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1دورية أكاديمية
المؤلفون: René H. M. Raeven, Naomi van Vlies, Merijn L. M. Salverda, Larissa van der Maas, Joost P. Uittenbogaard, Tim H. E. Bindels, Jolanda Rigters, Lisa M. Verhagen, Sabine Kruijer, Elly van Riet, Bernard Metz, Arno A. J. van der Ark
المصدر: Vaccines, Vol 8, Iss 3, p 429 (2020)
مصطلحات موضوعية: Bordetella pertussis, virulence factors, pertussis vaccine, OMV, outer membrane vesicles, bvg, Medicine
وصف الملف: electronic resource
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المؤلفون: Corine Kruiswijk, Merijn L M Salverda, Guilhem Richard, William D. Martin, Anne S. De Groot, Pooja Hindocha, Elly van Riet
المصدر: Human Vaccines & Immunotherapeutics
مصطلحات موضوعية: Bordetella pertussis, In silico, 030231 tropical medicine, Immunology, Human leukocyte antigen, Major histocompatibility complex, immunoinformatics, 03 medical and health sciences, 0302 clinical medicine, Antigen, Pertussis, vaccine, medicine, Immunology and Allergy, 030212 general & internal medicine, JanusMatrix, Whooping cough, Pharmacology, tolerance, biology, Immunogenicity, OMV, biology.organism_classification, medicine.disease, Virology, T cell epitopes, Vaccine Potency, HLA class II, biology.protein, Research Paper, EpiMatrix
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3دورية أكاديمية
المؤلفون: Merijn L M Salverda, Eynat Dellus, Florien A Gorter, Alfons J M Debets, John van der Oost, Rolf F Hoekstra, Dan S Tawfik, J Arjan G M de Visser
المصدر: PLoS Genetics, Vol 7, Iss 3, p e1001321 (2011)
وصف الملف: electronic resource
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المؤلفون: Mark P. Zwart, Jeroen Koomen, Merijn L. M. Salverda, Bertha Koopmanschap, J. Arjan G. M. de Visser
المصدر: Proceedings of the National Academy of Sciences of the United States of America 114 (2017) 48
Proceedings of the National Academy of Sciences of the United States of America, 114(48), 12773-12778مصطلحات موضوعية: Protein Conformation, alpha-Helical, 0301 basic medicine, Genotype, Antibiotic resistance, Fitness landscape, Mutant, Gene Expression, Cefotaxime, Biology, Laboratorium voor Erfelijkheidsleer, Levensmiddelenmicrobiologie, beta-Lactam Resistance, beta-Lactamases, 03 medical and health sciences, Bacterial Proteins, Escherichia coli, Cloning, Molecular, Selection, Genetic, Adaptation, Allele, Alleles, Selection (genetic algorithm), Gene Library, Genetics, Experimental evolution, Multidisciplinary, Models, Genetic, Biological Sciences, PE&RC, Adaptation, Physiological, Recombinant Proteins, Anti-Bacterial Agents, Mutation supply, 030104 developmental biology, Sample Size, Mutation, Mutation (genetic algorithm), Food Microbiology, Laboratory of Genetics, Protein Conformation, beta-Strand, Directed Molecular Evolution, Plasmids
وصف الملف: application/pdf; application/octet-stream
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cad1d03a8656e1bd5f0cb0f2ba96827
https://doi.org/10.1073/pnas.1712999114 -
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المؤلفون: Sariette Witte, M.F. Schenk, J. Arjan G. M. de Visser, Bertha Koopmanschap, Joachim Krug, Merijn L. M. Salverda
المصدر: Evolutionary Applications, 8(3), 248-260
Evolutionary Applications 8 (2015) 3
Evolutionary Applicationsمصطلحات موضوعية: Cefotaxime, medicine.drug_class, Antibiotic resistance, Antibiotics, Ceftazidime, Trade-off, Biology, Laboratorium voor Erfelijkheidsleer, Pleiotropy, Genetics, medicine, Allele, Ecology, Evolution, Behavior and Systematics, TEM-1 β-lactamase, Original Articles, PE&RC, Epistasis, Protein evolution, Laboratory of Genetics, Adaptation, General Agricultural and Biological Sciences, medicine.drug
وصف الملف: application/octet-stream; application/pdf
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المؤلفون: Ivan G. Szendro, M.F. Schenk, J. Arjan G. M. de Visser, Joachim Krug, Merijn L. M. Salverda
المصدر: Molecular Biology and Evolution
Molecular Biology and Evolution, 30(8), 1779-1787
Molecular Biology and Evolution 30 (2013) 8مصطلحات موضوعية: epistasis, antibiotic resistance, fitness landscape, Genotype, Fitness landscape, metabolic-control-theory, natural evolution, Epistasis and functional genomics, Genetic Fitness, fitness landscape model, Fast Tracks, deleterious mutations, Cefotaxime, Biology, medicine.disease_cause, Laboratorium voor Erfelijkheidsleer, beta-Lactamases, Drug Resistance, Bacterial, Genetics, medicine, Escherichia coli, sign epistasis, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Mutation, Epistasis, Genetic, PE&RC, β-lactamase, Phenotype, Biological Evolution, beneficial mutations, Anti-Bacterial Agents, sequence space, tem-1 beta-lactamase, Epistasis, Laboratory of Genetics, escherichia-coli population, Adaptation, protein, diminishing returns
وصف الملف: application/octet-stream; application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b3a112d8b5db418cf543f3027eeca2
http://europepmc.org/articles/PMC3708503 -
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المؤلفون: Mikael Elias, Fabio Prati, Eynat Dellus-Gur, James S. Fraser, J. Arjan G. M. de Visser, Dan S. Tawfik, Emilia Caselli, Merijn L. M. Salverda
المصدر: Journal of molecular biology, vol 427, iss 14
Dellus-Gur, E; Elias, M; Caselli, E; Prati, F; Salverda, MLM; De Visser, JAGM; et al.(2015). Negative epistasis and evolvability in TEM-1 β-lactamase-The thin line between an enzyme's conformational freedom and disorder. Journal of Molecular Biology, 427(14), 2396-2409. doi: 10.1016/j.jmb.2015.05.011. UCSF: Retrieved from: http://www.escholarship.org/uc/item/53h2q73z
Journal of Molecular Biology 427 (2015) 14
Journal of Molecular Biology, 427(14), 2396-2409مصطلحات موضوعية: Models, Molecular, Secondary, Protein Folding, Drug Resistance, medicine.disease_cause, Crystallography, X-Ray, Protein Structure, Secondary, Protein structure, Microbial, Structural Biology, Models, Catalytic Domain, sign epistasis, protein folds, Genetics, Mutation, Crystallography, Omega loop, Drug Resistance, Microbial, PE&RC, antibiotic-resistance, sequence space, Protein folding, Laboratory of Genetics, Sequence space (evolution), conformational diversity, Protein Structure, Biochemistry & Molecular Biology, Evolution, Biology, Laboratorium voor Erfelijkheidsleer, Microbiology, beta-Lactamases, Article, Evolution, Molecular, Medicinal and Biomolecular Chemistry, Genetic, Hydrolase, evolution, medicine, Escherichia coli, protein evolution, Molecular Biology, protein disorder, interactions network, Molecular, Epistasis, Genetic, Evolvability, substrate-specificity, trade-offs, Amino Acid Substitution, protein structures, Biophysics, escherichia-coli, X-Ray, Epistasis, empirical fitness landscapes, Biochemistry and Cell Biology, omega-loop
وصف الملف: application/pdf; application/octet-stream
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المؤلفون: Pablo E. Tomatis, Merijn L. M. Salverda, Luciano A. Abriata
المصدر: FEBS Letters, 586(19), 3330-3335
FEBS Letters 586 (2012) 19مصطلحات موضوعية: Models, Molecular, Lactamase, Antibiotic resistance, Protein Conformation, natural evolution, pathways, Biophysics, Stability (learning theory), Function-stability tradeoff, Biology, in-vitro, Laboratorium voor Erfelijkheidsleer, Biochemistry, Structure–function relationship, beta-Lactamases, Protein evolution, Evolution, Molecular, 03 medical and health sciences, Structural Biology, global suppressor, Enzyme Stability, Genetics, directed evolution, Databases, Protein, Molecular Biology, 030304 developmental biology, Sequence (medicine), chemistry.chemical_classification, 0303 health sciences, 030306 microbiology, β lactamases, chemical-properties, Genetic Variation, Cell Biology, prediction, Directed evolution, Amino acid, Enzyme, antibiotic-resistance, chemistry, classification, Amino Acid Substitution, Mutation, TEM, Laboratory of Genetics, Function (biology), enterobacteriaceae
وصف الملف: application/octet-stream; application/pdf
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المؤلفون: J. Arjan G. M. de Visser, Merijn L. M. Salverda
المصدر: Current Biology 21 (2011) 10
Current Biology, 21(10), r398-r400مصطلحات موضوعية: Fitness landscape, fitness landscapes, Population Dynamics, Genetic Fitness, Adaptation, Biological, Variation (game tree), adaptation, virus, Biology, Laboratorium voor Erfelijkheidsleer, evolvability, General Biochemistry, Genetics and Molecular Biology, Escherichia coli, Selection, Genetic, Agricultural and Biological Sciences(all), Human evolutionary genetics, Biochemistry, Genetics and Molecular Biology(all), Epistasis, Genetic, Biological evolution, PE&RC, mutations, Biological Evolution, Evolvability, Futures studies, Evolutionary biology, Mutation, escherichia-coli, Laboratory of Genetics, Adaptation, asexual populations, General Agricultural and Biological Sciences
وصف الملف: application/pdf; application/octet-stream
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المؤلفون: John van der Oost, Eynat Dellus, Florien A. Gorter, J. Arjan G. M. de Visser, Alfons J. M. Debets, Dan S. Tawfik, Rolf F. Hoekstra, Merijn L. M. Salverda
المصدر: PLoS Genetics, Vol 7, Iss 3, p e1001321 (2011)
Plos Genetics 7 (2011) 3
Plos Genetics, 7(3)
PLoS Geneticsمصطلحات موضوعية: 0106 biological sciences, epistasis, Cancer Research, natural evolution, Cooperativity, Cefotaxime, adaptation, 01 natural sciences, Microbiologie, Genetics (clinical), Genetics, 0303 health sciences, Drug Resistance, Microbial, PE&RC, Adaptation, Physiological, Genetics and Genomics/Microbial Evolution and Genomics, antibiotic-resistance, Evolutionary Biology/Microbial Evolution and Genomics, sequence space, tem-1 beta-lactamase, Mutation (genetic algorithm), Laboratory of Genetics, Sequence space (evolution), Plasmids, Research Article, lcsh:QH426-470, Epistasis and functional genomics, Biology, in-vitro, Laboratorium voor Erfelijkheidsleer, 010603 evolutionary biology, Microbiology, beta-Lactamases, Evolution, Molecular, 03 medical and health sciences, Escherichia coli, trajectories, Amino Acid Sequence, Selection, Genetic, Allele, Molecular Biology, Alleles, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, VLAG, Models, Genetic, Evolutionary Biology/Evolutionary and Comparative Genetics, Mechanism (biology), Epistasis, Genetic, lcsh:Genetics, Mutation, escherichia-coli, Epistasis, empirical fitness landscapes, Adaptation
وصف الملف: application/pdf; application/octet-stream
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