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المؤلفون: Chamness LM; Department of Chemistry, Indiana University, Bloomington, United States., Kuntz CP; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, United States., McKee AG; Department of Chemistry, Indiana University, Bloomington, United States., Penn WD; Department of Chemistry, Indiana University, Bloomington, United States., Hemmerich CM; Center for Genomics and Bioinformatics, Indiana University, Bloomington, United States., Rusch DB; Center for Genomics and Bioinformatics, Indiana University, Bloomington, United States., Woods H; Department of Chemistry, Vanderbilt University, Nashville, United States.; Chemical and Physical Biology Program, Vanderbilt University, Nashville, United States., Dyotima; Department of Chemistry, Indiana University, Bloomington, United States., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, United States.; Institute for Drug Discovery, Leipzig University, Leipzig, Germany., Schlebach JP; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, United States.

المصدر: ELife [Elife] 2024 Jul 30; Vol. 12. Date of Electronic Publication: 2024 Jul 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Protein Folding* , Epistasis, Genetic* , Receptors, LHRH*/genetics , Receptors, LHRH*/metabolism , Receptors, LHRH*/chemistry , Membrane Proteins*/genetics , Membrane Proteins*/metabolism , Membrane Proteins*/chemistry, Humans ; Mutation ; Protein Stability ; Cell Membrane/metabolism

المؤلفون: Carmody P; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Roushar FJ; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Tedman A; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA 47907., Wang W; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA 35233., Herwig M; Department of Chemistry, Vanderbilt University, Nashville, TN, USA 37240., Kim M; Department of Chemistry, Vanderbilt University, Nashville, TN, USA 37240.; Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN, USA 37240., McDonald EF; Department of Chemistry, Vanderbilt University, Nashville, TN, USA 37240., Noguera K; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Wong-Roushar J; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Poirier JL; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Zelt NB; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Pockrass BT; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., McKee AG; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Kuntz CP; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA 47907., Raju SV; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA 35233., Plate L; Department of Chemistry, Vanderbilt University, Nashville, TN, USA 37240.; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA 37240., Penn WD; Department of Chemistry, Indiana University Bloomington, Bloomington, IN, USA 47401., Schlebach JP; The James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN, USA 47907.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 23. Date of Electronic Publication: 2024 Jul 23.

نوع المنشور: Journal Article; Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: McKee AG; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., McDonald EF; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA., Penn WD; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Kuntz CP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Noguera K; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Chamness LM; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Roushar FJ; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA; Institute for Drug Development, Leipzig University, Leipzig, SAC 04109, Germany., Oliver KE; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA., Plate L; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA., Schlebach JP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. Electronic address: jschleba@indiana.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2023 Jun 15; Vol. 30 (6), pp. 632-642.e5. Date of Electronic Publication: 2023 May 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cystic Fibrosis Transmembrane Conductance Regulator*/genetics , Cystic Fibrosis Transmembrane Conductance Regulator*/metabolism , Cystic Fibrosis*/drug therapy , Cystic Fibrosis*/genetics , Cystic Fibrosis*/metabolism, Humans ; Mutation ; Cell Membrane/metabolism ; Aminopyridines/pharmacology ; Aminopyridines/metabolism ; Aminopyridines/therapeutic use

المؤلفون: Ortega JT; Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA., McKee AG; Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405-7102, USA., Roushar FJ; Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405-7102, USA., Penn WD; Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405-7102, USA., Schlebach JP; Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN 47405-7102, USA., Jastrzebska B; Department of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

المصدر: Human molecular genetics [Hum Mol Genet] 2022 Oct 10; Vol. 31 (20), pp. 3439-3457.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Biological Products*/therapeutic use , Retinal Degeneration*/drug therapy , Retinal Degeneration*/genetics , Retinal Degeneration*/pathology , Retinitis Pigmentosa*/drug therapy , Retinitis Pigmentosa*/genetics , Retinitis Pigmentosa*/metabolism, Animals ; Cattle ; Ligands ; Mice ; Receptors, G-Protein-Coupled ; Rhodopsin/genetics ; Rhodopsin/metabolism ; Rod Opsins/genetics

المؤلفون: Roushar FJ; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., McKee AG; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Kuntz CP; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Ortega JT; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA., Penn WD; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Woods H; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, Tennessee, USA., Chamness LM; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Most V; Institute for Drug Development, Leipzig University, Leipzig, SAC, Germany., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Institute for Drug Development, Leipzig University, Leipzig, SAC, Germany., Jastrzebska B; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA., Schlebach JP; Department of Chemistry, Indiana University, Bloomington, Indiana, USA. Electronic address: jschleba@indiana.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102266. Date of Electronic Publication: 2022 Jul 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Eye Diseases, Hereditary*/genetics , Rhodopsin*/drug effects , Rhodopsin*/genetics , Rhodopsin*/metabolism, Diterpenes/pharmacology ; Drug Resistance/genetics ; HEK293 Cells ; Humans ; Mutation ; Retinaldehyde/pharmacology

المؤلفون: Kuntz CP; Department of Chemistry, Indiana University, Bloomington, Indiana., Woods H; Department of Chemistry, Vanderbilt University, Nashville, Tennessee; Chemical and Physical Biology Program, Vanderbilt University, Nashville, Tennessee., McKee AG; Department of Chemistry, Indiana University, Bloomington, Indiana., Zelt NB; Department of Chemistry, Indiana University, Bloomington, Indiana., Mendenhall JL; Department of Chemistry, Vanderbilt University, Nashville, Tennessee; Chemical and Physical Biology Program, Vanderbilt University, Nashville, Tennessee., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, Tennessee; Institute for Drug Discovery, Leipzig University Medical School, Leipzig, Saxony, Germany. Electronic address: jens@meilerlab.org., Schlebach JP; Department of Chemistry, Indiana University, Bloomington, Indiana. Electronic address: jschleba@indiana.edu.

المصدر: Biophysical journal [Biophys J] 2022 Jul 19; Vol. 121 (14), pp. 2712-2720. Date of Electronic Publication: 2022 Jun 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

مواضيع طبية MeSH: KCNQ1 Potassium Channel*/metabolism , Potassium Channels, Voltage-Gated*/metabolism, Mutagenesis ; Mutation ; Rhodopsin/chemistry

المؤلفون: McKee AG; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Kuntz CP; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Ortega JT; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA., Woods H; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Chemical and Physical Biology Program, Vanderbilt University, Nashville, Tennessee, USA., Most V; Institute for Drug Development, Leipzig University, Leipzig, SAC, Germany., Roushar FJ; Department of Chemistry, Indiana University, Bloomington, Indiana, USA., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Institute for Drug Development, Leipzig University, Leipzig, SAC, Germany., Jastrzebska B; Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA., Schlebach JP; Department of Chemistry, Indiana University, Bloomington, Indiana, USA. Electronic address: jschleba@indiana.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2021 Dec; Vol. 297 (6), pp. 101359. Date of Electronic Publication: 2021 Oct 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Retinaldehyde/*metabolism , Rhodopsin/*metabolism, HEK293 Cells ; Humans ; Rhodopsin/genetics ; Temperature

المؤلفون: Penn WD; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., McKee AG; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Kuntz CP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Woods H; Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.; Chemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37235, USA., Nash V; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Gruenhagen TC; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Roushar FJ; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Chandak M; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA., Hemmerich C; Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, USA., Rusch DB; Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, USA., Meiler J; Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA., Schlebach JP; Department of Chemistry, Indiana University, Bloomington, IN 47405, USA.

المصدر: Science advances [Sci Adv] 2020 Mar 04; Vol. 6 (10), pp. eaay7505. Date of Electronic Publication: 2020 Mar 04 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: eCollection Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Cell Membrane/*chemistry , Lipid Bilayers/*chemistry , Rhodopsin/*chemistry, Cell Membrane/metabolism ; Gene Expression ; HEK293 Cells ; Humans ; Hydrophobic and Hydrophilic Interactions ; Lipid Bilayers/metabolism ; Models, Molecular ; Mutation ; Protein Domains ; Protein Folding ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Rhodopsin/genetics ; Rhodopsin/metabolism ; Solubility ; Thermodynamics