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المؤلفون: Guedes-da-Silva FH; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Batista DG; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Meuser MB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Demarque KC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Fulco TO; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Da Silva PB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Da Silva CF; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Patrick DA; University of North Carolina, Chapel Hill, North Carolina, USA., Bakunova SM; University of North Carolina, Chapel Hill, North Carolina, USA., Bakunov SA; University of North Carolina, Chapel Hill, North Carolina, USA., Tidwell RR; University of North Carolina, Chapel Hill, North Carolina, USA., Oliveira GM; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Britto C; Laboratório de Biologia Molecular e Doenças Endêmicas Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Moreira OC; Laboratório de Biologia Molecular e Doenças Endêmicas Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Soeiro MN; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Mar 25; Vol. 60 (4), pp. 2425-34. Date of Electronic Publication: 2016 Mar 25 (Print Publication: 2016).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*pharmacology , Chagas Disease/*drug therapy , Parasitemia/*drug therapy , Terphenyl Compounds/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, Amides/chemical synthesis ; Amidines/pharmacology ; Animals ; Chagas Disease/mortality ; Chagas Disease/parasitology ; Disease Models, Animal ; Drug Administration Schedule ; Drug Dosage Calculations ; Drug Synergism ; Drug Therapy, Combination ; Female ; Mice ; Nitroimidazoles/pharmacology ; Parasite Load ; Parasitemia/mortality ; Parasitemia/parasitology ; Parasitic Sensitivity Tests ; Structure-Activity Relationship ; Survival Analysis ; Terphenyl Compounds/chemical synthesis ; Trypanocidal Agents/chemical synthesis ; Trypanosoma cruzi/growth & development

المؤلفون: Guedes-da-Silva FH; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Batista DG; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., da Silva CF; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Meuser MB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Simões-Silva MR; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., de Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Ferreira CG; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Moreira OC; Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Britto C; Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil., Lepesheva GI; Department of Biochemistry, Institute for Global Health, Vanderbilt University, Nashville, Tennessee, USA., Soeiro Mde N; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Dec; Vol. 59 (12), pp. 7564-70. Date of Electronic Publication: 2015 Sep 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: 14-alpha Demethylase Inhibitors/*pharmacology , Chagas Disease/*drug therapy , Imidazoles/*pharmacology , Oxadiazoles/*pharmacology , Parasitemia/*drug therapy , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects, Animals ; Chagas Disease/immunology ; Chagas Disease/parasitology ; Chagas Disease/pathology ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Disease Models, Animal ; Drug Administration Schedule ; Drug Evaluation, Preclinical/methods ; Female ; Gene Expression ; Immunosuppressive Agents/pharmacology ; Male ; Mice ; Nitroimidazoles/pharmacology ; Parasitemia/immunology ; Parasitemia/parasitology ; Parasitemia/pathology ; Sex Factors ; Treatment Outcome ; Trypanosoma cruzi/enzymology ; Trypanosoma cruzi/genetics

المؤلفون: De Araújo JS; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Da Silva CF; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Batista DG; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Da Silva PB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Meuser MB; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Aiub CA; Departamento de Genética e Biologia Molecular, Universidade do Estado do Rio de Janeiro, Instituto Biomédico, Departamento de Genética e Biologia Molecular, Laboratório de Genotoxicidade, Rio de Janeiro, Brazil., da Silva MF; Departamento de Genética e Biologia Molecular, Universidade do Estado do Rio de Janeiro, Instituto Biomédico, Departamento de Genética e Biologia Molecular, Laboratório de Genotoxicidade, Rio de Janeiro, Brazil., Araújo-Lima CF; Departamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Banerjee M; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA., Farahat AA; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Stephens CE; Department of Chemistry and Physics, Georgia Regents University, Augusta, Georgia, USA., Kumar A; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA., Boykin DW; Department of Chemistry, Georgia State University, Atlanta, Georgia, USA., Soeiro MN; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil soeiro@ioc.fiocruz.br.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2014 Jul; Vol. 58 (7), pp. 4191-5. Date of Electronic Publication: 2014 Mar 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amidines/*therapeutic use , Chagas Disease/*drug therapy , Parasitemia/*drug therapy , Trypanocidal Agents/*therapeutic use , Trypanosoma cruzi/*drug effects, Amidines/chemistry ; Animals ; Chagas Disease/mortality ; Chagas Disease/parasitology ; Male ; Mice ; Parasitemia/mortality ; Parasitemia/parasitology ; Parasitic Sensitivity Tests ; Trypanocidal Agents/chemistry

المؤلفون: Silva CF; Laboratory de Biologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, 21040-900 Rio de Janeiro, RJ, Brazil., Meuser MB, De Souza EM, Meirelles MN, Stephens CE, Som P, Boykin DW, Soeiro MN

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2007 Nov; Vol. 51 (11), pp. 3803-9. Date of Electronic Publication: 2007 Aug 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0066-4804 (Print) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Amidines/*pharmacology , Trypanocidal Agents/*pharmacology , Trypanosoma cruzi/*drug effects , Trypanosoma cruzi/*ultrastructure, Amidines/chemistry ; Animals ; Chlorocebus aethiops ; Dose-Response Relationship, Drug ; Furans/pharmacology ; Guanidine/analogs & derivatives ; Guanidine/pharmacology ; Inhibitory Concentration 50 ; Microscopy, Electron, Transmission ; Molecular Structure ; Parasitic Sensitivity Tests ; Structure-Activity Relationship ; Trypanocidal Agents/chemistry ; Vero Cells