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المؤلفون: Alvarez N; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Adam GC; Merck & Co., Inc., Rahway, NJ 07065, USA., Howe JA; Merck & Co., Inc., Rahway, NJ 07065, USA., Sharma V; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Zimmerman MD; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Dolgov E; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Rasheed R; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Nizar F; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Sahay K; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Nelson AM; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Park S; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA., Zhou X; Merck & Co., Inc., Rahway, NJ 07065, USA., Burlein C; Merck & Co., Inc., Rahway, NJ 07065, USA., Fay JF; Merck & Co., Inc., Rahway, NJ 07065, USA., Iwamoto DV; Merck & Co., Inc., Rahway, NJ 07065, USA., Bahnck-Teets CM; Merck & Co., Inc., Rahway, NJ 07065, USA., Getty KL; Merck & Co., Inc., Rahway, NJ 07065, USA., Lin Goh S; Merck & Co., Inc., Rahway, NJ 07065, USA., Salhab I; Merck & Co., Inc., Rahway, NJ 07065, USA., Smith K; Merck & Co., Inc., Rahway, NJ 07065, USA., Boyce CW; Merck & Co., Inc., Rahway, NJ 07065, USA., Cabalu TD; Merck & Co., Inc., Rahway, NJ 07065, USA., Murgolo N; Merck & Co., Inc., Rahway, NJ 07065, USA., Fox NG; Merck & Co., Inc., Rahway, NJ 07065, USA., Mayhood TW; Merck & Co., Inc., Rahway, NJ 07065, USA., Shurtleff VW; Merck & Co., Inc., Rahway, NJ 07065, USA., Layton ME; Merck & Co., Inc., Rahway, NJ 07065, USA., Parish CA; Merck & Co., Inc., Rahway, NJ 07065, USA., McCauley JA; Merck & Co., Inc., Rahway, NJ 07065, USA., Olsen DB; Merck & Co., Inc., Rahway, NJ 07065, USA., Perlin DS; Center for Discovery and Innovation, Hackensack Meridian Health, 111 Ideation Way, Nutley, NJ 07110, USA.

المصدر: Viruses [Viruses] 2024 Jul 18; Vol. 16 (7). Date of Electronic Publication: 2024 Jul 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

مواضيع طبية MeSH: SARS-CoV-2*/drug effects , Antiviral Agents*/pharmacology, Animals ; Mice ; Humans ; Coronavirus 3C Proteases/antagonists & inhibitors ; Middle East Respiratory Syndrome Coronavirus/drug effects ; Middle East Respiratory Syndrome Coronavirus/genetics ; COVID-19 Drug Treatment ; Protease Inhibitors/pharmacology ; COVID-19/virology ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology

المؤلفون: Dong S; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Zhao Z; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tang H; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Li G; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Pan J; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Gu X; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Jiang J; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Xiao L; Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Scapin G; Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hunter DN; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Yang D; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Huang Y; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bennett F; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Yang SW; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mandal M; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tang H; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Su J; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Tudge C; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., deJesus RK; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Ding FX; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Lombardo M; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Hicks JD; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Fischmann T; Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mirza A; Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Dayananth P; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Painter RE; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Villafania A; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Garlisi CG; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Zhang R; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Mayhood TW; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Si Q; Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Li N; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Amin RP; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Bhatt B; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Chen F; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Regan CP; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Regan H; Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Lin X; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu J; Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Leithead A; Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Pollack SR; Discovery Process Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Scott JD; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Nargund RP; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States., Therien AG; Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02139, United States., Black T; Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Young K; Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Pasternak A; Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3400-3418. Date of Electronic Publication: 2024 Feb 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: beta-Lactamase Inhibitors*/pharmacology , beta-Lactamase Inhibitors*/therapeutic use , beta-Lactamase Inhibitors*/chemistry , Anti-Bacterial Agents*/chemistry, Humans ; Imipenem/pharmacology ; beta-Lactamases ; Gram-Negative Bacteria ; Microbial Sensitivity Tests

المؤلفون: Shurtleff VW; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Layton ME; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Parish CA; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Perkins JJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Schreier JD; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Wang Y; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Adam GC; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Alvarez N; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Bahmanjah S; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Bahnck-Teets CM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Boyce CW; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Burlein C; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Cabalu TD; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Campbell BT; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Carroll SS; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Chang W; Merck & Co., Inc., Rahway, New Jersey 07065, United States., de Lera Ruiz M; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Dolgov E; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Fay JF; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Fox NG; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Goh SL; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hartingh TJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Hurzy DM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kelly MJ 3rd; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Klein DJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Klingler FM; MSD (U.K.) Limited, London EC2M 6UR, U.K., Krishnamurthy H; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kudalkar S; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Mayhood TW; Merck & Co., Inc., Rahway, New Jersey 07065, United States., McKenna PM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Murray EM; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Nahas D; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Nawrat CC; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Park S; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Qian D; Viva Biotech Ltd., Shanghai 201318, China., Roecker AJ; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Sharma V; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Shipe WD; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Su J; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Taggart RV; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Truong Q; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wu Y; Viva Biotech Ltd., Shanghai 201318, China., Zhou X; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Zhuang N; Viva Biotech Ltd., Shanghai 201318, China., Perlin DS; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States., Olsen DB; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Howe JA; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., McCauley JA; Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3935-3958. Date of Electronic Publication: 2024 Feb 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Glutamine*/chemistry , COVID-19*, Humans ; SARS-CoV-2 ; Cysteine Endopeptidases/chemistry ; Inventions ; Protease Inhibitors/pharmacology ; Amides ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry

المؤلفون: Mandal M; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Xiao L; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Pan W; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Scapin G; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Li G; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Tang H; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Yang SW; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Pan J; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Root Y; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., de Jesus RK; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Yang C; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Prosise W; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Dayananth P; In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Mirza A; Antibacterial/antifungal, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Therien AG; Antibacterial/antifungal, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Young K; Antibacterial/antifungal, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Flattery A; In vivo biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Garlisi C; In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Zhang R; In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Chu D; In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Sheth P; In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Chu I; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Wu J; Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Markgraf C; Nonclinical Drug Safety, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Kim HY; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Painter R; In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Mayhood TW; In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., DiNunzio E; In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Wyss DF; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Buevich AV; Analytical Research and Development, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Fischmann T; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Pasternak A; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Dong S; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Hicks JD; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Villafania A; In-vitro biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Liang L; In vivo biology, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Murgolo N; Antibacterial/antifungal, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Black T; Antibacterial/antifungal, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Hagmann WK; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Tata J; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Parmee ER; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Weber AE; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Su J; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States., Tang H; Medicinal Chemistry, Merck & Co., Inc., Kenilworth, New Jersey07033, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Dec 22; Vol. 65 (24), pp. 16234-16251. Date of Electronic Publication: 2022 Dec 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: beta-Lactamase Inhibitors*/pharmacology , beta-Lactamase Inhibitors*/therapeutic use , beta-Lactamase Inhibitors*/chemistry , Bacterial Infections*, Animals ; Mice ; Imipenem/pharmacology ; Imipenem/therapeutic use ; beta-Lactamases/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/chemistry ; Microbial Sensitivity Tests

المؤلفون: Deng Y; Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA. Electronic address: yongqi.deng@merck.com., Shipps GW Jr; Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA., Zhao L; Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA., Siddiqui MA; Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA., Popovici-Muller J; Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA., Curran PJ; Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA., Duca JS; Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA., Hruza AW; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Fischmann TO; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Madison VS; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Zhang R; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., McNemar CW; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Mayhood TW; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Syto R; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Annis A; Merck Research Laboratories, 320 Bent Street, Cambridge, MA 02141, USA., Kirschmeier P; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA., Lees EM; Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA., Parry DA; Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA., Windsor WT; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: william.windsor@merck.com.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Jan 01; Vol. 24 (1), pp. 199-203. Date of Electronic Publication: 2013 Nov 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Cyclin A/*antagonists & inhibitors , Cyclin-Dependent Kinase 2/*antagonists & inhibitors , Protein Kinase Inhibitors/*pharmacology , Quinolines/*pharmacology, Crystallography, X-Ray ; Cyclin A/chemistry ; Cyclin A/metabolism ; Cyclin-Dependent Kinase 2/chemistry ; Cyclin-Dependent Kinase 2/metabolism ; Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemistry ; Quinolines/chemistry ; Structure-Activity Relationship

المؤلفون: Sheth PR; Protein Science Department, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. payal.sheth@merck.com, Liu Y, Hesson T, Zhao J, Vilenchik L, Liu YH, Mayhood TW, Le HV

المصدر: Biochemistry [Biochemistry] 2011 Sep 20; Vol. 50 (37), pp. 7964-76. Date of Electronic Publication: 2011 Aug 26.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Benzamides/*metabolism , Butadienes/*metabolism , Diphenylamine/*analogs & derivatives , Mitogen-Activated Protein Kinase 1/*metabolism , Nitriles/*metabolism, Allosteric Regulation/drug effects ; Allosteric Regulation/physiology ; Animals ; Benzamides/pharmacology ; Butadienes/pharmacology ; Cell Line ; Diphenylamine/metabolism ; Diphenylamine/pharmacology ; Enzyme Activation/drug effects ; Enzyme Activation/physiology ; Insecta ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors ; Nitriles/pharmacology ; Protein Binding/drug effects ; Protein Binding/physiology ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology

المؤلفون: Fischmann TO; Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA. thierry.fischmann@spcorp.com, Smith CK, Mayhood TW, Myers JE, Reichert P, Mannarino A, Carr D, Zhu H, Wong J, Yang RS, Le HV, Madison VS

المصدر: Biochemistry [Biochemistry] 2009 Mar 31; Vol. 48 (12), pp. 2661-74.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*chemistry , MAP Kinase Kinase 1/*chemistry , Nucleotides/*chemistry, Adenosine Diphosphate/chemistry ; Adenosine Diphosphate/metabolism ; Allosteric Regulation ; Binding Sites ; Carbazoles/chemistry ; Carbazoles/metabolism ; Crystallography, X-Ray ; Enzyme Inhibitors/metabolism ; Indole Alkaloids/chemistry ; Indole Alkaloids/metabolism ; MAP Kinase Kinase 1/metabolism ; Models, Molecular ; Nucleotides/metabolism ; Protein Conformation ; Structure-Activity Relationship ; Substrate Specificity

المؤلفون: Smith CK; Department of Protein Engineering and Biochemistry, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. catherine.smith15@spcorp.com, Carr D, Mayhood TW, Jin W, Gray K, Windsor WT

المصدر: Protein expression and purification [Protein Expr Purif] 2007 Apr; Vol. 52 (2), pp. 446-56. Date of Electronic Publication: 2006 Nov 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1046-5928 (Print) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression/*physiology , MAP Kinase Kinase 1/*metabolism, Animals ; Blotting, Western ; Cells, Cultured ; Chromatography, Liquid ; Circular Dichroism ; Humans ; Insecta/cytology ; MAP Kinase Kinase 1/chemistry ; MAP Kinase Kinase 1/genetics ; MAP Kinase Kinase 1/isolation & purification ; Mass Spectrometry ; Phosphorylation ; Serine/metabolism