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المؤلفون: So J; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Mabe NW; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts, USA., Englinger B; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts, USA.; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Chow KH; Department of Oncologic Pathology and.; Center for Patient Derived Models, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Moyer SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Yerrum S; Department of Oncologic Pathology and.; Center for Patient Derived Models, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Trissal MC; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts, USA., Marques JG; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts, USA., Kwon JJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Shim B; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Pal S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Panditharatna E; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts, USA., Quinn T; Department of Oncologic Pathology and.; Center for Patient Derived Models, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Schaefer DA; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts, USA., Jeong D; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts, USA., Mayhew DL; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts, USA., Hwang J; Department of Medicine and.; Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA., Beroukhim R; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Ligon KL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.; Department of Oncologic Pathology and., Stegmaier K; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts, USA., Filbin MG; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorder Center and Harvard Medical School, Boston, Massachusetts, USA., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

المصدر: JCI insight [JCI Insight] 2022 Oct 10; Vol. 7 (19). Date of Electronic Publication: 2022 Oct 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: Glioma*/genetics , Neuroblastoma*/genetics , Vaccinia*, Child ; Humans ; Intracellular Signaling Peptides and Proteins ; Nervous System ; Protein Serine-Threonine Kinases/genetics ; Vaccinia virus

المؤلفون: Kwon JJ; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Hajian B; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bian Y; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Young LC; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Amor AJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fuller JR; Helix Biostructures, Indianapolis, IN, USA., Fraley CV; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sykes AM; Harvard Medical School, Boston, Massachusetts, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., So J; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Pan J; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Baker L; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lee SJ; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Wheeler DB; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Mayhew DL; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Persky NS; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yang X; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Root DE; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Barsotti AM; Deerfield Discovery and Development, Deerfield Management, New York, NY, USA., Stamford AW; Deerfield Discovery and Development, Deerfield Management, New York, NY, USA., Perry CK; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Burgin A; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., McCormick F; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA., Lemke CT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. clemke@broadinstitute.org., Hahn WC; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. william_hahn@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. william_hahn@dfci.harvard.edu.; Harvard Medical School, Boston, Massachusetts, USA. william_hahn@dfci.harvard.edu.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. william_hahn@dfci.harvard.edu., Aguirre AJ; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. andrew_aguirre@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. andrew_aguirre@dfci.harvard.edu.; Harvard Medical School, Boston, Massachusetts, USA. andrew_aguirre@dfci.harvard.edu.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. andrew_aguirre@dfci.harvard.edu.

المصدر: Nature [Nature] 2022 Sep; Vol. 609 (7926), pp. 408-415. Date of Electronic Publication: 2022 Jul 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cryoelectron Microscopy* , Intracellular Signaling Peptides and Proteins*/chemistry , Intracellular Signaling Peptides and Proteins*/genetics , Intracellular Signaling Peptides and Proteins*/metabolism , Multiprotein Complexes*/chemistry , Multiprotein Complexes*/metabolism , Multiprotein Complexes*/ultrastructure , Protein Phosphatase 1*/chemistry , Protein Phosphatase 1*/metabolism , Protein Phosphatase 1*/ultrastructure , ras Proteins*/chemistry , ras Proteins*/metabolism , ras Proteins*/ultrastructure, Amino Acid Motifs ; Binding Sites ; Guanosine Triphosphate/metabolism ; Humans ; MAP Kinase Signaling System ; Mutation, Missense ; Phosphorylation ; Protein Binding ; Protein Stability ; raf Kinases

المؤلفون: Bekele RT; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Samant AS; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA., Nassar AH; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Medical Oncology and., So J; Department of Medical Oncology and., Garcia EP; Brigham and Women's Hospital, Boston, Massachusetts, USA., Curran CR; Department of Medical Oncology and., Hwang JH; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Medical Oncology and., Mayhew DL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Medical Oncology and., Nag A; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Thorner AR; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Börcsök J; Danish Cancer Society Research Center, Copenhagen, Denmark., Sztupinszki Z; Danish Cancer Society Research Center, Copenhagen, Denmark., Pan CX; VA Boston Healthcare System, Harvard Medical School, West Roxbury, Massachusetts, USA., Bellmunt J; Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Kwiatkowski DJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA., Sonpavde GP; Department of Medical Oncology and., Van Allen EM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Medical Oncology and., Mouw KW; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Brigham and Women's Hospital, Boston, Massachusetts, USA.

المصدر: The Journal of clinical investigation [J Clin Invest] 2021 Nov 15; Vol. 131 (22).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Gene Amplification*, Mitogen-Activated Protein Kinase Kinases/*antagonists & inhibitors , Proto-Oncogene Proteins c-raf/*genetics , Urinary Bladder Neoplasms/*genetics, Animals ; Cell Line, Tumor ; Female ; GTP Phosphohydrolases/genetics ; Humans ; Membrane Proteins/genetics ; Mice ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-raf/antagonists & inhibitors ; Proto-Oncogene Proteins p21(ras)/genetics ; Urinary Bladder Neoplasms/drug therapy

المؤلفون: Blitzer GC; Department of Human Oncology, University of Wisconsin, Madison, Wisconsin., Parekh AD; Department of Radiation Oncology, University of Florida, Gainesville, Florida., Chen S; Department of Public Health Sciences, University of California-Davis, Sacramento, California., Taparra K; Gundersen Lutheran Health System, La Crosse, Wisconsin., Kahn JM; Department of Radiation Oncology, Oregon Health and Science University, Portland, Oregon., Fields EC; Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia., Stahl JM; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama., Rosenberg SA; Department of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida., Buatti JM; Department of Radiation Oncology, University of Iowa, Iowa City, Iowa., Laucis AM; Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan., Wang Y; Department of Mathematical Sciences, University of Liverpool, Liverpool, United Kingdom., Mayhew DL; Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., McDonald AM; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama., Harari PM; Department of Human Oncology, University of Wisconsin, Madison, Wisconsin., Brower JV; Department of Human Oncology, University of Wisconsin, Madison, Wisconsin.; Radiation Oncology Associates-New England, Manchester, New Hampshire.

المصدر: Advances in radiation oncology [Adv Radiat Oncol] 2021 Jun 24; Vol. 6 (5), pp. 100743. Date of Electronic Publication: 2021 Jun 24 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101677247 Publication Model: eCollection Cited Medium: Print ISSN: 2452-1094 (Print) Linking ISSN: 24521094 NLM ISO Abbreviation: Adv Radiat Oncol Subsets: PubMed not MEDLINE

المؤلفون: Roberts BM; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Lavin KM; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Many GM; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Thalacker-Mercer A; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Merritt EK; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Bickel CS; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Physical Therapy, Samford University, Birmingham, AL 35229, United States., Mayhew DL; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Tuggle SC; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Cross JM; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Kosek DJ; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Petrella JK; Department of Kinesiology, Samford University, Birmingham, AL 35229, United States., Brown CJ; Geriatric Research, Education, and Clinical Center, VA Medical Center, Birmingham, AL, 35233, United States; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Division of Geriatrics, Gerontology, and Palliative Care, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Hunter GR; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Human Studies, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Windham ST; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Allman RM; Geriatric Research, Education, and Clinical Center, VA Medical Center, Birmingham, AL, 35233, United States; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Division of Geriatrics, Gerontology, and Palliative Care, University of Alabama at Birmingham, Birmingham, AL 35294, United States., Bamman MM; Geriatric Research, Education, and Clinical Center, VA Medical Center, Birmingham, AL, 35233, United States; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States; Division of Geriatrics, Gerontology, and Palliative Care, University of Alabama at Birmingham, Birmingham, AL 35294, United States. Electronic address: mbamman@uab.edu.

المصدر: Experimental gerontology [Exp Gerontol] 2018 Jun; Vol. 106, pp. 116-124. Date of Electronic Publication: 2018 Feb 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0047061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6815 (Electronic) Linking ISSN: 05315565 NLM ISO Abbreviation: Exp Gerontol Subsets: MEDLINE

مواضيع طبية MeSH: Sex Characteristics*, Aging/*pathology , Muscle Fibers, Skeletal/*pathology , Muscular Atrophy/*pathology, Adult ; Aged ; Aged, 80 and over ; Alabama ; Female ; Humans ; Male ; Middle Aged ; Muscle Strength ; Organ Size ; Quality of Life ; Young Adult