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1دورية أكاديمية
المؤلفون: Robert P. Hayes, Mee Ra Heo, Mark Mason, John Reid, Christine Burlein, Kira A. Armacost, David M. Tellers, Izzat Raheem, Anthony W. Shaw, Edward Murray, Philip M. McKenna, Pravien Abeywickrema, Sujata Sharma, Stephen M. Soisson, Daniel Klein
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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المؤلفون: Daniel J. Klein, Philip M. McKenna, Pravien Abeywickrema, Stephen M. Soisson, Edward M. Murray, Sujata Sharma, David M. Tellers, Kira A. Armacost, Mee Ra Heo, Christine Burlein, John C. Reid, Anthony W. Shaw, Izzat T. Raheem, Robert P Hayes, Mark Mason
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, DNA polymerase, viruses, Science, 030106 microbiology, General Physics and Astronomy, DNA-Directed DNA Polymerase, Virus Replication, medicine.disease_cause, Antiviral Agents, Article, General Biochemistry, Genetics and Molecular Biology, Viral Proteins, 03 medical and health sciences, chemistry.chemical_compound, Drug Resistance, Viral, medicine, Herpes virus, Nucleotide, Herpesviridae, Polymerase, X-ray crystallography, chemistry.chemical_classification, Binding Sites, Multidisciplinary, biology, Nucleotides, General Chemistry, Molecular biology, Exodeoxyribonucleases, 030104 developmental biology, Herpes simplex virus, chemistry, Coding strand, Quinolines, biology.protein, Viral genome replication, Nucleoside, DNA
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المؤلفون: Xavier Fradera, Meredeth A. McGowan, Mangeng Cheng, Pravien Abeywickrema, Karin M. Otte, Prasanthi Geda, Nunzio Sciammetta, Catherine White, Konstanze von Köenig, Charles A. Lesburg, Hyun Chong Woo, Nadya Smotrov, Sarah E Trewick, Patrick J. Curran, Martin Augustin, Christine Andrews, Elizabeth Joshi, Wensheng Yu, Elliott B. Nickbarg, Phillip M. Cowley, Ian Knemeyer, Jongwon Lim, Hua Zhou, Yongxin Han, Xuelei Song, David Jonathan Bennett, Mee Ra Heo, Peter Spacciapoli, J. Richard Miller
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: 010405 organic chemistry, medicine.medical_treatment, Organic Chemistry, Pharmacology, Ligand (biochemistry), 01 natural sciences, Biochemistry, Immune checkpoint, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Immune system, chemistry, Cancer immunotherapy, Drug Discovery, medicine, Potency, Indoleamine 2,3-dioxygenase, Heme, Whole blood
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581b064473f176e3696647f1e7fc716c
https://europepmc.org/articles/PMC7153270/ -
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المؤلفون: Michelle F. Homsher, Louis Locco, Shannon L. Stahler, Michael Weber, Jennifer E. Nothstein, Eleftheria N. Finger, Evelyn Boots, Mee Ra Heo, Amita Patel, Gregory O'Donnell, Alex Wolicki, Michael F.A. Finley, J. Christopher Culberson, Paul Zuck, Juncai Meng, Kenneth Roberts, David J. Bell, Peter S. Kutchukian, Gregory C. Adam, Carissa Quinn, Patrick Cocchiarella, Meir Glick, S. Alex May, Victor N. Uebele, Edward Hudak, Brian Squadroni, Daniel Riley, Andrew Rusinko, Kelli Solly, Michelle Hartnett, Dante A. Pertusi, Adam Amoss, Anthony Kreamer, Tara White, Anne Mai Wassermann
المصدر: SLAS Discovery. 22:995-1006
مصطلحات موضوعية: 0301 basic medicine, Prioritization, Engineering, Drug Evaluation, Preclinical, computer.software_genre, 01 natural sciences, Biochemistry, Analytical Chemistry, Machine Learning, User-Computer Interface, 03 medical and health sciences, Heuristics, Iterative and incremental development, Virtual screening, Drug discovery, business.industry, 0104 chemical sciences, Weighting, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Cheminformatics, Benchmark (computing), Molecular Medicine, Data mining, business, computer, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e5ff95861fbde45cdff3f2132d673
https://doi.org/10.1177/2472555217706058 -
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المؤلفون: Steven S. Carroll, Jeffrey Heath, Antonella Converso, John M. Sanders, Tracy L. Diamond, Kartik Narayan, Mee Ra Heo, Mark W. Stahlhut, Triveni Bhatt, Min Xu, Daniel Krosky, Christine Burlein, Pravien Abeywickrema, Jay A. Grobler, Daniel J. Klein, Yangsi Ou, Gregory C. Adam, Cheng Wang, Sujata Sharma
المصدر: ACS chemical biology. 12(11)
مصطلحات موضوعية: 0301 basic medicine, Proviral integration, Allosteric regulation, Integrase inhibitor, HIV Infections, Computational biology, HIV Integrase, Biochemistry, Cell Line, 03 medical and health sciences, Allosteric Regulation, Drug Discovery, Humans, HIV Integrase Inhibitors, Protein Interaction Maps, Viral maturation, Sulfonamides, 030102 biochemistry & molecular biology, biology, Target engagement, General Medicine, Virology, Phenotype, Integrase, 030104 developmental biology, biology.protein, Hiv 1 integrase, HIV-1, Molecular Medicine, Intercellular Signaling Peptides and Proteins