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المؤلفون: Krister Wennerberg, Olli Kallioniemi, Kimmo Porkka, Caroline A. Heckman, Tero Aittokallio, Jonathan Knowles, Maija Wolf, Imre Västrik, Laura Turunen, Minna Suvela, Maria E. Rämet, Tero Pirttinen, Alun Parsons, Aino Palva, Satu Mustjoki, Astrid Murumägi, Pirkko Mattila, Jesus M. Lopez Marti, Muntasir Mamun Majumder, Tuija Lundán, Maija Lepistö, Anna Lehto, Sonja Lagström, Evgeny Kulesskiy, Riikka Karjalainen, Bjørn T. Gjertsen, Erkki Elonen, Pekka Ellonen, Maxim M. Bespalov, Henrikki Almusa, Agnieszka Szwajda, Samuli Eldfors, Henrik Edgren, Bhagwan Yadav, Mika Kontro, Tea Pemovska
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3d9a1a3b523ca3e416409b924c68ae
https://doi.org/10.1158/2159-8290.22528544 -
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المؤلفون: Krister Wennerberg, Olli Kallioniemi, Kimmo Porkka, Caroline A. Heckman, Tero Aittokallio, Jonathan Knowles, Maija Wolf, Imre Västrik, Laura Turunen, Minna Suvela, Maria E. Rämet, Tero Pirttinen, Alun Parsons, Aino Palva, Satu Mustjoki, Astrid Murumägi, Pirkko Mattila, Jesus M. Lopez Marti, Muntasir Mamun Majumder, Tuija Lundán, Maija Lepistö, Anna Lehto, Sonja Lagström, Evgeny Kulesskiy, Riikka Karjalainen, Bjørn T. Gjertsen, Erkki Elonen, Pekka Ellonen, Maxim M. Bespalov, Henrikki Almusa, Agnieszka Szwajda, Samuli Eldfors, Henrik Edgren, Bhagwan Yadav, Mika Kontro, Tea Pemovska
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46538d99dce5bf5e0626b55a4e516035
https://doi.org/10.1158/2159-8290.22528547 -
3دورية أكاديمية
المؤلفون: Pia Runeberg-Roos, Elisa Piccinini, Anna-Maija Penttinen, Kert Mätlik, Hanna Heikkinen, Satu Kuure, Maxim M. Bespalov, Johan Peränen, Enrique Garea-Rodríguez, Eberhard Fuchs, Mikko Airavaara, Nisse Kalkkinen, Richard Penn, Mart Saarma
المصدر: Neurobiology of Disease, Vol 96, Iss , Pp 335-345 (2016)
مصطلحات موضوعية: NRTN, Neurturin, GDNF, GFRα1, GFRα2, RET, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: Yulia A. Sidorova, Maxim M. Bespalov, Agnes W. Wong, Oleg Kambur, Viljami Jokinen, Tuomas O. Lilius, Ilida Suleymanova, Gunnar Karelson, Pekka V. Rauhala, Mati Karelson, Peregrine B. Osborne, Janet R. Keast, Eija A. Kalso, Mart Saarma
المصدر: Frontiers in Pharmacology, Vol 8 (2017)
مصطلحات موضوعية: neuropathic pain, glial cell line-derived neurotrophic factor (GDNF), GDNF family ligands (GFLs), artemin (ARTN), small molecule RET agonist, GFL mimetic, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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المؤلفون: Mart Saarma, Ilari Korhonen, Raimo K. Tuominen, Tanel Visnapuu, Juho-Matti Renko, Eric Ronken, Yulia Sidorova, Merja H. Voutilainen, T. Petteri Piepponen, Arun Kumar Mahato, Maxim M. Bespalov, Mati Karelson, Nita Pulkkinen, Andrii Domanskyi, Jaakko Kopra
المساهمون: Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Division of Pharmacology and Pharmacotherapy, Regenerative pharmacology group, Regenerative Neuroscience, Centre of Excellence in Stem Cell Metabolism, STEMM - Stem Cells and Metabolism Research Program, Drug Research Program, Timo Petteri Piepponen / Principal Investigator, Mart Saarma / Principal Investigator
المصدر: Movement Disorders
مصطلحات موضوعية: 0301 basic medicine, receptor tyrosine kinase RET agonist, Dopamine, Neurturin, Parkinson's disease, GENE DELIVERY, Mice, DOUBLE-BLIND, 0302 clinical medicine, PARKINSONS-DISEASE, Neurotrophic factors, Glial cell line-derived neurotrophic factor, Clustered Regularly Interspaced Short Palindromic Repeats, Research Articles, NEUROPROTECTION, glial cell line‐derived neurotrophic factor (GDNF), SUBSTANTIA-NIGRA, biology, Chemistry, Neurodegeneration, INFUSION, Parkinson Disease, dopamine neurons, 3. Good health, Cell biology, Substantia Nigra, Neurology, medicine.drug, Research Article, Agonist, Glial Cell Line-Derived Neurotrophic Factor Receptors, medicine.drug_class, Substantia nigra, Neuroprotection, 03 medical and health sciences, FACTOR GDNF, medicine, Animals, GFR-ALPHA-1, Glial Cell Line-Derived Neurotrophic Factor, Parkinson Disease, Secondary, Oxidopamine, CRISPR associated protein 9, Dopaminergic Neurons, Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR associated protein 9, glial cell line-derived neurotrophic factor (GDNF), 3112 Neurosciences, medicine.disease, Corpus Striatum, MODEL, 030104 developmental biology, nervous system, biology.protein, Neurology (clinical), NEURTURIN, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e84d74f4678924375a4685dbc5c959
http://hdl.handle.net/10138/320194 -
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المؤلفون: Ras Trokovic, Eeva-Mari Jouhilahti, Juha Kere, Jere Weltner, Diego Balboa, Maxim M. Bespalov, Kaarel Krjutškov, Shintaro Katayama, Timo Otonkoski
المساهمون: Centre of Excellence in Stem Cell Metabolism, Research Programs Unit, Research Programme for Molecular Neurology, Juha Kere / Principal Investigator, Children's Hospital, Timo Pyry Juhani Otonkoski / Principal Investigator, Clinicum, Lastentautien yksikkö, HUS Children and Adolescents
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Weltner, J, Balboa, D, Katayama, S, Bespalov, M, Krjutškov, K, Jouhilahti, E M, Trokovic, R, Kere, J & Otonkoski, T 2018, ' Human pluripotent reprogramming with CRISPR activators ', Nature Communications, vol. 9, no. 1, 2643, pp. 1-12 . https://doi.org/10.1038/s41467-018-05067-x
Nature Communicationsمصطلحات موضوعية: Male, 0301 basic medicine, Transcription, Genetic, General Physics and Astronomy, 0302 clinical medicine, Neural Stem Cells, CRISPR-Associated Protein 9, MEDIATED REGULATION, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, Induced pluripotent stem cell, lcsh:Science, Genetics, 0303 health sciences, Multidisciplinary, Gene Expression Regulation, Developmental, Nanog Homeobox Protein, Cellular Reprogramming, Cell biology, GENOME, DIFFERENTIATION, KLF4, embryonic structures, Stem cell, STEM-CELLS, Reprogramming, RNA, Guide, Kinetoplastida, EXPRESSION, Homeobox protein NANOG, FIBROBLASTS, REGULATORY ELEMENTS, Science, Rex1, Induced Pluripotent Stem Cells, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Kruppel-Like Factor 4, 03 medical and health sciences, SOX2, Alu Elements, Humans, Nucleotide Motifs, 030304 developmental biology, Base Sequence, Cas9, General Chemistry, Embryo, Mammalian, SINGLE-CELL TRANSCRIPTOME, ENHANCERS, HEK293 Cells, 030104 developmental biology, lcsh:Q, 3111 Biomedicine, 030217 neurology & neurosurgery, GENERATION
وصف الملف: application/pdf
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المؤلفون: Risto Kostiainen, Päivi Pöhö, Maxim M. Bespalov, Tapio Kotiaho, Tiina Sikanen, Katriina Lipponen
المساهمون: Division of Pharmaceutical Chemistry and Technology, Divisions of Faculty of Pharmacy, Drug Research Program, STEMM - Stem Cells and Metabolism Research Program, Centre of Excellence in Stem Cell Metabolism, Tiina Sikanen / Chemical Microsystems Lab, Tapio Kotiaho / Principal Investigator, Department of Chemistry, Risto Kostiainen / Principal Investigator
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Electrospray, Electrospray ionization, Cells, Induced Pluripotent Stem Cells, Cell, 116 Chemical sciences, Microchip, Pharmaceutical Science, Ion suppression in liquid chromatography–mass spectrometry, 02 engineering and technology, Mass spectrometry, 030226 pharmacology & pharmacy, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Metabolomics, Liquid chromatography–mass spectrometry, medicine, Direct infusion mass spectrometry, Humans, Liquid chromatography-mass spectrometry, Chromatography, High Pressure Liquid, Chromatography, Chemistry, Small sample, MS, Fibroblasts, 021001 nanoscience & nanotechnology, medicine.anatomical_structure, 317 Pharmacy, DISCOVERY, Metabolome, 0210 nano-technology, STEM-CELLS
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25673ac605c53d4ee5c24ce51b29c586
http://hdl.handle.net/10138/318221 -
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المؤلفون: Mart Saarma, Juho-Matti Renko, Maxim M. Bespalov, Arun Kumar Mahato, Jaakko Kopra, Timo Petteri Piepponen, Nita Pulkkinen, Eric Ronken, Tanel Visnapuu, Yulia Sidorova, Raimo K. Tuominen, Merja H. Voutilainen, Mati Karelson, Korhonen I
مصطلحات موضوعية: Agonist, 0303 health sciences, biology, Chemistry, medicine.drug_class, Neurodegeneration, Dopaminergic, medicine.disease, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, nervous system, In vivo, Neurotrophic factors, Dopamine, Glial cell line-derived neurotrophic factor, biology.protein, medicine, Receptor, Neuroscience, 030217 neurology & neurosurgery, 030304 developmental biology, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d24cf449776e447a8412b9e53d7514
https://doi.org/10.1101/540021 -
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المؤلفون: Olli Vapalahti, Suvi Kuivanen, Denis E. Kainov, Aleksandr Ianevski, Maxim M. Bespalov, Vidya Velagapudi, Jef K. De Brabander, Jatin Nandania
المصدر: Antiviral research. 139
مصطلحات موضوعية: 0301 basic medicine, Cell signaling, Indoles, Retinal Pigment Epithelium, Caspase 8, Virus Replication, Antiviral Agents, Deoxycytidine, Zika virus, 03 medical and health sciences, chemistry.chemical_compound, Fetus, Virology, Humans, Pyrroles, Enzyme Inhibitors, Caspase, Pharmacology, biology, Brain, Zika Virus, biology.organism_classification, Amides, Gemcitabine, Salicylates, 3. Good health, Drug Combinations, 030104 developmental biology, Viral replication, chemistry, Caspases, biology.protein, RNA, Viral, Viral disease, Signal transduction, Metabolic Networks and Pathways, Obatoclax, Signal Transduction
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المؤلفون: Jonathan Knowles, Erkki Elonen, Laura Turunen, Tero Aittokallio, Maria E. Rämet, Kimmo Porkka, Satu Mustjoki, Aino Palva, Pekka Ellonen, Henrikki Almusa, Mika Kontro, Samuli Eldfors, Tuija Lundán, Caroline A. Heckman, Tea Pemovska, Agnieszka Szwajda, Bhagwan Yadav, Maija Lepistö, Tero Pirttinen, Anna Lehto, Krister Wennerberg, Maxim M. Bespalov, Olli Kallioniemi, Muntasir Mamun Majumder, Sonja Lagström, Jesus M. Lopez Marti, Minna Suvela, Imre Vastrik, Maija Wolf, Pirkko Mattila, Henrik Edgren, Astrid Murumägi, Evgeny Kulesskiy, Bjørn Tore Gjertsen, Alun Parsons, Riikka Karjalainen
المصدر: Cancer Discovery. 3:1416-1429
مصطلحات موضوعية: 0303 health sciences, Myeloid, business.industry, Myeloid leukemia, Drug resistance, medicine.disease, Bioinformatics, Somatic evolution in cancer, 3. Good health, Systems medicine, 03 medical and health sciences, Drug repositioning, 0302 clinical medicine, Breast cancer, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, medicine, Personalized medicine, business, 030304 developmental biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::227929232ae96810c2a22f9baae3e798
https://doi.org/10.1158/2159-8290.cd-13-0350