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1
المؤلفون: Lee-Yuh Pai, Aaron Corona, Harry R. Chobanian, John P. Felix, Matthew J. Clements, Karen Owens, Haifeng Tang, Brande Thomas-Fowlkes, Kathleen A. Sullivan, Alexander Pasternak, Caryn Hampton, Jessica Frie, Vincent Tong, Ron Ferguson, Jessica Liu, Birgit T. Priest, Barbara Pio, Yan Guo, Elizabeth Joshi, Nardos Teumelsan, Ling Xu, Martin Köhler, Joseph M. Metzger, Zach Guo, Kevin M. Maloney
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1109-1114
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, hERG, Pharmaceutical Science, Diuresis, Biochemistry, Natriuresis, Sulfone, 03 medical and health sciences, chemistry.chemical_compound, Heterocyclic Compounds, Rats, Inbred SHR, Drug Discovery, medicine, Animals, Moiety, Organic chemistry, Sulfones, Enzyme Inhibitors, Potassium Channels, Inwardly Rectifying, Diuretics, Molecular Biology, biology, Chemistry, Organic Chemistry, Rats, 030104 developmental biology, Drug Design, ROMK, biology.protein, Molecular Medicine, Diuretic, Selectivity
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2
المؤلفون: Melissa Kirkland, Randal M. Bugianesi, Melodie Christensen, Maria E. Trujillo, Michele Pachanski, Richard Tschirret-Guth, Josien Hubert B, Adam B. Weinglass, Sarah Souza, Ravi P. Nargund, Christopher W. Plummer, Andrew D. Howard, Joel Mane, Louis-Charles Campeau, Robert K. Orr, Daniel Kosinski, Xiaoping Zhang, Boonlert Cheewatrakoolpong, Jerry Di Salvo, Michael W. Miller, William K. Hagmann, Helen Chen, Steven L. Colletti, Andrew Nolting, Michael Wright, Matthew J. Clements, Murali Rajagopalan
المصدر: ACS Medicinal Chemistry Letters. 8:221-226
مصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, business.industry, Pancreatic islets, Organic Chemistry, Tachyphylaxis, Hypoglycemia, medicine.disease, Biochemistry, Partial agonist, 03 medical and health sciences, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Tolerability, Internal medicine, Diabetes mellitus, Free fatty acid receptor 1, Drug Discovery, medicine, Receptor, business
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3
المؤلفون: Julie A. DeMartino, James A. Milligan, Edward C. Sherer, Thomas F. Walsh, Richard Hajdu, Russell B. Lingham, Xinchun Tong, Michael Wolff, Denise M. Visco, Mikhail Reibarkh, Matthew J. Clements, Jeffrey T. Kuethe, Randy R. Miller, Christina B. Madsen-Duggan, Lisa M. Sonatore, Scott P. Salowe, Dominique Stickens, Jianmei Pang, Jeffrey J. Hale, Dan Zhou, John S. Debenham
المصدر: Journal of medicinal chemistry. 59(24)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, medicine.medical_specialty, Pyrimidine, medicine.drug_class, Anemia, Administration, Oral, Carboxamide, Pharmacology, Hypoxia-Inducible Factor-Proline Dioxygenases, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Internal medicine, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, medicine.disease, Bioavailability, Rats, Mice, Inbred C57BL, Pyridazines, Dose–response relationship, 030104 developmental biology, Endocrinology, Pyrimidines, Hypoxia-inducible factors, 030220 oncology & carcinogenesis, Molecular Medicine, Erythropoiesis
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4
المؤلفون: Yong Zhang, Jeffrey J. Hale, Andreas Verras, Shirly Pinto, Huaibing He, Zhu Shen, Urmi R. Bhatt, Elaine C. Tung, John S. Debenham, Matthew J. Clements, Dunlu Chen, Dong-Ming Shen, Wayne M. Geissler, Thomas H. Graham, JeanMarie Lisnock, Qing Chen, Suoyu Xu, Xiaohua Li, Margarita Garcia-Calvo, Wensheng Liu, Xinchun Tong, Judyann Wiltsie, Christina B. Madsen-Duggan, Jeffrey T. Kuethe
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:6228-6233
مصطلحات موضوعية: Male, Oral dose, Cyclohexane, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Carboxypeptidases, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Cyclohexanes, Drug Discovery, Animals, Obesity, Enzyme Inhibitors, Molecular Biology, Binding affinities, Serine protease, Molecular Structure, biology, Organic Chemistry, Mice, Inbred C57BL, Orally active, chemistry, biology.protein, Molecular Medicine, Ex vivo
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5
المؤلفون: Jeffrey J. Hale, Andrea Frassetto, Jing Chen Xiao, Xinchun Tong, Matthew J. Clements, Junying Wang, Richard Z. Chen, Tung M. Fong, Thomas F. Walsh, Julie Z. Lao, Ruey-Ruey C. Huang
المصدر: European journal of pharmacology. 584(2-3)
مصطلحات موضوعية: Male, medicine.medical_specialty, Cannabinoid receptor, Drug Inverse Agonism, medicine.medical_treatment, CHO Cells, Pharmacology, Transfection, Weight Gain, Binding, Competitive, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB2, Eating, Mice, Radioligand Assay, Cricetulus, Receptor, Cannabinoid, CB1, In vivo, Internal medicine, Cricetinae, medicine, Cannabinoid receptor type 2, Cyclic AMP, Inverse agonist, Animals, Humans, Receptor, Mice, Knockout, Dose-Response Relationship, Drug, Chemistry, Triazoles, Cyclohexanols, Recombinant Proteins, Rats, Mice, Inbred C57BL, Endocrinology, Mechanism of action, Blood-Brain Barrier, Injections, Intravenous, Cannabinoid, Anti-Obesity Agents, medicine.symptom, Injections, Intraperitoneal, Protein Binding