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المؤلفون: Wen X; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Liu C; SCIEX, Concord, Ontario L4K 4V8, Canada., Tovar K; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Curran P; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Richards M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Agrawal S; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Johnstone R; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Loy RE; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Methot JL; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Mansueto MS; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Koglin M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Wildey MJ; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Burton L; SCIEX, Concord, Ontario L4K 4V8, Canada., Covey TR; SCIEX, Concord, Ontario L4K 4V8, Canada., Bateman KP; Merck & Co., Inc., Rahway, New Jersey 07065, United States., Kavana M; Merck & Co., Inc., Rahway, New Jersey 07065, United States., McLaren DG; Merck & Co., Inc., Rahway, New Jersey 07065, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2024 Jul 24; Vol. 146 (29), pp. 19792-19799. Date of Electronic Publication: 2024 Jul 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Mass Spectrometry*/methods , High-Throughput Screening Assays*/methods, Small Molecule Libraries/chemistry ; Humans ; Acoustics ; Drug Discovery/methods ; Ligands

المؤلفون: Candito DA; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Simov V; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Gulati A; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Kattar S; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Chau RW; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Lapointe BT; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Methot JL; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., DeMong DE; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Graham TH; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Kurukulasuriya R; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Keylor MH; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Tong L; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey07033, United States., Morriello GJ; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey07033, United States., Acton JJ; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey07033, United States., Pio B; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey07033, United States., Liu W; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey07033, United States., Scott JD; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey07033, United States., Ardolino MJ; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Martinot TA; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Maddess ML; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Yan X; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Gunaydin H; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Palte RL; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., McMinn SE; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Nogle L; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Yu H; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Minnihan EC; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Lesburg CA; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Liu P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Su J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey07033, United States., Hegde LG; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Moy LY; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Woodhouse JD; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Faltus R; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Xiong T; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Ciaccio P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Piesvaux JA; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Otte KM; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Kennedy ME; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Bennett DJ; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., DiMauro EF; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Fell MJ; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Neelamkavil S; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey07033, United States., Wood HB; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey07033, United States., Fuller PH; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States., Ellis JM; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts02115, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Dec 22; Vol. 65 (24), pp. 16801-16817. Date of Electronic Publication: 2022 Dec 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/drug therapy, Rats ; Humans ; Animals ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; Indazoles/pharmacology ; Indazoles/therapeutic use ; Leukocytes, Mononuclear/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/chemistry ; Brain/metabolism ; Adenosine Triphosphate

المؤلفون: Fradera X; Computational and Structural Chemistry, Merck & Co., Inc., Boston, MA, USA. Electronic address: xavier.fradera@merck.com., Deng Q; Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Achab A; Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., Garcia Y; Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., Kattar SD; Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., McGowan MA; Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., Methot JL; Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., Wilson K; Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., Zhou H; Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA., Shaffer L; Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Goldenblatt P; Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Tong V; PPDM, Merck & Co., Inc., Boston, MA, USA., Augustin MA; Proteros Biostructures GmbH, Martinsried, Germany., Altman MD; Computational and Structural Chemistry, Merck & Co., Inc., Boston, MA, USA., Lesburg CA; Computational and Structural Chemistry, Merck & Co., Inc., Boston, MA, USA., Shah S; Quantitative Biosciences, Merck & Co., Inc., Boston, MA, USA., Katz JD; Discovery Chemistry, Merck & Co., Inc., Boston, MA, USA.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Jun 15; Vol. 42, pp. 128046. Date of Electronic Publication: 2021 Apr 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitors , Phosphoinositide-3 Kinase Inhibitors/*pharmacology , Phthalimides/*pharmacology, Class I Phosphatidylinositol 3-Kinases/metabolism ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Humans ; Molecular Structure ; Phosphoinositide-3 Kinase Inhibitors/chemical synthesis ; Phosphoinositide-3 Kinase Inhibitors/chemistry ; Phthalimides/chemical synthesis ; Phthalimides/chemistry ; Structure-Activity Relationship