موضوعية: chemistry.chemical_classification, Materials science, Chromatography, technology transfer, Organic Chemistry, multigram-scale microwave-assisted peptide synthesis, Peptide, generic peptide drug, Microwave assisted, peptide production scale-up, peptide production pilot plant, chemistry, Phase (matter), generic peptide drug, peptide production scale-up, multigram-scale microwave-assisted peptide synthesis, technology transfer, peptide production pilot plant, Eptifibatide, medicine, Physical and Theoretical Chemistry, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29c2a766b49246c4ffd343dfd85a016
https://publications.cnr.it/doc/464122

7

An Optimized Scalable Fully Automated Solid-Phase Microwave-Assisted cGMP-Ready Process for the Preparation of Eptifibatide

المؤلفون: L. Pacini, Annunziata D’Ercole, Matteo Zini, Alfredo Paio, Paolo Rovero, Anna Maria Papini, Giuseppina Sabatino, Arianna Ribecai

المصدر: Organic process research & development (2021). doi:10.1021/acs.oprd.0c00490
info:cnr-pdr/source/autori:Papini, Anna Maria; Sabatino, Giuseppina; D'Ercole, Annunziata; Pacini, Lorenzo; Zini, Matteo; Ribecai, Arianna; Paio, Alfredo; Rovero, Paolo/titolo:An optimized scalable fully automated solid-phase microwave-assisted cGMP-ready process for the preparation of eptifibatide/doi:10.1021%2Facs.oprd.0c00490/rivista:Organic process research & development/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume

مصطلحات موضوعية: Materials science, Scale-up, Nanotechnology, active pharmaceutical ingredient, peptide, scale-up, oxidation, automated on-resin disulfide bond formation, off-resin disulfide bond formation, single reactor solid-phase synthesis, 010402 general chemistry, 01 natural sciences, Microwave assisted, chemistry.chemical_compound, Phase (matter), Oxidation, medicine, Peptide synthesis, Physical and Theoretical Chemistry, Active ingredient, 010405 organic chemistry, Organic Chemistry, Off-resin disulfide bond formation, 0104 chemical sciences, Fully automated, chemistry, Scientific method, Peptide, Single reactor solid-phase synthesis, Scalability, Eptifibatide, Active pharmaceutical ingredient, Automated on-resin disulfide bond formation, medicine.drug