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1
المؤلفون: Guozhang Xu, Zhijie Liu, Xinkang Wang, Tianbao Lu, Renee L. DesJarlais, Tho Thieu, Jing Zhang, Zheng Huang Devine, Fuyong Du, Qiu Li, Cynthia M. Milligan, Paul Shaffer, Peder E. Cedervall, John C. Spurlino, Christopher F. Stratton, Beth Pietrak, Lawrence M. Szewczuk, Victoria Wong, Ruth A. Steele, Wouter Bruinzeel, Madhu Chintala, Jose Silva, Michael D. Gaul, Mark J. Macielag, Ravi Nargund
المصدر: Journal of medicinal chemistry. 65(15)
مصطلحات موضوعية: Dogs, Pyridines, Drug Design, Drug Discovery, Molecular Medicine, Animals, Anticoagulants, Rabbits, Factor XIa, Rats
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المؤلفون: Shyh-Ming, Yang, Yuting, Tang, Rui, Zhang, Huajun, Lu, Gee-Hong, Kuo, Michael D, Gaul, Yaxin, Li, George, Ho, James G, Conway, Yin, Liang, James M, Lenhard, Keith T, Demarest, William V, Murray
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:6773-6776
مصطلحات موضوعية: Body Weight, Organic Chemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Diet, Rats, Enzyme Activation, Mice, Inbred C57BL, Mice, Structure-Activity Relationship, Piperidines, Drug Discovery, Animals, Urea, Molecular Medicine, Obesity, Enzyme Inhibitors, Molecular Biology, Stearoyl-CoA Desaturase, Protein Binding
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المؤلفون: Jeremy M. Travins, Carl Crysler, Hufnagel Heather Rae, Karen DiLoreto, Norman Huebert, Michael X. Kolpak, Nalin L. Subasinghe, Jennifer Kirkpatrick, Stephen H. Eisennagel, Bruce E. Tomczuk, Wenxi Pan, Christopher J. Molloy, Ehab Khalil, Nisha S. Ninan, Shelley K. Ballentine, Kristi A. Leonard, Roger F. Bone, Richard Soll, Farah Ali, Michael D. Gaul
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5303-5307
مصطلحات موضوعية: ARDS, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Polyethylene glycol, Pharmacology, Biochemistry, Polyethylene Glycols, Classical complement pathway, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Potency, Protease Inhibitors, Molecular Biology, Complement C1s, Protease, Chemistry, Organic Chemistry, medicine.disease, Amides, Rats, Drug Design, PEGylation, Molecular Medicine, Half-Life
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المؤلفون: Kimberly G. Petrov, Thomas R. Caferro, Octerloney B. McDonald, David W. Rusnak, Dana E. Vanderwall, Kelly Horne Donaldson, Tara Renae Rheault, David E. Uehling, Lisa M. Shewchuk, Scott Howard Dickerson, Robert J. Mullin, Michael D. Gaul, Aaron S. Goetz, Glenn M. Spehar, Anne T. Truesdale, Edgar R. Wood
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:817-820
مصطلحات موضوعية: Pyrimidine, Receptor, ErbB-2, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Antineoplastic Agents, Lapatinib, Biochemistry, Sulfone, Inhibitory Concentration 50, chemistry.chemical_compound, ErbB, Cell Line, Tumor, Drug Discovery, medicine, Humans, Epidermal growth factor receptor, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, biology, Chemistry, Kinase, Organic Chemistry, In vitro, ErbB Receptors, Pyrimidines, Models, Chemical, Enzyme inhibitor, Drug Design, Quinazolines, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, medicine.drug
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المؤلفون: M. Anthony Leesnitzer, Kimberly G. Petrov, Marcia L. Moss, Darryl Lynn Mcdougald, J. David Becherer, David J. Cowan, Robert W. Wiethe, Millard H. Lambert, David Lee Musso, Robert Andrews, D. Mark Bickett, Jennifer Gabriel Badiang, Michael D. Gaul, Andersen Marc W, Daniel B. Kassel, Michael H. Rabinowitz, R. Kevin Blackburn, Janet Warner, Daniel S. Kinder, Theresa D. Seaton
المصدر: Combinatorial Chemistry & High Throughput Screening. 8:327-339
مصطلحات موضوعية: chemistry.chemical_classification, Streptavidin, Methionine sulfoxide, Stereochemistry, Organic Chemistry, Peptide, General Medicine, Computer Science Applications, Amino acid, chemistry.chemical_compound, chemistry, Affinity chromatography, Biochemistry, Biotinylation, Drug Discovery, Peptide library, Peptide sequence
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e9c38b38823234fe10e050a50c9a3d7a
https://doi.org/10.2174/1386207054020840 -
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المؤلفون: Elizabeth J. Beaudet, Ron Laethem, Steven J. Novick, Zhiyang Zhao, Thomas A. Brodie, Debie J. Hoivik, Andrews Robert Carl, Timothy K. Tippin, Edward L. LeCluyse, J. David Becherer, Jürgen M. Lehmann, Linda B. Moore, Darryl L. McDougald, Summer Jolley, Steven A. Kliewer, Michael D. Gaul, G. Hamilton, Kathy Mellon-Kusibab
المصدر: Drug Metabolism and Disposition. 31:870-877
مصطلحات موضوعية: Male, Receptors, Steroid, Matrix metalloproteinase inhibitor, Cell Culture Techniques, Drug Evaluation, Preclinical, Administration, Oral, Aminopyridines, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, ADAM17 Protein, Matrix Metalloproteinase Inhibitors, chemistry.chemical_compound, In vivo, medicine, Animals, Cytochrome P-450 CYP3A, Humans, Rats, Wistar, Enzyme inducer, Pharmacology, chemistry.chemical_classification, Pregnane X receptor, Dose-Response Relationship, Drug, Formamides, biology, Pregnane, Pregnane X Receptor, Metalloendopeptidases, Oxidoreductases, N-Demethylating, Dipeptides, Amides, Molecular biology, Matrix Metalloproteinases, Rats, ADAM Proteins, Thiazoles, medicine.anatomical_structure, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Enzyme Induction, Hepatocyte, Hepatocytes, biology.protein, Drug Evaluation, Aryl Hydrocarbon Hydroxylases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728180f659f051cfc4b785f829bf565b
https://doi.org/10.1124/dmd.31.7.870 -
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المؤلفون: Sarva M. Tadepalli, Alex G. Waterson, Perry Scott Brignola, Scott Howard Dickerson, Robert J. Mullin, Thomas R. Caferro, Craig D. Wagner, Hamilton D. Dickson, Dana E. Vanderwall, Kimberly G. Petrov, John C. Ulrich, Michael D. Gaul, Lisa M. Shewchuk, Anne M. Hassell, Kelly Horne Donaldson, Edgar R. Wood, David E. Uehling, Jon D. Williams, Ronald L. Brashear, Barry R. Keith, Wendy L. White, David W. Rusnak, Byron Ellis, Robert J. Griffin, Michael J. Reno
مصطلحات موضوعية: Isatin, Models, Molecular, Stereochemistry, Mice, SCID, Crystallography, X-Ray, Mass Spectrometry, Adduct, Mice, Structure-Activity Relationship, ErbB, Moiety, Transferase, Structure–activity relationship, Animals, Cell Proliferation, Multidisciplinary, Aniline Compounds, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Receptor Protein-Tyrosine Kinases, Biological activity, Xenograft Model Antitumor Assays, ErbB Receptors, Pyrimidines, Covalent bond, Alkynes, Physical Sciences, Female, Cysteine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee325f04de0f7f4e5e90c473b3e261b
https://europepmc.org/articles/PMC2268535/ -
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المؤلفون: Millard H, Lambert, R Kevin, Blackburn, Theresa D, Seaton, Daniel B, Kassel, Daniel S, Kinder, M Anthony, Leesnitzer, D Mark, Bickett, Janet R, Warner, Marc W, Andersen, Jennifer G, Badiang, David J, Cowan, Michael D, Gaul, Kimberly G, Petrov, Michael H, Rabinowitz, Robert W, Wiethe, J David, Becherer, Darryl L, McDougald, David L, Musso, Robert C, Andrews, Marcia L, Moss
المصدر: Combinatorial chemistryhigh throughput screening. 8(4)
مصطلحات موضوعية: Models, Molecular, Binding Sites, Protein Conformation, Tumor Necrosis Factor-alpha, Drug Evaluation, Preclinical, Biotin, Metalloendopeptidases, ADAM17 Protein, Mass Spectrometry, Recombinant Proteins, Substrate Specificity, ADAM Proteins, Structure-Activity Relationship, Peptide Library, Drug Design, Protein Interaction Mapping, Image Processing, Computer-Assisted, Protease Inhibitors, Peptides, Chromatography, Liquid
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::993edb682148101da04f2a40507a6ade
https://pubmed.ncbi.nlm.nih.gov/16101009 -
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المؤلفون: Marcia L. Moss, David J. Cowan, Bubacz Dulce Garrido, Timothy K. Tippin, Stanford Jennifer Badiang, Michele C. Rizzolio, Robert W. Wiethe, Darryl Lynn Mcdougald, Lee T. Schaller, Joseph H. Chan, James G. Conway, Millard H. Lambert, Justin L. Mitchell, Robert Carl Andrews, M. Anthony Leesnitzer, David Lee Musso, Janet Warner, Andersen Marc W, Michael H. Rabinowitz, J. David Becherer, Kimberly C. Glennon, D. Mark Bickett, Michael D. Gaul, L.Graham Whitesell, Elizabeth J. Beaudet, Richard Austin, Kevin M. Hedeen
المصدر: Bioorganicmedicinal chemistry letters. 11(16)
مصطلحات موضوعية: Peptidomimetic, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Matrix metalloproteinase, ADAM17 Protein, Matrix Metalloproteinase Inhibitors, Biochemistry, Structure-Activity Relationship, Dogs, Pharmacokinetics, Oral administration, Drug Discovery, Animals, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Metalloproteinase, biology, Formamides, Chemistry, Organic Chemistry, Metalloendopeptidases, In vitro, Rats, ADAM Proteins, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Oligopeptides
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المؤلفون: Michael D. Gaul, Robert K. Boeckman, Scott G. Nelson
المصدر: Journal of the American Chemical Society. 114:2258-2260
مصطلحات موضوعية: Chiral auxiliary, Bicyclic molecule, General Chemistry, Biochemistry, Catalysis, Cycloaddition, Camphor, chemistry.chemical_compound, Colloid and Surface Chemistry, chemistry, Lactam, Organic chemistry, Lewis acids and bases, Aliphatic compound, Imide
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f3e96c9fd68ddbcd77a660e6e5b48d1f
https://doi.org/10.1021/ja00032a051