المؤلفون: Wang Q; Key laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China., Lin W; Key laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China., Ni Y; Key laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China., Zhou J; National Engineering Research Center for Enzyme Technology in Medicine and Chemical Industry, Hunan Flag Bio-tech Co., Ltd., Changsha 410100, China.; National Research Center of Engineering and Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China., Xu G; National Engineering Research Center for Enzyme Technology in Medicine and Chemical Industry, Hunan Flag Bio-tech Co., Ltd., Changsha 410100, China., Han R; Key laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China.

المصدر: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jul 31; Vol. 72 (30), pp. 16900-16910. Date of Electronic Publication: 2024 Jul 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

مواضيع طبية MeSH: Methionine Adenosyltransferase*/genetics , Methionine Adenosyltransferase*/metabolism , Methionine Adenosyltransferase*/chemistry , S-Adenosylmethionine*/metabolism , S-Adenosylmethionine*/chemistry , Escherichia coli*/genetics , Escherichia coli*/metabolism, Protein Engineering ; Kinetics ; Molecular Dynamics Simulation ; Enzyme Stability ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Escherichia coli Proteins/chemistry

المؤلفون: Yang B; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA.; Department of Geriatric Endocrinology and Metabolism, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China., Lu L; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA.; Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Xiong T; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA.; Department of Pharmacy, The Third Hospital of Changsha, Changsha, Hunan, 410015, China., Fan W; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Wang J; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Barbier-Torres L; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Chhimwal J; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Sinha S; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Tsuchiya T; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Mavila N; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Tomasi ML; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Cao D; Department of Biomedical Sciences, CSMC LA, Los Angeles, CA, 90048, USA., Zhang J; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA.; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Peng H; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Mato JM; CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Technology, Park of Bizkaia, 48120, Derio, Bizkaia, Spain., Liu T; Department of Gastroenterology, Xiangya Hospital, Key Laboratory of Cancer proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Yang X; Department of Geriatric Endocrinology and Metabolism, Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention, Guangxi Clinical Research Center for Cardio-cerebrovascular Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China., Kalinichenko VV; Phoenix Children's Research Institute, Department of Child Health, University of Arizona College of Medicine, Phoenix, AZ, 85004, USA.; Division of Neonatology, Phoenix Children's Hospital, Phoenix, AZ, 85016, USA., Ramani K; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Han J; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA.; Department of Society and Genetics, UCLA LA, Los Angeles, CA, 92620, USA., Seki E; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA., Yang H; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA. Heping.yang@cshs.org., Lu SC; Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, LA, Los Angeles, CA, 90048, USA. shelly.lu@cshs.org.

المصدر: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8388. Date of Electronic Publication: 2024 Sep 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Methionine Adenosyltransferase*/metabolism , Methionine Adenosyltransferase*/genetics , Forkhead Box Protein M1*/metabolism , Forkhead Box Protein M1*/genetics , Liver Cirrhosis*/metabolism , Liver Cirrhosis*/pathology , Liver Cirrhosis*/genetics , Hepatocytes*/metabolism , Hepatocytes*/pathology , Kupffer Cells*/metabolism , Carbon Tetrachloride*/toxicity , Hepatic Stellate Cells*/metabolism, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Liver/pathology ; Liver/metabolism ; Mice, Knockout ; Mice, Transgenic ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/genetics ; Humans ; Bile Ducts/pathology ; Bile Ducts/metabolism ; Bile Ducts/surgery

المؤلفون: Cacciatore A; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Shinde D; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Musumeci C; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Sandrini G; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.; Swiss Institute of Bioinformatics, Bioinformatics Core Unit, 6500, Bellinzona, Switzerland., Guarrera L; Istituto di Ricerche Farmacologiche 'Mario Negri' IRCCS, 20156, Milano, Italy., Albino D; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Civenni G; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Storelli E; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Mosole S; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Federici E; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Fusina A; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Iozzo M; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Rinaldi A; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Pecoraro M; Institute for Research in Biomedicine (IRB), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Geiger R; Institute for Research in Biomedicine (IRB), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Bolis M; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.; Istituto di Ricerche Farmacologiche 'Mario Negri' IRCCS, 20156, Milano, Italy., Catapano CV; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland., Carbone GM; Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland. pina.carbone@ior.usi.ch.

المصدر: Nature communications [Nat Commun] 2024 Aug 06; Vol. 15 (1), pp. 6672. Date of Electronic Publication: 2024 Aug 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Transcriptional Regulator ERG*/genetics , Transcriptional Regulator ERG*/metabolism , Methionine Adenosyltransferase*/genetics , Methionine Adenosyltransferase*/metabolism , Prostatic Neoplasms, Castration-Resistant*/genetics , Prostatic Neoplasms, Castration-Resistant*/drug therapy , Prostatic Neoplasms, Castration-Resistant*/metabolism , Prostatic Neoplasms, Castration-Resistant*/pathology , Gene Expression Regulation, Neoplastic*/drug effects , Epigenesis, Genetic*/drug effects, Male ; Humans ; Cell Line, Tumor ; Animals ; Androgens/metabolism ; Epigenome ; Mice ; Histones/metabolism ; Receptors, Androgen/metabolism ; Receptors, Androgen/genetics ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/antagonists & inhibitors

المؤلفون: Huang J; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, 300308, People's Republic of China., Liu J; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.; Henan Engineering Research Center of Food Microbiology, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, 471023, People's Republic of China., Dong H; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.; School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan, 430205, People's Republic of China., Shi J; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China.; National Center of Technology Innovation for Synthetic Biology, Tianjin, 300308, People's Republic of China., You X; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China. youxy@tib.cas.cn.; Henan Engineering Research Center of Food Microbiology, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, 471023, People's Republic of China. youxy@tib.cas.cn., Zhang Y; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, People's Republic of China. zhangyf@tib.cas.cn.; National Center of Technology Innovation for Synthetic Biology, Tianjin, 300308, People's Republic of China. zhangyf@tib.cas.cn.

المصدر: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2024 Aug; Vol. 196 (8), pp. 5161-5180. Date of Electronic Publication: 2023 Dec 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Biosensing Techniques*/methods , Escherichia coli*/genetics , Escherichia coli*/metabolism , Methionine Adenosyltransferase*/genetics , Methionine Adenosyltransferase*/metabolism , Methionine*/metabolism, Substrate Specificity ; S-Adenosylmethionine/metabolism ; Protein Engineering/methods

المؤلفون: Fogal V; Oncology Safety, Safety Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK., Michopoulos F; Bioscience, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK., Jarnuczak AF; Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Hamza GM; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, R&D Boston, Waltham, USA., Harlfinger S; DMPK, Oncology R&D, AstraZeneca, Cambridge, UK., Davey P; Chemistry, Oncology R&D AstraZeneca, Cambridge, UK., Hulme H; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Atkinson SJ; Chemistry, Oncology R&D AstraZeneca, Cambridge, UK., Gabrowski P; Biological Insights Knowledge Graph, R&D IT, AstraZeneca, Barcelona, Spain., Cheung T; Oncology R&D, AstraZeneca, R&D Boston, Waltham, USA., Grondine M; Oncology R&D, AstraZeneca, R&D Boston, Waltham, USA., Hoover C; Oncology Safety Pathology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, R&D Boston, Waltham, USA., Rose J; Animal Science & Technologies, R&D, AstraZeneca, Cambridge, UK., Bray C; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK., Foster AJ; Regulatory Toxicology and Safety Pharmacology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Askin S; Advanced Drug Delivery, Pharmaceutical Sci, R&D, AstraZeneca, Cambridge, UK., Majumder MM; Safety Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Fitzpatrick P; Safety Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Miele E; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, R&D Boston, Waltham, USA., Macdonald R; Animal Science & Technologies, R&D, AstraZeneca, Cambridge, UK., Keun HC; Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery and Cancer, Imperial College London, London, UK., Coen M; Oncology Safety, Safety Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK. muireann.coen@astrazeneca.com.

المصدر: Archives of toxicology [Arch Toxicol] 2024 Aug; Vol. 98 (8), pp. 2589-2603. Date of Electronic Publication: 2024 May 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Methionine Adenosyltransferase*/genetics , Methionine Adenosyltransferase*/metabolism , S-Adenosylmethionine*/metabolism, Animals ; Male ; Liver/drug effects ; Liver/metabolism ; Rats ; Methionine/metabolism ; Rats, Sprague-Dawley ; Purine-Nucleoside Phosphorylase/metabolism ; Purine-Nucleoside Phosphorylase/genetics ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/metabolism ; Protein-Arginine N-Methyltransferases/antagonists & inhibitors ; Multiomics

المؤلفون: Gasiulė L; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania., Stankevičius V; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania., Kvederavičiu Tė K; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania., Rimšelis JM; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania., Klimkevičius V; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.; Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, LT-03225 Vilnius, Lithuania., Petraitytė G; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.; Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, LT-03225 Vilnius, Lithuania., Rukšėnaitė A; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania., Masevičius V; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.; Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, LT-03225 Vilnius, Lithuania., Klimašauskas S; Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2024 Jul 10; Vol. 146 (27), pp. 18722-18729. Date of Electronic Publication: 2024 Jun 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Methionine Adenosyltransferase*/metabolism , Methionine Adenosyltransferase*/genetics , Methionine Adenosyltransferase*/chemistry , DNA Methylation*, Animals ; Mice ; Protein Engineering ; Epigenome ; S-Adenosylmethionine/metabolism ; S-Adenosylmethionine/chemistry ; DNA (Cytosine-5-)-Methyltransferase 1/metabolism ; DNA (Cytosine-5-)-Methyltransferase 1/genetics ; Humans

المؤلفون: Xuan YF; State Key Laboratory of Drug Research, Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China., Lu S; State Key Laboratory of Drug Research, Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China., Ou YJ; State Key Laboratory of Drug Research, Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China., Bao XB; State Key Laboratory of Drug Research, Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China., Huan XJ; State Key Laboratory of Drug Research, Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China., Song SS; State Key Laboratory of Drug Research, Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China., Miao ZH; State Key Laboratory of Drug Research, Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China. Electronic address: zhmiao@simm.ac.cn., Wang YQ; State Key Laboratory of Drug Research, Cancer Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China. Electronic address: yqwang@simm.ac.cn.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jul 05; Vol. 716, pp. 150011. Date of Electronic Publication: 2024 Apr 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis*/drug effects , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/metabolism , Drug Synergism* , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Methionine Adenosyltransferase*/metabolism , Methionine Adenosyltransferase*/antagonists & inhibitors , Methionine Adenosyltransferase*/genetics , Methyltransferases*/metabolism , Methyltransferases*/antagonists & inhibitors, Animals ; Humans ; Mice ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Enzyme Inhibitors/pharmacology ; Mice, Inbred BALB C ; Mice, Nude ; Xenograft Model Antitumor Assays

المؤلفون: Floris A; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Chandla S; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Lim Y; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA., Barbier-Torres L; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Seth K; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Khangholi A; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Li TWH; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Robison A; Advanced Clinical Biosystems Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Murray BJ; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Lee S; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Matsuda M; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Murali R; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA., Tomasi ML; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA., Lu SC; Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2024 Jul 01; Vol. 80 (1), pp. 102-118. Date of Electronic Publication: 2023 Dec 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Methionine Adenosyltransferase*/metabolism , Methionine Adenosyltransferase*/genetics , Sumoylation* , Liver Diseases, Alcoholic*/metabolism , Liver Diseases, Alcoholic*/etiology , Liver Diseases, Alcoholic*/genetics, Animals ; Mice ; Humans ; Mitochondria, Liver/metabolism ; Male ; Hepatocytes/metabolism ; Liver/metabolism

المؤلفون: Han J; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Song Y; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Xie J; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Tano V; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Shen H; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Gan WL; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Ng L; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Ng BYL; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Ng VHE; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Sui X; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Tang SJ; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore., Chen L; Cancer Science Institute of Singapore, 8, Singapore 117599, Singapore.; National University of Singapore (NUS) Centre for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore.; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct; Vol. 121 (40), pp. e2404509121. Date of Electronic Publication: 2024 Sep 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Adenosine*/analogs & derivatives , Adenosine*/metabolism , Methyltransferases*/metabolism , Methyltransferases*/genetics , Methionine Adenosyltransferase*/metabolism , Methionine Adenosyltransferase*/genetics , Neoplasms*/genetics , Neoplasms*/metabolism, Humans ; Methylation ; Cell Line, Tumor ; S-Adenosylmethionine/metabolism ; Apoptosis Regulatory Proteins/metabolism ; Apoptosis Regulatory Proteins/genetics ; Gene Expression Regulation, Neoplastic ; RNA-Binding Proteins/metabolism ; RNA-Binding Proteins/genetics ; RNA Splicing/genetics ; Animals ; Mice ; RNA/metabolism ; RNA/genetics ; RNA Processing, Post-Transcriptional ; RNA Methylation

المؤلفون: Lin W; Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China., Wang Q; Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China., Han R; Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. hanrz@jiangnan.edu.cn., Zhou J; National Engineering Research Center for Enzyme Technology in Medicine and Chemical Industry, Hunan Flag Bio-Tech Co., Ltd., Changsha, 410100, China., Xu G; National Engineering Research Center for Enzyme Technology in Medicine and Chemical Industry, Hunan Flag Bio-Tech Co., Ltd., Changsha, 410100, China., Ni Y; Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. yni@jiangnan.edu.cn.

المصدر: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2024 Jun; Vol. 196 (6), pp. 3246-3259. Date of Electronic Publication: 2023 Aug 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Methionine Adenosyltransferase*/genetics , Methionine Adenosyltransferase*/chemistry , Methionine Adenosyltransferase*/metabolism , Static Electricity*, Bacteroides fragilis/enzymology ; Bacteroides fragilis/genetics ; Protein Engineering/methods ; Molecular Docking Simulation ; Biocatalysis ; S-Adenosylmethionine/metabolism ; S-Adenosylmethionine/chemistry ; Kinetics ; Mutagenesis, Site-Directed