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المؤلفون: Brian Belmontes, Jodi Moriguchi, Grace Chung, Jan Sun, Maria Stefania S. Ninniri, Kelly Hanestad, Kui Chen, John D. McCarter, Upendra P. Dahal, Sudipa Ghimire-Rijal, Yue Hao, Christopher P. Mohr, Xinchao Yu, Matthew G. Rees, Melissa Ronan, Jennifer Roth, Sheroy Minocherhomji, Jennifer R. Allen, Matthew P. Bourbeau, Paul E. Hughes, Nuria A Tamayo, Marc N. Payton
المصدر: Cancer Research. 83:516-516
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f35caf28e90cc86d95a85ee0af8c0a54
https://doi.org/10.1158/1538-7445.am2023-516 -
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المؤلفون: Nuria A. Tamayo, Matthew P. Bourbeau, Jennifer R. Allen, Kate S. Ashton, Jian Jeffrey Chen, Matthew R. Kaller, Thomas T. Nguyen, Nobuko Nishimura, Liping H. Pettus, Mary Walton, Brian Belmontes, Jodi Moriguchi, Kui Chen, John D. McCarter, Kelly Hanestad, Grace Chung, Maria Stefania S. Ninniri, Jan Sun, Leszek Poppe, Chris Spahr, John Hui, Lei Jia, Tian Wu, Upendra P. Dahal, Katheryne Z. Edson, Marc Payton
المصدر: Journal of medicinal chemistry. 65(6)
مصطلحات موضوعية: Cell Death, Tubulin, Neoplasms, Drug Discovery, Molecular Medicine, Humans, Kinesins, Mitosis, Spindle Apparatus
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المؤلفون: Jan Sun, Brain Belmontes, Jodi Moriguchi, Grace Chung, Kui Chen, John D. McCarter, Upendra P. Dahal, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Sheroy Minocherhomji, Matthew P. Bourbeau, Jennifer R. Allen, Angela Coxon, Paul E. Hughes, Nuria Tamayo, Marc N. Payton
المصدر: Cancer Research. 82:LB202-LB202
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c3d40cb33041e429cf2ff723239d4fd0
https://doi.org/10.1158/1538-7445.am2022-lb202 -
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المؤلفون: Paul H. Wen, Stephen J. Wood, Qingyian Liu, Aaron C. Siegmund, Liping H. Pettus, Adrian Nanez, Matthew P. Bourbeau, Jennifer R. Allen, Michael D. Bartberger, Douglas A. Whittington, Jodi Bradley, James R. Manning, Kui Chen, Dean Hickman, Michael E. Johnson
المصدر: Journal of medicinal chemistry. 63(5)
مصطلحات موضوعية: Cyclopropanes, Male, Models, Molecular, Thiazines, Pharmacology, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, In vivo, Alzheimer Disease, mental disorders, Drug Discovery, Amyloid precursor protein, medicine, Animals, Aspartic Acid Endopeptidases, Humans, Enzyme Inhibitors, IC50, 030304 developmental biology, Hypopigmentation, Melanosome, chemistry.chemical_classification, 0303 health sciences, Amyloid beta-Peptides, biology, Chemistry, Brain, Peptide Fragments, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Pharmacodynamics, biology.protein, Molecular Medicine, medicine.symptom, Amyloid Precursor Protein Secretases, Selectivity
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المؤلفون: Michael D. Bartberger, Michael Croghan, Carolyn Moyer, David Lloyd, Rod Cupples, Seifu Tadesse, Nobuko Nishimura, Ke Kong, Gwyneth Van, Christopher H. Fotsch, Randall W. Hungate, David J. St. Jean, Kevin Yang, Kate Ashton, Mark H. Norman, Samer Chmait, Longbin Liu, Lewis D. Pennington, Fang-Tsao Hong, Matthew P. Bourbeau, Clarence Hale, Jiandong Zhang, Aaron C. Siegmund, Jie Chen, Christopher M. Tegley, Steven R. Jordan, Kristin L. Andrews, Klaus Michelsen, Guomin Yao, Glenn Sivits, Andreas Reichelt, Joan Helmering
المصدر: Journal of Medicinal Chemistry. 58:9663-9679
مصطلحات موضوعية: Blood Glucose, Male, Models, Molecular, Cytoplasm, Stereochemistry, Active Transport, Cell Nucleus, Molecular Conformation, Stereoisomerism, Thiophenes, Plasma protein binding, Crystallography, X-Ray, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Glucokinase, Drug Discovery, medicine, Animals, Hypoglycemic Agents, Structure–activity relationship, Lone pair, Adaptor Proteins, Signal Transducing, Cell Nucleus, Sulfonamides, Glucokinase regulatory protein, biology, Chemistry, medicine.anatomical_structure, Microsomes, Liver, biology.protein, Molecular Medicine, Nucleus, Lead compound, Protein Binding
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المؤلفون: Wenyuan Qian, Michael J. Frohn, Michael D. Bartberger, Stephen J. Wood, Albert Amegadzie, Aaron C. Siegmund, Ning Chen, Jennifer R. Allen, Dean Hickman, Helming Tan, Paul H. Wen, Longbin Liu, Matthew P. Bourbeau, Douglas A. Whittington
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127240
مصطلحات موضوعية: Hydrocarbons, Fluorinated, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Alkenes, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Development, Amide, Drug Discovery, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, ADME, Olefin fiber, Dose-Response Relationship, Drug, 010405 organic chemistry, Organic Chemistry, Stereoisomerism, Amides, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, chemistry, Molecular Medicine, Bioisostere, Amyloid Precursor Protein Secretases
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المؤلفون: Michael D. Bartberger, Matthew P. Bourbeau
المصدر: Journal of Medicinal Chemistry. 58:525-536
مصطلحات موضوعية: Drug, Human disease, Research groups, Chemistry, In vivo, media_common.quotation_subject, Drug Discovery, Acetyl-CoA carboxylase, Molecular Medicine, Pharmacology, Metabolic disease, media_common, Pyruvate carboxylase
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المؤلفون: James Meyer, Kevin Salyers, Minghan Wang, Matthew P. Bourbeau, Yang Xu, Melissa Graham, Christopher H. Fotsch, John G. Allen, Wei Gu, Michael D. Bartberger, Mark R. Fielden, Murielle M. Véniant, Ki-Won Kim, James Busby, Aaron C. Siegmund, Renee Komorowski, Hong Shu
المصدر: Journal of Medicinal Chemistry. 56:10132-10141
مصطلحات موضوعية: Mice, Obese, Oxadiazole, Pharmacology, Piperazines, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Mice, Knockout, Oxadiazoles, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Acetyl-CoA carboxylase, Metabolism, Diet, Pyruvate carboxylase, Mice, Inbred C57BL, Piperazine, Biochemistry, Molecular Medicine, Acetyl-CoA Carboxylase
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المؤلفون: Matthew P. Bourbeau, Rider James Thomas, Douglas Hoffman, Xin Huang, Randall W. Hungate, Holger Monenschein, Qingping Zeng, Daniel J. Freeman, Shiwen Zhang, Andrew Tasker, Matthew R. Lee, Celia Dominguez, Elizabeth Tominey, Chun Li, Xiaoling Zhang, Vellarkad N. Viswanadhan, G. Erich Wohlhieter, Guomin Yao, Harvey Yamane, Julie A. Lofgren
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1652-1656
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, Biochemistry, MAP2K7, Mice, Structure-Activity Relationship, Catalytic Domain, Neoplasms, Thiadiazoles, Drug Discovery, Animals, Phosphorylation, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, Aminothiadiazole, biology, Chemistry, Akt/PKB signaling pathway, Cyclin-Dependent Kinase 2, Organic Chemistry, Cyclin-dependent kinase 2, Isoquinolines, Cyclic AMP-Dependent Protein Kinases, Rats, Thiazoles, Cyclin-dependent kinase complex, biology.protein, Molecular Medicine, Proto-Oncogene Proteins c-akt
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المؤلفون: Fang-Tsao Hong, Christopher H. Fotsch, Xianghong Wang, Qingping Zeng, John G. Allen, G. Erich Wohlhieter, Chun Li, Yihong Zhou, Guomin Yao, Seifu Tadesse, Matthew P. Bourbeau, Chester Chenguang Yuan, Sekhar Surapaneni, Matthew R. Lee, Gary L. Skiles, Raju Subramanian, Xiaochun Zhu
المصدر: Chemical Research in Toxicology. 23:653-663
مصطلحات موضوعية: In silico, Toxicology, Models, Biological, Serine, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Animals, Humans, Threonine, Protein kinase B, Molecular Structure, biology, Chemistry, Cytochrome P450, General Medicine, Glutathione, In vitro, Rats, Thiazoles, Biochemistry, Microsomes, Liver, Microsome, biology.protein, Epoxy Compounds, Proto-Oncogene Proteins c-akt