المؤلفون: Preiss LC; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (L.C.P., V.M.L.); Department of Drug Metabolism and Pharmacokinetics (DMPK), The Healthcare Business of Merck KGaA, Darmstadt, Germany (L.C.P., K.G., C.P.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tuebingen, Tuebingen, Germany (V.M.L.)., Georgi K; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (L.C.P., V.M.L.); Department of Drug Metabolism and Pharmacokinetics (DMPK), The Healthcare Business of Merck KGaA, Darmstadt, Germany (L.C.P., K.G., C.P.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tuebingen, Tuebingen, Germany (V.M.L.)., Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (L.C.P., V.M.L.); Department of Drug Metabolism and Pharmacokinetics (DMPK), The Healthcare Business of Merck KGaA, Darmstadt, Germany (L.C.P., K.G., C.P.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tuebingen, Tuebingen, Germany (V.M.L.)., Petersson C; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (L.C.P., V.M.L.); Department of Drug Metabolism and Pharmacokinetics (DMPK), The Healthcare Business of Merck KGaA, Darmstadt, Germany (L.C.P., K.G., C.P.); Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (V.M.L.); and University of Tuebingen, Tuebingen, Germany (V.M.L.) carl.petersson@merckgroup.com.

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 May 16; Vol. 52 (6), pp. 539-547. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article; Comparative Study

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Coculture Techniques*/methods , Hepatocytes*/metabolism , Liver*/metabolism , Models, Biological* , Metabolic Clearance Rate* , Spheroids, Cellular*/metabolism, Humans ; Pharmaceutical Preparations/metabolism

المؤلفون: Zhong XB, Ding X

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2023 Aug; Vol. 51 (8), pp. 902-903.

نوع المنشور: Editorial

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Metabolic Clearance Rate*, Inactivation, Metabolic

المؤلفون: Sugano K; Molecular Pharmaceutics Lab., College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, Kusatsu, Shiga 525-8577, Japan. Electronic address: suganok@fc.ritsumei.ac.jp.

المصدر: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Jul 01; Vol. 198, pp. 106799. Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article; Letter

بيانات الدورية: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

مواضيع طبية MeSH: Liver*/metabolism , Models, Biological*, Humans ; Administration, Oral ; Pharmaceutical Preparations/metabolism ; Pharmaceutical Preparations/administration & dosage ; Metabolic Clearance Rate ; Pharmacokinetics ; Animals

المؤلفون: Smets NG; Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, location AMC, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences Research Institute, Amsterdam, the Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, the Netherlands., Strijkers GJ; Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, location AMC, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences Research Institute, Amsterdam, the Netherlands., Vinje V; Expert Analytics AS, Oslo, Norway., Bakker ENTP; Department of Biomedical Engineering and Physics, Amsterdam University Medical Center, location AMC, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences Research Institute, Amsterdam, the Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, the Netherlands.

المصدر: NMR in biomedicine [NMR Biomed] 2024 Jul; Vol. 37 (7), pp. e5029. Date of Electronic Publication: 2023 Sep 02.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 8915233 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1492 (Electronic) Linking ISSN: 09523480 NLM ISO Abbreviation: NMR Biomed Subsets: MEDLINE

مواضيع طبية MeSH: Brain*/diagnostic imaging , Brain*/metabolism , Cerebrospinal Fluid*/metabolism, Humans ; Animals ; Magnetic Resonance Imaging ; Aging/physiology ; Metabolic Clearance Rate

المؤلفون: Margolis LM; United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Wilson MA; United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Drummer DJ; United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.; Oak Ridge Institute for Science and Education, Belcamp, Maryland, United States., Carrigan CT; United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Murphy NE; United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Allen JT; United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Dawson MA; United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Mantzoros CS; Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States.; Department of Medicine, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, United States., Young AJ; United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.; Oak Ridge Institute for Science and Education, Belcamp, Maryland, United States., Pasiakos SM; Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland, United States.

المصدر: American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2024 Jul 01; Vol. 327 (1), pp. R25-R34. Date of Electronic Publication: 2024 Apr 29.

نوع المنشور: Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Pioglitazone*/administration & dosage , Pioglitazone*/pharmacology , Oxidation-Reduction* , Exercise*/physiology , Cross-Over Studies* , Glucose*/metabolism , Altitude* , Hypoglycemic Agents*/administration & dosage , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/pharmacokinetics, Humans ; Male ; Young Adult ; Adult ; Metabolic Clearance Rate ; Blood Glucose/metabolism ; Blood Glucose/drug effects ; Insulin/blood ; Insulin/metabolism

المؤلفون: Muchiri RN; Department of Pharmaceutical Sciences, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA., Rocha J; Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA., Tandon A; Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA., Chen YL; Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA., Alemani R; Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA., Ahmad I; Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA., McDonald Z; Department of Anesthesiology, University of Illinois, Chicago, Illinois 60612, USA., Lindeblad M; Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA., Rubinstein I; Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA.; Research & Development Service, Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA., van Breemen RB; Department of Pharmaceutical Sciences, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA., Feinstein DL; Department of Pharmaceutical Sciences, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA.; Research & Development Service, Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA.

المصدر: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2024 Jun 26; Vol. 200 (1), pp. 137-145.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Rodenticides*/pharmacokinetics , Rodenticides*/blood , Cholestyramine Resin* , Anticoagulants*/administration & dosage , Anticoagulants*/pharmacokinetics , Vitamin K 1*/blood , Vitamin K 1*/administration & dosage , Blood Coagulation*/drug effects , Feces*/chemistry, Animals ; Rabbits ; Male ; Half-Life ; Prothrombin Time ; Metabolic Clearance Rate

المؤلفون: D'Agate S; Clinical Pharmacology & Therapeutics Group, University College London, London, UK., Ruiz Gabarre D; Clinical Pharmacology & Therapeutics Group, University College London, London, UK., Della Pasqua O; Clinical Pharmacology & Therapeutics Group, University College London, London, UK.

المصدر: Pharmacology research & perspectives [Pharmacol Res Perspect] 2024 Jun; Vol. 12 (3), pp. e1193.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 101626369 Publication Model: Print Cited Medium: Internet ISSN: 2052-1707 (Electronic) Linking ISSN: 20521707 NLM ISO Abbreviation: Pharmacol Res Perspect Subsets: MEDLINE

مواضيع طبية MeSH: Acyclovir*/pharmacokinetics , Acyclovir*/administration & dosage , Antiviral Agents*/pharmacokinetics , Antiviral Agents*/administration & dosage , Herpes Simplex*/drug therapy, Humans ; Infant, Newborn ; Female ; Male ; Models, Biological ; Creatinine/blood ; Dose-Response Relationship, Drug ; Metabolic Clearance Rate ; Computer Simulation

المؤلفون: Stojanova J; Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital, Sydney, NSW, Australia; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, NSW, Australia. Electronic address: jana.stojanova@svha.org.au., Brown JD; Clinical Microbiology and Infectious Diseases Department, St. Vincent's Hospital, Sydney, NSW, Australia., Reuter SE; UniSA Clinical & Health Sciences, University of South Australia, Adelaide, SA, Australia., Marriott DJE; Clinical Microbiology and Infectious Diseases Department, St. Vincent's Hospital, Sydney, NSW, Australia; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, NSW, Australia.

المصدر: International journal of antimicrobial agents [Int J Antimicrob Agents] 2024 Jun; Vol. 63 (6), pp. 107170. Date of Electronic Publication: 2024 Apr 09.

نوع المنشور: Case Reports; Letter

بيانات الدورية: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 9111860 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7913 (Electronic) Linking ISSN: 09248579 NLM ISO Abbreviation: Int J Antimicrob Agents Subsets: MEDLINE

مواضيع طبية MeSH: Linezolid*/pharmacokinetics , Linezolid*/therapeutic use , Critical Illness* , Anti-Bacterial Agents*/pharmacokinetics , Anti-Bacterial Agents*/therapeutic use, Humans ; Male ; Metabolic Clearance Rate ; Middle Aged ; Aged

المؤلفون: Zercher M; FMC Agricultural Solutions, Newark, Delaware, USA., Coral JA; FMC Agricultural Solutions, Newark, Delaware, USA., Nabb D; FMC Agricultural Solutions, Newark, Delaware, USA., Powers G; KJ Scientific, Georgetown, Texas, USA., Jones A, Johanning K; KJ Scientific, Georgetown, Texas, USA.

المصدر: Environmental toxicology and chemistry [Environ Toxicol Chem] 2024 Jun; Vol. 43 (6), pp. 1390-1405. Date of Electronic Publication: 2024 Apr 23.

نوع المنشور: Journal Article; Comparative Study

بيانات الدورية: Publisher: SETAC Press Country of Publication: United States NLM ID: 8308958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-8618 (Electronic) Linking ISSN: 07307268 NLM ISO Abbreviation: Environ Toxicol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Liver*/metabolism , Water Pollutants, Chemical*/metabolism, Animals ; Fishes/metabolism ; Oncorhynchus mykiss/metabolism ; Quantitative Structure-Activity Relationship ; Metabolic Clearance Rate

المؤلفون: Yan Z; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California lexington1528@gmail.com., Ma L; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California., Hwang N; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California., Huang J; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California., Kenny JR; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California., Hop CECA; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California.

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 May 16; Vol. 52 (6), pp. 548-554. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Organic Anion Transporters*/metabolism , Liver*/metabolism , Models, Biological*, Humans ; Albumins/metabolism ; Biological Transport/physiology ; Metabolic Clearance Rate ; Protein Binding ; Pharmaceutical Preparations/metabolism ; Animals