لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Sadee W; Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.; Pain and Addiction Center Laboratory, Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, CA 94158, USA.; Aether Therapeutics Inc., Austin, TX 78756, USA., McKew JC; Aether Therapeutics Inc., Austin, TX 78756, USA.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Sep 08; Vol. 27 (18). Date of Electronic Publication: 2022 Sep 08.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Analgesia* , Opioid-Related Disorders*/drug therapy, Analgesics, Opioid/pharmacology ; Analgesics, Opioid/therapeutic use ; Humans ; Ligands ; Morphine/pharmacology ; Naloxone/pharmacology ; Naltrexone/pharmacology ; Narcotic Antagonists/pharmacology ; Narcotic Antagonists/therapeutic use ; Pain/drug therapy ; Receptors, Opioid, mu/metabolism

المؤلفون: Wallery JJ; Battelle, Columbus, OH, USA., Kale VP; Battelle, Columbus, OH, USA. Electronic address: vkale02@amgen.com., Novak J; Battelle, Columbus, OH, USA., Gibbs S; Battelle, Columbus, OH, USA., Do MT; Lumos Pharma, Austin, TX, USA., McKew JC; Lumos Pharma, Austin, TX, USA., Terse PS; National Center for Advancing Translational Sciences, National Institute of Health, Bethesda, MD, USA. Electronic address: tersep@mail.nih.gov.

المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Nov 01; Vol. 430, pp. 115680. Date of Electronic Publication: 2021 Aug 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Toxicity Tests, Chronic*, Creatinine/*analogs & derivatives, Administration, Oral ; Animals ; Creatinine/administration & dosage ; Creatinine/pharmacokinetics ; Creatinine/toxicity ; Dogs ; Dose-Response Relationship, Drug ; Female ; Half-Life ; Kidney/drug effects ; Kidney/pathology ; Lung/drug effects ; Lung/pathology ; Lung/physiopathology ; Lung Diseases/chemically induced ; Lung Diseases/pathology ; Lung Diseases/physiopathology ; Male ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/pathology ; Muscle, Smooth/drug effects ; Muscle, Smooth/pathology ; Myocardium/pathology ; No-Observed-Adverse-Effect Level ; Risk Assessment ; Time Factors ; Toxicokinetics ; Vacuoles/drug effects ; Vacuoles/pathology

المؤلفون: Do MT; Lumos Pharma, 4200 Marathon Blvd Suite 200, Austin, TX, 78756, USA., Cavagnaro J; Access Bio, P.O. Box 240, Boyce, VA, 22620, USA., Butt M; Tox Path Specialists, 8420 Gas House Pike Suite G, Frederick, MD, 21701, USA., Terse PS; National Center for Advancing Translational Sciences, National Institute of Health, 9800 Medical Center Drive, Rockville, MD, 20850, USA., McKew JC; Lumos Pharma, 4200 Marathon Blvd Suite 200, Austin, TX, 78756, USA. Electronic address: jmckew@lumos-pharma.com.

المصدر: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2021 Jul; Vol. 123, pp. 104939. Date of Electronic Publication: 2021 May 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0295 (Electronic) Linking ISSN: 02732300 NLM ISO Abbreviation: Regul Toxicol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Disease Models, Animal*, Antineoplastic Agents/*toxicity , Creatinine/*analogs & derivatives, Animals ; Brain ; Brain Diseases, Metabolic, Inborn ; Creatine/deficiency ; Creatinine/toxicity ; Humans ; Membrane Transport Proteins ; Mental Retardation, X-Linked ; Mice ; No-Observed-Adverse-Effect Level ; Plasma Membrane Neurotransmitter Transport Proteins/deficiency ; Seizures ; Tissue Distribution

SCR Disease Name: Creatine deficiency, X-linked

المؤلفون: Bright GM; Lumos Pharma, Inc., 4200 Marathon Blvd., Suite 200, Austin, Texas 78756, USA., Do MT; Lumos Pharma, Inc., 4200 Marathon Blvd., Suite 200, Austin, Texas 78756, USA., McKew JC; Lumos Pharma, Inc., 4200 Marathon Blvd., Suite 200, Austin, Texas 78756, USA., Blum WF; Center of Child and Adolescent Medicine, Justus-Liebig University, 35390 Giessen, Germany., Thorner MO; Lumos Pharma, Inc., 4200 Marathon Blvd., Suite 200, Austin, Texas 78756, USA.

المصدر: Journal of the Endocrine Society [J Endocr Soc] 2021 Feb 25; Vol. 5 (6), pp. bvab030. Date of Electronic Publication: 2021 Feb 25 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Endocrine Society Country of Publication: United States NLM ID: 101697997 Publication Model: eCollection Cited Medium: Internet ISSN: 2472-1972 (Electronic) Linking ISSN: 24721972 NLM ISO Abbreviation: J Endocr Soc Subsets: PubMed not MEDLINE