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المؤلفون: Oreskovic E; Department of Genetics, Harvard Medical School, Boston, MA 02115.; HHMI, Harvard Medical School, Boston, MA 02115.; Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA 02115., Wheeler EC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Mengwasser KE; Department of Genetics, Harvard Medical School, Boston, MA 02115.; HHMI, Harvard Medical School, Boston, MA 02115.; Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA 02115., Fujimura E; Department of Genetics, Harvard Medical School, Boston, MA 02115.; HHMI, Harvard Medical School, Boston, MA 02115.; Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA 02115.; Chemical Biology Program, Harvard University, Cambridge, MA 02138., Martin TD; Department of Genetics, Harvard Medical School, Boston, MA 02115.; HHMI, Harvard Medical School, Boston, MA 02115.; Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA 02115., Tothova Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; zuzana_tothova@dfci.harvard.edu selledge@genetics.med.harvard.edu.; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Elledge SJ; Department of Genetics, Harvard Medical School, Boston, MA 02115; zuzana_tothova@dfci.harvard.edu selledge@genetics.med.harvard.edu.; HHMI, Harvard Medical School, Boston, MA 02115.; Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA 02115.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Feb 15; Vol. 119 (7).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: B7-H1 Antigen/*metabolism , CCCTC-Binding Factor/*metabolism , Cell Cycle Proteins/*metabolism , Chromosomal Proteins, Non-Histone/*metabolism , Gene Expression Regulation, Neoplastic/*physiology , Neoplasms/*metabolism, B7-H1 Antigen/genetics ; CCCTC-Binding Factor/genetics ; Cell Cycle Proteins/genetics ; Cell Line ; Chromosomal Proteins, Non-Histone/genetics ; Humans ; Janus Kinases/genetics ; Janus Kinases/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; STAT Transcription Factors/genetics ; STAT Transcription Factors/metabolism ; Up-Regulation ; Cohesins

المؤلفون: Elman JS; Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA; Raymond & Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA., Ni TK; Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA; Raymond & Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA., Mengwasser KE; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Jin D; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Wronski A; Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA; Raymond & Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA., Elledge SJ; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Ludwig Center at Harvard, Boston, MA, USA; Department of Genetics, Program in Virology, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA., Kuperwasser C; Department of Developmental, Chemical and Molecular Biology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA; Raymond & Beverly Sackler Convergence Laboratory, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA. Electronic address: charlotte.kuperwasser@tufts.edu.

المصدر: Cell reports [Cell Rep] 2019 Sep 24; Vol. 28 (13), pp. 3435-3449.e5.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Alternative Splicing/*genetics , DNA-Binding Proteins/*genetics , Neoplasms/*genetics , Oncogenes/*genetics , RNA-Binding Proteins/*genetics, Genes, Tumor Suppressor ; Humans

المؤلفون: Mengwasser KE; Howard Hughes Medical Institute, Department of Genetics, Ludwig Center, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA., Adeyemi RO; Howard Hughes Medical Institute, Department of Genetics, Ludwig Center, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA., Leng Y; Howard Hughes Medical Institute, Department of Genetics, Ludwig Center, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA., Choi MY; Howard Hughes Medical Institute, Department of Genetics, Ludwig Center, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA., Clairmont C; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., D'Andrea AD; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Elledge SJ; Howard Hughes Medical Institute, Department of Genetics, Ludwig Center, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: selledge@genetics.med.harvard.edu.

المصدر: Molecular cell [Mol Cell] 2019 Mar 07; Vol. 73 (5), pp. 885-899.e6. Date of Electronic Publication: 2019 Jan 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Genes, Lethal* , RNA Interference* , Synthetic Lethal Mutations*, BRCA2 Protein/*genetics , DNA-(Apurinic or Apyrimidinic Site) Lyase/*genetics , Flap Endonucleases/*genetics , Neoplasms/*genetics, Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; BRCA2 Protein/metabolism ; Cell Death ; Cell Line, Tumor ; DNA Damage ; DNA End-Joining Repair ; DNA-(Apurinic or Apyrimidinic Site) Lyase/metabolism ; Endonucleases ; Flap Endonucleases/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Multifunctional Enzymes ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Neoplasms/pathology ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Proliferating Cell Nuclear Antigen/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; RNA, Small Interfering/genetics

المؤلفون: Davoli T; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Mengwasser KE; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Duan J; Department of Neurobiology, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Department of Cellular and Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, Connecticut 06511, USA., Chen T; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA., Christensen C; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA., Wooten EC; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Anselmo AN; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Li MZ; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA., Wong KK; Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA., Kahle KT; Department of Neurobiology, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Department of Cellular and Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, Connecticut 06511, USA., Elledge SJ; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

المصدر: Genes & development [Genes Dev] 2016 Dec 15; Vol. 30 (24), pp. 2684-2695.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic*, Colorectal Neoplasms/*enzymology , Colorectal Neoplasms/*genetics , Phosphatidylinositol 3-Kinases/*genetics , Phosphatidylinositol 3-Kinases/*metabolism , Signal Transduction/*genetics, Animals ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/physiopathology ; Genomics ; HCT116 Cells ; HEK293 Cells ; Humans ; Mice ; Mutation ; Proteasome Endopeptidase Complex/genetics ; Ribosomes/genetics

المؤلفون: Davoli T; Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115, USA., Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ

المصدر: Cell [Cell] 2013 Nov 07; Vol. 155 (4), pp. 948-62. Date of Electronic Publication: 2013 Oct 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Algorithms* , Aneuploidy* , Genes, Tumor Suppressor* , Oncogenes*, Neoplasms/*genetics, Gene Dosage ; Humans

المؤلفون: Mengwasser KE; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., Bryant CE, Gay NJ, Gangloff M

المصدر: Protein expression and purification [Protein Expr Purif] 2011 Apr; Vol. 76 (2), pp. 173-83. Date of Electronic Publication: 2010 Dec 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0279 (Electronic) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

مواضيع طبية MeSH: Culture Media*, Antigens, Surface/*biosynthesis , Lipopolysaccharides/*pharmacology , Lymphocyte Antigen 96/*biosynthesis , Lymphocyte Antigen 96/*isolation & purification , Pichia/*metabolism , Recombinant Fusion Proteins/*biosynthesis, Animals ; Antigens, Surface/chemistry ; Antigens, Surface/genetics ; Antigens, Surface/isolation & purification ; Chromatography, Gel ; Cloning, Molecular ; Disulfides/chemistry ; Disulfides/metabolism ; Electrophoresis, Polyacrylamide Gel ; Horses ; Humans ; Ligands ; Lymphocyte Antigen 96/chemistry ; Lymphocyte Antigen 96/genetics ; Phenotype ; Pichia/chemistry ; Pichia/genetics ; Protein Multimerization ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/isolation & purification

المؤلفون: Yun CH; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, Eck MJ

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2008 Feb 12; Vol. 105 (6), pp. 2070-5. Date of Electronic Publication: 2008 Jan 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Adenosine Triphosphate/*metabolism , Drug Resistance/*genetics , ErbB Receptors/*genetics, Animals ; Crystallography, X-Ray ; Enzyme Inhibitors/pharmacology ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/chemistry ; ErbB Receptors/metabolism ; Gefitinib ; Insecta ; Kinetics ; Protein Conformation ; Quinazolines/pharmacology