نتائج البحث - "Michael M, Kitt"

1

Treatment with the P2X3-Receptor Antagonist Gefapixant for Acute Cough in Induced Viral Upper Respiratory Tract Infection: A Phase 2a, Randomized, Placebo-Controlled Trial

المؤلفون: Jaclyn A, Smith, Michael M, Kitt, Alan, Bell, Nicolas, Noulin, Anjela, Tzontcheva, Megan McGratty, Seng, Susan, Lu

المصدر: Smith, J A, Kitt, M M, Bell, A, Noulin, N, Tzontcheva, A, Seng, M M & Lu, S 2022, ' Treatment with the P2X3-Receptor Antagonist Gefapixant for Acute Cough in Induced Viral Upper Respiratory Tract Infection : A Phase 2a, Randomized, Placebo-Controlled Trial ', Pulmonary therapy, vol. 8, no. 3, pp. 297-310 . https://doi.org/10.1007/s41030-022-00193-w

مصطلحات موضوعية: Acute cough, Cough frequency, Pulmonary and Respiratory Medicine, URTI, Respiratory Care, Common cold, Antitussives, P2X3-receptor antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038b3392d5b6562e2c888710db6b71b4
https://doi.org/10.1007/s41030-022-00193-w

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2

Treatment of Persistent Cough in Subjects with Idiopathic Pulmonary Fibrosis (IPF) with Gefapixant, a P2X3 Antagonist, in a Randomized, Placebo-Controlled Clinical Trial

المؤلفون: Fernando J, Martinez, Amna Sadaf, Afzal, Jaclyn A, Smith, Anthony P, Ford, Jerry Jing, Li, Yuping, Li, Michael M, Kitt, Murali, Ramaswamy

المصدر: Pulmonary Therapy
Chronic Cough in IPF Study Group, Martinez, F J, Afzal, A S, Smith, J A, Ford, A P, Li, J J, Li, Y & Kitt, M M 2021, ' Treatment of Persistent Cough in Subjects with Idiopathic Pulmonary Fibrosis (IPF) with Gefapixant, a P2X3 Antagonist, in a Randomized, Placebo-Controlled Clinical Trial ', Pulmonary therapy . https://doi.org/10.1007/s41030-021-00162-9

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58682a6e9f33e7a4abb1f43461f81e0
https://doi.org/10.1007/s41030-021-00162-9

Find this article in full text from Springer Verlag.

3

The discovery and development of gefapixant

المؤلفون: Michael M. Kitt, Anthony P.D.W. Ford, Michael Patrick Dillon, Joel R Gever

المصدر: Autonomic neuroscience : basicclinical. 235

مصطلحات موضوعية: Sulfonamides, Purinergic P2X Receptor Antagonists, Endocrine and Autonomic Systems, business.industry, Authorization, Successful completion, Bioinformatics, Cellular and Molecular Neuroscience, Chronic cough, Adenosine Triphosphate, Pyrimidines, Cough, Afferent, Medicine, Humans, Neurology (clinical), medicine.symptom, business, Receptors, Purinergic P2X3

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e9408547f2851f3147246f17f06a78
https://pubmed.ncbi.nlm.nih.gov/34403981

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Full Text via ClinicalKey

4

The Efficacy of Bradanicline in Refractory Chronic Cough

المؤلفون: Peter Butera, Vivek N. Iyer, Peter V. Dicpinigaitis, Jaclyn A. Smith, Brendan J. Canning, Michael M. Kitt, Yoshihiro Kanemitsu

المصدر: Airway pharmacology and treatment.

مصطلحات موضوعية: Regimen, Chronic cough, Tolerability, business.industry, Cough reflex, Anesthesia, Clinical endpoint, Medicine, medicine.symptom, Placebo, business, Crossover study, Loading dose

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2276a55c192eb84bc029a0b85427f805
https://doi.org/10.1183/13993003.congress-2020.4564

5

Rationale and design of two, phase 3, randomized controlled trials (COUGH-1 and COUGH-2) of gefapixant, a P2X3 receptor antagonist, in refractory and unexplained chronic cough

المؤلفون: David Muccino, Lorcan McGarvey, Ian D. Pavord, Andrew M. Tershakovec, Jacky Smith, Christopher Assaid, Alyn H. Morice, Surinder S. Birring, George Philip, Michael M. Kitt, Peter V. Dicpinigaitis

المصدر: World Allergy Organization Journal, Vol 13, Iss 8, Pp 100203-(2020)

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, lcsh:Immunologic diseases. Allergy, medicine.medical_specialty, business.industry, Immunology, Antagonist, Gastroenterology, law.invention, Chronic cough, Randomized controlled trial, Refractory, law, Internal medicine, medicine, Immunology and Allergy, medicine.symptom, business, lcsh:RC581-607, P2X3 Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc912dc45c650a6ae795472a01a8f9a
http://www.sciencedirect.com/science/article/pii/S193945512030106X

6

Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial

المؤلفون: Lorcan P McGarvey, Zhi Jin Xu, Vivek Iyer, James Krainson, James H. Hull, Mark H Gotfried, Jaclyn A Smith, David Muccino, Gary C Steven, Douglas McQuaid, David I. Bernstein, Gregory Daniel Brooks, David Elkayam, Wen-Chi Wu, Selwyn Spangenthal, Mandel R Sher, Jaclyn A. Smith, Yu-Ping Li, John J Condemi, Ellen R Sher, John R Holcomb, W. Carr, Gary N Gross, SM Parker, Gary D Berman, Ratko Djukanovic, Thomas B. Casale, Jason H Friesen, Krishna Sundar, Christopher E. Brightling, Michael Denenberg, Neil Ettinger, S S Birring, Faisal Alfonso Fakih, Bruce M Prenner, Lorcan McGarvey, Niran J Amar, Jonathan Corren, Tim Harrison, Shaila U Gogate, William W. Storms, Alyn H. Morice, Iftikhar Hussain, Leon S Greos, Anthony Montanaro, Anthony P. Ford, James S Good, Eric J Schenkel, Surinder S. Birring, Thomas R Murphy, Michael S Kaplan, William R Lumry, Jonathan Matz, Michael M. Kitt, Mandel Sher, Alan B Goldsobel, Ian D. Pavord

المصدر: Protocol 012 Investigators 2020, ' Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial ', The Lancet Respiratory Medicine . https://doi.org/10.1016/S2213-2600(19)30471-0

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed8062bd34a8ad548083ad97ee59fbd
https://pure.qub.ac.uk/en/publications/gefapixant-a-p2x3-receptor-antagonist-for-the-treatment-of-refractory-or-unexplained-chronic-cough-a-randomised-doubleblind-controlled-parallelgroup-phase-2b-trial(5aa94b05-a819-433a-a265-b0ce6c143476).html

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Gefapixant in two randomised dose-escalation studies in chronic cough

المؤلفون: Kimberley Holt, Shilpi Sen, Jaclyn A. Smith, Peter Butera, Mandel R. Sher, Steven Smith, Zhi Jin Xu, Anthony P. Ford, Michael M. Kitt, Yu-Ping Li

المصدر: Smith, J, Kitt, M M, Butera, P, Smith, S A, Li, Y, Xu, Z J, Holt, K, Sen, S, Sher, M R & Ford, A P 2020, ' Gefapixant in two randomised dose-escalation studies in chronic cough ', European Respiratory Journal . https://doi.org/10.1183/13993003.01615-2019