المؤلفون: Mabesoone MFJ; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland., Leopold-Messer S; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland., Minas HA; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland., Chepkirui C; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland., Chawengrum P; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.; Chemical Biology Program, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, Thailand., Reiter S; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland., Meoded RA; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland., Wolf S; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland., Genz F; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland., Magnus N; Institute for Biological Sciences, University of Rostock, Albert-Einstein-Straße 3, 18059 Rostock, Germany., Piechulla B; Institute for Biological Sciences, University of Rostock, Albert-Einstein-Straße 3, 18059 Rostock, Germany., Walker AS; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.; Department of Chemistry, Vanderbilt University, 1234 Stevenson Center Lane, Nashville, TN 37240, USA.; Department of Biological Sciences, Vanderbilt University, 465 21st Avenue S, Nashville, TN 37232, USA., Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.

المصدر: Science (New York, N.Y.) [Science] 2024 Mar 22; Vol. 383 (6689), pp. 1312-1317. Date of Electronic Publication: 2024 Mar 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Acyltransferases*/genetics , Acyltransferases*/chemistry , Polyketide Synthases*/chemistry , Polyketide Synthases*/genetics , Polyketides*/chemistry , Directed Molecular Evolution* , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics , Recombinant Fusion Proteins*/chemistry , Recombinant Fusion Proteins*/genetics, Serratia ; Amino Acid Motifs

SCR Organism: Serratia plymuthica

المؤلفون: Ogonkov A; Department of Biology, Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.; Institute of Biology, Leipzig University, Johannisallee 23, 04107, Leipzig, Germany., Dieterich CL; Department of Biology, Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Meoded RA; Department of Biology, Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Piel J; Department of Biology, Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Fraley AE; Department of Biology, Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Sasso S; Institute of Biology, Leipzig University, Johannisallee 23, 04107, Leipzig, Germany.

المصدر: Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Sep 15; Vol. 24 (18), pp. e202300209. Date of Electronic Publication: 2023 May 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

مواضيع طبية MeSH: Escherichia coli* , Serine C-Palmitoyltransferase*, Fatty Acids ; Serine

المؤلفون: Minas HA; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland., François RMM; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.; Université de Lorraine, CNRS, IMoPA, 54000, Nancy, France., Hemmerling F; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland., Fraley AE; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland., Dieterich CL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland., Rüdisser SH; Institute of Molecular Biology and Biophysics, Biomolecular NMR Spectroscopy Platform, Eidgenössische Technische Hochschule (ETH) Zürich, Hönggerbergring 64, 8093, Zürich, Switzerland., Meoded RA; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland., Collin S; Université de Lorraine, CNRS, IMoPA, 54000, Nancy, France., Weissman KJ; Université de Lorraine, CNRS, IMoPA, 54000, Nancy, France., Gruez A; Université de Lorraine, CNRS, IMoPA, 54000, Nancy, France., Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zürich, Vladimir-Prelog-Weg 4, 8093, Zürich, Switzerland.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Aug 21; Vol. 62 (34), pp. e202304481. Date of Electronic Publication: 2023 Jul 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Polyketide Synthases*/genetics , Polyketide Synthases*/chemistry , Polyketides*, Catalysis

المؤلفون: Fraley AE; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland., Dell M; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland., Schmalhofer M; Chair of Biochemistry, Center for Protein Assemblies, Technical University of Munich, Ernst-Otto-Fischer-Strasse 8, 85748 Garching, Germany., Meoded RA; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland., Bergande C; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland., Groll M; Chair of Biochemistry, Center for Protein Assemblies, Technical University of Munich, Ernst-Otto-Fischer-Strasse 8, 85748 Garching, Germany., Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland. Electronic address: jpiel@ethz.ch.

المصدر: Structure (London, England : 1993) [Structure] 2023 May 04; Vol. 31 (5), pp. 565-572.e4. Date of Electronic Publication: 2023 Mar 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

مواضيع طبية MeSH: Polyketide Synthases*/genetics , Polyketide Synthases*/metabolism , Polyketides*/metabolism, Halogenation ; Bacteria/metabolism

المؤلفون: Fraley AE; Department of Biology, Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Dieterich CL; Department of Biology, Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Mabesoone MFJ; Department of Biology, Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Minas HA; Department of Biology, Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Meoded RA; Department of Biology, Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Hemmerling F; Department of Biology, Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Piel J; Department of Biology, Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Sep 26; Vol. 61 (39), pp. e202206385. Date of Electronic Publication: 2022 Aug 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Polyketides*/metabolism, Acylation ; Catalytic Domain ; Fatty Acids ; Polyketide Synthases/metabolism ; Secondary Metabolism

المؤلفون: Hemmerling F; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Meoded RA; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Fraley AE; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Minas HA; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Dieterich CL; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Rust M; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Ueoka R; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.; School of Marine Bioscience, Kitasato University, 1-15-1, Kitazato, Minami-ku, Sagamirhara-shi Kanagawa, 252-0373, Japan., Jensen K; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Helfrich EJN; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.; Institute of Molecular Bio Science, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt am Main, Germany.; LOEWE Center for Translational Biodiversity Genomics (TBG), Senckenberganlage 25, 60325, Frankfurt am Main, Germany., Bergande C; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Biedermann M; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Magnus N; Institute for Biological Sciences, University of Rostock, Albert-Einstein-Straße 3, 18059, Rostock, Germany., Piechulla B; Institute for Biological Sciences, University of Rostock, Albert-Einstein-Straße 3, 18059, Rostock, Germany., Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Mar 07; Vol. 61 (11), pp. e202116614. Date of Electronic Publication: 2022 Jan 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Polyketide Synthases/*metabolism , Polyketides/*metabolism, Acylation ; Biocatalysis ; Halogenation ; Hydroxylation ; Polyketide Synthases/chemistry ; Polyketides/chemistry ; Serratia/enzymology

المؤلفون: Ueoka R, Meoded RA, Gran-Scheuch A, Bhushan A, Fraaije MW, Piel J

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Jul 13; Vol. 59 (29), pp. 11698.

نوع المنشور: Journal Article; Published Erratum

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Ueoka R; Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Meoded RA; Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Gran-Scheuch A; Molecular Enzymology Group, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands.; Department of Chemical and Bioprocesses Engineering, Pontificia Universidad Católica de Chile, Avenida Vicuña Mackenna 4860, 7820436, Santiago, Chile., Bhushan A; Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland., Fraaije MW; Molecular Enzymology Group, University of Groningen, Nijenborgh 4, 9747AG, Groningen, The Netherlands., Piel J; Institute of Microbiology, ETH Zurich, Vladimir-Prelog-Weg 4, 8093, Zurich, Switzerland.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 May 11; Vol. 59 (20), pp. 7761-7765. Date of Electronic Publication: 2020 Mar 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Data Mining* , Genomics*, Macrolides/*metabolism , Polyketide Synthases/*genetics , Polyketide Synthases/*metabolism , Salicylates/*metabolism, Gammaproteobacteria/enzymology ; Gammaproteobacteria/genetics ; Gammaproteobacteria/physiology ; Oxidation-Reduction ; Polyketides/metabolism ; Substrate Specificity ; Symbiosis

SCR Organism: Gynuella sunshinyii

المؤلفون: Helfrich EJN; Institute of Microbiology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland., Ueoka R; Institute of Microbiology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland., Dolev A; Institute of Microbiology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland., Rust M; Institute of Microbiology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland., Meoded RA; Institute of Microbiology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland., Bhushan A; Institute of Microbiology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland., Califano G; Centre of Marine Sciences, University of Algarve, Faro, Portugal.; Institute for Inorganic and Analytical Chemistry, Friedrich-Schiller-Universität Jena, Jena, Germany., Costa R; Centre of Marine Sciences, University of Algarve, Faro, Portugal.; Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal., Gugger M; Institut Pasteur, Collection des Cyanobactéries, Paris, France., Steinbeck C; Institute for Inorganic and Analytical Chemistry, Friedrich-Schiller-Universität Jena, Jena, Germany.; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, UK., Moreno P; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, UK. pmoreno@ebi.ac.uk., Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland. jpiel@ethz.ch.

المصدر: Nature chemical biology [Nat Chem Biol] 2019 Aug; Vol. 15 (8), pp. 813-821. Date of Electronic Publication: 2019 Jul 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Bacteria/*enzymology , Polyketide Synthases/*metabolism , Polyketides/*metabolism, Amino Acid Sequence ; Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biological Products ; Models, Chemical ; Phylogeny ; Polyketide Synthases/genetics ; Polyketides/chemistry ; Porifera/microbiology ; Protein Domains ; Substrate Specificity

المؤلفون: Schleyer G; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Shahaf N; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Ziv C; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Postharvest Science of Fresh Produce, Institute of Postharvest and Food Sciences, The Volcani Center, Bet Dagan, Israel., Dong Y; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Meoded RA; Institute of Microbiology, ETH Zurich, Zurich, Switzerland., Helfrich EJN; Institute of Microbiology, ETH Zurich, Zurich, Switzerland., Schatz D; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Rosenwasser S; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.; Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel., Rogachev I; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Aharoni A; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel., Piel J; Institute of Microbiology, ETH Zurich, Zurich, Switzerland., Vardi A; Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel. assaf.vardi@weizmann.ac.il.

المصدر: Nature microbiology [Nat Microbiol] 2019 Mar; Vol. 4 (3), pp. 527-538. Date of Electronic Publication: 2019 Feb 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Eutrophication* , Host Microbial Interactions* , Mass Spectrometry*, Fatty Acids/*analysis , Haptophyta/*virology , Phycodnaviridae/*physiology, Metabolomics ; Spatio-Temporal Analysis ; Viral Plaque Assay ; Virus Diseases/metabolism