المؤلفون: Clémence Dudeffant, Matthias Vandesquille, Kelly Herbert, Clément M. Garin, Sandro Alves, Véronique Blanchard, Emmanuel E. Comoy, Fanny Petit, Marc Dhenain

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/5e93a4a65928455e9bb7593b8b3d98c9

المؤلفون: Michael Green, Marie-Claude Asselin, Inga B. Fricke, Marco Mottinelli, Andreas H. Jacobs, Christopher R. McCurdy, Hervé Boutin, Andrew C Robinson, Michael Kassiou, David M. A. Mann, Samuel D. Banister, Matthias Vandesquille, Elizabeth Barnett, Christophe Mesangeau, Christian Prenant, Francois-Xavier Lepelletier

المصدر: Theranostics
Lepelletier, F-X, Vandesquille, M, Asselin, M-C, Prenant, C, Robinson, A, Mann, D, Green, M, Barnett, E, Banister, S D, Mottinelli, M, Mesangeau, C, McCurdy, C R, Fricke, I, Jacobs, A H, Kassiou, M & Boutin, H 2020, ' Evaluation of 18F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue ', Theranostics, pp. 7938-7955 . https://doi.org/10.7150/thno.47585
Lepelletier, F-X, Vandesquille, M, Asselin, M-C, Prenant, C, Robinson, A C, Mann, D M A, Green, M, Barnett, E, Banister, S D, Mottinelli, M, Mesangeau, C, McCurdy, C R, Fricke, I B, Jacobs, A H, Kassiou, M & Boutin, H 2020, ' Evaluation of F-18-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue ', Theranostics, vol. 10, no. 18, pp. 7938-7955 . https://doi.org/10.7150/thno.47585

مصطلحات موضوعية: Male, 0301 basic medicine, Fluorine Radioisotopes, Parkinson's disease, Medicine (miscellaneous), PET radiotracer, Striatum, 0302 clinical medicine, Positron Emission Tomography Computed Tomography, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Aged, 80 and over, biology, Chemistry, Neurodegeneration, Brain, Human brain, Middle Aged, Alzheimer's disease, Molecular Imaging, Globus pallidus, medicine.anatomical_structure, Female, medicine.symptom, Research Paper, medicine.medical_specialty, Substantia nigra, AMPA receptor, Lesion, 03 medical and health sciences, Alzheimer Disease, Internal medicine, medicine, Animals, Humans, Receptors, sigma, Animal model, Parkinson Disease, Secondary, Rats, Wistar, Oxidopamine, Aged, animal model, medicine.disease, Rats, Disease Models, Animal, 030104 developmental biology, Endocrinology, nervous system, biology.protein, Autoradiography, Sigma 1 receptor, Radiopharmaceuticals, NeuN, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b66b6d22f18230f2146945e0b49917
https://doi.org/10.7150/thno.47585

المؤلفون: François-Xavier Lepelletier, Matthias Vandesquille, Marie-Claude Asselin, Christian Prenant, Andrew C Robinson, David M A Mann, Michael Green, Elizabeth Barnett, Samuel D Banister, Marco Mottinelli, Christophe Mesangeau, Christopher R McCurdy, Inga B Fricke, Andreas H. Jacobs, Michael Kassiou, Hervé Boutin

المصدر: Theranostics. 12:5335-5336

مصطلحات موضوعية: Medicine (miscellaneous), Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c1d8a796f2dcfbc8b868824f171f523b
https://doi.org/10.7150/thno.76351

المؤلفون: J.L. Ulloa, Hervé Boutin, Ben R Dickie, Matthias Vandesquille, Geoff J M Parker, Laura M. Parkes

المصدر: Dickie, B R, Vandesquille, M, Ulloa, J, Boutin, H, Parkes, L M & Parker, G J M 2019, ' Water-exchange MRI detects subtle blood-brain barrier breakdown in Alzheimer's disease rats ', NeuroImage, vol. 184, pp. 349-358 . https://doi.org/10.1016/j.neuroimage.2018.09.030

مصطلحات موضوعية: Cerebrovascular dysfunction, Cognitive Neuroscience, MRI contrast agent, Rat model, Disease, Water exchange, Blood–brain barrier, Occludin, 050105 experimental psychology, Capillary Permeability, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, medicine, Animals, 0501 psychology and cognitive sciences, Blood-brain barrier, Tight junction, business.industry, 05 social sciences, Water-exchange, Brain, Water, Alzheimer's disease, Magnetic Resonance Imaging, Uncorrelated, Rats, medicine.anatomical_structure, nervous system, Neurology, Blood-Brain Barrier, cardiovascular system, Rats, Transgenic, Permeability surface-area product, business, Neuroscience, 030217 neurology & neurosurgery, MRI

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353e06696278a36165a7f5bd993de8c2
https://doi.org/10.1016/j.neuroimage.2018.09.030

المؤلفون: Johnny Vercouillie, Michael Kassiou, Karen Davies, Francisco R. López-Picón, Clovis Tauber, Llwyd David Orton, Anniina Snellman, Sylvie Chalon, Dervis A. Salih, Julie Busson, Aisling Chaney, Sylvain Routier, Matthias Vandesquille, Juha O. Rinne, Frédéric Buron, Hervé Boutin, Rui Wang, Michael K. Harte, Johanna Rokka, Christina Georgiadou, Tristan A. Reekie, Catherine E. Lawrence, Samuel David Webb, Stephen R. Williams, Daniela Bochicchio, Sophie Serrière, Frances A. Edwards

المصدر: Theranostics

مصطلحات موضوعية: Male, Aging, Fluorine Radioisotopes, Magnetic Resonance Spectroscopy, positron emission tomography, Neurologi, Medicine (miscellaneous), Hippocampus, Plaque, Amyloid, Hippocampal formation, neuroinflammation, Thalamus, Receptors, Cholinergic, Gliosis, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Neurons, biology, Chemistry, Alzheimer's disease, Immunohistochemistry, magnetic resonance spectroscopy, animal models, Frontal Lobe, Astrogliosis, Neurology, Female, Rats, Transgenic, Locomotion, Neurovetenskaper, Research Paper, medicine.medical_specialty, tau Proteins, Alzheimer Disease, In vivo, Internal medicine, medicine, Animals, Cognitive Dysfunction, Florbetaben, Neuroinflammation, Inflammation, Neurosciences, medicine.disease, Rats, Disease Models, Animal, Endocrinology, Positron-Emission Tomography, Behavior Rating Scale, biology.protein, Cholinergic, NeuN

وصف الملف: application/pdf; text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1a1486fea5b6684e7478cf0207e266
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-444788

المؤلفون: Tengfei Li, Matthias Vandesquille, Pierre Lafaye, Benoît Delatour, Marc Dhenain, Sylvie Bay

المساهمون: Université Paris Diderot - Paris 7 (UPD7), Ingénierie des Anticorps (plate-forme) - Antibody Engineering (Platform), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Chimie des Biomolécules - Chemistry of Biomolecules, Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN), Service MIRCEN (MIRCEN), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Lassailly-Bondaz, Anne

المصدر: Immunology Letters
Immunology Letters, 2017, 188, pp.89-95. ⟨10.1016/j.imlet.2017.07.001⟩
Immunology Letters, Elsevier, 2017, 188, pp.89-95. ⟨10.1016/j.imlet.2017.07.001⟩

مصطلحات موضوعية: 0301 basic medicine, Phage display, [SDV.IMM] Life Sciences [q-bio]/Immunology, Immunology, Antibody Affinity, Ribosome display, Anti GFAP VHH, VHH, Ribosome, Workflow, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, Glial Fibrillary Acidic Protein, Immunology and Allergy, Animals, Humans, Amino Acid Sequence, Gene Library, biology, Single-Domain Antibodies, biology.organism_classification, Virology, Cell biology, 030104 developmental biology, biology.protein, [SDV.IMM]Life Sciences [q-bio]/Immunology, Paratope, Antibody, Cell Surface Display Techniques, 030217 neurology & neurosurgery, VH, Camelid, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f762809b312cb93b02b629e8df0729b5
https://hal-pasteur.archives-ouvertes.fr/pasteur-01580563/file/1-s2.0-S0165247817301165-main(1).pdf

المؤلفون: Charles Duyckaerts, Christelle Ganneau, Fiona Grueninger, Clémence Dudeffant, Benoît Delatour, Pascal Lenormand, Marc Dhenain, Chrystelle Po, Matthias Vandesquille, Christian Czech, Sylvie Bay, Tengfei Li, Pierre Lafaye

المساهمون: Chimie des Biomolécules - Chemistry of Biomolecules, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Ingénierie des Anticorps (plate-forme) - Antibody Engineering (Platform), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), F. Hoffmann-La Roche [Basel], CEA [Fontenay-aux-Roses] (UGRA / SETA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), We gratefully acknowledge financial support from the Institut Roche de Recherche et Médecine Translationnelle. This work was also supported by the program 'Investissements d'avenir' ANR-10-IAIHU-06, the Pompidou Foundation and the France Alzheimer Foundation that are acknowledged. This work was partly carried out on the HISTOMICS platform of the ICM and the MRI platform of CEA-MIRCen, and we thank all technical staff involved., We are grateful to F. Bonhomme for the MS analyses by direct infusion, to F. Groh for the Amino Acid Analysis, to H. Cahuzac for helping in the synthesis of VHH conjugates, and to A. Louie (UC Davis) for providing access to 1.4 Tesla spectrometer and for training and advice on relaxometric analyses., ANR-10-IAHU-0006,IHU-A-ICM,Institut de Neurosciences Translationnelles de Paris(2010), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

المصدر: mAbs
mAbs, 2017, 9 (6), pp.1016-1027. ⟨10.1080/19420862.2017.1342914⟩
mAbs, Taylor & Francis, 2017, 9 (6), pp.1016-1027. ⟨10.1080/19420862.2017.1342914⟩

مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, Amyloid, amyloid deposits, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Immunology, Blood–brain barrier, 03 medical and health sciences, Antigen, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Report, medicine, Alzheimer's disease diagnosis, Immunology and Allergy, magnetic resonance imaging, single-domain antibody, Bioconjugation, medicine.diagnostic_test, Chemistry, Magnetic resonance imaging, site-specific conjugation, Small molecule, 3. Good health, 030104 developmental biology, Single-domain antibody, medicine.anatomical_structure, Biophysics, Molecular imaging, chemically-defined imaging probe

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25c77679e16644f75ec995c3476eaf2
https://hal-pasteur.archives-ouvertes.fr/pasteur-01671738

المؤلفون: Kelly Herbert, Sandro Alves, Clémence Dudeffant, Marc Dhenain, Emmanuel Comoy, Fanny Petit, Matthias Vandesquille

المصدر: Alzheimer's & Dementia. 13

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Epidemiology, business.industry, Health Policy, media_common.quotation_subject, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Microscopy, medicine, Contrast (vision), Neurology (clinical), Geriatrics and Gerontology, business, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7a0c8a085391157462fed2a49f06aa65
https://doi.org/10.1016/j.jalz.2017.07.351

المؤلفون: Benoît Delatour, Ihsen Youssef, Tengfei Li, Christelle Ganneau, Pascal Lenormand, Matthias Vandesquille, Charles Duyckaerts, Pierre Lafaye, Fiona Grueninger, Uwe Maskos, Christian Czech, Clémence Dudeffant, Sylvie Bay, Marc Dhenain, Fani Koukouli

المساهمون: Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ingénierie des Anticorps (plate-forme) - Antibody Engineering (Platform), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN), Service MIRCEN (MIRCEN), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Chimie des biomolécules, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut d'Imagerie BioMédicale (I2BM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Neurobiologie intégrative des Systèmes cholinergiques (NISC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), F. Hoffmann-La Roche AG, Pharmaceutical Research and Early Development, NORD DTA, We gratefully acknowledge financial support from the Institut Roche de Recherche et Médecine TranslationnelleN° 1799764611. This work was also supported by the 'Foundation France AlzheimerAP2014 758321' and the 'Foundation Georges Pompidou'. The present work was also supported by funding from the program 'Investissements d'avenirANR-10-IAIHU-06'. The immunohistochemistry of this work was carried out on the HISTOMICS platform of the ICM and we sincerely acknowledge all staff involved., ANR-10-IAHU-0006,IHU-A-ICM,Institut de Neurosciences Translationnelles de Paris(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Lafaye, pierre, Institut de Neurosciences Translationnelles de Paris - - IHU-A-ICM2010 - ANR-10-IAHU-0006 - IAHU - VALID, Université Paris-Saclay-Institut de Biologie François JACOB (JACOB)

المصدر: Journal of Controlled Release
Journal of Controlled Release, Elsevier, 2016, 243, pp.1-10. ⟨10.1016/j.jconrel.2016.09.019⟩
Journal of Controlled Release, 2016, 243, pp.1-10. ⟨10.1016/j.jconrel.2016.09.019⟩

مصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Male, Pathology, medicine.medical_specialty, Amyloid, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Pharmaceutical Science, Mice, Transgenic, Plaque, Amyloid, VHH, Biology, Blood–brain barrier, 03 medical and health sciences, Mice, In vivo, Alzheimer Disease, medicine, Extracellular, Animals, Tissue Distribution, Blood-brain barrier, Microscopy, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, [SCCO.NEUR] Cognitive science/Neuroscience, Brain, Neurofibrillary Tangles, Single-Domain Antibodies, Alzheimer's disease, Extravasation, 3. Good health, Cell biology, Disease Models, Animal, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, 030104 developmental biology, medicine.anatomical_structure, In vivo imaging, Abeta, Administration, Intravenous, Tau, Camelids, New World, Preclinical imaging, Intracellular

وصف الملف: application/force-download

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062c700438fcb7cb21a9d02d891e5144
https://hal-pasteur.archives-ouvertes.fr/pasteur-01375692/document

المؤلفون: P. Lestage, Caroline Louis, Daniel Béracochéa, Matthias Vandesquille, Ali Krazem

المصدر: Psychopharmacology. 215:709-720

مصطلحات موضوعية: Male, Aging, medicine.medical_specialty, S-18986, Benzothiadiazines, Spatial memory, Mice, chemistry.chemical_compound, Alzheimer Disease, Memantine, Internal medicine, medicine, Animals, Memory disorder, Receptors, AMPA, Maze Learning, Pharmacology, Memory Disorders, Behavior, Animal, Working memory, Cognitive disorder, medicine.disease, Mice, Inbred C57BL, Memory, Short-Term, Endocrinology, chemistry, Ageing, NMDA receptor, Psychology, Excitatory Amino Acid Antagonists, Neuroscience, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce0ebcee640ac1e1b228f85eeb2ab422
https://doi.org/10.1007/s00213-011-2168-9