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1
المؤلفون: Todd A. Brugel, Vijayasurian Easwaran, Mark Sabat, John C. VanRens, Biswanath De, Artem G. Evdokimov, Adam Golebiowski, Jennifer A. Maier, R.L. Walter, Michael J. Janusz, Marlene Mekel, Matthew J. Laufersweiler, Lily C. Hsieh
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5973-5977
مصطلحات موضوعية: Benzimidazole, Proto-Oncogene Proteins c-hck, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Structure–activity relationship, Src family kinase, Protein Kinase Inhibitors, Molecular Biology, Tyrosine-protein kinase CSK, Molecular Structure, Kinase, Organic Chemistry, Hydrogen Bonding, Biological activity, Pyrimidines, chemistry, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Interleukin-2, Molecular Medicine, Benzimidazoles, Signal transduction
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2
المؤلفون: Biswanath De, Michael J. Janusz, Vijayasurian Easwaran, Jennifer A. Maier, Todd A. Brugel, Matthew J. Laufersweiler, Corey R. Hopkins, Adam Golebiowski, Kimberly K. Brown, Mark Sabat, Lily C. Hsieh, John C. VanRens
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:3646-3650
مصطلحات موضوعية: Pyrimidine, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Jurkat cells, Chemical synthesis, Jurkat Cells, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Phenylurea Compounds, Organic Chemistry, hemic and immune systems, Arthritis, Experimental, Rats, Pyrimidines, Enzyme, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Enzyme inhibitor, biology.protein, Interleukin-2, Molecular Medicine, Signal transduction, Tyrosine kinase
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3
المؤلفون: Timothy R. Baker, Biswanath De, Michael J. Janusz, Sandra A. Heitmeyer, Stanislaw Pikul, Neil Gregory Almstead, Michael George Natchus, Y.O. Taiwo, Vikram S. Patel, Sean X. Peng, Kimberly K. Brown, E.B. Hookfin, Lily C. Hsieh
المصدر: Inflammation Research. 55:60-65
مصطلحات موضوعية: Male, Knee Joint, Matrix metalloproteinase inhibitor, Phenylalanine, Carboxylic acid, Immunology, Carboxylic Acids, Iodoacetates, Osteoarthritis, Matrix Metalloproteinase Inhibitors, Pharmacology, Matrix metalloproteinase, Hydroxamic Acids, High-performance liquid chromatography, Rats, Sprague-Dawley, Plasma, chemistry.chemical_compound, In vivo, medicine, Animals, Humans, Protease Inhibitors, Sulfones, Amino Acids, chemistry.chemical_classification, Sulfonamides, Hydroxamic acid, Molecular Structure, Chemistry, Cartilage, medicine.disease, Rats, Disease Models, Animal, medicine.anatomical_structure, Biochemistry
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4
المؤلفون: Michael J. Janusz, R.L. Walter, John C. VanRens, Biswanath De, Lily C. Hsieh, Jane Far-Jine Djung, Cynthia Monesa Clark, Steven K. Laughlin, Marlene Mekel, Mark Sabat, Matthew J. Laufersweiler, Todd A. Brugel, Townes Jennifer Anne, Adam Golebiowski, Roger G. Bookland, Mark E. Webster, Michael P. Clark
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:2285-2289
مصطلحات موضوعية: Lipopolysaccharides, Models, Molecular, Molecular model, Stereochemistry, Clinical Biochemistry, Molecular Conformation, Pyrazolone, Pharmaceutical Science, p38 Mitogen-Activated Protein Kinases, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Biosynthesis, In vivo, Osteoarthritis, Drug Discovery, medicine, Animals, Transferase, Enzyme Inhibitors, Pyrazolones, Molecular Biology, chemistry.chemical_classification, Tumor Necrosis Factor-alpha, Organic Chemistry, In vitro, Rats, Disease Models, Animal, Kinetics, Enzyme, chemistry, Cytokines, Molecular Medicine, medicine.drug
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5
المؤلفون: R.L. Walter, Adam Golebiowski, Townes Jennifer Anne, Biswanath De, Michael J. Janusz, Roger G. Bookland, Susan C. Xu, John C. VanRens, Steve K. Laughlin, Matthew J. Laufersweiler, Michael P. Clark, Todd A. Brugel, Mark Sabat, Lily C. Hsieh
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:4945-4948
مصطلحات موضوعية: Lipopolysaccharides, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, p38 Mitogen-Activated Protein Kinases, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Enzyme Inhibitors, Protein kinase A, Molecular Biology, chemistry.chemical_classification, biology, Bicyclic molecule, Tumor Necrosis Factor-alpha, Organic Chemistry, Biological activity, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine
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6
المؤلفون: A R Poole, Michael J. Janusz, Y.O. Taiwo, E.B. Hookfin, Bruce Caterson, Lindsay King, Kimberly K. Brown, Christopher B. Little, Sandra A. Heitmeyer
المصدر: Osteoarthritis and Cartilage. 12(9):720-728
مصطلحات موضوعية: Cartilage, Articular, Male, Time Factors, Type II collagen, Biomedical Engineering, Iodoacetates, Osteoarthritis, Rats, Sprague-Dawley, Glycosaminoglycan, Epitopes, Rheumatology, Endopeptidases, medicine, Animals, Lectins, C-Type, Orthopedics and Sports Medicine, Aggrecans, Collagen Type II, Aggrecan, Aggrecanase, Extracellular Matrix Proteins, biology, Chemistry, Cartilage, Neoepitopes, medicine.disease, Molecular biology, Matrix Metalloproteinases, Rats, Matrix metalloproteinase, medicine.anatomical_structure, Proteoglycan, Biochemistry, Models, Animal, Collagenase, biology.protein, Proteoglycans, Collagen, Iodoacetate-induced arthritis, medicine.drug
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7
المؤلفون: John C. VanRens, Adam Golebiowski, Matthew J. Laufersweiler, Lily C. Hsieh, Steven K. Laughlin, Biswanath De, Todd A. Brugel, Marlene Mekel, Michael J. Janusz, Townes Jennifer Anne, Roger G. Bookland, Karen Juergens, R.L. Walter, Sandra A. Heitmeyer, Kimberly K. Brown, Mark Sabat, Michael P. Clark
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:4267-4272
مصطلحات موضوعية: Lipopolysaccharides, Models, Molecular, Lipopolysaccharide, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Pyrazolones, Molecular Biology, Bicyclic molecule, Tumor Necrosis Factor-alpha, Kinase, Organic Chemistry, In vitro, Rats, Cytokine, chemistry, Molecular Medicine, Tumor necrosis factor alpha
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8
المؤلفون: Judith A. Hoyland, Michael George Natchus, Y.O. Taiwo, Sandra A. Heitmeyer, Anthony J. Freemont, Kimberly K. Brown, Michael J. Janusz, Lily C. Hsieh, Stanislaw Pikul, J.F. Woessner, E.B. Hookfin, Biswanath De, Neil Gregory Almstead
المصدر: Osteoarthritis and Cartilage. 9(8):751-760
مصطلحات موضوعية: Male, medicine.medical_specialty, Pathology, Antagonists & inhibitors, Matrix metalloproteinase inhibitor, Biomedical Engineering, Arthritis, Iodoacetates, Osteoarthritis, Matrix metalloproteinase, Matrix Metalloproteinase Inhibitors, Injections, Intra-Articular, Rats, Sprague-Dawley, Rheumatology, Internal medicine, medicine, Image Processing, Computer-Assisted, Gelatinase, Animals, Orthopedics and Sports Medicine, Collagenases, Enzyme Inhibitors, Chemistry, Cartilage, Matrix metalloproteinase inhibitors, Iodoacetate-induced arthritis, Collagenase, Gelatinase, medicine.disease, Rats, Up-Regulation, medicine.anatomical_structure, Endocrinology, Gelatinases, Collagenase, Electrophoresis, Polyacrylamide Gel, medicine.drug
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9
المؤلفون: Todd M. Branch, Michael George Natchus, Neil Gregory Almstead, Tomas Hudlicky, Yingkun Y. Jin, Stanislaw Pikul, Tullis Joshua S, Roger G. Bookland, Lily C. Hsieh, Biswanath De, Michael J. Janusz, Matthew J. Laufersweiler, Sean X. Peng, John C. VanRens, Oppong Kofi Abeka
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1975-1979
مصطلحات موضوعية: Stereochemistry, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Glycine, Pharmaceutical Science, Matrix Metalloproteinase Inhibitors, Matrix metalloproteinase, Biochemistry, Chemical synthesis, Stromelysin 1, Inhibitory Concentration 50, Structure-Activity Relationship, Matrix Metalloproteinase 13, Drug Discovery, Animals, Potency, Collagenases, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Metalloendopeptidases, In vitro, Rats, Enzyme, Enzyme inhibitor, Matrix Metalloproteinase 7, biology.protein, Matrix Metalloproteinase 2, Molecular Medicine, Matrix Metalloproteinase 3, Matrix Metalloproteinase 1, Protein Binding
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10
المؤلفون: Fei Gu, Michael J. Janusz, Michael George Natchus, Barbara A. Hynd, Stanislaw Pikul, Lily C. Hsieh, Biswanath De, Kelly McDow Dunham, Yetunde Olabisi Taiwo, Neil Gregory Almstead, Lisa E. Williams, Glen E. Mieling
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1009-1013
مصطلحات موضوعية: Gelatinases, Macromolecular Substances, Matrix metalloproteinase inhibitor, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Matrix Metalloproteinase Inhibitors, Crystallography, X-Ray, Sensitivity and Specificity, Biochemistry, Stromelysin 1, Heterocyclic Compounds, 1-Ring, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Matrix Metalloproteinase 13, Drug Discovery, Structure–activity relationship, Collagenases, Enzyme Inhibitors, Matrilysin, Molecular Biology, chemistry.chemical_classification, Sulfonamides, biology, Chemistry, Organic Chemistry, Active site, Sulfonamide, biology.protein, Molecular Medicine