المؤلفون: Haas KM; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., McGregor MJ; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Bouhaddou M; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Polacco BJ; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Kim EY; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Nguyen TT; J. David Gladstone Institutes, San Francisco, CA, 94158, USA., Newton BW; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA., Urbanowski M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Kim H; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Williams MAP; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Rezelj VV; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Paris, France., Hardy A; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Paris, France., Fossati A; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Stevenson EJ; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Sukerman E; Division of Infectious Diseases, Oregon Health & Science University, Portland, OR, 97239, USA., Kim T; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Penugonda S; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Moreno E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, Madrid, Spain.; Centro de Investigación en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain., Braberg H; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Zhou Y; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Metreveli G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Harjai B; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Tummino TA; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA.; Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, CA, 94158, USA., Melnyk JE; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Soucheray M; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Batra J; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Pache L; Infectious and Inflammatory Disease Center, Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA., Martin-Sancho L; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.; Department of Infectious Disease, Imperial College London, London, SW7 2BX, UK., Carlson-Stevermer J; Synthego Corporation, Redwood City, CA, 94063, USA.; Serotiny Inc., South San Francisco, CA, 94080, USA., Jureka AS; Molecular Virology and Vaccine Team, Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization & Respiratory Diseases, Centers for Disease Control & Prevention, Atlanta, GA, 30333, USA.; General Dynamics Information Technology, Federal Civilian Division, Atlanta, GA, 30329, USA., Basler CF; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Shokat KM; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA., Shoichet BK; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA., Shriver LP; Department of Chemistry, Washington University in St. Louis, St. Louis, MO, 63105, USA.; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO, 63105, USA., Johnson JR; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Shaw ML; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Department of Medical Biosciences, University of the Western Cape, Bellville, 7535, Western Cape, South Africa., Chanda SK; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, 92037, USA., Roden DM; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Carter TC; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI, 54449, USA., Kottyan LC; Center of Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA., Chisholm RL; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Pacheco JA; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Smith ME; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Schrodi SJ; Laboratory of Genetics, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, 53706, USA., Albrecht RA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Vignuzzi M; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Institut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Paris, France., Zuliani-Alvarez L; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Swaney DL; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Eckhardt M; J. David Gladstone Institutes, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA., Wolinsky SM; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., White KM; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Hultquist JF; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA. judd.hultquist@northwestern.edu.; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. judd.hultquist@northwestern.edu.; Center for Pathogen Genomics and Microbial Evolution, Northwestern University Havey Institute for Global Health, Chicago, IL, 60611, USA. judd.hultquist@northwestern.edu., Kaake RM; J. David Gladstone Institutes, San Francisco, CA, 94158, USA. robyn.kaake@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA. robyn.kaake@ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA. robyn.kaake@ucsf.edu.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA. robyn.kaake@ucsf.edu., García-Sastre A; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA. adolfo.garcia-sastre@mssm.edu.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. adolfo.garcia-sastre@mssm.edu., Krogan NJ; J. David Gladstone Institutes, San Francisco, CA, 94158, USA. nevan.krogan@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94158, USA. nevan.krogan@ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA. nevan.krogan@ucsf.edu.; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA, 94158, USA. nevan.krogan@ucsf.edu.

المصدر: Nature communications [Nat Commun] 2023 Sep 27; Vol. 14 (1), pp. 6030. Date of Electronic Publication: 2023 Sep 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Influenza A virus*/genetics , Influenza, Human*/genetics , Influenza A Virus, H5N1 Subtype*/genetics , COVID-19*, Humans ; Influenza A Virus, H3N2 Subtype/metabolism ; Proteomics ; Virus Replication/genetics ; SARS-CoV-2 ; Antiviral Agents/metabolism ; Host-Pathogen Interactions/genetics

المؤلفون: Melnyk JE; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA., Steri V; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Preclinical Therapeutics Core, University of California San Francisco, San Francisco, CA, 94158, USA., Nguyen HG; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, 94143, USA., Hwang YC; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Medicine and Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Gordan JD; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Medicine and Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA, 94158, USA., Hann B; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Preclinical Therapeutics Core, University of California San Francisco, San Francisco, CA, 94158, USA., Feng FY; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Urology, University of California, San Francisco, San Francisco, CA, 94143, USA.; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, 94143, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA., Shokat KM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA. Kevan.shokat@ucsf.edu.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, 94143, USA. Kevan.shokat@ucsf.edu.

المصدر: Oncogene [Oncogene] 2022 Mar; Vol. 41 (11), pp. 1536-1549. Date of Electronic Publication: 2022 Jan 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

مواضيع طبية MeSH: Prostatic Neoplasms*/drug therapy , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/metabolism , Prostatic Neoplasms, Castration-Resistant*/genetics, Protein Kinase C beta/*metabolism, Androgen Antagonists/pharmacology ; Androgen Antagonists/therapeutic use ; Drug Resistance ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; RNA Splicing/genetics ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism

المؤلفون: Reuschl AK; Division of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom., Thorne LG; Division of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom., Zuliani-Alvarez L; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Bouhaddou M; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Obernier K; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Hiatt J; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA.; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco,CA 94143, USA., Soucheray M; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Turner J; Division of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom., Fabius JM; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA., Nguyen GT; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA., Swaney DL; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Rosales R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Avilés P; PharmaMar, Research and Development Department, 28770 Colmenar Viejo, Madrid, Spain., Kirby IT; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., Melnyk JE; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., Shi Y; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., Zhang Z; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., Shokat KM; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Jolly C; Division of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom., Towers GJ; Division of Infection and Immunity, University College London, London, WC1E 6BT, United Kingdom., Krogan NJ; Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG), San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2021 Feb 04. Date of Electronic Publication: 2021 Feb 04.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Melnyk JE; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Steri V; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Preclinical Therapeutics Core, University of California San Francisco, San Francisco, CA 94158, USA., Nguyen HG; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA., Hann B; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Preclinical Therapeutics Core, University of California San Francisco, San Francisco, CA 94158, USA., Feng FY; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Urology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Shokat KM; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: kevan.shokat@ucsf.edu.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Oct 15; Vol. 28 (20), pp. 115712. Date of Electronic Publication: 2020 Aug 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Prostatic Neoplasms/*drug therapy , Receptors, Androgen/*genetics , Sulfonamides/*pharmacology, Alternative Splicing/drug effects ; Alternative Splicing/genetics ; Animals ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; RNA, Messenger/drug effects ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Receptors, Androgen/metabolism ; Structure-Activity Relationship ; Sulfonamides/chemistry ; Tumor Cells, Cultured

المؤلفون: Bouhaddou M; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Memon D; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Meyer B; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France., White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Rezelj VV; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France., Correa Marrero M; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Polacco BJ; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Melnyk JE; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute., Ulferts S; Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany., Kaake RM; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Batra J; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Richards AL; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. 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David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Fabius JM; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Soucheray M; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Moreno E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Koh C; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France., Tran QD; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France., Hardy A; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France., Robinot R; Virus & Immunity Unit, Department of Virology, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France; Vaccine Research Institute, 94000 Creteil, France., Vallet T; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France., Nilsson-Payant BE; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hernandez-Armenta C; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Dunham A; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Weigang S; Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany., Knerr J; Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany., Modak M; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. 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David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Dugourd A; Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany., Valdeolivas A; Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany., Patil T; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Li Q; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Hüttenhain R; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. 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David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Kim M; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Jang G; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Tutuncuoglu B; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Hiatt J; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Guo JZ; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Xu J; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA., Bouhaddou S; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA., Mathy CJP; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA., Gaulton A; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Manners EJ; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Félix E; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Shi Y; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute., Goff M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lim JK; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., McBride T; Zoic Labs, Culver City, CA 90232, USA., O'Neal MC; Zoic Labs, Culver City, CA 90232, USA., Cai Y; Zoic Labs, Culver City, CA 90232, USA., Chang JCJ; Zoic Labs, Culver City, CA 90232, USA., Broadhurst DJ; Zoic Labs, Culver City, CA 90232, USA., Klippsten S; Zoic Labs, Culver City, CA 90232, USA., De Wit E; NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840, USA., Leach AR; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Kortemme T; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94158, USA., Shoichet B; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA., Ott M; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Saez-Rodriguez J; Institute for Computational Biomedicine, Bioquant, Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Heidelberg 69120, Germany., tenOever BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mullins RD; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute., Fischer ER; NIH/NIAID/Rocky Mountain Laboratories, Hamilton, MT 59840, USA., Kochs G; Institute of Virology, Medical Center - University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany., Grosse R; Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg, Freiburg 79104, Germany; Faculty of Medicine, University of Freiburg, Freiburg 79008, Germany; Centre for Integrative Biological Signalling Studies (CIBSS), Freiburg 79104, Germany. Electronic address: robert.grosse@pharmakol.uni-freiburg.de., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: adolfo.garcia-sastre@mssm.edu., Vignuzzi M; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724 Paris, Cedex 15, France. Electronic address: marco.vignuzzi@pasteur.fr., Johnson JR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: jeffrey.johnson@mssm.edu., Shokat KM; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Howard Hughes Medical Institute. Electronic address: kevan.shokat@ucsf.edu., Swaney DL; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: danielle.swaney@ucsf.edu., Beltrao P; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. Electronic address: pbeltrao@ebi.ac.uk., Krogan NJ; QBI COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), University of California, San Francisco, San Francisco, CA 94158, USA; J. David Gladstone Institutes, San Francisco, CA 94158, USA; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: nevan.krogan@ucsf.edu.

المصدر: Cell [Cell] 2020 Aug 06; Vol. 182 (3), pp. 685-712.e19. Date of Electronic Publication: 2020 Jun 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Betacoronavirus/*metabolism , Coronavirus Infections/*metabolism , Drug Evaluation, Preclinical/*methods , Pneumonia, Viral/*metabolism , Proteomics/*methods, A549 Cells ; Angiotensin-Converting Enzyme 2 ; Animals ; Antiviral Agents/pharmacology ; COVID-19 ; Caco-2 Cells ; Casein Kinase II/antagonists & inhibitors ; Casein Kinase II/metabolism ; Chlorocebus aethiops ; Coronavirus Infections/virology ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Cyclin-Dependent Kinases/metabolism ; HEK293 Cells ; Host-Pathogen Interactions ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Phosphorylation ; Pneumonia, Viral/virology ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/metabolism ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/metabolism ; Vero Cells ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases/metabolism ; Axl Receptor Tyrosine Kinase

المؤلفون: Gordon DE; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Jang GM; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Bouhaddou M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Xu J; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Obernier K; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., O'Meara MJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Rezelj VV; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Guo JZ; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Swaney DL; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Tummino TA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Hüttenhain R; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Kaake RM; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Richards AL; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Tutuncuoglu B; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Foussard H; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Batra J; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Haas K; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Modak M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Kim M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Haas P; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Polacco BJ; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Braberg H; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Fabius JM; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Eckhardt M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Soucheray M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Bennett MJ; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Cakir M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., McGregor MJ; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Li Q; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Meyer B; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Roesch F; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Vallet T; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Mac Kain A; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Miorin L; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Moreno E; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Naing ZZC; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Zhou Y; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Peng S; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Shi Y; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Zhang Z; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Shen W; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Kirby IT; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Melnyk JE; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Chorba JS; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Lou K; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Dai SA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Barrio-Hernandez I; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK., Memon D; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK., Hernandez-Armenta C; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK., Lyu J; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Mathy CJP; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA., Perica T; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Pilla KB; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Ganesan SJ; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Saltzberg DJ; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Rakesh R; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Liu X; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Rosenthal SB; Center for Computational Biology and Bioinformatics, Department of Medicine, University of California San Diego, San Diego, CA, USA., Calviello L; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA., Venkataramanan S; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA., Liboy-Lugo J; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA., Lin Y; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA., Huang XP; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Liu Y; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Wankowicz SA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Biophysics Graduate Program, University of California San Francisco, San Francisco, CA, USA., Bohn M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Safari M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Ugur FS; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Koh C; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Savar NS; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Tran QD; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Shengjuler D; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., Fletcher SJ; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France., O'Neal MC; Zoic Labs, Culver City, CA, USA., Cai Y; Zoic Labs, Culver City, CA, USA., Chang JCJ; Zoic Labs, Culver City, CA, USA., Broadhurst DJ; Zoic Labs, Culver City, CA, USA., Klippsten S; Zoic Labs, Culver City, CA, USA., Sharp PP; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Wenzell NA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Kuzuoglu-Ozturk D; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Urology, University of California San Francisco, San Francisco, CA, USA., Wang HY; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Trenker R; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., Young JM; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Cavero DA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; George William Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Hiatt J; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Medical Scientist Training Program, University of California San Francisco, San Francisco, CA, USA., Roth TL; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; George William Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.; Medical Scientist Training Program, University of California San Francisco, San Francisco, CA, USA., Rathore U; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; George William Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Subramanian A; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; George William Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Noack J; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; George William Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Hubert M; Virus and Immunity Unit, Institut Pasteur, Paris, France., Stroud RM; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Frankel AD; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Rosenberg OS; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Verba KA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Agard DA; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA., Ott M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Emerman M; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Jura N; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA., von Zastrow M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA., Verdin E; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Buck Institute for Research on Aging, Novato, CA, USA., Ashworth A; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Schwartz O; Virus and Immunity Unit, Institut Pasteur, Paris, France., d'Enfert C; Direction Scientifique, Institut Pasteur, Paris, France., Mukherjee S; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; George William Hooper Foundation, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA., Jacobson M; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Malik HS; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Fujimori DG; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Ideker T; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Division of Genetics, Department of Medicine, University of California San Diego, San Diego, CA, USA., Craik CS; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Floor SN; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Fraser JS; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Gross JD; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Sali A; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA., Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA., Ruggero D; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Urology, University of California San Francisco, San Francisco, CA, USA., Taunton J; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Kortemme T; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California San Francisco, San Francisco, CA, USA., Beltrao P; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA.; European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK., Vignuzzi M; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, Paris, France. marco.vignuzzi@pasteur.fr., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Adolfo.Garcia-Sastre@mssm.edu.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Adolfo.Garcia-Sastre@mssm.edu.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Adolfo.Garcia-Sastre@mssm.edu.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Adolfo.Garcia-Sastre@mssm.edu., Shokat KM; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA. Kevan.Shokat@ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA. Kevan.Shokat@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA. Kevan.Shokat@ucsf.edu.; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA. Kevan.Shokat@ucsf.edu., Shoichet BK; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA. shoichet@cgl.ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA. shoichet@cgl.ucsf.edu.; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA. shoichet@cgl.ucsf.edu., Krogan NJ; QBI COVID-19 Research Group (QCRG), San Francisco, CA, USA. nevan.krogan@ucsf.edu.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA. nevan.krogan@ucsf.edu.; J. David Gladstone Institutes, San Francisco, CA, USA. nevan.krogan@ucsf.edu.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA. nevan.krogan@ucsf.edu.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. nevan.krogan@ucsf.edu.

المصدر: Nature [Nature] 2020 Jul; Vol. 583 (7816), pp. 459-468. Date of Electronic Publication: 2020 Apr 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Drug Repositioning* , Molecular Targeted Therapy* , Protein Interaction Maps*, Betacoronavirus/*drug effects , Coronavirus Infections/*drug therapy , Coronavirus Infections/*metabolism , Pneumonia, Viral/*drug therapy , Pneumonia, Viral/*metabolism , Viral Proteins/*metabolism, Animals ; Antiviral Agents/classification ; Antiviral Agents/pharmacology ; Betacoronavirus/genetics ; Betacoronavirus/metabolism ; Betacoronavirus/pathogenicity ; COVID-19 ; Chlorocebus aethiops ; Cloning, Molecular ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Drug Evaluation, Preclinical ; HEK293 Cells ; Host-Pathogen Interactions/drug effects ; Humans ; Immunity, Innate ; Mass Spectrometry ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Protein Binding ; Protein Biosynthesis/drug effects ; Protein Domains ; Protein Interaction Mapping ; Receptors, sigma/metabolism ; SARS-CoV-2 ; SKP Cullin F-Box Protein Ligases/metabolism ; Vero Cells ; Viral Proteins/genetics ; COVID-19 Drug Treatment

المؤلفون: Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Lin Y, Wankowicz SA, Bohn M, Trenker R, Young JM, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Agard D, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2020 Mar 22. Date of Electronic Publication: 2020 Mar 22.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Schaefer AK; Department of Chemistry and Biochemistry and ‡Department of Biological Sciences, University of Delaware , Newark, Delaware 19716, United States., Wastyk HC; Department of Chemistry and Biochemistry and ‡Department of Biological Sciences, University of Delaware , Newark, Delaware 19716, United States., Mohanan V; Department of Chemistry and Biochemistry and ‡Department of Biological Sciences, University of Delaware , Newark, Delaware 19716, United States., Hou CW; Department of Chemistry and Biochemistry and ‡Department of Biological Sciences, University of Delaware , Newark, Delaware 19716, United States., Lauro ML; Department of Chemistry and Biochemistry and ‡Department of Biological Sciences, University of Delaware , Newark, Delaware 19716, United States., Melnyk JE; Department of Chemistry and Biochemistry and ‡Department of Biological Sciences, University of Delaware , Newark, Delaware 19716, United States., Burch JM; Department of Chemistry and Biochemistry and ‡Department of Biological Sciences, University of Delaware , Newark, Delaware 19716, United States., Grimes CL; Department of Chemistry and Biochemistry and ‡Department of Biological Sciences, University of Delaware , Newark, Delaware 19716, United States.

المصدر: Biochemistry [Biochemistry] 2017 Aug 29; Vol. 56 (34), pp. 4445-4448. Date of Electronic Publication: 2017 Aug 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Mutation, Missense*, Crohn Disease/*metabolism , HSP70 Heat-Shock Proteins/*metabolism , Nod2 Signaling Adaptor Protein/*metabolism, Amino Acid Substitution ; Crohn Disease/genetics ; Crohn Disease/immunology ; HSP70 Heat-Shock Proteins/chemistry ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/immunology ; Humans ; Nod2 Signaling Adaptor Protein/chemistry ; Nod2 Signaling Adaptor Protein/genetics ; Nod2 Signaling Adaptor Protein/immunology ; Protein Domains ; Protein Stability

المؤلفون: Schaefer AK; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States., Melnyk JE; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States., Baksh MM; School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332, United States., Lazor KM; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States., Finn MG; School of Chemistry and Biochemistry, Georgia Institute of Technology , Atlanta, Georgia 30332, United States., Grimes CL; Department of Chemistry and Biochemistry, University of Delaware , Newark, Delaware 19716, United States.; Department of Biological Sciences, University of Delaware , Newark, Delaware 19716, United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2017 Aug 18; Vol. 12 (8), pp. 2216-2224. Date of Electronic Publication: 2017 Jul 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Immunity, Innate* , Ligands*, Nod2 Signaling Adaptor Protein/*metabolism, Binding Sites ; Cell Line ; Dipeptides/chemistry ; Humans ; Nod2 Signaling Adaptor Protein/chemistry ; Peptidoglycan/chemistry ; Substrate Specificity

المؤلفون: Melnyk JE; †Department of Chemistry and Biochemistry, and §Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, United States., Mohanan V; †Department of Chemistry and Biochemistry, and §Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, United States., Schaefer AK; †Department of Chemistry and Biochemistry, and §Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, United States., Hou CW; †Department of Chemistry and Biochemistry, and §Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, United States., Grimes CL; †Department of Chemistry and Biochemistry, and §Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2015 Jun 10; Vol. 137 (22), pp. 6987-90. Date of Electronic Publication: 2015 Jun 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Immunity, Innate*, Nod2 Signaling Adaptor Protein/*chemistry , Peptidoglycan/*chemistry