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1دورية أكاديمية
المؤلفون: Israel Salguero, Rimma Belotserkovskaya, Julia Coates, Matylda Sczaniecka-Clift, Mukerrem Demir, Satpal Jhujh, Marcus D. Wilson, Stephen P. Jackson
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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2دورية أكاديمية
المؤلفون: Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Ana C. Barros, Michael Woods, Beiyuan Fu, Fengtang Yang, Elisabeth Chen, Matthias Ostermaier, Tatjana Stankovic, Hannes Ponstingl, Mareike Herzog, Kosuke Yusa, Francisco Munoz Martinez, Stephen T. Durant, Yaron Galanty, Petra Beli, David J. Adams, Allan Bradley, Emmanouil Metzakopian, Josep V. Forment, Stephen P. Jackson
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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3دورية أكاديمية
المؤلفون: Anne Ramsay Bowden, David A Morales-Juarez, Matylda Sczaniecka-Clift, Maria Martin Agudo, Natalia Lukashchuk, John Christopher Thomas, Stephen P Jackson
المصدر: eLife, Vol 9 (2020)
مصطلحات موضوعية: CRISPR screening, TP53, DNA damage response, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: Jessica S. Brown, Natalia Lukashchuk, Matylda Sczaniecka-Clift, Sébastien Britton, Carlos le Sage, Patrick Calsou, Petra Beli, Yaron Galanty, Stephen P. Jackson
المصدر: Cell Reports, Vol 11, Iss 5, Pp 704-714 (2015)
مصطلحات موضوعية: Biology (General), QH301-705.5
وصف الملف: electronic resource
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المؤلفون: John Christopher Thomas, Anne Ramsay Bowden, Matylda Sczaniecka-Clift, Natalia Lukashchuk, David A Morales-Juarez, Stephen P. Jackson, Maria Martin Agudo
مصطلحات موضوعية: Computer science, CRISPR, Computational biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c00de501fd6b0c42deec7c343b8b0b90
https://doi.org/10.7554/elife.55325.sa2 -
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المؤلفون: Mukerrem Demir, Rimma Belotserkovskaya, Marcus D. Wilson, Matylda Sczaniecka-Clift, Israel Salguero, Julia Coates, Satpal Jhujh, Stephen P. Jackson
المساهمون: Salguero, Israel [0000-0001-8756-659X], Belotserkovskaya, Rimma [0000-0001-5363-251X], Jhujh, Satpal [0000-0001-5766-659X], Wilson, Marcus D. [0000-0001-9551-5514], Jackson, Stephen P. [0000-0001-9317-7937], Apollo - University of Cambridge Repository, Wilson, Marcus D [0000-0001-9551-5514], Jackson, Stephen P [0000-0001-9317-7937]
المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Salguero, I, Belotserkovskaya, R, Coates, J, Sczaniecka-clift, M, Demir, M, Jhujh, S, Wilson, M D & Jackson, S P 2019, ' MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance ', Nature Communications, vol. 10, no. 1, 5191 . https://doi.org/10.1038/s41467-019-12929-5مصطلحات موضوعية: 0301 basic medicine, DNA Repair, Molecular biology, 42/109, Amino Acid Motifs, General Physics and Astronomy, Cell Cycle Proteins, environment and public health, Histones, chemistry.chemical_compound, 42/44, 42/41, DNA Breaks, Double-Stranded, 14/19, lcsh:Science, Multidisciplinary, Histone H2AX, Chromatin, 3. Good health, Cell biology, 13/31, Histone, biological phenomena, cell phenomena, and immunity, Tumor Suppressor p53-Binding Protein 1, 631/337, DNA repair, DNA damage, Science, 13/106, 13/109, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, 14/34, Humans, Nucleosome, Adaptor Proteins, Signal Transducing, 030102 biochemistry & molecular biology, General Chemistry, MDC1, enzymes and coenzymes (carbohydrates), 42/35, 030104 developmental biology, chemistry, 14/63, biology.protein, lcsh:Q, 631/80, DNA, DNA Damage
وصف الملف: application/pdf; text/xml; application/zip
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المؤلفون: Stephen P. Jackson, Mareike Herzog, Alejandra Bruna, Luca Pellegrini, Violeta Serra, Mark J. O'Connor, Zhongwu Lai, Chloé Lescale, Jacqueline J.L. Jacobs, Fengtang Yang, Jonathan Lam, Matylda Sczaniecka-Clift, Abigail Shea, Carlos Caldas, Matthias Ostermaier, Gabriel Balmus, Julia Coates, Wenming Wei, Inge de Krijger, Yaron Galanty, Mukerrem Demir, Ludovic Deriano, Petra Beli, Domenic Pilger, Harveer Dev, Rimma Belotserkovskaya, Alistair Martin, Beiyuan Fu, Ting-Wei Will Chiang, Qian Wu
المساهمون: Dev, Harveer [0000-0003-2874-6894], Yang, Fengtang [0000-0002-3573-2354], Balmus, Gabriel [0000-0003-2872-4468], Serra, Violeta [0000-0001-6620-1065], Beli, Petra [0000-0001-9507-9820], Pellegrini, Luca [0000-0002-9300-497X], Deriano, Ludovic [0000-0002-9673-9525], Jacobs, Jacqueline JL [0000-0002-7704-4795], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge [UK] (CAM), Department of Biochemistry [Cambridge], Cambridge University Hospitals - NHS (CUH), Intégrité du génome, immunité et cancer - Genome integrity, Immunity and Cancer, Institut Pasteur [Paris] (IP), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Cancer Research UK Cambridge Institute [Cambridge, Royaume-Uni] (CRUK), Institute of Molecular Biology (IMB), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Wellcome Trust Sanger Institute [Hinxton, UK], AstraZeneca US [Waltham, USA], AstraZeneca [Cambridge, UK], The Wellcome Trust Sanger Institute [Cambridge], Vall d'Hebron Institute of Oncology [Barcelone] (VHIO), Vall d'Hebron University Hospital [Barcelona], The SPJ lab is largely funded by a Cancer Research UK (CRUK) Program Grant, C6/A18796, and a Wellcome Trust (WT) Investigator Award, 206388/Z/17/Z. Core infrastructure funding was provided by CRUK grant C6946/A24843 and WT grant WT203144. S.P.J. receives a salary from the University of Cambridge. H.D. is funded by WT Clinical Fellowship 206721/Z/17/Z. TWC was supported by a Cambridge International Scholarship. D.P. is funded by Cancer Research UK studentship C6/A21454. The P.B. lab is supported by the Emmy Noether Program (BE 5342/1-1) from the German Research Foundation and a Marie Curie Career Integration Grant from the European Commission (630763). The L.P. lab is funded by the WT (investigator award 104641/Z/14/Z) and the Medical Research Council (project grant MR/N000161/1). The C.C. lab was supported with funding from CRUK. The J.J. lab was supported by the European Research Council grant ERC-StG 311565, The Dutch Cancer Society (KWF) grant KWF 10999, and the Netherlands Organization for Scientific Research (NWO) as part of the National Roadmap Large-scale Research Facilities of the Netherlands, Proteins@Work (project no. 184.032.201 to the Proteomics Facility of the Netherlands Cancer Institute). The L.D. lab is funded by the Institut Pasteur, the Institut National du Cancer (no. PLBIO16-181) and the European Research Council (starting grant agreement no. 310917). W.W. is part of the Pasteur–Paris University (PPU) International PhD program and this project received funding from the CNBG company, China. Q.W. is funded by the Wellcome Trust (200814/Z/16/Z ). The V.S. lab work was funded by the Instituto de Salud Carlos III (ISCIII), an initiative of the Spanish Ministry of Economy and Innovation partially supported by European Regional Development FEDER Funds (PI17-01080 to VS), the European Research Area-NET, Transcan-2 (AC15/00063), a non-commercial research agreement with AstraZeneca UK, and structural funds from the Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 540) and the Orozco Family. V.S. received a salary and travel support to C.C.’s lab from ISCIII (CP14/00228, MV15/00041) and the FERO Foundation., The authors thank all S.P.J. laboratory members for support and advice, and Cambridge colleagues N. Lawrence for OMX super-resolution microscopy support and R. Butler for help with computational image analyses and programming. The authors also thank S. Selivanova and S. Hough for help with plasmid amplification, sample preparation and tissue culture maintenance, K. Dry for extensive editorial assistance, F. Muñoz-Martinez for assistance with CRISPR–Cas9 knockout generation, L. Radu for assistance with protein purification, C. Lord (Institute of Cancer Research, London) for SUM149PT cells, D. Durocher (University of Toronto, Canada) for U2OS LacSceIII cells, F. Alt (Harvard University, USA) for CH12F3 cells and 53bp1 knockout CH12F3 cell clones, T. Honjo (Kyoto University, Japan) for permission to use the CH12F3 cell line, and J. Serrat in the Jacobs lab for technical assistance, Institut Pasteur [Paris], Johannes Gutenberg - Universität Mainz (JGU)
المصدر: Nature Cell Biology
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩مصطلحات موضوعية: MESH: DNA Breaks, Double-Stranded, RAD51, Cell Cycle Proteins, Poly (ADP-Ribose) Polymerase Inhibitor, MESH: Recombinational DNA Repair, Mice, MESH: Animals, DNA Breaks, Double-Stranded, skin and connective tissue diseases, Cancer, Telomere-binding protein, Ovarian Neoplasms, MESH: Breast Neoplasms / metabolism, MESH: Telomere-Binding Proteins / metabolism, 3. Good health, Cell biology, MESH: HEK293 Cells, MESH: Proteins / genetics, MESH: Telomere-Binding Proteins / genetics, MESH: Tumor Suppressor p53-Binding Protein 1 / metabolism, MESH: Xenograft Model Antitumor Assays, Telomere-Binding Proteins, MESH: Ovarian Neoplasms / drug therapy, Bone Neoplasms, MESH: Ovarian Neoplasms / metabolism, Article, 03 medical and health sciences, MESH: Cell Cycle Proteins, MESH: Bone Neoplasms / metabolism, Humans, MESH: Osteosarcoma / metabolism, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, MESH: Tumor Suppressor p53-Binding Protein 1 / genetics, Dose-Response Relationship, Drug, HEK 293 cells, Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, DNA, MESH: BRCA1 Protein / deficiency, 030104 developmental biology, Multiprotein Complexes, MESH: Mad2 Proteins / metabolism, MESH: Breast Neoplasms / genetics, MESH: Bone Neoplasms / drug therapy, Cisplatin, Homologous recombination, MESH: Osteosarcoma / genetics, MESH: Female, 0301 basic medicine, DNA End-Joining Repair, MESH: Proteins / metabolism, MESH: Dose-Response Relationship, Drug, chemistry.chemical_compound, MESH: Osteosarcoma / pathology, MESH: Breast Neoplasms / pathology, Homologous Recombination, Polymerase, MESH: Breast Neoplasms / drug therapy, Osteosarcoma, biology, Chemistry, BRCA1 Protein, DNA damage and repair, MESH: Poly(ADP-ribose) Polymerase Inhibitors / pharmacology, MESH: Bone Neoplasms / genetics, DNA-Binding Proteins, MESH: Bone Neoplasms / pathology, Mad2 Proteins, Female, MESH: Ovarian Neoplasms / genetics, Tumor Suppressor p53-Binding Protein 1, MESH: Cisplatin / pharmacology, MESH: Cell Line, Tumor, Lymphocytes, Null, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: BRCA1 Protein / genetics, Poly(ADP-ribose) Polymerase Inhibitors, Cell Line, Tumor, MESH: Drug Resistance, Neoplasm* / genetics, MESH: Mad2 Proteins / genetics, MESH: Ovarian Neoplasms / pathology, Animals, MESH: Mice, MESH: Osteosarcoma / drug therapy, Oligonucleotide, Protective Devices, Recombinational DNA Repair, Cell Biology, MESH: Multiprotein Complexes, Xenograft Model Antitumor Assays, HEK293 Cells, Drug Resistance, Neoplasm, biology.protein, MESH: DNA End-Joining Repair, MESH: DNA-Binding Proteins
وصف الملف: application/pdf
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المؤلفون: Stephen P. Jackson, Matylda Sczaniecka-Clift, Domenic Pilger, Mukerrem Demir, Michael Woods, Petra Beli, Josep V. Forment, Kosuke Yusa, Stephen T. Durant, Julia Coates, Hannes Ponstingl, Elisabeth Chen, Anna Barros, Matthias Ostermaier, Beiyuan Fu, Gabriel Balmus, Allan Bradley, Fengtang Yang, Francisco Munoz Martinez, Tatjana Stankovic, Mareike Herzog, Emmanouil Metzakopian, David J. Adams, Yaron Galanty
المساهمون: Balmus, Gabriel [0000-0003-2872-4468], Pilger, Domenic [0000-0001-7339-0685], Yang, Fengtang [0000-0002-3573-2354], Chen, Elisabeth [0000-0003-2129-7985], Ponstingl, Hannes [0000-0001-7573-1703], Durant, Stephen T [0000-0003-4209-7499], Galanty, Yaron [0000-0001-7167-9004], Beli, Petra [0000-0001-9507-9820], Forment, Josep V [0000-0002-7797-2583], Jackson, Stephen P [0000-0001-9317-7937], Apollo - University of Cambridge Repository
المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)مصطلحات موضوعية: DNA End-Joining Repair, endocrine system diseases, Ataxia Telangiectasia Mutated Proteins, Piperazines, law.invention, chemistry.chemical_compound, DNA Ligase ATP, Mice, 0302 clinical medicine, law, Mice, Inbred NOD, DNA Breaks, Double-Stranded, lcsh:Science, chemistry.chemical_classification, Mice, Knockout, 0303 health sciences, biology, BRCA1 Protein, Mouse Embryonic Stem Cells, 3. Good health, Non-homologous end joining, 030220 oncology & carcinogenesis, Female, medicine.drug, DNA Replication, DNA damage, Cell Survival, Science, Antineoplastic Agents, Article, Olaparib, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, 030304 developmental biology, DNA ligase, Topoisomerase, Neoplasms, Experimental, chemistry, Drug Resistance, Neoplasm, Mutation, biology.protein, Cancer research, Suppressor, Phthalazines, lcsh:Q, Topotecan, CRISPR-Cas Systems, Homologous recombination
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdf76caefb39985120b8937ddce2cb2
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المؤلفون: Yaron Galanty, Mukerrem Demir, Julia Coates, Matthew Cornwell, Satpal Jhujh, Petra Beli, Stephen P. Jackson, Christine K. Schmidt, Matylda Sczaniecka-Clift
المساهمون: Galanty, Yaron [0000-0001-7167-9004], Jackson, Stephen [0000-0001-9317-7937], Apollo - University of Cambridge Repository
مصطلحات موضوعية: Genome instability, DNA repair, Cell Survival, Ubiquitin-Protein Ligases, Green Fluorescent Proteins, Immunoblotting, Ubiquitin-conjugating enzyme, medicine.disease_cause, Article, Ubiquitin, Cell Line, Tumor, medicine, Humans, DNA Breaks, Double-Stranded, Endodeoxyribonucleases, Microscopy, Confocal, biology, Cell Cycle, Ubiquitination, Nuclear Proteins, Recombinational DNA Repair, Cell Biology, Cell cycle, Ubiquitin ligase, Cell biology, HEK293 Cells, Ubiquitin-Conjugating Enzymes, biology.protein, RNA Interference, Homologous recombination, Carcinogenesis, Carrier Proteins
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23a017c5d9cb6663fd72eb942ef5acb
https://www.repository.cam.ac.uk/handle/1810/251109 -
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المؤلفون: Jessica S. Brown, Natalia Lukashchuk, Matylda Sczaniecka-Clift, Sébastien Britton, Carlos le Sage, Patrick Calsou, Petra Beli, Yaron Galanty, Stephen P. Jackson
المساهمون: Galanty, Yaron [0000-0001-7167-9004], Jackson, Stephen [0000-0001-9317-7937], Apollo - University of Cambridge Repository
المصدر: Cell Reports
Cell Reports, Vol 11, Iss 5, Pp 704-714 (2015)مصطلحات موضوعية: Proteomics, DNA End-Joining Repair, NEDD8 Protein, Cell Survival, Ubiquitination, Antigens, Nuclear, Cyclopentanes, Article, Cell Line, Protein Structure, Tertiary, DNA-Binding Proteins, Histones, Pyrimidines, lcsh:Biology (General), Radiation, Ionizing, Ubiquitin-Conjugating Enzymes, Humans, RNA Interference, RNA, Small Interfering, lcsh:QH301-705.5, Ku Autoantigen, Ubiquitins, DNA Damage, Protein Binding
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9c6f984e5b41b272a43de7f777af9e2e