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1دورية أكاديمية
المؤلفون: Paul-Christian Burda, Matthias A Roelli, Marco Schaffner, Shahid M Khan, Chris J Janse, Volker T Heussler
المصدر: PLoS Pathogens, Vol 11, Iss 3, p e1004760 (2015)
مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: Roch-Philippe Charles, Marc-David Ruepp, Matthias A. Roelli, Stefan Forster, Philippe Krebs, Renaud Maire, Frido Brühl, Matthias S. Dettmer, Sergio Di Pancrazio, Roland Giger, Marie-Hélène Wasmer, Aurel Perren, Anja Schmitt, Christian M. Schürch
المصدر: Schürch, C M, Roelli, M A, Forster, S, Wasmer, M-H, Brühl, F, Maire, R, Di Pancrazio, S, Ruepp, M-D, Giger, R, Perren, A, Schmitt, A, Krebs, P, Charles, R-P & Dettmer, M S 2019, ' Targeting CD47 in anaplastic thyroid carcinoma enhances tumor phagocytosis by macrophages and is a promising therapeutic strategy ', Thyroid, vol. 29, no. 7, pp. 979-992 . https://doi.org/10.1089/thy.2018.0555
Schürch, Christian M; Rölli, Matthias A.; Forster, Stefan; Wasmer, Marie-Hélène; Brühl, Frido; Maire, Renaud S.; Di Pancrazio, Sergio; Ruepp, Marc-David; Giger, Roland; Perren, Aurel; Schmitt, Anja M.; Krebs, Philippe; Charles, Roch-Philippe; Dettmer, Matthias S. (2019). Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy. Thyroid, 29(7), pp. 979-992. Mary Ann Liebert 10.1089/thy.2018.0555 <http://dx.doi.org/10.1089/thy.2018.0555>
Thyroidمصطلحات موضوعية: Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Thyroid Carcinoma, Anaplastic, B7-H1 Antigen, Mice, 0302 clinical medicine, Endocrinology, 540 Chemistry, Macrophage, Molecular Targeted Therapy, Receptors, Immunologic, 610 Medicine & health, CD47, Aged, 80 and over, medicine.diagnostic_test, tumor-associated macrophages, anaplastic thyroid carcinoma, phagocytosis, Middle Aged, Immunohistochemistry, programmed cell death 1, 030220 oncology & carcinogenesis, Female, Immunotherapy, Phagocytosis, CD47 Antigen, Mice, Transgenic, 030209 endocrinology & metabolism, In Vitro Techniques, Flow cytometry, 03 medical and health sciences, Immune system, Cell Line, Tumor, Signal-regulatory protein alpha, medicine, Animals, Humans, Thyroid Neoplasms, Aged, business.industry, Macrophages, Thyroid Cancer and Nodules, immune checkpoints, Antigens, Differentiation, Xenograft Model Antitumor Assays, Cancer cell, Cancer research, 570 Life sciences, biology, Tumor Escape, business, Neoplasm Transplantation
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca805573fdaeb1819e23f6886bd6eb3b
https://doi.org/10.1089/thy.2018.0555 -
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المؤلفون: Serafina Calarco, Guy T. Giuffredi, James B. Lorens, Roch-Philippe Charles, Lasse Evensen, Amandine Stooss, Lars Ruddigkeit, Jean-Louis Reymond, Mahendra Awale, Matthias A. Roelli, Marion Poirier
المصدر: ChemMedChem. 14:224-236
مصطلحات موضوعية: Models, Molecular, Angiogenesis, Phenotypic screening, Cell Culture Techniques, Drug Evaluation, Preclinical, 01 natural sciences, Biochemistry, Cell Line, Small Molecule Libraries, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Human Umbilical Vein Endothelial Cells, medicine, Humans, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, IC50, Cell Proliferation, Pharmacology, Molecular Structure, Triazines, 010405 organic chemistry, Chemistry, Kinase, Cell growth, Organic Chemistry, Assay, 0104 chemical sciences, 3. Good health, Angiogenesis inhibitor, 010404 medicinal & biomolecular chemistry, Phenotype, Mechanism of action, Molecular Medicine, Angiogenesis Inducing Agents, Biological Assay, medicine.symptom, Acyltransferases, Software, Protein Binding
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المؤلفون: Dorothée Ruffieux-Daidié, Matthias A. Roelli, Amandine Stooss, Roch-Philippe Charles, Matthias S. Dettmer, Oussama ElMokh, Wayne A. Phillips, Jürg Gertsch
المصدر: Oncotarget
El Mokh, Oussama; Ruffieux-Daidié, Dorothée; Rölli, Matthias Andreas; Stooss, Amandine; Phillips, Wayne A; Gertsch, Jürg; Dettmer, Matthias; Charles, Roch-Philippe (2017). Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo. OncoTarget, 8(15), pp. 24604-24620. Impact Journals LLC 10.18632/oncotarget.15599 <http://dx.doi.org/10.18632/oncotarget.15599>مصطلحات موضوعية: 0301 basic medicine, Combination therapy, 610 Medicine & health, BRAF, Thyroid carcinoma, 03 medical and health sciences, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, In vivo, Cell Line, Tumor, Survivin, medicine, thyroid cancer, Animals, Humans, Thyroid Neoplasms, Thyroid cancer, PI3K/AKT/mTOR pathway, Cell Proliferation, Mitogen-Activated Protein Kinase Kinases, business.industry, MEK inhibitor, Thyroid, genetically engineered mice, Drug Synergism, medicine.disease, Pi3K, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Immunology, Cancer research, combination treatment, 570 Life sciences, biology, Female, business, Research Paper
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2988557e014e34ca455e20037a426a9b
http://europepmc.org/articles/PMC5421873 -
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المؤلفون: Matthias S. Dettmer, Matthias A. Roelli, Rebecca A. Dumont, Roch-Philippe Charles, Oussama ElMokh, Wayne A. Phillips, Martin A. Walter, Amandine Stoss, Piotr Radojewski, Vincent Taelman
المصدر: El Mokh, Oussama; Taelmann, Vincent; Radojewski, Piotr; Rölli, Matthias Andreas; Stooss, Amandine; Dumont, Rebecca A; Dettmer, Matthias; Phillips, Wayne; Walter, Martin Alexander; Charles, Roch-Philippe (2019). MEK inhibition induces therapeutic iodine uptake in a murine model of anaplastic thyroid cancer. Journal of nuclear medicine, 60(7), pp. 917-923. Society of Nuclear Medicine 10.2967/jnumed.118.216721 <http://dx.doi.org/10.2967/jnumed.118.216721>
مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, medicine.medical_treatment, Intracellular Space, 610 Medicine & health, Mitogen-activated protein kinase kinase, Thyroid Carcinoma, Anaplastic, Targeted therapy, Iodine Radioisotopes, 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, RNA, Messenger, Thyroid Neoplasms, Anaplastic thyroid cancer, Vemurafenib, Protein kinase A, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase Kinases, Symporters, MEK inhibitor, Biological Transport, medicine.disease, Disease Models, Animal, 030104 developmental biology, 030220 oncology & carcinogenesis, Symporter, Cancer research, 570 Life sciences, biology, medicine.drug
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4511738edfa1ba4fc5b8b4d21bbb0704
https://pubmed.ncbi.nlm.nih.gov/30464041 -
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المؤلفون: Dorothée Ruffieux-Daidié, Roch-Philippe Charles, Oussama ElMokh, Matthias A. Roelli, Amandine Stooss, Matthias S. Dettmer, Wayne A. Phillips
المصدر: Rölli, Matthias Andreas; Ruffieux-Daidiée, Dorothée; Stooss, Amandine; El Mokh, Oussama; Phillips, Wayne A; Dettmer, Matthias; Charles, Roch-Philippe (2017). PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors. OncoTarget, 8(61), pp. 103207-103222. Impact Journals LLC 10.18632/oncotarget.21732 <http://dx.doi.org/10.18632/oncotarget.21732>
Oncotargetمصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, medicine.medical_specialty, endocrine system diseases, Mutant, 610 Medicine & health, Biology, medicine.disease_cause, BRAFV600E inhibitor resistance, Thyroid carcinoma, 03 medical and health sciences, 0302 clinical medicine, In vivo, Internal medicine, paradoxical ERK activation, medicine, aggressive thyroid cancer, Vemurafenib, Thyroid cancer, neoplasms, Mutation, Kinase, Melanoma, Cancer, medicine.disease, Endocrinology, 030104 developmental biology, Oncology, overcoming resistance, PI3’K inhibitors, 030220 oncology & carcinogenesis, Cancer research, 570 Life sciences, biology, medicine.drug, Research Paper
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1124a08075e4405f7107455444d678de
https://boris.unibe.ch/109404/1/21732-309056-4-PB.pdf -
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المؤلفون: Aurel Perren, Marc-David Ruepp, S. Di Pancrazio, Marie-Hélène Wasmer, Frido Brühl, Roch-Philippe Charles, Anja Schmitt, Christian M. Schürch, Philippe Krebs, Matthias A. Roelli, Renaud Maire, Matthias S. Dettmer, Stefan Forster
المصدر: Radiotherapy and Oncology. 132:91
مصطلحات موضوعية: Anaplastic thyroid carcinoma, Oncology, business.industry, CD47, Cancer research, Medicine, Radiology, Nuclear Medicine and imaging, Hematology, business, Signal
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المؤلفون: Lasse Evensen, Mahendra Awale, James B. Lorens, Guy T. Giuffredi, Jean-Louis Reymond, Roch-Philippe Charles, Serafina Calarco, Matthias A. Roelli, Marion Poirier, Amandine Stooss, Lars Ruddigkeit
المصدر: ChemMedChem. 14:189-189
مصطلحات موضوعية: Pharmacology, Chemistry, Angiogenesis, Phenotypic screening, Organic Chemistry, Biochemistry, Lysophosphatidic acid acyltransferase, Angiogenesis inhibitor, Cell biology, Front cover, Drug Discovery, Molecular Medicine, Polypharmacology, General Pharmacology, Toxicology and Pharmaceutics
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المؤلفون: Rebecca R. Stanway, Monica Prado, Volker Heussler, Paul-Christian Burda, Matthias A. Roelli, Nina Eickel, Gesine Kaiser
المصدر: Autophagy
مصطلحات موضوعية: Programmed cell death, Plasmodium berghei, ATG8, Green Fluorescent Proteins, Molecular Sequence Data, Schizonts, Protozoan Proteins, Saccharomyces cerevisiae, Plasmodium, Evolution, Molecular, Gene Knockout Techniques, Mice, Phagosomes, parasitic diseases, Autophagy, Animals, Humans, Parasites, Amino Acid Sequence, Databases, Protein, Molecular Biology, Conserved Sequence, Life Cycle Stages, Apicoplast, Sequence Homology, Amino Acid, biology, Genetic Complementation Test, Hep G2 Cells, Cell Biology, Lipid Metabolism, biology.organism_classification, Basic Research Paper, 3. Good health, Cell biology, Protein Transport, Liver, Apoptosis, Vacuoles, Protozoa
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f547e639cef3e46e9e91f802fead4714
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المؤلفون: Paul-Christian Burda, Matthias A Roelli, Marco Schaffner, Shahid M Khan, Chris J Janse, Volker T Heussler
المصدر: PLoS Pathogens
Burda, Paul-Christian; Rölli, Matthias; Schaffner, Marco; Khan, Shahid M; Janse, Chris J; Heussler, Volker (2015). A Plasmodium phospholipase is involved in disruption of the liver stage parasitophorous vacuole membrane. PLoS pathogens, 11(3), e1004760. Public Library of Science 10.1371/journal.ppat.1004760 <http://dx.doi.org/10.1371/journal.ppat.1004760>
PLOS PATHOGENS
Europe PubMed Central
PLoS Pathogens, Vol 11, Iss 3, p e1004760 (2015)مصطلحات موضوعية: lcsh:Immunologic diseases. Allergy, Plasmodium berghei, Reverse Transcriptase Polymerase Chain Reaction, Protozoan Proteins, Fluorescent Antibody Technique, 610 Medicine & health, 500 Science, Malaria, Disease Models, Animal, Mice, lcsh:Biology (General), Phospholipases, parasitic diseases, Vacuoles, Hepatocytes, 570 Life sciences, biology, Animals, lcsh:RC581-607, Transcriptome, lcsh:QH301-705.5, Research Article
وصف الملف: application/pdf