يعرض 1 - 10 نتائج من 16 نتيجة بحث عن '"Mattia Marchini"', وقت الاستعلام: 1.00s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Mechanistic and Structural Insights on Difluoromethyl-1,3,4-oxadiazole Inhibitors of HDAC6

    المؤلفون: Edoardo Cellupica, Aureliano Gaiassi, Ilaria Rocchio, Grazia Rovelli, Roberta Pomarico, Giovanni Sandrone, Gianluca Caprini, Paola Cordella, Cyprian Cukier, Gianluca Fossati, Mattia Marchini, Aleksandra Bebel, Cristina Airoldi, Alessandro Palmioli, Andrea Stevenazzi, Christian Steinkühler, Barbara Vergani

    المصدر: International Journal of Molecular Sciences, Vol 25, Iss 11, p 5885 (2024)

    مصطلحات موضوعية: histone deacetylase 6 (HDAC6), difluoromethyl-1,3,4-oxadiazole (DFMO), non hydroxamic inhibitors, NMR, LC-MS, X-ray crystallography, Biology (General), QH301-705.5, Chemistry, QD1-999

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/1422-0067/25/11/5885; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067

    URL الوصول: https://doaj.org/article/67b922ae71f94a929f6087719fe6a5c9

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  2. 2
    دورية أكاديمية
    The Importance of the 'Time Factor' for the Evaluation of Inhibition Mechanisms: The Case of Selected HDAC6 Inhibitors

    المؤلفون: Edoardo Cellupica, Gianluca Caprini, Gianluca Fossati, Doris Mirdita, Paola Cordella, Mattia Marchini, Ilaria Rocchio, Giovanni Sandrone, Andrea Stevenazzi, Barbara Vergani, Christian Steinkühler, Maria Antonietta Vanoni

    المصدر: Biology, Vol 12, Iss 8, p 1049 (2023)

    مصطلحات موضوعية: histone deacetylase, histone deacetylase 6, inhibition, kinetics, medicinal chemistry, hydroxamates, Biology (General), QH301-705.5

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/2079-7737/12/8/1049; https://doaj.org/toc/2079-7737

    URL الوصول: https://doaj.org/article/eede4c3d2c7646399c18c30c44895eaa

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  3. 3
    دورية أكاديمية
    HDAC Inhibition as Potential Therapeutic Strategy to Restore the Deregulated Immune Response in Severe COVID-19

    المؤلفون: Chiara Ripamonti, Valeria Spadotto, Pietro Pozzi, Andrea Stevenazzi, Barbara Vergani, Mattia Marchini, Giovanni Sandrone, Emanuele Bonetti, Luca Mazzarella, Saverio Minucci, Christian Steinkühler, Gianluca Fossati

    المصدر: Frontiers in Immunology, Vol 13 (2022)

    مصطلحات موضوعية: COVID-19, Histone deacetylases, inflammation, immune response, cytokines, T cell exhaustion, Immunologic diseases. Allergy, RC581-607

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.841716/full; https://doaj.org/toc/1664-3224

    URL الوصول: https://doaj.org/article/0c1ff99d0fea4886888c9748e6955d52

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  4. 4
    Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity

    المؤلفون: Edoardo Cellupica, Gianluca Caprini, Paola Cordella, Cyprian Cukier, Gianluca Fossati, Mattia Marchini, Ilaria Rocchio, Giovanni Sandrone, Maria Antonietta Vanoni, Barbara Vergani, Karol Źrubek, Andrea Stevenazzi, Christian Steinkühler

    مصطلحات موضوعية: epigenetics, Histone Deacetylase 6 (HDAC6), difluoro methyl oxadiazole (DFMO), Histone Deacetylase (HDAC), Histone Deacetylase Inhibitor (HDI), X-ray crystallography, Zinc Binding Group (ZBG), inhibition mechanism, mechanism-based inhibitor, Cell Biology, Biochemistry, Settore BIO/10 - Biochimica, Molecular Biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48949c8b7f44a53863b6996ad4b171f
    https://hdl.handle.net/2434/949372

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  5. 5
    Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors

    المؤلفون: Sandrone Giovanni, Barbara Vergani, Cyprian D Cukier, Gianluca Caprini, Christian Steinkühler, Andrea Stevenazzi, Gianluca Fossati, Karol Zrubek, Mattia Marchini

    المصدر: ACS Med Chem Lett

    مصطلحات موضوعية: Gene isoform, biology, Chemistry, Organic Chemistry, HDAC6, Highly selective, biology.organism_classification, Biochemistry, Combinatorial chemistry, Drug Discovery, Histone deacetylase, Selectivity, Linker, Zebrafish

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811c4890f270e1927ca903f03c6ecea1
    https://doi.org/10.1021/acsmedchemlett.1c00425

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  6. 6
    Abstract 2123: Reprogramming of myeloid and lymphoid cells in vitro by the HDAC6 selective inhibitor ITF3756

    المؤلفون: Chiara Ripamonti, Andrea Stevenazzi, Barbara Vergani, Giovanni Sandrone, Mattia Marchini, Christian Steinkuhler, Gianluca Fossati

    المصدر: Cancer Research. 82:2123-2123

    مصطلحات موضوعية: Cancer Research, Oncology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e76fd07b988bc7ae534a8ae6c3d30422
    https://doi.org/10.1158/1538-7445.am2022-2123

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  7. 7
    Abstract 1358: The selective HDAC6 inhibitor ITF3756 stimulates an antitumor immune response and leads to tumor regression in combination with anti CTLA-4 antibody in a colon carcinoma murine model

    المؤلفون: Gianluca Fossati, Chiara Ripamonti, Gianluca Caprini, Pietro Pozzi, Elisabetta Galbiati, Paola Cordella, Mattia Marchini, Barbara Vergani, Giovanni Sandrone, Andrea Stevenazzi, Christian Steinkuhler

    المصدر: Cancer Research. 82:1358-1358

    مصطلحات موضوعية: Cancer Research, Oncology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::38ff2181c402828299f113bd499b1c5a
    https://doi.org/10.1158/1538-7445.am2022-1358

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  8. 8
    Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation

    المؤلفون: Paolo Pagani, Andrea Stevenazzi, Christian Steinkühler, Maria Lattanzio, Sandrone Giovanni, Giulia Porro, Raffaella Perego, Elisabetta Galbiati, Paola Cordella, Ripamonti Chiara, Gianluca Fossati, Barbara Vergani, Pezzuto Marcello, Flavio Leoni, Gianluca Caprini, Pavich Gianfranco, Daniela Modena, Edoardo Cellupica, M. Skorupska, Pietro Pozzi, Ilaria Rocchio, Roberta Pomarico, Mattia Marchini

    المصدر: Journal of medicinal chemistry. 62(23)

    مصطلحات موضوعية: Cell Survival, Histone Deacetylase 6, Hydroxamic Acids, 01 natural sciences, T-Lymphocytes, Regulatory, Gene Expression Regulation, Enzymologic, Histones, 03 medical and health sciences, Mice, Tubulin, Heat shock protein, Drug Discovery, Cytotoxic T cell, Animals, Protein Isoforms, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, biology, Chemistry, FOXP3, HDAC6, In vitro, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Drug Design, biology.protein, Molecular Medicine, Cortactin, Spleen, Deacetylase activity

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb52f9824beecad31759a2e0374e8f0c
    https://pubmed.ncbi.nlm.nih.gov/31710483

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  9. 9
    Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands

    المؤلفون: Daniela Arosio, Donatella Potenza, Michele Mingozzi, Laura Belvisi, Francesca Vasile, Ileana Guzzetti, Cesare Gennari, Raffaele Colombo, Umberto Piarulli, Mattia Marchini

    المصدر: Chemistry (Weinh., Print) 18 (2012): 6195–6207. doi:10.1002/chem.201200457
    info:cnr-pdr/source/autori:Mattia Marchini; Michele Mingozzi; Raffaele Colombo; Ileana Guzzetti; Laura Belvisi; Francesca Vasile; Donatella Potenza; Umberto Piarulli; Daniela Arosio; Cesare Gennari/titolo:Cyclic RGD Peptidomimetics Containing Bifunctional Diketopiperazine Scaffolds as New Potent Integrin Ligands/doi:10.1002%2Fchem.201200457/rivista:Chemistry (Weinh., Print)/anno:2012/pagina_da:6195/pagina_a:6207/intervallo_pagine:6195–6207/volume:18

    مصطلحات موضوعية: Models, Molecular, Integrins, Molecular model, Peptidomimetic, Stereochemistry, Carboxylic acid, Integrin, Molecular Conformation, Ligands, Peptides, Cyclic, Catalysis, chemistry.chemical_compound, conformation analysis, Aspartic acid, Receptors, Vitronectin, Bifunctional, Nuclear Magnetic Resonance, Biomolecular, chemistry.chemical_classification, Molecular Structure, biology, molecular modeling, Chemistry, Organic Chemistry, General Chemistry, Integrin alphaVbeta3, Combinatorial chemistry, diketopiperazines, Docking (molecular), peptidomimetics, peptides, biology.protein, Oligopeptides, Two-dimensional nuclear magnetic resonance spectroscopy, Protein Binding

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89013e5eb68cc89027daad05c95fea36
    https://doi.org/10.1002/chem.201200457

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  10. 10
    ChemInform Abstract: Amino Acidic Scaffolds Bearing Unnatural Side Chains: An Old Idea Generates New and Versatile Tools for the Life Sciences

    المؤلفون: Mattia Marchini, Giovanni Sandrone, Andrea Stevenazzi, Maria Lattanzio, Barbara Vergani

    المصدر: ChemInform. 46

    مصطلحات موضوعية: chemistry.chemical_classification, chemistry, Side chain, Inorganic materials, General Medicine, Combinatorial chemistry, Amino acid

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::46808a2e7dedd85d0e7ab7564b636efe
    https://doi.org/10.1002/chin.201503267

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