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المؤلفون: Sultan Chowdhury, David Bogucki, Rostam Namdari, Girish Bankar, Wei Zhang, James Roy Empfield, Matthew Waldbrook, Stephanie M Lee, Lofstrand Verner Alexander, Karen Nelkenbrecher, Samuel J. Goodchild, Rhena Yoo, Noah G. Shuart, Wesolowski Steven Sigmund, Elaine Chang, Mandy Feng, Clint Young, Christoph Martin Dehnhardt, Jenny Li, Zhiwei Xie, Michael Edward Grimwood, Abid Hasan, Sophia Lin, Kristen Burford, Raymond J. Winquist, Charles J. Cohen, Alla Yurevna Zenova, Simon N. Pimstone, Michael R. Wilson, Parisa Karimi Tari, Kuldip Khakh, Celine Dube, Aaron M. Williams, Robin Sherrington, Luis Sojo, Andrea Lindgren, J. P. Johnson, Thilo Focken, Qi Jia, Jean-Christophe Andrez, Shannon Decker, Matthew Taron, Diana Weeratunge, Richard T. Dean, Janette Mezeyova, Shaoyi Sun, Wei Gong, Angela Hussainkhel, Gina de Boer, Alison Jane Cutts
مصطلحات موضوعية: Phenytoin, Glutamatergic, Lacosamide, Chemistry, Sodium channel, Excitatory postsynaptic potential, medicine, Carbamazepine, Pharmacology, Inhibitory postsynaptic potential, IC50, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::32e2e6674136369f3abcd5070b52e762
https://doi.org/10.1101/2021.08.29.458125 -
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المؤلفون: Parisa Karimi Tari, Charles J. Cohen, Matthew Waldbrook, Christoph Martin Dehnhardt, Clint Young, Maegan Soriano, Rainbow Kwan, Matt Taron, Kristen Burford, Sultan Chowdhury, Noah G. Shuart, Lofstrand Verner Alexander, Michael D. Wilson, Karen Nelkenbrecher, Jean-Christophe Andrez, Michael Edward Grimwood, Wei Gong, Robert J. DeVita, J. P. Johnson, James Roy Empfield, Alla Yurevna Zenova, Luis Sojo, Andrea Lindgren, Thilo Focken, Shannon Decker, Gina de Boer, Samuel J. Goodchild, Wesolowski Steven Sigmund, Sophia Lin, Stephanie Lee
المصدر: Journal of Medicinal Chemistry. 62:9618-9641
مصطلحات موضوعية: Drug, 0303 health sciences, media_common.quotation_subject, Sodium channel, medicine.medical_treatment, Pregnane, Pharmacology, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Epilepsy, chemistry.chemical_compound, Anticonvulsant, chemistry, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Efflux, Penetrant (biochemical), 030304 developmental biology, media_common
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المؤلفون: Qi Jia, Jean-Christophe Andrez, Charles J. Cohen, Jae H. Chang, Kuldip Khakh, J. P. Johnson, Chien-An Chen, Jun Li, Karen Nelkenbrecher, Thilo Focken, Zhiwei Xie, Daniel F. Ortwine, Brian Safina, Michael Edward Grimwood, Andrew D. White, Christoph Martin Dehnhardt, Shannon Decker, Ivan William Hemeon, David H. Hackos, Sophia Lin, Jodie Pang, Luis Sojo, Girish Bankar, Andrea Lindgren, Matthew Waldbrook, Elaine Chang, C. Lee Robinette, Shaoyi Sun, Antonio G. DiPasquale, Tao Sheng, Clint Young, Rainbow Kwan, Benjamin D. Sellers, Sultan Chowdhury, Michael Scott Wilson, Lunbin Deng, Daniel P. Sutherlin, Alla Yurevna Zenova
المصدر: Journal of Medicinal Chemistry. 62:908-927
مصطلحات موضوعية: 0303 health sciences, Chemistry, Sodium channel, Pharmacology, 01 natural sciences, Molecular Docking Simulation, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Pharmacokinetics, In vivo, Docking (molecular), Drug Discovery, Microsome, Molecular Medicine, Structure–activity relationship, Potency, 030304 developmental biology
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المؤلفون: Christoph Martin Dehnhardt, Karen Nelkenbrecher, Jean-Christophe Andrez, Zhiwei Xie, David H. Hackos, Michael Edward Grimwood, Jae H. Chang, Sultan Chowdhury, Clint Young, Charles J. Cohen, J. P. Johnson, Elaine Chang, Michelle Dourado, Kuldip Khakh, Noah G. Shuart, Jodie Pang, Matthew Waldbrook, C. Lee Robinette, Sarah Howard, Daniel P. Sutherlin, Girish Bankar, Luis Sojo, Andrea Lindgren, Shannon Decker, Brian Safina, Samuel J. Goodchild, Sophia Lin
المصدر: Cell Reports, Vol 24, Iss 12, Pp 3133-3145 (2018)
مصطلحات موضوعية: 0301 basic medicine, Diabetic neuropathy, business.industry, Sodium channel, Analgesic, Pharmacology, medicine.disease, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, lcsh:Biology (General), Neuropathic pain, Medicine, Potency, Dosing, business, lcsh:QH301-705.5, IC50, Sensitization
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المؤلفون: Girish Bankar, Charles J. Cohen, Bowen Li, Kuldip Khakh, Sultan Chowdhury, Elaine Chang, Paul Robert Bichler, Christoph Martin Dehnhardt, Daniel P. Sutherlin, Jodie Pang, Michael D. Wilson, Yi Zhang, Zhiwei Xie, Matthew Waldbrook, C. Lee Robinette, Jae H. Chang, Karen Nelkenbrecher, Ivan William Hemeon, Alla Yurevna Zenova, Tao Sheng, Samuel J. Goodchild, Clint Young, Navjot Chahal, Rainbow Kwan, Daniel F. Ortwine, Brian Safina, Sophia Lin, Andrew D. White, Parisa Karimi Tari, Qi Jia, J. P. Johnson, Thilo Focken, Chien-An Chen, David H. Hackos, Shannon Decker, Noah G. Shuart, Luis Sojo, Christine Chabot, Shaoyi Sun, Michael Edward Grimwood
المصدر: Journal of Medicinal Chemistry. 61:4810-4831
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Genetically modified mouse, Stereochemistry, Aryl, Sodium channel, In vitro, Sulfonamide, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, In vivo, Drug Discovery, Lipophilicity, Molecular Medicine, Potency, 030217 neurology & neurosurgery
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المؤلفون: Charles J. Cohen, Brian Safina, Daniel P. Sutherlin, Michael Edward Grimwood, Thilo Focken, J. P. Johnson, Shifeng Liu, Maxim Dauphinais, Matthew Waldbrook, C. Lee Robinette, Girish Bankar, Ivan William Hemeon, Noah G. Shuart, Jae H. Chang, Sultan Chowdhury, David Bogucki, Luis Sojo, Clint Young, Rainbow Kwan, Paul Robert Bichler, Renata Oballa, Tarek S. Mansour, Sophia Lin, Christoph Martin Dehnhardt, Jodie Pang, Navjot Chahal
المصدر: ACS Medicinal Chemistry Letters. 7:277-282
مصطلحات موضوعية: 0301 basic medicine, Drug, Gene isoform, biology, Aryl, Sodium channel, media_common.quotation_subject, Organic Chemistry, Analgesic, Pharmacology, Nav1.5, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, In vivo, Drug Discovery, biology.protein, Potency, 030217 neurology & neurosurgery, media_common
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المؤلفون: Brian Safina, Honorio Sampang, Bobby Brillantes, Christopher M. Koth, Hoangdung Ho, Shivani Ahuja, Sophia Lin, Christoph Martin Dehnhardt, Krista K. Bowman, Michael Edward Grimwood, Ping Wu, Melissa A. Starovasnik, David H. Hackos, Christine Tam, J. P. Johnson, Charles J. Cohen, Zhiwei Xie, Jian Payandeh, Yvonne Franke, Kuldip Khakh, Mary Coons, Kevin R Clark, Jun Li, Susmith Mukund, Elaine Chang, Jean-Christophe Andrez, Stephanie Shriver, Daniel F. Ortwine, Kyle Mortara, Clint Young, Alberto Estevez, Henry Verschoof, Thilo Focken, Daniel P. Sutherlin, Lunbin Deng
المصدر: Science. 350
مصطلحات موضوعية: Models, Molecular, Gene isoform, Stereochemistry, DNA Mutational Analysis, Molecular Sequence Data, Gating, Crystallography, X-Ray, Protein Engineering, Protein Structure, Secondary, Cell membrane, Protein structure, Thiadiazoles, medicine, Humans, Protein Isoforms, Amino Acid Sequence, Receptor, Sulfonamides, Multidisciplinary, Chemistry, Cell Membrane, NAV1.7 Voltage-Gated Sodium Channel, Pain Perception, Small molecule, Protein Structure, Tertiary, medicine.anatomical_structure, Helix, Biophysics, Crystallization, Sodium Channel Blockers
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ca24c2468f257b0ad883c68b2e4c30
https://doi.org/10.1126/science.aac5464
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