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1
المؤلفون: Steven P. Seitz, Sarah Cox, Pieter F. W. Stouten, Michael D. Boisclair, Stephen L. Brenner, Jay A. Markwalder, Karen A. Rossi, Leonardo Brizuela, Chong-Hwan Chang
المصدر: Journal of Computer-Aided Molecular Design. 19:111-122
مصطلحات موضوعية: Models, Molecular, Cyclin D, Molecular Sequence Data, Cyclin A, Drug Evaluation, Preclinical, Pyrimidinones, Substrate Specificity, Cyclin-dependent kinase, Proto-Oncogene Proteins, Drug Discovery, CDC2-CDC28 Kinases, Cyclin D1, Amino Acid Sequence, Enzyme Inhibitors, Physical and Theoretical Chemistry, Sequence Homology, Amino Acid, biology, Cyclin-dependent kinase 4, Cyclin-Dependent Kinase 2, Cyclin-Dependent Kinase 4, Hydrogen Bonding, Cyclin-Dependent Kinases, Computer Science Applications, Cell biology, Biochemistry, biology.protein, Cyclin-dependent kinase complex, Cyclin-dependent kinase 6, biological phenomena, cell phenomena, and immunity, Cyclin A2, CDK inhibitor
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2
المؤلفون: Jie Liu, John F. Boylan, Chong-Hwan Chang, Thais M. Sielecki, Haiying Chen, Robert H. Grafstrom, Angela Smallwood, Catherine R. Burton, Michael D. Boisclair, Steven P. Seitz, Tricia L. Johnson, Sarah Cox, George L. Trainor, Pamela A. Benfield, Jodi K. Muckelbauer
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1157-1160
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Binding, Competitive, Biochemistry, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Cyclin-dependent kinase, Drug Discovery, Quinazoline, Transferase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Kinase, Organic Chemistry, Cyclin-dependent kinase 2, Cyclin-Dependent Kinases, Enzyme, chemistry, Enzyme inhibitor, Quinazolines, biology.protein, Molecular Medicine, biological phenomena, cell phenomena, and immunity
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3
المؤلفون: Peter J. Worland, Christopher McClure, Muzammil M. Mansuri, Krishna K. Murthi, Marja Dubay, Leonardo Brizuela, Kollol Pal, Michael D. Boisclair
المصدر: Bioorganic & Medicinal Chemistry Letters. 10:1037-1041
مصطلحات موضوعية: Pyridines, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Tumor cells, Inhibitory postsynaptic potential, Biochemistry, Structure-Activity Relationship, Piperidines, Cyclin-dependent kinase, Drug Discovery, Tumor Cells, Cultured, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Cyclin, Flavonoids, biology, Chemistry, Kinase, Organic Chemistry, Cell cycle, Cyclin-Dependent Kinases, Cell biology, Chromones, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, biological phenomena, cell phenomena, and immunity
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4
المؤلفون: David Epstein, Gustave Bergnes, Carla L. Gilliam, Katharine V. Blake, Kollol Pal, Michael D. Boisclair, Jill Blanchard
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:2849-2854
مصطلحات موضوعية: Stereochemistry, Cdc25, Clinical Biochemistry, Phosphatase, Pharmaceutical Science, Peptide, macromolecular substances, Binding, Competitive, Biochemistry, Chemical synthesis, Phosphates, chemistry.chemical_compound, Peptide Library, Drug Discovery, cdc25 Phosphatases, Enzyme Inhibitors, Phosphorylation, Molecular Biology, chemistry.chemical_classification, Dipeptide, biology, Cell Cycle, Organic Chemistry, Biological activity, Dipeptides, enzymes and coenzymes (carbohydrates), Enzyme, chemistry, biology.protein, Molecular Medicine, Ugi reaction
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5
المؤلفون: Kollol Pal, Regina E. Cebula, Jill L. Blanchard, Michael D. Boisclair, Nicholas J. Bockovich
المصدر: Bioorganic & Medicinal Chemistry Letters. 7:2015-2020
مصطلحات موضوعية: chemistry.chemical_classification, CDC25A, biology, Chemistry, Carboxylic acid, Organic Chemistry, Clinical Biochemistry, Phosphatase, Pharmaceutical Science, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Malonate, Enzyme, Enzyme inhibitor, Drug Discovery, biology.protein, Molecular Medicine, Potency, Molecular Biology
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6
المصدر: ChemInform. 28
مصطلحات موضوعية: Terpene, Stereochemistry, Chemistry, Phosphatase, General Medicine, Inhibitory postsynaptic potential
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7
المؤلفون: David Epstein, Carla L. Gilliam, Katharine V. Blake, Kollol Pal, Michael D. Boisclair, Jill Blanchard, Gustave Bergnes
المصدر: ChemInform. 31
مصطلحات موضوعية: enzymes and coenzymes (carbohydrates), chemistry.chemical_compound, biology, chemistry, Cdc25, Phosphatase, biology.protein, Substrate (chemistry), Ugi reaction, macromolecular substances, General Medicine, Phosphate, Combinatorial chemistry
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8
المؤلفون: Leonardo Brizuela, Krishna K. Murthi, Peter J. Worland, Marja Dubay, Kollol Pal, Michael D. Boisclair, Christopher McClure, Muzammil M. Mansuri
المصدر: ChemInform. 31
مصطلحات موضوعية: biology, Chemistry, Kinase, Cyclin-dependent kinase, biology.protein, Structure–activity relationship, General Medicine, biological phenomena, cell phenomena, and immunity, Cell cycle, Inhibitory postsynaptic potential, Cell biology, Cyclin
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9
المؤلفون: Sarah Cox, Michael D. Boisclair, Charity L. Dean, Philip M. Czerniak, Pieter F. W. Stouten, David A. Nugiel, Steven P. Seitz, Chong-Hwan Chang, Catherine R. Burton, Marc R. Arnone, Lisa M. Sisk, Robert F. Kaltenbach, Barbara A. Harrison, Pamela A. Benfield, Robert H. Grafstrom, Jay A. Markwalder, Susan R. Sherk, Karen A. Rossi, Deborah Doleniak, Peter Worland, George L. Trainor
المصدر: Journal of medicinal chemistry. 47(24)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Transplantation, Heterologous, Antineoplastic Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Cyclin-dependent kinase, Cell Line, Tumor, Proto-Oncogene Proteins, Drug Discovery, Structure–activity relationship, Animals, Humans, Cyclin D1, Binding site, Phosphorylation, Cells, Cultured, Binding Sites, biology, Molecular Structure, Cyclin-dependent kinase 4, Kinase, Chemistry, Cyclin-dependent kinase 2, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases, Transplantation, Pyrimidines, Enzyme inhibitor, biology.protein, Molecular Medicine, Pyrazoles, Drug Screening Assays, Antitumor
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10
المؤلفون: Jie Liu, Robert H. Grafstrom, George L. Trainor, Kimberly Harrison, Diane M. Sharp, Jay A. Markwalder, David J. Carini, Yuki Nakano, Emeka Akamike, Pamela A. Benfield, Sarah Cox, John F. Boylan, Robert F. Kaltenbach, Catherine R. Burton, Thais M. Sielecki, Michael D. Boisclair, Steven P. Seitz, Barbara A. Harrison, Leonardo Brizuela
المصدر: Bioorganicmedicinal chemistry letters. 11(16)
مصطلحات موضوعية: Clinical Biochemistry, Carbazoles, Molecular Conformation, Pharmaceutical Science, Biochemistry, Isozyme, Structure-Activity Relationship, Cyclin-dependent kinase, Proto-Oncogene Proteins, Drug Discovery, Enzyme Inhibitors, Molecular Biology, biology, Cyclin-dependent kinase 4, Chemistry, Kinase, Organic Chemistry, Cyclin-dependent kinase 2, Cyclin-dependent kinase 3, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases, biology.protein, Cyclin-dependent kinase complex, Molecular Medicine, Cyclin-dependent kinase 9, biological phenomena, cell phenomena, and immunity