يعرض 1 - 10 نتائج من 58 نتيجة بحث عن '"Michael J Delves"', وقت الاستعلام: 1.06s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials.

    المؤلفون: Oleksiy Tsebriy, Andrii Khomiak, Celia Miguel-Blanco, Penny C Sparkes, Maurizio Gioli, Marco Santelli, Edgar Whitley, Francisco-Javier Gamo, Michael J Delves

    المصدر: PLoS Pathogens, Vol 19, Iss 10, p e1011711 (2023)

    مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

    وصف الملف: electronic resource

    Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011711&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

    URL الوصول: https://doaj.org/article/7b034271cfc6462c8a81ddc9cbfc1fd7

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  2. 2
    دورية أكاديمية
    Spatial localisation of actin filaments across developmental stages of the malaria parasite.

    المؤلفون: Fiona Angrisano, David T Riglar, Angelika Sturm, Jennifer C Volz, Michael J Delves, Elizabeth S Zuccala, Lynne Turnbull, Chaitali Dekiwadia, Maya A Olshina, Danushka S Marapana, Wilson Wong, Vanessa Mollard, Clare H Bradin, Christopher J Tonkin, Peter W Gunning, Stuart A Ralph, Cynthia B Whitchurch, Robert E Sinden, Alan F Cowman, Geoffrey I McFadden, Jake Baum

    المصدر: PLoS ONE, Vol 7, Iss 2, p e32188 (2012)

    مصطلحات موضوعية: Medicine, Science

    وصف الملف: electronic resource

    Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22389687/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

    URL الوصول: https://doaj.org/article/663f98ec3f0348a3a8e3f70f199f29f3

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  3. 3
    Machine Learning-based Phenotypic Imaging to Characterise the Targetable Biology ofPlasmodium falciparumMale Gametocytes for the Development of Transmission-Blocking Antimalarials

    المؤلفون: Oleksiy Tsebriy, Andrii Khomiak, Celia Miguel-Blanco, Penny C. Sparkes, Maurizio Gioli, Marco Santelli, Edgar Whitley, Francisco-Javier Gamo, Michael J. Delves

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::df9d220dc98cc172acf1d2141778c1fd
    https://doi.org/10.1101/2023.04.22.537818

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  4. 4
    A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein

    المؤلفون: Sabrina Yahiya, Charlie N. Saunders, Sarah Hassan, Ursula Straschil, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Silvia Haase, Gema Vizcay-Barrena, Mufuliat Toyin Famodimu, Sarah Jordan, Michael J. Delves, Edward W. Tate, Anna Barnard, Matthew J. Fuchter, Jake Baum

    المصدر: Disease Models & Mechanisms. 16

    مصطلحات موضوعية: Immunology and Microbiology (miscellaneous), Neuroscience (miscellaneous), Medicine (miscellaneous), General Biochemistry, Genetics and Molecular Biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd0eb7533fdd666abc3c84369122373
    https://doi.org/10.1242/dmm.049950

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  5. 5
    Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts

    المؤلفون: Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht

    المصدر: Journal of Medicinal Chemistry. 64:2291-2309

    مصطلحات موضوعية: Multiple stages, 0303 health sciences, biology, Plasmodium falciparum, Computational biology, biology.organism_classification, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Drug Discovery, High-Throughput Screening Assays, Gametocyte, medicine, Molecular Medicine, Structure–activity relationship, Parasite hosting, Malaria, 030304 developmental biology, Octane

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::748b270a5ec97aeb6e2aead9a27947b0
    https://doi.org/10.1021/acs.jmedchem.1c00034

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  6. 6
    The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite

    المؤلفون: Madeline R. Luth, Fernando Sánchez-Román Terán, Jake Baum, Ursula Straschil, Michael D. Edstein, Michael J. Delves, Leonardo Lucantoni, Elizabeth A. Winzeler, Stuart A. Ralph, Katherine M. Ellis, Marina Chavchich, Jonathan B. Baell, Darren J. Creek, Clemens H. M. Kocken, Amanda De Paoli, Vicky M. Avery, Anne-Marie Zeeman, Matthew Abraham

    المصدر: Antimicrob Agents Chemother

    مصطلحات موضوعية: Male, Plasmodium berghei, Biology, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Chloroquine, In vivo, parasitic diseases, Gametocyte, medicine, Animals, Pharmacology (medical), Parasites, Mechanisms of Action: Physiological Effects, 030304 developmental biology, 0303 health sciences, 030306 microbiology, Triazines, Plasmodium falciparum, biology.organism_classification, medicine.disease, In vitro, 3. Good health, Malaria, Infectious Diseases, chemistry, Artesunate, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0488fc3eba297e566a5bcc209793de5
    https://pubmed.ncbi.nlm.nih.gov/34460304

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  7. 7
    Plasmodium falciparumprotein Pfs16 is a target for transmission-blocking antimalarial drug development

    المؤلفون: Matthew J. Fuchter, Sarah Jordan, Gema Vizcay-Barrena, Sabrina Yahiya, Silvia Haase, Ainoa Rueda-Zubiaurre, Ursula Straschil, Oliver J. Fischer, Jake Baum, Michael J. Delves, Anna Barnard, Charlie N Saunders, Edward W. Tate, Saqib Hassan

    مصطلحات موضوعية: Thermal shift assay, biology, Chemistry, Phenotypic screening, Cell, Plasmodium falciparum, biology.organism_classification, Cell morphology, Cell biology, medicine.anatomical_structure, Membrane protein, medicine, Gametocyte, Gene

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::02205f69beb577d7768e18eb3fceacc4
    https://doi.org/10.1101/2021.06.14.448287

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  8. 8
    Substituted Aminoacetamides as Novel Leads for Malaria Treatment

    المؤلفون: Stephan Meister, Vicky M. Avery, Yevgeniya Antonova-Koch, Elizabeth A. Winzeler, Benigno Crespo, David Waterson, Alan H. Fairlamb, Jennifer Riley, Neil R. Norcross, Laura M. Sanz, Irene Hallyburton, Julie A. Frearson, Ian H. Gilbert, Paul Willis, Francisco-Javier Gamo, Simon F. Campbell, Suzanne Norval, Maria Osuna-Cabello, Cristina de Cozar, Robert E. Sinden, David W. Gray, Sandra Duffy, Andrea Ruecker, Caroline Wilson, Michael J. Delves, Beatriz Baragaña, Daniel A. Fletcher, Kevin D. Read

    المصدر: Chemmedchem

    مصطلحات موضوعية: Plasmodium berghei, Plasmodium falciparum, malaria, hit optimization, 01 natural sciences, Biochemistry, Antimalarials, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Parasitic Sensitivity Tests, Pharmacokinetics, Acetamides, Drug Discovery, medicine, Animals, Humans, Potency, Antimalarial Agent, antimalarial agents, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Full Paper, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, Full Papers, biology.organism_classification, Propanamide, 3. Good health, 0104 chemical sciences, aminoacetamides, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, chemistry, Microsomes, Liver, Microsome, Molecular Medicine, Gamete, Selectivity, Plasmodium cynomolgi

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc14ab7154c8bef7afa4b081371bf96
    https://doi.org/10.1002/cmdc.201900329

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  9. 9
    8‐Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual‐Stage Antiplasmodial Activity

    المؤلفون: Michael Leven, Vicky M. Avery, Stephan Meister, Jana Held, Michael J. Delves, Sandra Duffy, Krystina Kuna, Elizabeth A. Winzeler, Benjamin Mordmüller, Thomas Kurz, Leandro A. Alves Avelar, Serena Tschan, David Plouffe

    المصدر: ChemMedChem. 14:501-511

    مصطلحات موضوعية: Cell Survival, Stereochemistry, Plasmodium falciparum, Ring (chemistry), 01 natural sciences, Biochemistry, Antimalarials, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Side chain, Humans, General Pharmacology, Toxicology and Pharmaceutics, 8 aminoquinolines, Pharmacology, Life Cycle Stages, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Quinoline, Hep G2 Cells, biology.organism_classification, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Aminoquinolines, Molecular Medicine, Dual stage

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78defdef19417f9bc4af603611451eb1
    https://doi.org/10.1002/cmdc.201800691

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  10. 10
    The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957

    المؤلفون: Ernest Diez Benavente, Francisco-Javier Gamo, Jake Baum, Esperanza Herreros, James M. Murithi, David A. Fidock, Fiona Angrisano, Frank Schwach, Susana Campino, Oliver Billker, Katarzyna A. Sala, Andrew M. Blagborough, Taane G. Clark, Michael J. Delves, Manu Vanaerschot, Matthew J. Fuchter, Colin J. Sutherland, Celia Miguel-Blanco, Donelly A. van Schalkwyk

    المساهمون: Apollo - University of Cambridge Repository, Bill & Melinda Gates Foundation, Wellcome Trust, Medicines for Malaria Venture, van Schalkwyk, Donelly A [0000-0002-7375-3439], Clark, Taane G [0000-0001-8985-9265]

    المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
    Scientific Reports

    مصطلحات موضوعية: 0301 basic medicine, Drug, Plasmodium, Erythrocytes, Plasmodium berghei, Science, media_common.quotation_subject, Cell- och molekylärbiologi, Plasmodium falciparum, 030106 microbiology, Drug Resistance, Drug resistance, Apicomplexan parasite, Pharmacology, Host-Parasite Interactions, Antimalarials, Inhibitory Concentration 50, Mice, 03 medical and health sciences, Species Specificity, In vivo, medicine, Animals, Humans, 692/699/255/1629, Drug discovery and development, 631/154/309/2144, media_common, Multidisciplinary, Molecular Structure, biology, Mechanism (biology), article, Immunology in the medical area, biology.organism_classification, medicine.disease, Malaria, Cell and molecular biology, 030104 developmental biology, Immunologi inom det medicinska området, Medicine, Cell and Molecular Biology

    وصف الملف: application/pdf; text/xml

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8efc7f4767c5446f0bb7a7941be9a5
    http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180515

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