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المؤلفون: Khurana P; School of Biological Sciences, Mailpoint 840, Level D Lab & Path Block, Southampton General Hospital, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK., Cox A; School of Biological Sciences, Mailpoint 840, Level D Lab & Path Block, Southampton General Hospital, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK., Islam B; Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Eckert JJ; Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK., Willaime-Morawek S; Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK., Gould JM; Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK., Smyth NR; School of Biological Sciences, Mailpoint 840, Level D Lab & Path Block, Southampton General Hospital, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK., McHugh PC; Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Fleming TP; School of Biological Sciences, Mailpoint 840, Level D Lab & Path Block, Southampton General Hospital, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK. tpf@soton.ac.uk.

المصدر: Stem cell reviews and reports [Stem Cell Rev Rep] 2023 Apr; Vol. 19 (3), pp. 767-783. Date of Electronic Publication: 2022 Dec 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Science+Business Media Country of Publication: United States NLM ID: 101752767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2629-3277 (Electronic) Linking ISSN: 26293277 NLM ISO Abbreviation: Stem Cell Rev Rep Subsets: MEDLINE

مواضيع طبية MeSH: Mouse Embryonic Stem Cells* , Malnutrition*, Animals ; Mice ; Mice, Inbred C57BL ; Signal Transduction ; Diet, Protein-Restricted

المؤلفون: Young B; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.; Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Stephenson J; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.; School of Human and Health Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Islam B; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.; Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Burke NN; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; Centre for Pain Research, University of Galway, Galway, Ireland., Jennings EM; Centre for Pain Research, University of Galway, Galway, Ireland.; Galway Neuroscience Centre, University of Galway, Galway, Ireland., Finn DP; Centre for Pain Research, University of Galway, Galway, Ireland.; Galway Neuroscience Centre, University of Galway, Galway, Ireland.; Pharmacology and Therapeutics, University of Galway, Galway, Ireland., McHugh PC; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK. p.c.mchugh@hud.ac.uk.; Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK. p.c.mchugh@hud.ac.uk.

المصدر: Molecular neurobiology [Mol Neurobiol] 2023 Mar; Vol. 60 (3), pp. 1179-1194. Date of Electronic Publication: 2022 Nov 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

مواضيع طبية MeSH: Neuralgia*/diagnosis , Neuralgia*/genetics , Neuralgia*/therapy, Animals ; Humans ; Pain Measurement ; Chronic Disease ; Models, Animal ; Biomarkers ; Adaptor Proteins, Signal Transducing ; Proteins ; Membrane Proteins ; Mitochondrial Proteins

المؤلفون: O'Brien NL; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, UK., Quadri G; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, UK., Lightley I; Centre for Biomarker Research, University of Huddersfield, Huddersfield, UK., Sharp SI; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, UK., Guerrini I; Erith Health Centre, South London and Maudsley NHS Foundation Trust, London, UK.; Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK., Smith I; Alcohol Related Brain Injury Team, Stirling, UK., Heydtmann M; Department of Gastroenterology, Dumfries & Galloway Royal Infirmary, Cargenbridge, Dumfries, UK., Morgan MY; UCL Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, UK., Thomson AD; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, UK.; Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK., Bass NJ; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, UK., McHugh PC; Centre for Biomarker Research, University of Huddersfield, Huddersfield, UK., McQuillin A; Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, UK.

المصدر: Alcohol and alcoholism (Oxford, Oxfordshire) [Alcohol Alcohol] 2022 Sep 10; Vol. 57 (5), pp. 581-588.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8310684 Publication Model: Print Cited Medium: Internet ISSN: 1464-3502 (Electronic) Linking ISSN: 07350414 NLM ISO Abbreviation: Alcohol Alcohol Subsets: MEDLINE

مواضيع طبية MeSH: Alcoholism*/complications , Korsakoff Syndrome*/complications , Reduced Folate Carrier Protein*/genetics , Thiamine Deficiency*/genetics, Ethanol ; Folic Acid ; Genetic Variation/genetics ; HEK293 Cells ; Humans ; Thiamine ; Thiamine Pyrophosphate/metabolism

المؤلفون: Islam B; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.; School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Stephenson J; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.; School of Human and Health Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Young B; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.; School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Manca M; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.; School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Buckley DA; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK.; School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK., Radford H; St. James University Hospital, Leeds, LS9 7TF, UK., Zis P; Medical School, University of Cyprus, Nicosia, Cyprus., Johnson MI; Centre for Pain Research, School of Clinical and Applied Sciences, Leeds Beckett University, Leeds, LS1 3HE, UK., Finn DP; Pharmacology & Therapeutics, School of Medicine, Galway, Neuroscience Centre and Centre for Pain Research, National University of Ireland Galway, University Road, Galway, Ireland., McHugh PC; Centre for Biomarker Research, University of Huddersfield, Huddersfield, HD1 3DH, UK. p.c.mchugh@hud.ac.uk.; School of Applied Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK. p.c.mchugh@hud.ac.uk.

المصدر: Neuromolecular medicine [Neuromolecular Med] 2022 Sep; Vol. 24 (3), pp. 320-338. Date of Electronic Publication: 2021 Nov 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 101135365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1174 (Electronic) Linking ISSN: 15351084 NLM ISO Abbreviation: Neuromolecular Med Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers*/blood , Chronic Pain*/blood , Chronic Pain*/diagnosis , Chronic Pain*/genetics , Neuralgia*/blood , Neuralgia*/diagnosis , Neuralgia*/genetics, Case-Control Studies ; Humans ; Transcriptome

المؤلفون: Wang J; Clinical Research Center, Changhai Hospital, Shanghai, 200433, China., Zhang D; Arachna Skin Biotechnology Center, Eston Cell Technology (Shanghai) Co. Ltd, Shanghai, 201611, China., Zhu Y; Department of Respiratory & Critical Care Medicine, Seventh Medical Center of Chinese PLA General Hospital, Beijing, 100700, China., Mo X; Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China., McHugh PC; Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, HD1 3DH, UK., Tong Q; Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200235, China.

المصدر: Regenerative medicine [Regen Med] 2022 Apr; Vol. 17 (4), pp. 219-232. Date of Electronic Publication: 2022 Mar 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 101278116 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-076X (Electronic) Linking ISSN: 17460751 NLM ISO Abbreviation: Regen Med Subsets: MEDLINE

مواضيع طبية MeSH: Exosomes* , Mesenchymal Stem Cells*/metabolism, Animals ; Humans ; Mice ; Paracrine Communication ; Plant Extracts/metabolism ; Skin ; Wound Healing

المؤلفون: Moore BJR; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K.; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., Islam B; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K.; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., Ward S; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., Jackson O; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., Armitage R; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., Blackburn J; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., Haider S; UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, U.K., McHugh PC; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K.; Centre for Biomarker Research, School of Applied Sciences, Department of Pharmacy, School of Applied Sciences, Innovative Physical Organic Solutions (IPOS), Department of Chemical and Biological Sciences, and Department of Chemical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K.

المصدر: ACS omega [ACS Omega] 2019 Jul 10; Vol. 4 (7), pp. 11960-11972. Date of Electronic Publication: 2019 Jul 10 (Print Publication: 2019).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE

المؤلفون: Murray KN; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom., Edye ME; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom., Manca M; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom., Vernon AC; King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, 5 Cutcombe Road, London SE5 9RT, United Kingdom; King's College London, MRC Centre for Neurodevelopmental Disorders, New Hunt's House, Guy's Hospital Campus, London SE1 1UL, United Kingdom., Oladipo JM; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom., Fasolino V; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom., Harte MK; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom., Mason V; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom., Grayson B; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom., McHugh PC; Centre for Biomarker Research and Department of Pharmacy, School of Applied Sciences, University of Huddersfield, HD1 3DH, United Kingdom., Knuesel I; Roche Innovation Center Basel, 124 Grenzacherstrasse, Basel, CH 4070, Switzerland., Prinssen EP; Roche Innovation Center Basel, 124 Grenzacherstrasse, Basel, CH 4070, Switzerland., Hager R; Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom. Electronic address: Reinmar.Hager@manchester.ac.uk., Neill JC; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester M13 9PT, United Kingdom. Electronic address: joanna.neill@manchester.ac.uk.

المصدر: Brain, behavior, and immunity [Brain Behav Immun] 2019 Jan; Vol. 75, pp. 48-59. Date of Electronic Publication: 2018 Sep 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

مواضيع طبية MeSH: Immunity, Active/*physiology , Lymphocyte Activation/*immunology , Prenatal Exposure Delayed Effects/*immunology, Animals ; Behavior, Animal/physiology ; Cytokines/immunology ; Disease Models, Animal ; Female ; Hippocampus/drug effects ; Immunity, Active/immunology ; Interleukin-6/metabolism ; Lymphocyte Activation/physiology ; Male ; Models, Animal ; Motor Activity/drug effects ; Neurodevelopmental Disorders ; Placenta/metabolism ; Poly I-C/pharmacology ; Pregnancy ; Rats ; Rats, Wistar ; Schizophrenia/immunology ; T-Lymphocytes/immunology

المؤلفون: Zis P; Academic Department of Neurosciences, Royal Hallamshire Hospital, Glossop Rd, Sheffield, South Yorkshire, S10 2JF, UK. takiszis@gmail.com., McHugh PC; Centre for Biomarker Research and Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK., Manca M; Centre for Biomarker Research and Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK., Sarrigiannis PG; Academic Department of Neurosciences, Royal Hallamshire Hospital, Glossop Rd, Sheffield, South Yorkshire, S10 2JF, UK., Rao DG; Academic Department of Neurosciences, Royal Hallamshire Hospital, Glossop Rd, Sheffield, South Yorkshire, S10 2JF, UK., Hadjivassiliou M; Academic Department of Neurosciences, Royal Hallamshire Hospital, Glossop Rd, Sheffield, South Yorkshire, S10 2JF, UK.

المصدر: Journal of molecular neuroscience : MN [J Mol Neurosci] 2018 Dec; Vol. 66 (4), pp. 547-551. Date of Electronic Publication: 2018 Oct 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9002991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1166 (Electronic) Linking ISSN: 08958696 NLM ISO Abbreviation: J Mol Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Protein Carbonylation*, Polyneuropathies/*metabolism, 8-Hydroxy-2'-Deoxyguanosine ; Aged ; Case-Control Studies ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/blood ; Female ; Humans ; Male ; Middle Aged ; Polyneuropathies/blood ; Polyneuropathies/etiology

المؤلفون: Roberts RL; Department of Surgical Sciences (Dunedin), University of Otago, Otago, New Zealand., Wallace MC; Department of Surgical Sciences (Dunedin), University of Otago, Otago, New Zealand., Seinen ML; Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, the Netherlands.; Department of Internal Medicine, Gastroenterology and Geriatrics, Atrium-ORBIS Medical Center, Heerlen-Sittard, the Netherlands., van Bodegraven AA; Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, the Netherlands.; Department of Internal Medicine, Gastroenterology and Geriatrics, Atrium-ORBIS Medical Center, Heerlen-Sittard, the Netherlands., Krishnaprasad K; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Jones GT; Department of Surgical Sciences (Dunedin), University of Otago, Otago, New Zealand., van Rij AM; Department of Surgical Sciences (Dunedin), University of Otago, Otago, New Zealand., Baird A; Centre for Inflammatory Bowel Disease, Saint John of God Hospital, Subiaco, WA, Australia., Lawrance IC; Centre for Inflammatory Bowel Disease, Saint John of God Hospital, Subiaco, WA, Australia.; Harry Perkins Institute of Medical Research, School of Medicine and Pharmacology, University of Western Australia, Murdoch, WA, Australia., Prosser R; Flinders Medical Centre, Flinders University of South Australia, Bedford Park, South Australia, Australia., Bampton P; Flinders Medical Centre, Flinders University of South Australia, Bedford Park, South Australia, Australia., Grafton R; Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia., Simms LA; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Studd C; Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia., Bell SJ; Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia., Kennedy MA; Department of Pathology, University of Otago Christchurch, Christchurch, New Zealand., Halliwell J; Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, Huddersfield, UK., Gearry RB; Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand., Radford-Smith G; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Department of Gastroenterology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Andrews JM; Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia., McHugh PC; Centre for Biomarker Research, School of Applied Sciences, University of Huddersfield, Huddersfield, UK., Barclay ML; Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand.

المصدر: Inflammatory bowel diseases [Inflamm Bowel Dis] 2018 Nov 29; Vol. 24 (12), pp. 2606-2612.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9508162 Publication Model: Print Cited Medium: Internet ISSN: 1536-4844 (Electronic) Linking ISSN: 10780998 NLM ISO Abbreviation: Inflamm Bowel Dis Subsets: MEDLINE

مواضيع طبية MeSH: Azathioprine/*therapeutic use , Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor/*genetics , Inflammatory Bowel Diseases/*enzymology, Adult ; Cohort Studies ; Female ; Guanine Nucleotides/blood ; Humans ; Inflammatory Bowel Diseases/blood ; Inflammatory Bowel Diseases/drug therapy ; Male ; Mercaptopurine/analogs & derivatives ; Mercaptopurine/blood ; Middle Aged ; Polymorphism, Single Nucleotide ; Risk Factors ; Thionucleotides/blood ; Young Adult