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1دورية أكاديمية
المؤلفون: Wolfgang Fischer, Heike Franke, Ute Krügel, Heiko Müller, Klaus Dinkel, Brian Lord, Michael A Letavic, David C Henshall, Tobias Engel
المصدر: PLoS ONE, Vol 11, Iss 6, p e0156468 (2016)
وصف الملف: electronic resource
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2
المؤلفون: Christine F. Gelin, Brice Stenne, Heather Coate, Afton Hiscox, Akinola Soyode-Johnson, Jessica L. Wall, Brian Lord, Jeffrey Schoellerman, Kevin J. Coe, Kai Wang, Jesus Alcázar, Christa C. Chrovian, Curt A. Dvorak, Nicholas I. Carruthers, Tatiana Koudriakova, Bartosz Balana, Michael A. Letavic
المصدر: Journal of Medicinal Chemistry. 66:2877-2892
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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3
المؤلفون: Jason C. Rech, Bruce L. Grasberger, Michael A. Letavic, Jinquan Luo, Changlu Liu, Jichun Ma, Michael P. Maher, Renee L. DesJarlais, Jeffrey Schoellerman, Rebecca Hagan, Yi Liu, Robyn L. Miller, David Lin
المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biologyمصطلحات موضوعية: 0301 basic medicine, Gene isoform, Protein Conformation, QH301-705.5, Medicine (miscellaneous), Peptide, Gating, CHO Cells, General Biochemistry, Genetics and Molecular Biology, Article, Membrane Potentials, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Cricetulus, Membrane Transport Modulators, Psalmotoxin, Animals, Binding site, Tachyphylaxis, Biology (General), Ion channel, Acid-sensing ion channel, X-ray crystallography, Ion transport, chemistry.chemical_classification, Binding Sites, Small molecule, Acid Sensing Ion Channels, Kinetics, 030104 developmental biology, chemistry, Mutation, Biophysics, General Agricultural and Biological Sciences, Ion Channel Gating, 030217 neurology & neurosurgery, Protein Binding
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4
المؤلفون: Alexandra S Needham, Akinola Soyode-Johnson, Kevin J. Coe, Bartosz Balana, Freddy Schoetens, Xiaohui Jiang, Daniel J. Pippel, Kia Sepassi, Chungfang Xia, Stenne Brice M, Brian Scott, Leslie Nguyen, Tatiana Koudriakova, Christa C. Chrovian, Brian Lord, Michael A. Letavic, Jeffrey Schoellerman
المصدر: Journal of Medicinal Chemistry. 63:9181-9196
مصطلحات موضوعية: 0303 health sciences, Allosteric regulation, Target engagement, Pharmacology, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Mood disorders, chemistry, Drug Discovery, medicine, Molecular Medicine, Major depressive disorder, Structure–activity relationship, Ionotropic glutamate receptor, Receptor, Lead compound, 030304 developmental biology
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5
المؤلفون: Hartmuth C. Kolb, Cristian Constantinescu, Michael A. Letavic, Anindya Bhattacharya, Anna Katrin Szardenings, Wei Zhang, Gilles Tamagnan, Chunfang A. Xia, Chaofeng Huang, Gang Chen, Olivier Barret
المصدر: Journal of Nuclear Medicine. 60:1154-1159
مصطلحات موضوعية: 0303 health sciences, Chemistry, Ligand binding assay, Antagonist, Pharmacology, Adenosine, In vitro, 03 medical and health sciences, 0302 clinical medicine, In vivo, medicine, Radioligand, Radiology, Nuclear Medicine and imaging, Receptor, 030217 neurology & neurosurgery, Ex vivo, 030304 developmental biology, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f20c1d914780d4020b0f900288b0ebd0
https://doi.org/10.2967/jnumed.118.212696 -
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المؤلفون: Akinola Soyode-Johnson, Michael A. Letavic, Kevin J. Coe, Christa C. Chrovian, Brian Lord, Nicholas I. Carruthers, Wall Jessica L, Bartosz Balana, Xiaohui Jiang, Tatiana Koudriakova, Leslie Nguyen, Jason C. Rech, Jeff Schoellerman
المصدر: ACS Medicinal Chemistry Letters. 10:261-266
مصطلحات موضوعية: biology, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Allosteric regulation, hERG, Cytochrome P450, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Pyridine, biology.protein, Potency, Receptor
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7
المؤلفون: Chaofeng Huang, Gang Chen, Yingbo He, Anna Katrin Szardenings, Michael A. Letavic, Tamara Berdyyeva, Wei Zhang, Hartmuth C. Kolb, Anindya Bhattacharya, Chunfang Xia, Natalie Taylor
المصدر: Molecular Imaging and Biology. 21:871-878
مصطلحات موضوعية: Cancer Research, medicine.diagnostic_test, Chemistry, Antagonist, Standardized uptake value, Pharmacology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Real-time polymerase chain reaction, Oncology, Downregulation and upregulation, In vivo, Positron emission tomography, medicine, Radiology, Nuclear Medicine and imaging, Neuroinflammation, Ex vivo
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المصدر: Progress in medicinal chemistry. 59
مصطلحات موضوعية: Molecular Structure, Purinergic P2X Receptor Antagonists, Mood Disorders, Non-alcoholic Fatty Liver Disease, Humans, Receptors, Purinergic P2X7, Ligands
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::6b355b6cc114d012ee29fb54461fad77
https://pubmed.ncbi.nlm.nih.gov/32362329 -
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المؤلفون: Michael A. Letavic, Anindya Bhattacharya, Christine F. Gelin
مصطلحات موضوعية: business.industry, Central nervous system, Target engagement, Inflammation, Bioinformatics, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Pet ligand, Medicine, medicine.symptom, business, Receptor, P2x7 receptor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::add477254d752d2dc9b4736834f2975c
https://doi.org/10.1016/bs.pmch.2019.11.002 -
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المؤلفون: Leah Aluisio, Jan-Sebastian Grigoleit, Michael A. Letavic, Ian Fraser, Timothy W. Lovenberg, Natalie Taylor, Nicholas I. Carruthers, Jason C. O'Connor, Brian Lord, Anindya Bhattacharya, Shannon N. Campbell, Yingbo He, Mariusz Papp, Christa C. Chrovian
المصدر: Neuropsychopharmacology. 43:2586-2596
مصطلحات موضوعية: Lipopolysaccharides, Male, 0301 basic medicine, Anhedonia, Purinergic P2X Receptor Antagonists, Pyridines, Interleukin-1beta, Drug Evaluation, Preclinical, Pharmacology, Article, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, medicine, Animals, Chronic stress, Rats, Wistar, Cells, Cultured, Neuropharmacology, ED50, Neuroinflammation, Inflammation, Dose-Response Relationship, Drug, Microglia, business.industry, Antagonist, Rats, Mice, Inbred C57BL, Disease Models, Animal, Psychiatry and Mental health, Pyrimidines, 030104 developmental biology, medicine.anatomical_structure, Neuroimmunology, Receptors, Purinergic P2X7, Inflammation Mediators, medicine.symptom, business, 030217 neurology & neurosurgery