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المؤلفون: Kjell Arne Arntzen, Kai Ivar Müller, Geir Åsmund Myge Hansen, Sanne M C Savelberg, Attila Kovacs, Marie Falkenberg Smeland, Marijke Van Ghelue, Yan Huang, Conor McClenaghan, David F. Wozniak, Monica Sala-Rabanal, Helen I. Roessler, Soma S. Singareddy, Colin G. Nichols, Theresa M. Harter, Jamie Gunn, Sarah M. Kamel, Federico Tessadori, Maarten P.G. Massink, Chris H Emfinger, Andreas Rosenberger Dybesland, Jeroen Bakkers, Maria S. Remedi, Gijs van Haaften, Helene Hjellnes
المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research
المصدر: Nature Communications
Nature Communications, 10(1). Nature Publishing Group
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)مصطلحات موضوعية: 0301 basic medicine, Cantú syndrome, Male, Adenosine Triphosphate/metabolism, General Physics and Astronomy, medicine.disease_cause, Genetic Diseases, X-Linked/genetics, Sulfonylurea Receptors, Neurodevelopmental Disorders/genetics, Mediator Complex/metabolism, Mice, 0302 clinical medicine, Adenosine Triphosphate, Intellectual disability, Membrane proteins, lcsh:Science, Child, Zebrafish, Mutation, Multidisciplinary, Mediator Complex, Genetic Predisposition to Disease/genetics, Medical genetics, Neurodevelopmental disorders, Homozygote, Genetic Diseases, X-Linked, Heart, Muscular Diseases/genetics, Phenotype, Cardiomegaly/genetics, 3. Good health, Pedigree, X-Linked/genetics, Genetic Diseases, Hypertrichosis/genetics, Female, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Adult, medicine.medical_specialty, endocrine system, Heart Diseases, Adolescent, Science, Hypertrichosis, Cardiomegaly, Intellectual Disability/metabolism, Osteochondrodysplasias, General Biochemistry, Genetics and Molecular Biology, Article, ABCC9, Cell Line, 03 medical and health sciences, Young Adult, Channelopathy, Muscular Diseases, Internal medicine, Intellectual Disability, medicine, Animals, Humans, Genetic Predisposition to Disease, Sulfonylurea Receptors/genetics, VDP::Medisinske Fag: 700, Amino Acid Sequence, Myopathy, Loss function, Whole Genome Sequencing, business.industry, Animal, Osteochondrodysplasias/genetics, Facies, Channelopathies/metabolism, General Chemistry, medicine.disease, Rubidium, VDP::Medical disciplines: 700, Disease Models, Animal, 030104 developmental biology, Endocrinology, Heart Diseases/genetics, Disease Models, lcsh:Q, Channelopathies, Membrane Proteins/metabolism, business, 030217 neurology & neurosurgery
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المؤلفون: Zoé Lens, Xavier Hanoulle, Frédérique Dewitte, François-Xavier Cantrelle, Riccardo Peruzzini, Isabelle Landrieu, Marc Aumercier, Elisabeth Ferreira, Jean-Luc Baert, Vincent Villeret, Didier Monté, Alexis Verger
المساهمون: Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), The NMR facilities were funded by the Hauts-de-France Regional Council, CNRS, Pasteur Institute of Lille, European Community (FEDER), French Research Ministry and the University of Sciences and Technologies of Lille I. We acknowledge support from the TGE RMN THC (FR-3050, France), FRABio (FR-3688, France), 'Projets Emergents' Nord-Pas-de-Calais Regional Council and Lille NMR and RPE Health and Biology core facility. R.P. was funded by a fellowship from Nord-Pas-de-Calais Regional Council., The FP7 WeNMR (project no. 261572) and H2020 West-Life (project no. 675858) European e-Infrastructure projects are acknowledged for the use of their Web portals., Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), ANR-16-CE12-0021,MEDNET,Le complexe Médiateur: d'un réseau d'interactions protéine-protéine à la régulation génique in vivo(2016), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
المصدر: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2017, 429 (20), pp.3043-3055. ⟨10.1016/j.jmb.2017.09.001⟩
Journal of Molecular Biology, 2017, 429 (20), pp.3043-3055. ⟨10.1016/j.jmb.2017.09.001⟩مصطلحات موضوعية: 0301 basic medicine, Magnetic Resonance Spectroscopy, Protein Conformation, Protein subunit, RNA polymerase II, Biology, MESH: Transcription Factor TFIID/metabolism, 03 medical and health sciences, chemistry.chemical_compound, NMR spectroscopy, MESH: Protein Conformation, Structural Biology, Transcription (biology), RNA polymerase, Protein Interaction Mapping, Humans, MESH: Mediator Complex/metabolism, MESH: Protein Binding, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, protein structure, Molecular Biology, TATA-Binding Protein Associated Factors, MESH: Transcription Factors/metabolism, MESH: Humans, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], MEDiator complex, MESH: Magnetic Resonance Spectroscopy, MESH: Protein Interaction Mapping, MED26, MESH: Transcription Factor TFIID/chemistry, TAF7, Dissociation constant, Crystallography, MESH: Mediator Complex/chemistry, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], 030104 developmental biology, protein–protein interaction, chemistry, MESH: TATA-Binding Protein Associated Factors/chemistry, MESH: TATA-Binding Protein Associated Factors/metabolism, Helix, biology.protein, Biophysics, Transcription Factor TFIID, transcription regulation, Protein Binding, Transcription Factors
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المؤلفون: Joy L. Nishikawa, Dominique Sanglard, Anders M. Näär, Riccardo Torelli, Luís A. Vale-Silva, Maurizio Sanguinetti, Brunella Posteraro, Haribabu Arthanari, Andras Boeszoermenyi, Ruslan I. Sadreyev, Jayaram Bhyravabhotla, Goutam Dev Mukherjee, Gerhard Wagner, Fei Ji, Sara J. Buhrlage, Nathanael S. Gray, Yoo-Jin Sohn, Vladimir Gelev
المصدر: Nature
Europe PubMed Central
Nature, vol. 530, no. 7591, pp. 485-489مصطلحات موضوعية: Models, Molecular, Transcriptional Activation, 0301 basic medicine, Antifungal Agents, Saccharomyces cerevisiae Proteins, 030106 microbiology, Candida glabrata, Biology, Article, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, Microbiology, Fungal Proteins, Mice, 03 medical and health sciences, Mediator, Drug Resistance, Fungal, Transcription (biology), Drug Resistance, Multiple, Fungal, Gene Expression Regulation, Fungal, Animals, Fluconazole, Nuclear Magnetic Resonance, Biomolecular, Transcription factor, Regulation of gene expression, Fungal protein, Binding Sites, Mediator Complex, Multidisciplinary, Activator (genetics), Eukaryotic transcription, Candidiasis, Thiourea, Antifungal Agents/pharmacology, Binding Sites/drug effects, Candida glabrata/drug effects, Candida glabrata/genetics, Candidiasis/drug therapy, Candidiasis/microbiology, DNA-Binding Proteins/genetics, DNA-Binding Proteins/metabolism, Drug Resistance, Fungal/drug effects, Drug Resistance, Multiple, Fungal/drug effects, Fluconazole/pharmacology, Fungal Proteins/metabolism, Gene Expression Regulation, Fungal/drug effects, Hydrazines/pharmacokinetics, Hydrazines/pharmacology, Ketoconazole/pharmacology, Mediator Complex/chemistry, Mediator Complex/metabolism, Protein Binding/drug effects, Protein Structure, Tertiary, Saccharomyces cerevisiae Proteins/chemistry, Saccharomyces cerevisiae Proteins/genetics, Thiourea/analogs & derivatives, Thiourea/pharmacokinetics, Trans-Activators/chemistry, Trans-Activators/metabolism, Transcription Factors/genetics, Transcription Factors/metabolism, Transcriptional Activation/drug effects, Up-Regulation/drug effects, biology.organism_classification, Up-Regulation, 3. Good health, DNA-Binding Proteins, Hydrazines, Ketoconazole, 030104 developmental biology, Trans-Activators, Protein Binding, Transcription Factors
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387b05bb85fa8b6fb9b167c377f136ee
http://hdl.handle.net/10807/72311 -
4مورد إلكتروني
المصدر: Nature Communications vol.10 (2019) date: 2019-10-01 nr.1 p.4457 [ISSN 2041-1723]
مصطلحات الفهرس: Adenosine Triphosphate/metabolism, Adolescent, Adult, Amino Acid Sequence, Animals, Cardiomegaly/genetics, Cell Line, Channelopathies/metabolism, Child, Disease Models, Animal, Facies, Female, Genetic Diseases, X-Linked/genetics, Genetic Predisposition to Disease/genetics, Heart, Heart Diseases/genetics, Homozygote, Humans, Hypertrichosis/genetics, Intellectual Disability/metabolism, Male, Mediator Complex/metabolism, Membrane Proteins/metabolism, Mice, Muscular Diseases/genetics, Mutation, Neurodevelopmental Disorders/genetics, Osteochondrodysplasias/genetics, Pedigree, Phenotype, Rubidium, Sulfonylurea Receptors/genetics, Whole Genome Sequencing, Young Adult, Zebrafish, Artikel, Article
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5مورد إلكتروني
المصدر: Nature Communications vol.10 (2019) date: 2019-10-01 nr.1 p.4457 [ISSN 2041-1723]
مصطلحات الفهرس: Adenosine Triphosphate/metabolism, Adolescent, Adult, Amino Acid Sequence, Animals, Cardiomegaly/genetics, Cell Line, Channelopathies/metabolism, Child, Disease Models, Animal, Facies, Female, Genetic Diseases, X-Linked/genetics, Genetic Predisposition to Disease/genetics, Heart, Heart Diseases/genetics, Homozygote, Humans, Hypertrichosis/genetics, Intellectual Disability/metabolism, Male, Mediator Complex/metabolism, Membrane Proteins/metabolism, Mice, Muscular Diseases/genetics, Mutation, Neurodevelopmental Disorders/genetics, Osteochondrodysplasias/genetics, Pedigree, Phenotype, Rubidium, Sulfonylurea Receptors/genetics, Whole Genome Sequencing, Young Adult, Zebrafish, Artikel, Article
