نتائج البحث - "Memapsin 2"

1

كتاب إلكتروني

The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease

المؤلفون: Ghosh, Arun K.^{Aff11, Aff12}, Cárdenas, Emilio L.^Aff11, Osswald, Heather L.^Aff11

المساهمون: Bernstein, Peter R., Series editor^Aff1, Georg, Gunda I., Series editor^Aff2, Keller, Thomas, Series editor^Aff3, Lowe, John A., Series editor^Aff4, Meanwell, Nicholas A., Series editor^Aff5, Saxena, Anil Kumar, Series editor^Aff6, Stilz, Ulrich, Series editor^Aff7, Supuran, Claudiu T., Series editor^Aff8, Zhang, Ao, Series editor^Aff9, Wolfe, Michael S., editor^Aff10

المصدر: Alzheimer’s Disease II. 24:27-85

2

دورية أكاديمية

Study of memapsin 2 (β-secretase) and strategy of inhibitor design

المؤلفون: Tang, Jordan^{Aff1, Aff2, IDArt203299_cor1}, Ghosh, Arun K., Hong, Lin, Koelsch, Gerald, Turner, Robert T.^{Aff1, Aff2}, Chang, Wanpin

المصدر: Journal of Molecular Neuroscience. 20(3):299-304

Find this article in full text from Springer Verlag.

Find this article in full text from ProQuest

Full Text Finder

3

Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand

المؤلفون: Nagaswamy Kumaragurubaran, Koena Ghosh, Andrew D. Mesecar, Arun K. Ghosh, Emma K. Lendy, Jordan Tang, Margherita Brindisi, Yu-Chen Yen, Xiangping Huang

المساهمون: Ghosh, A. K., Ghosh, K., Brindisi, M., Lendy, E. K., Yen, Y. -C., Kumaragurubaran, N., Huang, X., Tang, J., Mesecar, A. D.

مصطلحات موضوعية: 0301 basic medicine, Amide, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Isoxazole, Catalytic Domain, Drug Discovery, Aspartic Acid Endopeptidases, β-secretase, Aspartic Acid Endopeptidase, Amyloid Precursor Protein Secretase, Memapsin 2, Alanine, Crystallography, biology, Bicyclic molecule, Molecular Structure, Chemistry, BACE-1, Alzheimer's disease, symbols, Molecular Medicine, van der Waals force, Carboxylic Acid, Human, Stereochemistry, Isoxazoline, Amides, Amyloid Precursor Protein Secretases, Bridged Bicyclo Compounds, Cysteine, Humans, Isoxazoles, Protease Inhibitors, 010402 general chemistry, Article, 03 medical and health sciences, symbols.namesake, mental disorders, Hydrolase, Molecule, Molecular Biology, Ligand, Organic Chemistry, Active site, 0104 chemical sciences, 030104 developmental biology, biology.protein, X-Ray, Bridged Bicyclo Compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ab8582625d739744a324e7c35a80f3
http://hdl.handle.net/11588/771102

4

Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand

المؤلفون: Andrew D. Mesecar, Thippeswamy Devasamudram, Xiao Ming Xu, Jordan Tang, Yu-Chen Yen, Xiangping Huang, Gerald Koelsch, Arun K. Ghosh, Geoffrey Bilcer, Margherita Brindisi, Hui Lei

المساهمون: Ghosh, Arun K., Brindisi, Margherita, Yen, Yu Chen, Xu, Xiaoming, Huang, Xiangping, Devasamudram, Thippeswamy, Bilcer, Geoffrey, Lei, Hui, Koelsch, Gerald, Mesecar, Andrew D., Tang, Jordan

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:668-672

مصطلحات موضوعية: Protease Inhibitor, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, Crystallography, X-Ray, Ligands, Biochemistry, chemistry.chemical_compound, Catalytic Domain, Drug Discovery, β-secretase, Moiety, Amyloid Precursor Protein Secretase, Alzheimer's disease, BACE-1, Memapsin 2, Protease inhibitors, Amyloid Precursor Protein Secretases, Binding Sites, Kinetics, Molecular Dynamics Simulation, Protease Inhibitors, Protein Binding, Pyrazoles, Structure-Activity Relationship, Thiazoles, Drug Design, Molecular Medicine, Molecular Biology, 3003, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Crystallography, biology, Stereochemistry, Ligand, Article, Structure–activity relationship, Binding site, Thiazole, Kinetic, Binding Site, Active site, Combinatorial chemistry, chemistry, X-Ray, biology.protein, Amyloid precursor protein secretase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ca53b6dd2a23f1f20f45eecab6420d
https://doi.org/10.1016/j.bmcl.2014.11.087

View record from ScienceDirect

5

Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1 '-P2 ' ligands

المؤلفون: Andrew D. Mesecar, Emilio L. Cárdenas, Jordan Tang, Yu-Chen Yen, Margherita Brindisi, Xiangping Huang, Nagaswamy Kumaragurubaran, Jean Rene Ella-Menye, Arun K. Ghosh

المساهمون: Ghosh, Arun K., Brindisi, Margherita, Yen, Yu-Chen, Cã¡rdenas, Emilio L., Ella-Menye, Jean-Rene, Kumaragurubaran, Nagaswamy, Huang, Xiangping, Tang, Jordan, Mesecar, Andrew D.

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Phthalic Acids, Pharmaceutical Science, Crystal structure, 01 natural sciences, Biochemistry, Piperazines, Article, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Î²-Secretase, mental disorders, Drug Discovery, Aspartic Acid Endopeptidases, Structure–activity relationship, Aspartic Acid Endopeptidase, Amyloid Precursor Protein Secretase, Memapsin 2, Phthalic Acid, Piperazine, Molecular Biology, Bicyclic molecule, 010405 organic chemistry, BACE-1, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, X-ray, Protease inhibitors, Alzheimer's disease, 0104 chemical sciences, Phthalic acid, 030104 developmental biology, Design synthesis, chemistry, Protease inhibitor, β secretase, Amyloid Precursor Protein Secretases, Molecular Medicine, 3003