المؤلفون: Lee-Yuh Pai, Aaron Corona, Harry R. Chobanian, John P. Felix, Matthew J. Clements, Karen Owens, Haifeng Tang, Brande Thomas-Fowlkes, Kathleen A. Sullivan, Alexander Pasternak, Caryn Hampton, Jessica Frie, Vincent Tong, Ron Ferguson, Jessica Liu, Birgit T. Priest, Barbara Pio, Yan Guo, Elizabeth Joshi, Nardos Teumelsan, Ling Xu, Martin Köhler, Joseph M. Metzger, Zach Guo, Kevin M. Maloney

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1109-1114

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, hERG, Pharmaceutical Science, Diuresis, Biochemistry, Natriuresis, Sulfone, 03 medical and health sciences, chemistry.chemical_compound, Heterocyclic Compounds, Rats, Inbred SHR, Drug Discovery, medicine, Animals, Moiety, Organic chemistry, Sulfones, Enzyme Inhibitors, Potassium Channels, Inwardly Rectifying, Diuretics, Molecular Biology, biology, Chemistry, Organic Chemistry, Rats, 030104 developmental biology, Drug Design, ROMK, biology.protein, Molecular Medicine, Diuretic, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c5ab8a2efa0d6babaaad56a9277a67
https://doi.org/10.1016/j.bmcl.2016.10.032

المؤلفون: Melissa Kirkland, Randal M. Bugianesi, Melodie Christensen, Maria E. Trujillo, Michele Pachanski, Richard Tschirret-Guth, Josien Hubert B, Adam B. Weinglass, Sarah Souza, Ravi P. Nargund, Christopher W. Plummer, Andrew D. Howard, Joel Mane, Louis-Charles Campeau, Robert K. Orr, Daniel Kosinski, Xiaoping Zhang, Boonlert Cheewatrakoolpong, Jerry Di Salvo, Michael W. Miller, William K. Hagmann, Helen Chen, Steven L. Colletti, Andrew Nolting, Michael Wright, Matthew J. Clements, Murali Rajagopalan

المصدر: ACS Medicinal Chemistry Letters. 8:221-226

مصطلحات موضوعية: 0301 basic medicine, endocrine system, medicine.medical_specialty, business.industry, Pancreatic islets, Organic Chemistry, Tachyphylaxis, Hypoglycemia, medicine.disease, Biochemistry, Partial agonist, 03 medical and health sciences, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Tolerability, Internal medicine, Diabetes mellitus, Free fatty acid receptor 1, Drug Discovery, medicine, Receptor, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6942c1dd589ae2364bd7ea069018de04
https://doi.org/10.1021/acsmedchemlett.6b00443

المؤلفون: Julie A. DeMartino, James A. Milligan, Edward C. Sherer, Thomas F. Walsh, Richard Hajdu, Russell B. Lingham, Xinchun Tong, Michael Wolff, Denise M. Visco, Mikhail Reibarkh, Matthew J. Clements, Jeffrey T. Kuethe, Randy R. Miller, Christina B. Madsen-Duggan, Lisa M. Sonatore, Scott P. Salowe, Dominique Stickens, Jianmei Pang, Jeffrey J. Hale, Dan Zhou, John S. Debenham

المصدر: Journal of medicinal chemistry. 59(24)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, medicine.medical_specialty, Pyrimidine, medicine.drug_class, Anemia, Administration, Oral, Carboxamide, Pharmacology, Hypoxia-Inducible Factor-Proline Dioxygenases, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Internal medicine, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, medicine.disease, Bioavailability, Rats, Mice, Inbred C57BL, Pyridazines, Dose–response relationship, 030104 developmental biology, Endocrinology, Pyrimidines, Hypoxia-inducible factors, 030220 oncology & carcinogenesis, Molecular Medicine, Erythropoiesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d6d174fbd4111c1eb7c610defd4bfd
https://pubmed.ncbi.nlm.nih.gov/28002958

المؤلفون: Yong Zhang, Jeffrey J. Hale, Andreas Verras, Shirly Pinto, Huaibing He, Zhu Shen, Urmi R. Bhatt, Elaine C. Tung, John S. Debenham, Matthew J. Clements, Dunlu Chen, Dong-Ming Shen, Wayne M. Geissler, Thomas H. Graham, JeanMarie Lisnock, Qing Chen, Suoyu Xu, Xiaohua Li, Margarita Garcia-Calvo, Wensheng Liu, Xinchun Tong, Judyann Wiltsie, Christina B. Madsen-Duggan, Jeffrey T. Kuethe

المصدر: Bioorganic & Medicinal Chemistry Letters. 23:6228-6233

مصطلحات موضوعية: Male, Oral dose, Cyclohexane, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Carboxypeptidases, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Cyclohexanes, Drug Discovery, Animals, Obesity, Enzyme Inhibitors, Molecular Biology, Binding affinities, Serine protease, Molecular Structure, biology, Organic Chemistry, Mice, Inbred C57BL, Orally active, chemistry, biology.protein, Molecular Medicine, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a2d166f3f282c60327beda62c09726
https://doi.org/10.1016/j.bmcl.2013.09.094

المؤلفون: Jeffrey J. Hale, Andrea Frassetto, Jing Chen Xiao, Xinchun Tong, Matthew J. Clements, Junying Wang, Richard Z. Chen, Tung M. Fong, Thomas F. Walsh, Julie Z. Lao, Ruey-Ruey C. Huang

المصدر: European journal of pharmacology. 584(2-3)

مصطلحات موضوعية: Male, medicine.medical_specialty, Cannabinoid receptor, Drug Inverse Agonism, medicine.medical_treatment, CHO Cells, Pharmacology, Transfection, Weight Gain, Binding, Competitive, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB2, Eating, Mice, Radioligand Assay, Cricetulus, Receptor, Cannabinoid, CB1, In vivo, Internal medicine, Cricetinae, medicine, Cannabinoid receptor type 2, Cyclic AMP, Inverse agonist, Animals, Humans, Receptor, Mice, Knockout, Dose-Response Relationship, Drug, Chemistry, Triazoles, Cyclohexanols, Recombinant Proteins, Rats, Mice, Inbred C57BL, Endocrinology, Mechanism of action, Blood-Brain Barrier, Injections, Intravenous, Cannabinoid, Anti-Obesity Agents, medicine.symptom, Injections, Intraperitoneal, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc57d479efe58f8443f39c928588e2e6
https://pubmed.ncbi.nlm.nih.gov/18336811