المؤلفون: Shen, Qingshan, Zhang, Chunhui, Qin, Xiaojie, Zhang, Hongru, Zhang, Zhiqiang, Richel, Aurore

المصدر: Carbohydrate Polymers, 266, 118099 (2021-08-15)

مصطلحات موضوعية: Anti-osteoporosis, Bone mineral density, Bone turnover markers, Chondroitin sulfate calcium complex, Gut microbiota, Chondroitin Sulfates, Calcium, Animals, Bacteria/metabolism, Bone Density/drug effects, Calcium/therapeutic use, Chondroitin Sulfates/therapeutic use, Dietary Supplements, Feces/microbiology, Femur/drug effects, Femur/pathology, Femur/ultrastructure, Gastrointestinal Microbiome/drug effects, Gastrointestinal Microbiome/physiology, Male, Metabolome/drug effects, Osteoporosis/diet therapy, Rats, Sprague-Dawley, Bone turnover marker, Calcium complexes, Chondroitin sulphate calcium complex, Chondroitinsulfate, In-vitro, Metabolite profiles, Ovariectomized rats, Organic Chemistry, Polymers and Plastics, Materials Chemistry, Physical, chemical, mathematical & earth Sciences, Chemistry, Physique, chimie, mathématiques & sciences de la terre, Chimie

Relation: https://api.elsevier.com/content/article/PII:S0144861721004860?httpAccept=text/xml; urn:issn:0144-8617; urn:issn:1879-1344

URL الوصول: https://orbi.uliege.be/handle/2268/295476

المؤلفون: Dimitrios Karamichos, Garrett Frank, Rabab Sharif, Henrik Sejersen, Jesper Hjortdal

المصدر: Sharif, R, Sejersen, H, Frank, G, Hjortdal, J & Karamichos, D 2018, ' Effects of collagen cross-linking on the keratoconus metabolic network ', Eye, vol. 32, no. 7, pp. 1271-1281 . https://doi.org/10.1038/s41433-018-0075-6

مصطلحات موضوعية: 0301 basic medicine, Male, Riboflavin, Pharmacology, medicine.disease_cause, Biomarkers/metabolism, Cornea, chemistry.chemical_compound, 0302 clinical medicine, OXIDATIVE STRESS, Cells, Cultured, Photosensitizing Agents, CORNEAS, Cross-Linking Reagents/pharmacology, Cross-Linking Reagents, Cornea/cytology, Urea cycle, Metabolome, HORMONES, Female, Collagen, Vitamin, Adult, Keratoconus, Ultraviolet Rays, Corneal Stroma, RIBOFLAVIN, Article, 03 medical and health sciences, Downregulation and upregulation, ULTRAVIOLET-A LIGHT, Collagen/metabolism, medicine, Humans, Corneal Stroma/metabolism, Photosensitizing Agents/pharmacology, Analysis of Variance, Metabolome/drug effects, Keratoconus/drug therapy, Riboflavin/pharmacology, Metabolism, Fibroblasts, Ascorbic acid, medicine.disease, Fibroblasts/drug effects, Ophthalmology, 030104 developmental biology, chemistry, Case-Control Studies, 030221 ophthalmology & optometry, Glutathione disulfide, Biomarkers, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09631480b2f264aeb776a26721c9f2ff
https://pure.au.dk/portal/da/publications/effects-of-collagen-crosslinking-on-the-keratoconus-metabolic-network(12bfad82-8c7c-4bc3-88ab-43448965c273).html

المؤلفون: Verónica Nogueira, Bruno Araujo, Fátima Gärtner, Nuno Vale, Maria João Gouveia

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Molecules, Vol 24, Iss 21, p 3842 (2019)
Molecules
Volume 24
Issue 21

مصطلحات موضوعية: 0301 basic medicine, Carcinogenesis, Metabolite, Drug repurposing, Schistosoma haematobium / drug effects, Pharmaceutical Science, Pharmacology, Resveratrol, medicine.disease_cause, Schistosomiasis haematobia / drug therapy, Antioxidants, Analytical Chemistry, Carcinogenesis / pathology, chemistry.chemical_compound, 0302 clinical medicine, Schistosomiasis haematobia / metabolism, Drug Discovery, Opisthorchis viverrini, Schistosomiasis haematobia / complications, Drug combination, Neoplasms / metabolism, CYP enzymes, media_common, drug repurposing, biology, Resveratrol / pharmacology, Opisthorchiasis / metabolism, Opisthorchiasis / parasitology, Praziquantel / pharmacology, Neoplasms / drug therapy, Acetylcysteine / chemistry, helminth infections, Drug Combinations, Drug repositioning, antioxidants, Chemistry (miscellaneous), Molecular Medicine, carcinogenesis, Drug, Helminth infections, DNA Adducts / drug effects, Carcinogenesis / drug effects, media_common.quotation_subject, 030231 tropical medicine, drug combination, Opisthorchis / pathogenicity, cyp enzymes, Opisthorchiasis / complications, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, parasitic diseases, medicine, Animals, Humans, Neoplasms / parasitology, Physical and Theoretical Chemistry, Opisthorchiasis / drug therapy, Schistosomiasis haematobia / parasitology, Carcinogen, Opisthorchis / drug effects, Antioxidants / pharmacology, Metabolome / drug effects, Organic Chemistry, DNA adducts, Schistosoma haematobium / pathogenicity, biology.organism_classification, Carcinogens / chemistry, In vitro, 030104 developmental biology, Metabolome / genetics, chemistry, dna adducts

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b4ee668b60493c520f7b076eb4b022
https://doi.org/10.3390/molecules24213842

المؤلفون: Joffrey Zoll, Jean-François Decaux, Mathias Mericskay, Marie Breton, Anne Garnier, Boris Manoury, Mélanie Gressette, Cynthia Tannous, Jérôme Piquereau, Charles Brenner, Nicolas Diguet, István Baczkó, Samuel A.J. Trammell, Jocelyne Blanc, Zhenlin Li, Anne Gouge, Nathalie Mougenot, Gareth G. Lavery, Robin Deloux

المساهمون: Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Signalisation et physiopathologie cardiovasculaire (UMRS1180), Institut National de la Santé et de la Recherche Médicale (INSERM), Phénotypage du petit animal (UMS28), Université Pierre et Marie Curie - Paris 6 (UPMC), Détoxication et réparation tissulaire, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires (PPSM), École normale supérieure - Cachan (ENS Cachan)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Cardiovasculaire de Lariboisiere, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was supported by the Association Française contre les Myopathies (AFM N 16282), the Agence Nationale de la Recherche (ANR) grant NAD-Heart ANR-17-CE17-0015-01 and ANR-08-GENOPAT-038, Fondation de France grant 00075811 and fundings from Institut National pour la Santé Et la Recherche Médicale (INSERM), Center National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie Paris 6, and University Paris Sud. Drs Diguet and Tannous, and Mr Deloux were supported by a PhD fellowship of French Ministère de la Recherche et de l’Enseignement Supérieur. Dr Diguet was further supported by a 1-year PhD fellowship from AFM. Dr Brenner is supported by the Roy J. Carver Trust. GGL is supported by a Wellcome Trust Senior Fellowship (104612/Z/14/Z)., The authors thank V. Veksler and R. Ventura-Clapier (Inserm UMR-S 1180) for expert advice on respiration assays, Luc Bertrand (UCL, Belgium) for expert advice on AMPK detection, A. Angelini (UMR 8256) for technical help in these assays, A. Grosfeld (UMR 8256) for preliminary setup experiments for Nmrk2 cloning, Florence Lefebvre for adult rat cardiomyocyte isolation., ANR-17-CE17-0015,NAD-HEART,Supplémentation en précurseur du NAD+ pour le traitement de l'insuffisance cardiaque(2017), ANR-08-GENO-0038,REMODEL-SRF,Remodelage des organes creux musculaires et dilatations: établir un lien avec le Facteur de Réponse au Sérum(2008), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), SIGNALISATION ET PHYSIOPATHOLOGIE CARDIOVASCULAIRE (UMRS1180, LabEx LERMIT), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-IFR140-Institut National de la Santé et de la Recherche Médicale (INSERM), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), ANR-17-CE17-0015,NAD-HEART,Supplémentation en précurseur du NAD+ pour le traitement de l’insuffisance cardiaque(2017), DECAUX, Jean-François, Supplémentation en précurseur du NAD+ pour le traitement de l'insuffisance cardiaque - - NAD-HEART2017 - ANR-17-CE17-0015 - AAPG2017 - VALID, Du gène à la physiopathologie, des maladies rares aux maladies communes - Remodelage des organes creux musculaires et dilatations: établir un lien avec le Facteur de Réponse au Sérum - - REMODEL-SRF2008 - ANR-08-GENO-0038 - GENOPAT - VALID

المصدر: Circulation
Circulation, 2018, 137 (21), pp.2256-2273. ⟨10.1161/CIRCULATIONAHA.116.026099⟩
Circulation, American Heart Association, 2018, 137 (21), pp.2256-2273. ⟨10.1161/CIRCULATIONAHA.116.026099⟩

مصطلحات موضوعية: 0301 basic medicine, MESH: Niacinamide/analogs & derivatives, Serum Response Factor, MESH: Cytokines/genetics, Cardiomyopathy, MESH: Dietary Supplements, Pyridinium Compounds, Pharmacology, MESH: Acrylamides/therapeutic use, MESH: Myocytes, Cardiac/cytology, AMP-Activated Protein Kinases, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, nicotinamide-beta-riboside, MESH: Cardiomyopathy, Dilated/drug therapy, chemistry.chemical_compound, Mice, Piperidines, energy metabolism, Glycolysis, MESH: Animals, MESH: PPAR alpha/metabolism, Myocytes, Cardiac, MESH: Piperidines/therapeutic use, Nicotinamide Phosphoribosyltransferase, Dilated cardiomyopathy, glycolysis, MESH: Myocytes, Cardiac/metabolism, MESH: Phosphotransferases (Alcohol Group Acceptor)/metabolism, Phosphotransferases (Alcohol Group Acceptor), MESH: Heart Failure/prevention & control, Metabolome, Cytokines, MESH: NAD/metabolism, Cardiology and Cardiovascular Medicine, dilated, acetyl coenzyme A, Cardiac function curve, Cardiomyopathy, Dilated, Niacinamide, MESH: Rats, MESH: Mice, Transgenic, Mice, Transgenic, Oxidative phosphorylation, MESH: Serum Response Factor/genetics, Citric Acid, MESH: Metabolome/drug effects, MESH: Nicotinamide Phosphoribosyltransferase/metabolism, 03 medical and health sciences, MESH: Gene Expression Profiling, MESH: Citric Acid/metabolism, Physiology (medical), medicine, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Niacinamide/therapeutic use, Animals, MESH: Serum Response Factor/deficiency, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, PPAR alpha, MESH: Myocytes, Cardiac/drug effects, MESH: Mice, Heart Failure, Acrylamides, business.industry, MESH: Phosphotransferases (Alcohol Group Acceptor)/genetics, Gene Expression Profiling, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, MESH: Nicotinamide Phosphoribosyltransferase/genetics, medicine.disease, NAD, Rats, MESH: AMP-Activated Protein Kinases/metabolism, Disease Models, Animal, 030104 developmental biology, chemistry, Heart failure, Nicotinamide riboside, Dietary Supplements, NAD+ kinase, MESH: Cytokines/metabolism, MESH: Disease Models, Animal, business, cardiomyopathy, MESH: Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff8c9d79a5527d8a72b3544c248b40d
https://pubmed.ncbi.nlm.nih.gov/29784693

المؤلفون: Emma Burgos-Ramos, Neira Sáinz, Victoria Catalán, Sara Becerril, Andoni Lancha, Gema Frühbeck, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez

المصدر: Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
PLoS ONE
PLoS ONE, Vol 7, Iss 1, p e29389 (2012)

مصطلحات موضوعية: Male, Leptin, Anatomy and Physiology, medicine.medical_treatment, Intracellular Space, lcsh:Medicine, Mice, Obese, Mice, Endocrinology, Molecular Cell Biology, Phosphorylation, lcsh:Science, Glucose Transporter Type 4, Multidisciplinary, Leptin Deficiency, GTPase-Activating Proteins, digestive, oral, and skin physiology, Nuclear Proteins, TBC1D1, Animal Models, Protein Transport, medicine.anatomical_structure, Metabolome, Medicine, hormones, hormone substitutes, and hormone antagonists, Research Article, medicine.medical_specialty, Endocrine System, Biology, GTPase-activating proteins, Model Organisms, Internal medicine, medicine, Animals, Glucose transporter type 4, Muscle, Skeletal, Endocrine Physiology, Insulin, Metabolome/drug effects, lcsh:R, Wild type, Skeletal muscle, Mice, Inbred C57BL, Gene Expression Regulation, Protein transport/drug effects, biology.protein, lcsh:Q, GLUT4

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1cd534aacffba53154e25f44d659dd4
https://hdl.handle.net/10171/36205

المؤلفون: Michael Watkinson, Ekaterine Berishvili, Maria R. Paiva Pessoa, Guy A. Rutter, Marco Bugliani, Elizabeth Haythorne, Philip Duncanson, Jorge Ferrer, Lorenzo Piemonti, Domenico Bosco, Dirk Trauner, David J. Hodson, Johannes Broichhagen, Piero Marchetti, Natalie R. Johnston, Ryan K. Mitchell, Francesca Semplici

المساهمون: Pathology/molecular and cellular medicine, Johnston, Natalie R., Mitchell, Ryan K., Haythorne, Elizabeth, Pessoa, Maria Paiva, Semplici, Francesca, Ferrer, Jorge, Piemonti, Lorenzo, Marchetti, Piero, Bugliani, Marco, Bosco, Domenico, Berishvili, Ekaterine, Duncanson, Philip, Watkinson, Michael, Broichhagen, Johanne, Trauner, Dirk, Rutter, Guy A, Hodson, David J., Wellcome Trust, Medical Research Council (MRC), Diabetes UK, Biotechnology and Biological Sciences Research Council (BBSRC), The Royal Society, Commission of the European Communities

المصدر: Cell Metabolism, Vol. 24, No 3 (2016) pp. 389-401
Cell Metabolism

مصطلحات موضوعية: HOMEOSTASIS, medicine.medical_treatment, Cellular differentiation, Cell, COMMUNICATION, CA2+, Mice, Insulin Secretion, QD, education.field_of_study, geography.geographical_feature_category, ddc:617, diabetes, RC660, Diabetes Mellitu, Glucose/pharmacology, Cell biology, HALORHODOPSIN, 1101 Medical Biochemistry and Metabolomics, diabetes mellitus, Cytokines, light, Human, medicine.medical_specialty, insulin, Diabetes Mellitus/pathology, INSULIN-SECRETION, Article, lipids, 03 medical and health sciences, Interferon-gamma, Species Specificity, Computer Systems, Homeostasi, computer systems, Gene silencing, Humans, Metabolomics, education, optogenetics, Molecular Biology, Science & Technology, Animal, SYNCHRONY, species specificity, Glucose, 030104 developmental biology, Endocrinology, Insulin-Secreting Cell, Cell Differentiation/drug effects, Homeostasis/drug effects/radiation effects, 0301 basic medicine, Light, Optical Phenomena, Physiology, 0601 Biochemistry and Cell Biology, Computer System, Epigenesis, Genetic, ACTIVATION, Insulin-Secreting Cells, HETEROGENEITY, glucose, Promoter Regions, Genetic, islets, islet, imaging, Cell Differentiation, Lipid, β cells, Cell Biology, Islet, β cell, medicine.anatomical_structure, Phenotype, Calcium Signaling/drug effects/radiation effects, Metabolome, Beta cell, Life Sciences & Biomedicine, Signal Transduction, mice, Population, Insulin-Secreting Cells/drug effects/metabolism, Metabolomic, optogenetic, Biology, calcium signaling, Endocrinology & Metabolism, Internal medicine, OSCILLATIONS, medicine, Journal Article, Animals, Calcium Signaling, Insulin/secretion, geography, CHANNELS, Insulin, Metabolome/drug effects, DYSFUNCTION, Lipids/toxicity, diabete, Homeostasis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f19e79a0ef3828d155a81b5d126dfd

المؤلفون: Blighe, Kevin, Chawes, Bo L, Kelly, Rachel S, Mirzakhani, Hooman, McGeachie, Michael, Litonjua, Augusto A, Weiss, Scott T, Lasky-Su, Jessica A

المصدر: Blighe , K , Chawes , B L , Kelly , R S , Mirzakhani , H , McGeachie , M , Litonjua , A A , Weiss , S T & Lasky-Su , J A 2017 , ' Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y ' , The American Journal of Clinical Nutrition , vol. 106 , no. 4 , pp. 1092-1099 .

مصطلحات الفهرس: Adult, Amines/blood, Asthma, Child Health, Child, Preschool, Dietary Supplements, Disease Susceptibility, Fatty Acids/blood, Female, Humans, Inflammation/blood, Inflammation Mediators/blood, Male, Metabolic Networks and Pathways, Metabolome/drug effects, Metabolomics, Pregnancy, Pregnancy Complications/blood, Prenatal Exposure Delayed Effects, Vitamin D/blood, Vitamin D Deficiency/blood, Vitamins/blood, Young Adult, article

URL: https://curis.ku.dk/portal/da/publications/vitamin-d-prenatal-programming-of-childhood-metabolomics-profiles-at-age-3-y(69397013-692d-4f45-bde1-db4e6cd3ee48).html
https://doi.org/10.3945/ajcn.117.158220

المؤلفون: Mueller, Daniel, Muller-Vieira, Ursula, Biemel, Klaus M., Tascher, Georg, Nussler, Andreas K., Noor, Fozia

مصطلحات الفهرس: 3-Hydroxybutyric Acid/metabolism, Biotransformation, Cells, Cultured, Cytochrome P-450 Enzyme System/metabolism, Diclofenac/administration & dosage/pharmacokinetics/toxicity, Drug-Related Side Effects and Adverse Reactions, Galactose/metabolism, Glucose/metabolism, Hepatocytes/drug effects/metabolism, Humans, Lactic Acid/metabolism, Liver/drug effects/metabolism, Metabolic Detoxication, Phase I/physiology, Metabolic Detoxication, Phase II/physiology, Metabolome/drug effects, info:eu-repo/semantics/article

URL: http://orbilu.uni.lu/handle/10993/32233

المؤلفون: Strigun, Alexander, Noor, Fozia, Pironti, Alejandro, Niklas, Jens, Yang, Tae Hoon, Heinzle, Elmar

مصطلحات الفهرس: Alanine/metabolism, Animals, Calcium Channel Blockers/pharmacology, Carbon Isotopes, Cell Growth Processes/physiology, Cell Line, Cell Line, Tumor, Culture Media, Serum-Free, Glucose/metabolism, Glutamic Acid/metabolism, Glutamine/metabolism, Glycolysis/drug effects, Hydrogen-Ion Concentration, Lactic Acid/metabolism, Metabolome/drug effects, Mice, Myocytes, Cardiac/drug effects/metabolism, Oxygen/metabolism, Verapamil/pharmacology, info:eu-repo/semantics/article

URL: http://orbilu.uni.lu/handle/10993/32235

المؤلفون: Strigun, Alexander, Wahrheit, Judith, Beckers, Simone, Heinzle, Elmar, Noor, Fozia

مصطلحات الفهرس: Cells, Cultured, Chromatography, High Pressure Liquid/methods, Dose-Response Relationship, Drug, Humans, Metabolome/drug effects/physiology, Myocytes, Cardiac/drug effects/metabolism, Pharmaceutical Preparations/chemistry/classification, info:eu-repo/semantics/article

URL: http://orbilu.uni.lu/handle/10993/32239