المؤلفون: Babbe H; Janssen Research and Development, LLC., Spring House, PA 19477., Sundberg TB; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Tichenor M; Janssen Research and Development, LLC., San Diego, CA 92121., Seierstad M; Janssen Research and Development, LLC., San Diego, CA 92121., Bacani G; Janssen Research and Development, LLC., San Diego, CA 92121., Berstler J; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Chai W; Janssen Research and Development, LLC., San Diego, CA 92121., Chang L; Janssen Research and Development, LLC., San Diego, CA 92121., Chung M; Janssen Research and Development, LLC., San Diego, CA 92121., Coe K; Janssen Research and Development, LLC., San Diego, CA 92121., Collins B; Janssen Research and Development, LLC., San Diego, CA 92121., Finley M; Janssen Research and Development, LLC., Spring House, PA 19477., Guletsky A; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Lemke CT; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Mak PA; Janssen Research and Development, LLC., San Diego, CA 92121., Mathur A; Janssen Research and Development, LLC., Spring House, PA 19477., Mercado-Marin EV; Janssen Research and Development, LLC., San Diego, CA 92121., Metkar S; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Raymond DD; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Rives ML; Janssen Research and Development, LLC., San Diego, CA 92121., Rizzolio M; Janssen Research and Development, LLC., San Diego, CA 92121., Shaffer PL; Janssen Research and Development, LLC., Spring House, PA 19477., Smith R; Janssen Research and Development, LLC., San Diego, CA 92121., Smith J; Janssen Research and Development, LLC., San Diego, CA 92121., Steele R; Janssen Research and Development, LLC., Spring House, PA 19477., Steffens H; Janssen Research and Development, LLC., San Diego, CA 92121., Suarez J; Janssen Research and Development, LLC., Spring House, PA 19477., Tian G; Janssen Research and Development, LLC., Spring House, PA 19477., Majewski N; Janssen Research and Development, LLC., Spring House, PA 19477., Volak LP; Janssen Research and Development, LLC., San Diego, CA 92121., Wei J; Janssen Research and Development, LLC., San Diego, CA 92121., Desai PT; Janssen Research and Development, LLC., Spring House, PA 19477., Ong LL; Janssen Research and Development, LLC., Spring House, PA 19477., Koudriakova T; Janssen Research and Development, LLC., San Diego, CA 92121., Goldberg SD; Janssen Research and Development, LLC., San Diego, CA 92121., Hirst G; Janssen Research and Development, LLC., San Diego, CA 92121., Kaushik VK; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Ort T; Janssen Research and Development, LLC., Spring House, PA 19477., Seth N; Janssen Research and Development, LLC., Spring House, PA 19477., Graham DB; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Plevy S; Janssen Research and Development, LLC., Spring House, PA 19477., Venable JD; Janssen Research and Development, LLC., San Diego, CA 92121., Xavier RJ; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Towne JE; Janssen Research and Development, LLC., San Diego, CA 92121.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jan 02; Vol. 121 (1), pp. e2307086120. Date of Electronic Publication: 2023 Dec 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Protein Serine-Threonine Kinases*/metabolism , Cyclic AMP Response Element-Binding Protein*/metabolism, Mice ; Humans ; Animals ; Cytokines ; Inflammation/drug therapy ; Protein Isoforms ; Anti-Inflammatory Agents/pharmacology ; Immunity, Innate ; Transcription Factors

المؤلفون: Seierstad M; Janssen Research and Development, San Diego, California 92121, United States., Tichenor MS; Janssen Research and Development, San Diego, California 92121, United States., DesJarlais RL; Janssen Research and Development, Spring House, Pennsylvania 19477, United States., Na J; Janssen Research and Development, San Diego, California 92121, United States., Bacani GM; Janssen Research and Development, San Diego, California 92121, United States., Chung M; Janssen Research and Development, San Diego, California 92121, United States., Mercado-Marin EV; Janssen Research and Development, San Diego, California 92121, United States., Steffens HC; Janssen Research and Development, San Diego, California 92121, United States., Mirzadegan T; Janssen Research and Development, San Diego, California 92121, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Oct 25; Vol. 12 (11), pp. 1853-1860. Date of Electronic Publication: 2021 Oct 25 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Roque JB; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: rsarpong@berkeley.edu., Mercado-Marin EV; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: rsarpong@berkeley.edu., Richter SC; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: rsarpong@berkeley.edu., Pereira de Sant'Ana D; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: rsarpong@berkeley.edu., Mukai K; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: rsarpong@berkeley.edu., Ye Y; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: rsarpong@berkeley.edu., Sarpong R; Department of Chemistry , University of California , Berkeley , California 94720 , USA . Email: rsarpong@berkeley.edu.

المصدر: Chemical science [Chem Sci] 2020 May 28; Vol. 11 (23), pp. 5929-5934. Date of Electronic Publication: 2020 May 28 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

المؤلفون: Mukai K; Department of Chemistry, University of California, Berkeley, California 94720, USA., de Sant'Ana DP; Department of Chemistry, University of California, Berkeley, California 94720, USA., Hirooka Y; Department of Chemistry, University of California, Berkeley, California 94720, USA., Mercado-Marin EV; Department of Chemistry, University of California, Berkeley, California 94720, USA., Stephens DE; Department of Chemistry, University of California, Berkeley, California 94720, USA., Kou KGM; Department of Chemistry, University of California, Berkeley, California 94720, USA., Richter SC; Department of Chemistry, University of California, Berkeley, California 94720, USA., Kelley N; Department of Chemistry, University of California, Berkeley, California 94720, USA., Sarpong R; Department of Chemistry, University of California, Berkeley, California 94720, USA.

المصدر: Nature chemistry [Nat Chem] 2018 Jan; Vol. 10 (1), pp. 38-44. Date of Electronic Publication: 2017 Sep 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE

مواضيع طبية MeSH: Dimerization*, Biological Products/*chemical synthesis , Indole Alkaloids/*chemical synthesis , Indole Alkaloids/*chemistry, Biological Products/chemistry ; Molecular Conformation ; Stereoisomerism

المؤلفون: Fraley AE, Garcia-Borràs M; Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States., Tripathi A, Khare D, Mercado-Marin EV; Department of Chemistry, University of California , Berkeley, California 94720, United States., Tran H, Dan Q, Webb GP, Watts KR; Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States., Crews P; Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States., Sarpong R; Department of Chemistry, University of California , Berkeley, California 94720, United States., Williams RM; Department of Chemistry, Colorado State University , Fort Collins, Colorado 80523, United States., Smith JL, Houk KN; Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States., Sherman DH

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2017 Aug 30; Vol. 139 (34), pp. 12060-12068. Date of Electronic Publication: 2017 Aug 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Ascomycota/*enzymology , Fungal Proteins/*metabolism , Indole Alkaloids/*metabolism, Ascomycota/chemistry ; Ascomycota/metabolism ; Biosynthetic Pathways ; Fungal Proteins/chemistry ; Halogenation ; Indole Alkaloids/chemistry ; Kinetics ; Models, Molecular

المؤلفون: Mercado-Marin EV; Department of Chemistry University of California-Berkeley Berkeley, CA 94720, USA., Sarpong R; Department of Chemistry University of California-Berkeley Berkeley, CA 94720, USA.

المصدر: Chemical science [Chem Sci] 2015 Aug 01; Vol. 6 (8), pp. 5048-5052. Date of Electronic Publication: 2015 Jun 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

المؤلفون: Mercado-Marin EV; Department of Chemistry, University of California, Berkeley, CA 94720, USA., Garcia-Reynaga P; Department of Chemistry, University of California, Berkeley, CA 94720, USA., Romminger S; Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, CP 780, CEP 13560-970, Sao Carlos, SP, Brazil., Pimenta EF; Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, CP 780, CEP 13560-970, Sao Carlos, SP, Brazil., Romney DK; Department of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut 06520, USA., Lodewyk MW; Department of Chemistry, University of California, Davis, CA 95616, USA., Williams DE; Department of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, V6T IZI, Canada., Andersen RJ; Department of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia, V6T IZI, Canada., Miller SJ; Department of Chemistry, Yale University, P. O. Box 208107, New Haven, Connecticut 06520, USA., Tantillo DJ; Department of Chemistry, University of California, Davis, CA 95616, USA., Berlinck RGS; Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, CP 780, CEP 13560-970, Sao Carlos, SP, Brazil., Sarpong R; Department of Chemistry, University of California, Berkeley, CA 94720, USA.

المصدر: Nature [Nature] 2014 May 15; Vol. 509 (7500), pp. 318-324.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Alkaloids/*chemical synthesis , Alkaloids/*isolation & purification , Biological Products/*chemical synthesis , Indole Alkaloids/*chemical synthesis , Indole Alkaloids/*isolation & purification , Indolizidines/*chemical synthesis , Indolizidines/*isolation & purification, Alkaloids/biosynthesis ; Alkaloids/chemistry ; Biological Products/chemistry ; Chemistry Techniques, Synthetic ; Indole Alkaloids/chemistry ; Indole Alkaloids/metabolism ; Indolizidines/chemistry ; Indolizidines/metabolism ; Molecular Structure ; Nitrogen/chemistry ; Oxidation-Reduction ; Oxygen/metabolism ; Stereoisomerism