المؤلفون: Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f450290df0d613596edbab94a5a07a69
https://doi.org/10.1158/1535-7163.22503433.v1

المؤلفون: Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e7619544c11452e1775f6d92101867
https://doi.org/10.1158/1535-7163.22503430.v1

المؤلفون: Kathy Sarris, Ying Wang, Gary G. Chiang, Yupeng He, Mikkel Algire, Ramzi F. Sweis, Huan-Qiu Li, Marina A. Pliushchev, Zhiqin Ji, Paul L. Richardson, Maricel Torrent, Bailin Shaw, Richard F. Clark, Michael L. Curtin, Justin D. Dietrich, Clarissa G. Jakob, Chaohong Sun, Sujatha Selvaraju, Haizhong Zhu, Hongyu Zhao, Michael R. Michaelides

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:1576-1583

مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Stereoisomerism, macromolecular substances, Plasma protein binding, Ligands, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Mouse xenograft, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, PRC2 complex, Molecular Biology, Indole test, Sulfonamides, biology, Novel protein, Chemistry, Organic Chemistry, Polycomb Repressive Complex 2, Xenograft Model Antitumor Assays, 030104 developmental biology, 030220 oncology & carcinogenesis, Microsomes, Liver, biology.protein, Molecular Medicine, PRC2, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9b193e84408c501ad0a0b9d7c9b5bc
https://doi.org/10.1016/j.bmcl.2017.02.030

المؤلفون: Nirupama B. Soni, Anil Vasudevan, Jun Guo, Marina A. Pliushchev, Julie L. Wilsbacher, H. Robin Heyman, Michael R. Michaelides, Kathy Sarris, Bryan K. Sorensen, Richard F. Clark, Noah Tu, Min Cheng, George Doherty, Alla Korepanova, Anurupa Shrestha, Michael L. Curtin, Mikkel Algire, Badagnani Ilaria, Kenton L. Longenecker, Chris Tse, Diana Raich, Woller Kevin R, Robin R. Frey, Violeta L. Marin, Gary G. Chiang, T. Matthew Hansen, Ana L. Aguirre, F. Greg Buchanan, Peter Kovar, David Maag, Dong Cheng, Paul L. Richardson, Ramzi F. Sweis

المصدر: Bioorganicmedicinal chemistry letters. 27(15)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Clinical Biochemistry, Nicotinamide phosphoribosyltransferase, Pharmaceutical Science, Antineoplastic Agents, Isoindoles, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Neoplasms, Drug Discovery, Structure–activity relationship, Animals, Humans, Urea, Enzyme Inhibitors, Nicotinamide Phosphoribosyltransferase, Molecular Biology, Cell Proliferation, Antitumor activity, Drug discovery, Cell growth, Organic Chemistry, Substrate (chemistry), Isoindoline, 030104 developmental biology, chemistry, Molecular Medicine, Cytokines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1bc793c61a6d664d259131a9672269
https://pubmed.ncbi.nlm.nih.gov/28610984

المؤلفون: Alla Korepanova, Danli L. Towne, F. Gregory Buchanan, Jun Guo, Stormy L. Koeniger, Diana Raich, Yan Shi, Michael L. Curtin, Gary G. Chiang, Bryan K. Sorensen, Yupeng He, Hua Tang, Vivek C. Abraham, H. Robin Heyman, Richard F. Clark, Kenton L. Longenecker, Saul H. Rosenberg, Paul L. Richardson, Badagnani Ilaria, Wenqing Gao, Julie L. Wilsbacher, Peter Kovar, David Maag, Samuel A.J. Trammell, Dong Cheng, T. Matthew Hansen, Shaun M. McLoughlin, Chris Tse, Min Cheng, Steven Cepa, Michael R. Michaelides, Sujatha Selvaraju, Charles Brenner

المصدر: Molecular cancer therapeutics. 16(7)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, DNA Repair, Nicotinamide phosphoribosyltransferase, 03 medical and health sciences, chemistry.chemical_compound, Enzyme activator, Mice, 0302 clinical medicine, Adenosine Triphosphate, In vivo, Animals, Humans, Calcium Signaling, Enzyme Inhibitors, Nicotinamide Phosphoribosyltransferase, chemistry.chemical_classification, Nicotinamide, Chemistry, HCT116 Cells, NAD, Xenograft Model Antitumor Assays, Enzyme Activation, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Enzyme, Oncology, Biochemistry, 030220 oncology & carcinogenesis, Cancer cell, Cytokines, NAD+ kinase, Colorectal Neoplasms, Adenosine triphosphate

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52767e3106bf204068387e3e1747ff90
https://pubmed.ncbi.nlm.nih.gov/28468779

المؤلفون: Kenneth M. Comess, Steven Kennedy, Donald J. Osterling, Michael L. Curtin, Masoud Vedadi, Ramzi F. Sweis, Guillermo Senisterra, Mikkel Algire, Evelyne Lima-Fernandes, Dalia Barsyte-Lovejoy, Justin D. Dietrich, William N. Pappano, Bailin Shaw, David Maag, Dong Cheng, Cheryl H. Arrowsmith, Fengling Li, Marina A. Pliushchev, Kelly L Klinge, Jun Guo, Chaohong Sun, Andrew M. Petros, Gary G. Chiang, Magdalena M. Szewczyk, Huan-Qiu Li, Maricel Torrent, Scott Galasinski, Sujatha Selvaraju, Yupeng He, David Lindley, Clarissa G. Jakob, Sanjay C. Panchal, Wenqing Gao, Lance J Bigelow, Haizhong Zhu, Fritz G. Buchanan, Qin Wu

المصدر: Nature chemical biology. 13(4)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cell Survival, Protein subunit, Allosteric regulation, Antineoplastic Agents, macromolecular substances, Protein–protein interaction, 03 medical and health sciences, Histone H3, Structure-Activity Relationship, 0302 clinical medicine, Cell Line, Tumor, Tumor Cells, Cultured, Gene silencing, Humans, Epigenetics, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Sulfonamides, biology, Dose-Response Relationship, Drug, Molecular Structure, Polycomb Repressive Complex 2, Cell Biology, 030104 developmental biology, Enzyme, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Indans, biology.protein, Drug Screening Assays, Antitumor, PRC2, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df1801f71a6c72b86efbe30951bf648
https://pubmed.ncbi.nlm.nih.gov/28853738

المؤلفون: Patrick A. Marcotte, Jun Guo, Michael R. Michaelides, Steven K. Davidsen, David R. Reuter, Junling Li, Yanping Luo, Lori J. Pease, Chris Tse, Terrance J. Magoc, Ru-Qi Wei, Paul Tapang, Eric F. Johnson, Cherrie K. Donawho, Zehan Chen, Amanda M. Olson, Donald J. Osterling, Daniel H. Albert, Michael L. Curtin, Keith B. Glaser, Jennifer J. Bouska, Mai H. Bui, Robin R. Frey

المصدر: Journal of Pharmacology and Experimental Therapeutics. 343:617-627

مصطلحات موضوعية: Male, Time Factors, Aminopyridines, Antineoplastic Agents, Mice, SCID, Protein Serine-Threonine Kinases, Histones, Mice, chemistry.chemical_compound, Growth factor receptor, Aurora Kinases, Cell Line, Tumor, Human Umbilical Vein Endothelial Cells, Animals, Aurora Kinase B, Humans, Receptors, Platelet-Derived Growth Factor, Pharmacology, Mice, Inbred BALB C, Leukemia, Experimental, Dose-Response Relationship, Drug, Molecular Structure, biology, Phenylurea Compounds, Autophosphorylation, Xenograft Model Antitumor Assays, Molecular biology, Vascular endothelial growth factor, Vascular endothelial growth factor A, Receptors, Vascular Endothelial Growth Factor, src-Family Kinases, chemistry, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, Tyrosine kinase, Platelet-derived growth factor receptor, Proto-oncogene tyrosine-protein kinase Src

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ff4def0b6e7aabec77986594da503f
https://doi.org/10.1124/jpet.112.197087

المؤلفون: Melinda Yates, Lori J. Pease, Patrick A. Marcotte, Jennifer J. Bouska, Niru B. Soni, Daniel H. Albert, Robin R. Frey, Steven K. Davidsen, Michael L. Curtin, Keith B. Glaser, Michael R. Michaelides, Peter J. Dandliker, Asma A Ahmed, Paul Rafferty, Kent D. Stewart, Maria D Moskey, Candace Black-Schaefer, Peter F. Bousquet, H. Robin Heyman, George A. Cunha

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1246-1249

مصطلحات موضوعية: Models, Molecular, Thienopyridine, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Edema, Urea, Structure–activity relationship, Kinase activity, Molecular Biology, Uterine Diseases, chemistry.chemical_classification, Estradiol, Kinase, Organic Chemistry, Biological activity, Kinase insert domain receptor, Vascular Endothelial Growth Factor Receptor-2, Disease Models, Animal, Enzyme, chemistry, Molecular Medicine, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0affa478acc38849cf981621ca7094cd
https://doi.org/10.1016/j.bmcl.2006.12.015

المؤلفون: Teresa Barlozzari, Shannon S Arries, Keith B. Glaser, Michael L. Curtin, Lori J. Pease, Patrick A. Marcotte, Robin R. Frey, Daniel H. Albert, Neil Wishart, George A. Cunha, Yan Guo, Jennifer J. Bouska, Lee D. Arnold, Jun Guo, Michael R. Michaelides, Kennan C. Marsh, Steven K. Davidsen, Joy Bauch, Asma A Ahmed, Peter F. Bousquet, Maria D Moskey, Paul Tapang, Kent D. Stewart, Yujia Dai, Zhiqin Ji, Vincent S. Stoll, Junling Li

المصدر: Journal of Medicinal Chemistry. 48:6066-6083

مصطلحات موضوعية: Models, Molecular, Platelet-derived growth factor, Antineoplastic Agents, Mice, SCID, Receptor tyrosine kinase, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Adenosine Triphosphate, Growth factor receptor, Drug Discovery, Animals, Edema, Humans, Urea, Receptors, Platelet-Derived Growth Factor, Phosphorylation, Mice, Inbred BALB C, Estradiol, biology, Uterus, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Vascular endothelial growth factor, Pyrimidines, chemistry, Biochemistry, Enzyme inhibitor, NIH 3T3 Cells, biology.protein, Molecular Medicine, Female, Signal transduction, Platelet-derived growth factor receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b70dc03317044f34818ffeb418063c2
https://doi.org/10.1021/jm050458h

المؤلفون: Michael L. Curtin, Keith B. Glaser

المصدر: Current Medicinal Chemistry. 10:2373-2392

مصطلحات موضوعية: Mice, Nude, Antineoplastic Agents, In Vitro Techniques, Hydroxamic Acids, Biochemistry, Histone Deacetylases, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Gene knockdown, Hydroxamic acid, biology, Organic Chemistry, Small molecule, Histone Deacetylase Inhibitors, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, HT1080, Histone deacetylase, Drug Screening Assays, Antitumor, Cell Division

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18ad286d833a0bbd0707f949a3c63f2
https://doi.org/10.2174/0929867033456576