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المؤلفون: Nuria A. Tamayo, Matthew P. Bourbeau, Jennifer R. Allen, Kate S. Ashton, Jian Jeffrey Chen, Matthew R. Kaller, Thomas T. Nguyen, Nobuko Nishimura, Liping H. Pettus, Mary Walton, Brian Belmontes, Jodi Moriguchi, Kui Chen, John D. McCarter, Kelly Hanestad, Grace Chung, Maria Stefania S. Ninniri, Jan Sun, Leszek Poppe, Chris Spahr, John Hui, Lei Jia, Tian Wu, Upendra P. Dahal, Katheryne Z. Edson, Marc Payton
المصدر: Journal of medicinal chemistry. 65(6)
مصطلحات موضوعية: Cell Death, Tubulin, Neoplasms, Drug Discovery, Molecular Medicine, Humans, Kinesins, Mitosis, Spindle Apparatus
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المؤلفون: Robert P. Farrell, Ted Judd, Matthew R. Kaller, Paul John Dransfield
المصدر: ACS Symposium Series ISBN: 9780841298644
ACS Symposium Seriesمصطلحات موضوعية: Agonist, business.industry, medicine.drug_class, Heart failure, Medicine, Identification (biology), Pharmacology, business, medicine.disease
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::746f490493d43b492a9639bd3526d61c
https://doi.org/10.1021/bk-2020-1369.ch004 -
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المؤلفون: Jeffrey Clarine, Qingyian Liu, Beth D. Youngblood, Chester Chenguang Yuan, Michelle Horner, James Brown, Jian J. Chen, Michael D. Bartberger, Vu Van Ma, Matthew R. Kaller, Carl D. Davis, Maosheng Zhang, Thomas T. Nguyen, Narender R. Gavva, Scott Harried, Sonya G. Lehto, Jennifer R. Allen, Holger Monenschein, Daniel B. Horne, Vijay Keshav Gore, Wenge Zhong, Kaustav Biswas
المصدر: Journal of medicinal chemistry. 61(18)
مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, Migraine Disorders, TRPM Cation Channels, Pyrimidinones, Pharmacology, Niacin, Pathogenesis, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Seizures, Drug Discovery, TRPM8, medicine, Animals, Humans, Molecular Structure, Drug discovery, Chemistry, Antagonist, medicine.disease, Rats, Clinical trial, Calcium Channel Agonists, 030104 developmental biology, Nicotinic agonist, medicine.anatomical_structure, Migraine, 030220 oncology & carcinogenesis, Peripheral nervous system, Microsomes, Liver, Molecular Medicine, Anticonvulsants
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المؤلفون: Essa Hu, Samer Chmait, Thomas T. Nguyen, Amy Porter, Kristin L. Andrews, Silke Miller, Carl Davis, Jennifer R. Allen, Robert M. Rzasa, James J. S. Treanor, Alexander J. Pickrell, Adrie D. Jones, Roxanne Kunz, Daniel B. Horne, Xiaoning Zhao, Matthew R. Kaller, Holger Monenschein, Ning Chen, Heather Eastwood, Jeffrey Clarine, Michael J. Frohn, Andreas Reichelt
المصدر: Bioorganic & Medicinal Chemistry. 22:6570-6585
مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Stereochemistry, Clinical Biochemistry, Azetidine, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Solubility, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Phosphoric Diester Hydrolases, Chemistry, Organic Chemistry, Bioavailability, Enzyme, Quinolines, Alkoxy group, Molecular Medicine, Lead compound, Ex vivo
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المؤلفون: Kathleen S. Keegan, Hong Shu, Michael D. Bartberger, Julie M. Bailis, Guomin Yao, Jennifer Dao, Matthew R. Kaller, Andreas Reichelt, John G. Allen, Margaret F. Weidner
المصدر: European Journal of Medicinal Chemistry. 80:364-382
مصطلحات موضوعية: Male, Cell Cycle Proteins, Chemistry Techniques, Synthetic, Protein Serine-Threonine Kinases, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Viability assay, Phosphorylation, Kinase activity, Protein kinase A, Protein Kinase Inhibitors, Pharmacology, DNA synthesis, Chemistry, Kinase, Organic Chemistry, DNA replication, Minichromosome Maintenance Complex Component 2, General Medicine, HCT116 Cells, Xenograft Model Antitumor Assays, Rats, Molecular Docking Simulation, Thiazoles, Biochemistry, Cancer cell, Female
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المؤلفون: Kui Chen, Daniel La, Michael D. Bartberger, Russell Graceffa, Thomas T. Nguyen, Tisha San Miguel, E. Allen Sickmier, Ryan Brown, Vivian S. W. Li, Stephen J. Wood, Lewis D. Pennington, James Brown, Jianhua Zhang, Craig E. Masse, Holger Monenschein, Patricia Lopez, Dean Hickman, Brian K. Albrecht, May Xue, Michael Croghan, Scott Harried, Safura Babu-Khan, Yuan Cheng, Yi Luo, Martin Citron, Matthew R. Kaller, Patricia Amarante, Wenge Zhong, Paul H. Wen, Bryant Yang, Robert C. Wahl, Matthew Weiss, Chuck Kriemen, Stephen Hitchcock, Vinod F. Patel, Ted Judd, Toni Williamson
المصدر: ACS Medicinal Chemistry Letters. 3:886-891
مصطلحات موضوعية: chemistry.chemical_classification, Enzyme, biology, Chemistry, Cerebral Spinal Fluid, Organic Chemistry, Drug Discovery, β secretase, Amyloid precursor protein, biology.protein, Potency, Pharmacology, Biochemistry
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المؤلفون: Yuan Cheng, Matthew R. Kaller, Steven W. Louie, Martin Citron, Lewis D. Pennington, Daniel S. La, Matthew Weiss, Stephen J. Wood, Wenge Zhong, Michael Croghan, Toni Williamson, Scott Harried, James Brown, Kui Chen, Tisha San Miguel, Ronke Imbeah-Ampiah, Holger Monenschein, Qiufen Xue, Hongbing Huang, Patricia Lopez, Claire Rattan, Thomas Dineen, Daniel B. Horne, E. Allen Sickmier, Dean Hickman, Safura Babu-Khan, Charles Kreiman, Vivian S. W. Li, Paul H. Wen, Michael D. Bartberger, Russell Graceffa, Robert C. Wahl, Thomas T. Nguyen, Bryant Yang, Ted Judd, Joel Esmay, Vinod F. Patel, Stephen Hitchcock
المصدر: Journal of Medicinal Chemistry. 55:9009-9024
مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Administration, Oral, Biological Availability, Stereoisomerism, Pharmacology, Crystallography, X-Ray, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Pharmacokinetics, Oral administration, Drug Discovery, Ethylamines, Animals, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, ATP Binding Cassette Transporter, Subfamily B, Member 1, chemistry.chemical_classification, Amyloid beta-Peptides, Brain, Dioxolanes, Macaca mulatta, Peptide Fragments, Rats, Bioavailability, Protein Transport, Enzyme, chemistry, Biochemistry, Drug Design, Microsomes, Liver, Microsome, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases
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المؤلفون: Paul H. Wen, Robert C. Wahl, Michael Croghan, Ronke Imbeah-Ampiah, Paul Acton, Stephen J. Wood, Charles Kreiman, Vivian S. W. Li, Qiufen Xue, Lewis D. Pennington, Safura Babu-Khan, Daniel B. Horne, Thomas Dineen, Wenge Zhong, Scott Harried, Douglas A. Whittington, Dean Hickman, James Brown, Martin Citron, Matthew Weiss, Daniel S. La, Holger Monenschein, Bryant Yang, E. Allen Sickmier, Tisha San Miguel, Robert T. Dunn, Russell Graceffa, Patricia Lopez, Toni Williamson, Hongbing Huang, Yuan Cheng, Kui Chen, Matthew R. Kaller, Michael D. Bartberger, Steven W. Louie, Hugo M. Vargas, Stephen Hitchcock, Thomas T. Nguyen, Vinod F. Patel, Ted Judd, Joel Esmay
المصدر: Journal of Medicinal Chemistry. 55:9025-9044
مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Swine, Administration, Oral, Peptide, In Vitro Techniques, Pharmacology, Crystallography, X-Ray, Inhibitory postsynaptic potential, Cell Line, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Pharmacokinetics, mental disorders, Drug Discovery, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Humans, Spiro Compounds, Dosing, chemistry.chemical_classification, Amyloid beta-Peptides, Cardiovascular safety, biology, Brain, Stereoisomerism, Blood Proteins, Peptide Fragments, Rats, Bioavailability, Thiazoles, Enzyme, Biochemistry, chemistry, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Protein Binding
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المؤلفون: Matthew R. Kaller, Stephen Hitchcock, Michael D. Bartberger, Wenge Zhong, Holger Monenschein, Daniel B. Horne
المصدر: Tetrahedron Letters. 50:5452-5455
مصطلحات موضوعية: Aryl, Organic Chemistry, Xenon difluoride, Biochemistry, Combinatorial chemistry, Chloride, chemistry.chemical_compound, chemistry, Drug Discovery, Pyridine, medicine, Computational analysis, Methylene, medicine.drug
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المؤلفون: Michael Croghan, Patricia Lopez, Scott Harried, Matthew R. Kaller, Randall W. Hungate, Paul J. Reider, Wenge Zhong
المصدر: The Journal of Organic Chemistry. 74:5975-5982
مصطلحات موضوعية: Nucleophilic addition, Nitrogen, Stereochemistry, Chemistry, Organic Chemistry, Synthon, Imine, Sulfonium Compounds, Epoxide, Stereoisomerism, Glyceraldehyde, Chemical synthesis, Substrate Specificity, chemistry.chemical_compound, Reagent, Epoxy Compounds, Stereoselectivity, Amino Acids