المؤلفون: James Yarmolinsky, Virginia Díez-Obrero, Tom G Richardson, Marie Pigeyre, Jennifer Sjaarda, Guillaume Paré, Venexia M Walker, Emma E Vincent, Vanessa Y Tan, Mireia Obón-Santacana, Demetrius Albanes, Jochen Hampe, Andrea Gsur, Heather Hampel, Rish K Pai, Mark Jenkins, Steven Gallinger, Graham Casey, Wei Zheng, Christopher I Amos, International Lung Cancer Consortium, PRACTICAL consortium, MEGASTROKE consortium, George Davey Smith, Richard M Martin, Victor Moreno

المصدر: PLoS Medicine, Vol 19, Iss 2, p e1003897 (2022)
Yarmolinsky, J, Díez-Obrero, V, Richardson, T G, Pigeyre, M, Sjaarda, J, Paré, G, Walker, V M, Vincent, E E, Tan, V Y, Obón-Santacana, M, Albanes, D, Hampe, J, Gsur, A, Hampel, H, Pai, R K, Jenkins, M, Gallinger, S, Casey, G, Zheng, W, Amos, C I, International Lung Cancer Consortium, The PRACTICAL Consortium, The MEGASTROKE consortium, Smith, G D, Martin, R M & Moreno, V 2022, ' Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers : A mendelian randomization analysis ', PLOS Medicine, vol. 19, no. 2, e1003897 . https://doi.org/10.1371/journal.pmed.1003897
the PRACTICAL Consortium 2022, ' Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers : A mendelian randomization analysis ', PLoS Medicine, vol. 19, no. 2, e1003897 . https://doi.org/10.1371/journal.pmed.1003897
Dipòsit Digital de la UB
Universidad de Barcelona

مصطلحات موضوعية: Male, Polymorphism, Single Nucleotide/drug effects, Antihypertensive Agents/adverse effects, Mendelian Randomization Analysis/methods, Peptidyl-Dipeptidase A/genetics, General Medicine, Receptors, Adrenergic, beta-1/genetics, Blood Pressure/drug effects, Risk Factors, Neoplasms/chemically induced, Hypertension, Genome-Wide Association Study/methods, Humans, Medicine, Female, Hipertensió, ICEP, Solute Carrier Family 12, Member 3/genetics, Càncer, Cancer

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ebdcff10cb8f88caaecd212f39594e
https://doaj.org/article/34b1a0c7008a49a584262cd8aef7a5ec

المؤلفون: Martin Konrad, David H. Ellison, Shih-Hua Lin, Rosa Vargas-Poussou, Anne Blanchard, Olivier Devuyst, Detlef Bockenhauer, Davide Bolignano, Lorenzo A. Calò, Nine V A M Knoers, Fiona E. Karet Frankl, Etienne Cosyns

المساهمون: University of Zurich, Devuyst, Olivier, Blanchard, Anne [0000-0002-0815-0586], Bolignano, Davide [0000-0003-3032-245X], Ellison, David H [0000-0003-2915-265X], Apollo - University of Cambridge Repository, CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University College of London [London] (UCL), Great Ormond Street Hospital for Children [London] (GOSH), Consiglio Nazionale delle Ricerche / National Research Council [Calabria, Italy] (CNR), Universita degli Studi di Padova, Wanze [Belgium], Universität Zürich [Zürich] = University of Zurich (UZH), Oregon Health and Science University [Portland] (OHSU), University of Cambridge [UK] (CAM), Cambridge University Hospitals - NHS (CUH), University Medical Center [Utrecht], University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), National Taiwan University [Taiwan] (NTU), Centre de Référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte (MARHEA), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli Studi di Padova = University of Padua (Unipd), Centre de Référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte [CHU-Necker] (MARHEA), HULOT, Jean-Sébastien

المصدر: Kidney International, 91(1), 24-33. ELSEVIER SCIENCE INC
Kidney International, 91(1), 24. Nature Publishing Group
Kidney International
Kidney International, Nature Publishing Group, 2017, 91 (1), pp.24-33. ⟨10.1016/j.kint.2016.09.046⟩
Kidney International, 2017, 91 (1), pp.24-33. ⟨10.1016/j.kint.2016.09.046⟩

مصطلحات موضوعية: Calcium/urine, Sodium Chloride, Dietary/therapeutic use, Consensus Development Conferences as Topic, 030232 urology & nephrology, Anti-Inflammatory Agents, Angiotensin-Converting Enzyme Inhibitors, Disease, 030204 cardiovascular system & hematology, Sodium Chloride, thiazide-sensitive sodium-chloride cotransporter, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 10052 Institute of Physiology, 0302 clinical medicine, Gitelman Syndrome/complications, Diagnosis, salt-losing tubulopathy, Medicine, Potassium/administration & dosage, Magnesium, Solute Carrier Family 12, Member 3, Ultrasonography, 2727 Nephrology, Magnesium/administration & dosage, medicine.diagnostic_test, Anti-Inflammatory Agents, Non-Steroidal, Dietary/therapeutic use, Bartter Syndrome/blood, Angiotensin Receptor Antagonists/therapeutic use, 3. Good health, Angiotensin-Converting Enzyme Inhibitors/therapeutic use, Chondrocalcinosis/etiology, Phenotype, Nephrology, Practice Guidelines as Topic, Anti-Inflammatory Agents, Non-Steroidal/therapeutic use, medicine.symptom, Gitelman Syndrome, medicine.medical_specialty, Non-Steroidal/therapeutic use, Solute Carrier Family 12, Chloride Channels/genetics, 610 Medicine & health, Chondrocalcinosis, Hypokalemia, Hypocalciuria, Diagnosis, Differential, 03 medical and health sciences, hypomagnesemia, Angiotensin Receptor Antagonists, Rare Diseases/genetics, Rare Diseases, Tubulopathy, Chloride Channels, Journal Article, Humans, Genetic Testing, Salt intake, Sodium Chloride, Dietary, Intensive care medicine, Genetic testing, business.industry, Bartter Syndrome, Gitelman syndrome, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, hypokalemic metabolic alkalosis, Differential, Member 3/genetics, Dietary Supplements, Mutation, Hypokalemia/blood, Potassium, Quality of Life, 570 Life sciences, biology, Calcium, SLC12A3, Differential diagnosis, Solute Carrier Family 12, Member 3/genetics, business, Kidney disease

وصف الملف: application/pdf; image/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b887761584db08d9bc6a00bdec07adc7

المؤلفون: Nanna MacAulay, Olivier Staub, Lena Lindtoft Rosenbaek, Robert A. Fenton, Federica Rizzo

المصدر: American journal of physiology. Renal physiology, vol. 313, no. 2, pp. F495-F504
Rosenbaek, L L, Rizzo, F, MacAulay, N, Staub, O & Fenton, R A 2017, ' Functional assessment of sodium chloride cotransporter NCC mutants in polarized mammalian epithelial cells ', American Journal of Physiology: Renal Physiology, vol. 313, no. 2, pp. F495-F504 . https://doi.org/10.1152/ajprenal.00088.2017

مصطلحات موضوعية: 0301 basic medicine, Genotype, Physiology, Sodium Chloride Symporter Inhibitors, Sodium, Potassium, Cell Culture Techniques, chemistry.chemical_element, Biology, Transfection, Madin Darby Canine Kidney Cells, 03 medical and health sciences, Dogs, Chlorides, Animals, Cell Polarity, Chlorides/metabolism, Dose-Response Relationship, Drug, Epithelial Cells/drug effects, Epithelial Cells/metabolism, High-Throughput Screening Assays, Kinetics, Mutation, Phenotype, Phosphorylation, Potassium/metabolism, Protein Processing, Post-Translational, Sodium/metabolism, Sodium Chloride Symporter Inhibitors/pharmacology, Solute Carrier Family 12, Member 3/drug effects, Solute Carrier Family 12, Member 3/genetics, Solute Carrier Family 12, Member 3/metabolism, Na+/Cl− cotransporter, Slc12a3, cotransporter, phosphorylation, sodium flux assay, thiazide-sensitive cotransporter, parasitic diseases, Cell polarity, Journal Article, Solute Carrier Family 12, Member 3, Comparative Study, urogenital system, Epithelial Cells, Molecular biology, 030104 developmental biology, chemistry, Biochemistry, Cell culture, embryonic structures, Cotransporter

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a99364160e0dd865f8d98f1c941802
https://doi.org/10.1152/ajprenal.00088.2017

المؤلفون: Raoul D. Nelson, Edith Hummler, Helle Hasager Damkier, Lance Edward Miller, Birgitte Mønster Christensen, Søren Brandt Poulsen, Jeppe Praetorius

المصدر: American Journal of Physiology. Renal Physiology, vol. 310, no. 4, pp. F300-F310
Poulsen, S B, Praetorius, J, Damkier, H H, Miller, L, Nelson, R D, Hummler, E & Christensen, B M 2016, ' Reducing αENaC expression in kidney connecting tubule induces pseudohypoaldosteronism type 1 symptoms during K+ loading ', American Journal of Physiology: Renal Physiology, vol. 310, no. 4, pp. F300-F310 . https://doi.org/10.1152/ajprenal.00258.2015

مصطلحات موضوعية: 0301 basic medicine, Epithelial sodium channel, Male, medicine.medical_specialty, Physiology, Colon, Sodium, Pseudohypoaldosteronism, 030232 urology & nephrology, chemistry.chemical_element, Excretion, 03 medical and health sciences, chemistry.chemical_compound, Eating, Mice, 0302 clinical medicine, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, Internal medicine, medicine, Animals, Solute Carrier Family 12, Member 3, Kidney Tubules, Collecting, Phosphorylation, Epithelial Sodium Channels, Aldosterone, Solute Carrier Family 12, Member 1, Mice, Knockout, Chemistry, Body Weight, medicine.disease, Connecting tubule, Diet, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Potassium, Aldosterone/metabolism, Colon/metabolism, Epithelial Sodium Channels/biosynthesis, Epithelial Sodium Channels/genetics, Female, Kidney Tubules, Collecting/metabolism, Kidney Tubules, Collecting/pathology, Potassium/blood, Potassium/metabolism, Pseudohypoaldosteronism/genetics, Pseudohypoaldosteronism/metabolism, Sodium/blood, Sodium/metabolism, Solute Carrier Family 12, Member 1/biosynthesis, Solute Carrier Family 12, Member 1/genetics, Solute Carrier Family 12, Member 3/biosynthesis, Solute Carrier Family 12, Member 3/genetics, Cotransporter, Homeostasis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872b578644a2ebae89ef677482a31b51
https://serval.unil.ch/resource/serval:BIB_4DB30CE2E35B.P001/REF.pdf

المؤلفون: Omar A. Z. Tutakhel, Jaap Deinum, René J. M. Bindels, Marco A. Valdez-Flores, Jacques W.M. Lenders, Henrik Dimke, Sander R. Piersma, Sabina Jeleń, Joost G. J. Hoenderop, Connie R. Jimenez

المساهمون: ICaR - Circulation and metabolism, Medical oncology laboratory

المصدر: Tutakhel, O A Z, Jelen, S, Valdez-Flores, M, Dimke, H, Piersma, S R, Jimenez, C R, Deinum, J, Lenders, J W, Hoenderop, J G J & Bindels, R J M 2016, ' Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling ', American Journal of Physiology. Renal Physiology, vol. 310, no. 3, pp. F204-F216 . https://doi.org/10.1152/ajprenal.00429.2015
American Journal of Physiology : Renal Physiology, 310, 3, pp. F204-16
American Journal of Physiology : Renal Physiology, 310, F204-16
American Journal of Physiology. Renal Physiology, 310(3), F204-F216. American Physiological Society
Tutakhel, O A Z, Jeleń, S, Valdez-Flores, M, Dimke, H, Piersma, S R, Jimenez, C R, Deinum, J, Lenders, J W, Hoenderop, J G J & Bindels, R J M 2016, ' Alternative splice variant of the thiazide-sensitive NaCl cotransporter : a novel player in renal salt handling ', American Journal of Physiology: Renal Physiology, vol. 310, no. 3, pp. F204-F216 . https://doi.org/10.1152/ajprenal.00429.2015

مصطلحات موضوعية: 0301 basic medicine, Male, Proteomics, Time Factors, Physiology, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], RNA, Messenger/metabolism, Xenopus, Fluorescent Antibody Technique, Sodium Chloride, Exosomes, Kidney, Xenopus laevis, Tandem Mass Spectrometry, Protein Isoforms, Solute Carrier Family 12, Member 3, Phosphorylation, Aldosterone-sensitive distal part of the nephron, biology, Reabsorption, Anatomy, WNK4, Cell biology, Exosomes/metabolism, medicine.anatomical_structure, Hypertension, embryonic structures, Proteomics/methods, Gene isoform, Adult, Sodium Chloride/metabolism, Blotting, Western, Molecular Sequence Data, Drinking, Transfection, 03 medical and health sciences, parasitic diseases, medicine, Animals, Humans, Distal convoluted tubule, Amino Acid Sequence, RNA, Messenger, Base Sequence, urogenital system, Cell Membrane/metabolism, Sodium, HEK 293 cells, Cell Membrane, Biological Transport, biology.organism_classification, Renal Reabsorption, Kidney/metabolism, Alternative Splicing, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 030104 developmental biology, HEK293 Cells, Gene Expression Regulation, Mutation, Solute Carrier Family 12, Member 3/genetics, Cotransporter

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3cf436a2c73bedcb255dc3e4c7a7de
https://pubmed.ncbi.nlm.nih.gov/26561651