نتائج البحث - "Matthew E. Cuellar"

1

Data from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863cc18ace5c45681a8e51a753a51ac2
https://doi.org/10.1158/1078-0432.c.6530129.v1

2

Supplementary Data Clean from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628f1d65cb215164fa22d2124af0f093
https://doi.org/10.1158/1078-0432.22479095

3

Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314

المؤلفون: Merlin Bresinsky, Jessica M. Strasser, Bernadette Vallaster, Peng Liu, William M. McCue, Jessica Fuller, Alexander Hubmann, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Carrie M. Wilmot, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, Steffen Pockes

المصدر: ACS Pharmacol Transl Sci

مصطلحات موضوعية: Pharmacology, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d23dbfa9d69eedac74f0ee60beb7c20
https://doi.org/10.1021/acsptsci.1c00251

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4

Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis

المؤلفون: Merlin Bresinsky, Jessica M. Strasser, Alexander Hubmann, Bernadette Vallaster, William M. McCue, Jessica Fuller, Gurpreet Singh, Kathryn M. Nelson, Matthew E. Cuellar, Barry C. Finzel, Karen H. Ashe, Michael A. Walters, Steffen Pockes

المصدر: Arch Pharm (Weinheim)

مصطلحات موضوعية: Alzheimer's disease, caspase‐2, caspase‐2 inhibitors, protein cleavage, tauopathies, Structure-Activity Relationship, 615 Pharmazie, Caspase 3, Drug Discovery, Proteolysis, Caspase 2, Pharmaceutical Science, Caspase Inhibitors, ddc:615, Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68b4fd317071c944f65f1b4f880f97e
https://pubmed.ncbi.nlm.nih.gov/35642311

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5

Synthesis of Guaianolide Analogues with a Tunable α-Methylene−γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity

المؤلفون: Matthew E. Cuellar, Daniel P Dempe, Kay M. Brummond, Paul A. Jackson, John C. Widen, Katherine F. M. Jones, Michael A. Walters, Henry A M Schares, Francois Grillet, Daniel A. Harki

المصدر: J Med Chem

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8068a1bbd168bb116fba4b4339fc5e39
https://doi.org/10.1021/acs.jmedchem.0c01464

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6

Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α

المصدر: Clin Cancer Res

مصطلحات موضوعية: Adult, Oncology, Cancer Research, medicine.medical_specialty, Antineoplastic Agents, Hormonal, medicine.drug_class, Estrogen receptor, Anastrozole, Breast Neoplasms, Clinical Trials, Phase IV as Topic, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Breast cancer, Exemestane, Internal medicine, medicine, Humans, Multicenter Studies as Topic, Prospective Studies, Aromatase, Aged, Randomized Controlled Trials as Topic, 030304 developmental biology, Aged, 80 and over, 0303 health sciences, biology, business.industry, Estrogen receptor binding, Letrozole, Estrogen Receptor alpha, Estrogens, Middle Aged, Prognosis, medicine.disease, Clinical Trials, Phase III as Topic, chemistry, Estrogen, Case-Control Studies, 030220 oncology & carcinogenesis, biology.protein, Female, business, Follow-Up Studies, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62b2345f3e9dce8b0043d62e7610287
https://doi.org/10.1158/1078-0432.ccr-19-3091

7

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

المصدر: Journal of Medicinal Chemistry. 63:4655-4684

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaf3a6eb34ac40b5b8c570155ff2a49
https://doi.org/10.1021/acs.jmedchem.9b02071

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8

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

المؤلفون: Girdhar Singh Deora, Aaron J. Oakley, Philip G. Board, Yuji Nakano, Jayme L. Dahlin, Padmaja Tummala, Jonathan B. Baell, Jessica M. Strasser, Yiyue Xie, Michael A. Walters, Melissa Rooke, Matthew E. Cuellar, Marco G. Casarotto

المصدر: Journal of Medicinal Chemistry. 63:2894-2914

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d34d91fc9b9fcdcb3312475033c026
https://doi.org/10.1021/acs.jmedchem.9b01391

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9

ALARM NMR for HTS Triage and Chemical Probe Validation

المؤلفون: Youlin Xia, Matthew E. Cuellar, Todd M. Rappe, Jessica M. Strasser, Kathryn M. Nelson, Michael A. Walters, Gianluigi Veglia, Gurpreet Singh, Jayme L. Dahlin

المصدر: Current Protocols in Chemical Biology. 10:91-117

مصطلحات موضوعية: 0301 basic medicine, 010405 organic chemistry, Drug discovery, Chemistry, High-throughput screening, Chemical biology, General Medicine, Mass spectrometry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Protein–protein interaction, NMR spectra database, 03 medical and health sciences, 030104 developmental biology, Molecule, Reactivity (chemistry)

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https://doi.org/10.1002/cpch.35

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10

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

المؤلفون: Dalia Barsyte-Lovejoy, Jonathan H. Shrimp, Jonathan B. Baell, Jayme L. Dahlin, Gurpreet Singh, Nghi H. Nguyen, Jessica M. Strasser, Matthew E. Cuellar, Kathryn M. Nelson, Magdalena M. Szewczyk, Jordan L. Meier, Michael A. Walters, Cheryl H. Arrowsmith, Peter Brown, Shawna Organ

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, Cell Survival, High-throughput screening, Science, Chemical biology, General Physics and Astronomy, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Drug Discovery, Bioassay, Humans, Epigenetics, Sulfhydryl Compounds, Enzyme Inhibitors, lcsh:Science, Histone Acetyltransferases, Multidisciplinary, biology, Molecular Structure, 010405 organic chemistry, Chemistry, Drug discovery, HEK 293 cells, General Chemistry, Histone acetyltransferase, In vitro, 0104 chemical sciences, 3. Good health, High-Throughput Screening Assays, 030104 developmental biology, HEK293 Cells, Biochemistry, biology.protein, MCF-7 Cells, lcsh:Q

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de9d782d92b733af7157eaa3d780672
https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f30

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