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المؤلفون: Andrew Scholte, Jinyu Liu, Maria Fitzgerald, Jie Ge, D. Niu, Haibo Liu, Beatriz Ospina, Michael Kothe, Laura Akullian D’Agostino, Joshua Murtie, Gang Zheng, Fangxian Sun, Elvis Shehu, Zhendong Zhu, Mcdonald Joseph John, Matthieu Barrague, Kelly Fahnoe, Darren Harvey, Mark Munson, Zhigang Wang, Jennifer Rocnik, Robert Tjin Tham Sjin, Keli Perron, Alex Dubrovskiy
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Antitumor activity, 010405 organic chemistry, business.industry, Organic Chemistry, Cancer, FGF19, Fibroblast growth factor receptor 4, medicine.disease, 01 natural sciences, Biochemistry, Small molecule, digestive system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, In vivo, Covalent bond, Hepatocellular carcinoma, Drug Discovery, medicine, Cancer research, business
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2Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III
المؤلفون: Andrew Hebert, Paul Erdman, Maniar Sachin, Anlai Wang, Alexandre Gross, Elina Tserlin, Claude Barberis, Vinod F. Patel, Jiang John Z, Mark Czekaj, Mikhail Levit, James Pribish, Frank Sun, Matthieu Barrague, Luke Fire, Shih-Min A. Huang
المصدر: Bioorganicmedicinal chemistry letters. 29(3)
مصطلحات موضوعية: Indoles, Clinical Biochemistry, hERG, Compound 17, Pharmaceutical Science, Antineoplastic Agents, 01 natural sciences, Biochemistry, Part iii, Mice, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Neoplasms, Experimental, Combinatorial chemistry, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Pim kinases, biology.protein, Molecular Medicine, Tumor growth inhibition, Drug Screening Assays, Antitumor
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المؤلفون: James Pribish, Claude Barberis, Liduo Shen, Mark Czekaj, Neil Moorcroft, Mikhail Levit, Elina Tserlin, Anlai Wang, Andrew Hebert, Sandra Moreno-Mazza, Matthieu Barrague, Tahir Majid, Joseph D. Batchelor, Paul Erdman, Alexandre Gross
المصدر: Bioorganicmedicinal chemistry letters. 27(20)
مصطلحات موضوعية: 0301 basic medicine, Indoles, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, PK/PD models, ADME, Kinase, Chemistry, Organic Chemistry, Hit to lead, Combinatorial chemistry, Rats, Enzyme Activation, 030104 developmental biology, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Identification (biology), Half-Life
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المؤلفون: Michael Ferro, Dirk Friedrich, Edwards Michael, John Airey, Gillespy Timothy Alan, Matthieu Barrague, Kwon Yon Musick, Jurcak John G, Philip M. Weintraub
المصدر: Synthesis. 46:96-100
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Organic Chemistry, Organic chemistry, Pyrazole, Combinatorial chemistry, Catalysis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::99ccc71fbb2189d1bf1e4b4d7c244c26
https://doi.org/10.1055/s-0033-1338577 -
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المؤلفون: Judith Sudhalter, Qiang Gao, Stephan Reiling, Isabelle Schreiber, Albane Courjaud, Jack Pollard, Eric Yang, Luc Bonnet, Joshua Murtie, Carlos Garcia-Echeverria, Matthieu Barrague, Fangxian Sun, Timothy He, Claudine Grepin, Monsif Bouaboula, Francisco Adrian, Bailin Zhang, Malvika Koundinya, M. Paola Castaldi, Gaetan Touyer, Bruno Lionne, Mark Munson, Richard Newcombe, Isabelle Menguy, Rosalia Arrebola, Stuart Licht, Yanjun Wang, Christopher Winter, Ronald Tomlinson, Patricia Gee, Hui Cao, Christelle Perrault, Stephanie Vougier, Aaron J. Morris, David Harper, Brigitte Benhamou, Hong Cheng, Ivan Cornella-Taracido, Daniel Simard
المصدر: Cell Chemical Biology. 25:705-717.e11
مصطلحات موضوعية: 0301 basic medicine, Oxidoreductases Acting on CH-CH Group Donors, Clinical Biochemistry, Mutant, Dihydroorotate Dehydrogenase, Antineoplastic Agents, Mice, SCID, Synthetic lethality, Biology, medicine.disease_cause, Biochemistry, Proto-Oncogene Proteins p21(ras), Small Molecule Libraries, Mice, 03 medical and health sciences, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, Chemoproteomics, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, Pharmacology, Drug discovery, Neoplasms, Experimental, Pancreatic Neoplasms, Metabolic pathway, Pyrimidines, 030104 developmental biology, Mutation, Pyrimidine metabolism, Cancer research, Dihydroorotate dehydrogenase, Molecular Medicine, Female, KRAS, Drug Screening Assays, Antitumor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8adef1cb348b566c4cf6075801bafc
https://doi.org/10.1016/j.chembiol.2018.03.005 -
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المؤلفون: Mei S. Duguid, Jurcak John G, Ram Dharanipragada, Rachel Wang, Matthew A. Smicker, Kwon Yon Musick, Xiping Bi, Ashfaq Parkar, Jane Peppard, Ying Zhang, Zhicheng Zhao, Nisha Zaidi, Choi Yong-Mi, Jeremy Fordham, Gillespy Timothy Alan, Dorothea Kominos, Matthieu Barrague, Larry R. McLean
المصدر: Bioorganicmedicinal chemistry letters. 22(9)
مصطلحات موضوعية: Steric effects, Interleukin 2, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Syk, Crystal structure, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Humans, Molecular Biology, Protein Kinase Inhibitors, Chemistry, Kinase, Organic Chemistry, Protein-Tyrosine Kinases, Combinatorial chemistry, Drug Design, Molecular Medicine, Pyrazoles, Selectivity, Tyrosine kinase, medicine.drug
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المؤلفون: Christoph Lengauer, Kin T. Yu, Brittain Scott, Marion Dorsch, Ronald Tomlinson, Francisco Adrian, Katherine Tang, Tieu-Binh Le, Ivan Cornella-Taracido, Carlos Garcia-Echeverria, Mikhail Levit, Lakshmi Srinivasan, Michael Lampa, Matthieu Barrague, Balin Zhang, Hong Cheng, Tahir Majid
المصدر: Cancer Research. 73:1135-1135
مصطلحات موضوعية: Cancer Research, Kinase, Phenotypic screening, Biology, Oncology, Proteasome, Biochemistry, Mechanism of action, medicine, Cancer research, Structure–activity relationship, Phosphorylation, medicine.symptom, Signal transduction, Receptor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4b47e870f98ba5afc801c6d3bbbb33e4
https://doi.org/10.1158/1538-7445.am2013-1135
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