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1
المؤلفون: Catherine Abbadie, Raul F. Alvaro, Lin-Lin Shiao, Mark Rosenbach, Lisa F. Frey, Marc D. Chioda, Ravi P. Nargund, Richard Hajdu, Kathleen Sullivan, Robert J. DeVita, Joseph F. Leone, Kevin M. Belyk, Jenna L. Terebetski, Amanda K. Makarewicz, Elliot J. Martel, Gino Salituro, Bindhu V. Karanam, Raman K. Bakshi, James Dellureficio, Selena Fung, Ping Liu, Linda Chang, Nina Jochnowitz, Shruti Mistry, Joyce Shuman, Linus S. Lin, Yan Guo, Maria Madeira, Shane W. Krska, Mark McLaughlin, Erin McGowan, Harry R. Chobanian, Jessica Alexander, Matthew J. Wyvratt, Qingmei Hong, Thomas J. Lanza
المصدر: ACS Medicinal Chemistry Letters. 5:717-721
مصطلحات موضوعية: business.industry, Organic Chemistry, Pharmacology, Biochemistry, In vitro, chemistry.chemical_compound, Pharmacokinetics, chemistry, In vivo, Fatty acid amide hydrolase, Drug Discovery, Neuropathic pain, Medicine, Potency, lipids (amino acids, peptides, and proteins), business, MK-4409, Oxazole
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2
المؤلفون: Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2330-2334
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, Partial agonist, Piperazines, Rats, Sprague-Dawley, Eating, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, In vivo, Drug Discovery, medicine, Animals, Urea, Obesity, Receptor, Molecular Biology, Organic Chemistry, Haplorhini, Rats, Disease Models, Animal, Piperazine, chemistry, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin
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3
المؤلفون: Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4399-4405
مصطلحات موضوعية: Agonist, medicine.medical_specialty, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Anti-Obesity Agents, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Spiro Compounds, Obesity, Molecular Biology, Mice, Knockout, Chemistry, Body Weight, Organic Chemistry, Amides, Rats, Endocrinology, Drug development, Anorectic, Receptor, Melanocortin, Type 4, Molecular Medicine
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4
المؤلفون: Howard Y. Chen, William J. Martin, D. Euan MacIntyre, Zhixiong Ye, Raman K. Bakshi, Alison M. Strack, Doreen E. Cashen, Jian Liu, Yingjie Lai, Tianying Jian, Constantin Tamvakopoulos, Nancy N. Tsou, Shuwen He, James Dellureficio, Tung M. Fong, Peter H. Dobbelaar, David H. Weinberg, Airu S. Chen, Qingmei Hong, Iyassu K. Sebhat, Tanya MacNeil, Christopher L. Franklin, Ravi P. Nargund, Ralph A. Stearns, Rui Tang, Richard G. Ball, Matthew J. Wyvratt, Randy R. Miller, Liangqin Guo, Qianping Peng
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2106-2110
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Cricetulus, Dogs, Erectile Dysfunction, Cricetinae, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Receptor, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Haplorhini, Rats, Bioavailability, Indans, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding
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5
المؤلفون: Marc L. Reitman, Cheng Guo, Theresa M. Kelly, Constantin Tamvakopoulos, Joseph M. Metzger, Tianying Jian, Howard Y. Chen, Arthur A. Patchett, Oksana C. Palyha, Alison M. Strack, Allan J. Goodman, Ravi P. Nargund, Peter H. Dobbelaar, Yanqing Kan, Mark Hadden, Larry Yet, Peter R. Guzzo, Qianping Peng, Linus S. Lin, Shuwen He, Lauren P. Shearman, Alan J. Henderson, Carina P. Tan, Sargent Bruce J, Xiao-Ming Guan, Scott D. Feighner, Iyassu K. Sebhat, Jie Pan, Jian Liu, Donald J. Marsh, Matthew J. Wyvratt, Andrew D. Howard, Megan Ruenz
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1913-1917
مصطلحات موضوعية: Agonist, medicine.drug_class, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Molecular Biology, Biphenyl, Chemistry, Drug discovery, fungi, Organic Chemistry, Imidazoles, Rats, Bombesin receptor, Bioavailability, Receptors, Bombesin, Molecular Medicine, Bombesin Receptor Subtype-3
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6
المؤلفون: Dan A. Ostlind, Marlene D. Drag, Matthew J. Wyvratt, Pierre deMontigny, David W. Fink, Steven L. Colletti, Wesley L. Shoop, Michelle B. Ayer, Chunshi Li, Steve Salva, Michelle Zakson, Lynn M. Warmke, Peter T. Meinke, Thomas L. Shih, Dong Ok, Michael H. Fisher, B.F. Michael, Dennis M. Schmatz, Julie Lim
المصدر: Journal of Medicinal Chemistry. 52:3505-3515
مصطلحات موضوعية: Male, Insecticides, Flea, Indoles, Administration, Oral, Pharmacology, Insect Control, Indole Alkaloids, Toxicology, Mice, chemistry.chemical_compound, Dogs, Ticks, Pharmacokinetics, Oral administration, In vivo, Drug Discovery, Animals, Potency, Tissue Distribution, Fipronil, biology, biology.organism_classification, Pulicidae, Adipose Tissue, chemistry, Cats, Siphonaptera, Molecular Medicine, Female, Ixodidae
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7
المؤلفون: Tesfaye Biftu, Dennis M. Schmatz, Penny Sue Leavitt, Paul A. Liberator, Matthew J. Wyvratt, Anne Gurnett, John Mathew, Michael H. Fisher, Donald Thompson, Gilles Ouvry, Andrew Scribner, Chris Brown, Joseph A. Moore
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:1517-1521
مصطلحات موضوعية: Indoles, Pyridines, Antiparasitic, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Poultry, chemistry.chemical_compound, In vivo, Drug Discovery, Cyclic GMP-Dependent Protein Kinases, medicine, Animals, Potency, Molecular Biology, Indole test, Coccidiosis, Chemistry, Organic Chemistry, Biological activity, Combinatorial chemistry, In vitro, Coccidiostats, Molecular Medicine, Amine gas treating, Eimeria tenella
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8
المؤلفون: Susan Meitz, John Mathew, Penny Sue Leavitt, Anne Gurnett, Donald Thompson, Paul A. Liberator, Michael H. Fisher, Tesfaye Biftu, Dennis M. Schmatz, Andrew Scribner, Matthew J. Wyvratt, Chris Brown
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:5263-5267
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Chemical synthesis, chemistry.chemical_compound, In vivo, Drug Discovery, Cyclic GMP-Dependent Protein Kinases, Animals, Combinatorial Chemistry Techniques, Potency, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Imidazoles, Biological activity, In vitro, Thiazoles, Enzyme, chemistry, Coccidiostats, Molecular Medicine, Eimeria, Amine gas treating
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9
المؤلفون: Heather L. Sings, Mark T. Goulet, Matthew J. Wyvratt, Iyassu K. Sebhat, Liangqin Guo, Rui Tang, Ravi P. Nargund, Qianping Peng, Euan Macintyre, Feroze Ujjainwalla, Constantin Tamvakopoulos, Zhixiong Ye, Lex H.T. Van der Ploeg, David H. Weinberg, Tanya MacNeil, John Huber
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3242-3247
مصطلحات موضوعية: Agonist, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Pyrrolidine, Structure-Activity Relationship, chemistry.chemical_compound, Melanocortin receptor, Drug Discovery, medicine, Humans, Structure–activity relationship, Receptor, Telomerase, Molecular Biology, G protein-coupled receptor, Molecular Structure, digestive, oral, and skin physiology, Organic Chemistry, Stereoisomerism, chemistry, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin
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10
المؤلفون: Matthew J. Wyvratt, Vivien A. Warren, John P. Felix, Maria L. Garcia, Scott B. Hoyt, William H. Parsons, Kathryn A. Lyons, Xiaohua Li, Michael H. Fisher, Clare London, McHardy M. Smith, Birgit T. Priest, Gregory J. Kaczorowski, Doreen E. Cashen, William J. Martin, D. Euan MacIntyre, Brande S. Williams
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1963-1966
مصطلحات موضوعية: medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, Epilepsy, Sodium channel blocker, Drug Discovery, Fluorescence Resonance Energy Transfer, medicine, Animals, Humans, Molecular Biology, Membrane potential, Benzodiazepinones, Electroshock, Molecular Structure, Chemistry, Sodium channel, Organic Chemistry, Biological activity, medicine.disease, Ether-A-Go-Go Potassium Channels, Rats, Electrophysiology, Anticonvulsant, Molecular Medicine, Anticonvulsants, Sodium Channel Blockers