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1
المؤلفون: Deborah S. Mortensen, Sayee G. Hegde, Sophie M. Perrin-Ninkovic, Sogole Bahmanyar, Meg McCarrick, Roy Harris, Robert Hilgraf, Branden G. S. Lee, Jeff McKie, Lisa Nadolny, John Sapienza, Alice Collette, Sarah Cox, James C. Gamez, Jennifer L. Hensel, Xuequn Helen Hua, Jim Leisten, Heather K. Raymon, Tam Tran, Rama Krishna Narla
المصدر: Medicinal Chemistry Research.
مصطلحات موضوعية: Organic Chemistry, General Pharmacology, Toxicology and Pharmaceutics
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2
المؤلفون: Mark A. Nagy, Robert Hilgraf, Deborah S. Mortensen, Jan Elsner, Stephen Norris, Jayashree Tikhe, Won Yoon, David Paisner, Mercedes Delgado, Paul Erdman, Jason Haelewyn, Godrej Khambatta, Li Xu, William J. Romanow, Kevin Condroski, Sogole Bahmanyar, Meg McCarrick, Brent Benish, Kate Blease, Laurie LeBrun, Mehran F. Moghaddam, Julius Apuy, Stacie S. Canan, Brydon L. Bennett, Yoshitaka Satoh
المصدر: Journal of Medicinal Chemistry. 64:18193-18208
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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3
المؤلفون: John Adams, Meg McCarrick, Colin O’Carroll
المصدر: Molecular Genetics and Metabolism. 138:107382
مصطلحات موضوعية: Endocrinology, Endocrinology, Diabetes and Metabolism, Genetics, Molecular Biology, Biochemistry
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4
المؤلفون: Mark A, Nagy, Robert, Hilgraf, Deborah S, Mortensen, Jan, Elsner, Stephen, Norris, Jayashree, Tikhe, Won, Yoon, David, Paisner, Mercedes, Delgado, Paul, Erdman, Jason, Haelewyn, Godrej, Khambatta, Li, Xu, William J, Romanow, Kevin, Condroski, Sogole, Bahmanyar, Meg, McCarrick, Brent, Benish, Kate, Blease, Laurie, LeBrun, Mehran F, Moghaddam, Julius, Apuy, Stacie S, Canan, Brydon L, Bennett, Yoshitaka, Satoh
المصدر: Journal of medicinal chemistry. 64(24)
مصطلحات موضوعية: Cyclohexylamines, Structure-Activity Relationship, Pyrimidines, Drug Discovery, JNK Mitogen-Activated Protein Kinases, Animals, Humans, Phosphorylation, Protein Kinase Inhibitors, Idiopathic Pulmonary Fibrosis, Substrate Specificity
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5
المؤلفون: Sunil K. Koovakkat, Brad O. Buckman, Keith Eagen, Shung Wu, Ng Howard P, Raju Mohan, Wei Xu, Elena Ho, Lan Trinh, Babu Subramanyam, Meg McCarrick, Gary Phillips, Morrissey Michael M, Michael Pinkerton, William J. Guilford, Marc Whitlow, Amy Liang, David D. Davey
المصدر: Journal of Medicinal Chemistry. 45:2484-2493
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, Stereochemistry, Factor Xa Inhibitor, Amidines, Crystallography, X-Ray, Chemical synthesis, Amidine, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, Drug Discovery, Catalytic triad, medicine, Animals, Humans, Trypsin, Chromatography, High Pressure Liquid, biology, Rats, chemistry, Enzyme inhibitor, Factor Xa, biology.protein, Molecular Medicine, Factor Xa Inhibitors, medicine.drug
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6
المؤلفون: Li Xu, Meg Mccarrick, Neil R. D'sidocky, Veronique Plantevin Krenitsky, Lisa Nadolny, Yoshitaka Satoh, April Bai, Sayee G. Hegde, Brian E. Cathers, Jonathan Wright, Ronald Albers, John Sapienza, Steven S. Clareen, David Giegel, Rachel Fan, Robert Hilgraf, Michael A. Shirley, Heather Raymon, Maria Celeridad, Leticia Ayala, Jason Katz, Philip P Chamberlain, Brent Benish, Brydon L. Bennett, Tracey Bodine, Mercedes Delgado, Sogole Bahmanyar, Mehran F. Moghaddam, Silvia L. Delker, Yang Tang, Kate Blease, Oleg Khatsenko, Jeff Lachowitzer, Jeff Muir
المصدر: Bioorganicmedicinal chemistry letters. 22(3)
مصطلحات موضوعية: Models, Molecular, Anti fibrotic, MAP Kinase Kinase 4, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Pharmacology, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, Dogs, Catalytic Domain, Drug Discovery, Potency, Structure–activity relationship, Animals, Enzyme Inhibitors, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Haplorhini, Multiple species, Cyclohexanols, Jnk inhibitor, Idiopathic Pulmonary Fibrosis, Rats, Enzyme Activation, Orally active, Plasma exposure, Purines, Molecular Medicine, Aminopurine
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7
المؤلفون: Amy Liang, Dao Lentz, Lan Trinh, Yuo-Ling Chou, Brad O. Buckman, David R. Light, Raju Mohan, Kenneth J. Shaw, Morrissey Michael M, Meg Mccarrick
المصدر: Bioorganicmedicinal chemistry letters. 15(9)
مصطلحات موضوعية: Models, Molecular, Proteases, Stereochemistry, Clinical Biochemistry, Amidines, Molecular Conformation, Pharmaceutical Science, Factor VIIa, Naphthols, Biochemistry, Reductive amination, Thromboplastin, Serine, Acylation, Amidine, chemistry.chemical_compound, Tissue factor, Structure-Activity Relationship, Drug Discovery, Humans, Molecular Biology, Binding Sites, Aryl, Organic Chemistry, Small molecule, Kinetics, chemistry, Molecular Medicine