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1
المؤلفون: Paul G. Richardson, Xiaoyun Meng, Karen A. Maegley, A.E. Stewart, Pei-Pei Kung, Jose L Montano, Ya-Li Deng, Jinqiao Wan, Michael R. Gehring, Jordan L. Meier, Brigitte S Naughton, Stephan Grant, Dou Dengfeng, Chakrapani Subramanyam, Anthony R. Harris, Samantha Elizabeth Greasley, Barry A. Morgan, Wen Yan, Xuemin Cheng, Prakash B. Palde, William K Sonnenburg, Junli Feng, Chen Qiuxia, Thomas A Paul, Gary M. Gallego, Sylvie K. Sakata, Sergei Timofeevski, Patrick Bingham, Benjamin J. Burke, Alex Shaginian
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, Target engagement, Substrate (chemistry), 01 natural sciences, Biochemistry, Cocrystal, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Mechanism of action, Acetyltransferase, Drug Discovery, medicine, A-DNA, medicine.symptom, Selectivity
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2
المؤلفون: Tanya Michelle Jewell, Robert Steven Kania, Anand Sistla, Bennett Michael John, Michael R. Gehring, Evan Smith, Zehnder Luke Raymond, Shinji Yamazaki, Karen A. Maegley, Elena Z. Dovalsantos, Ben Burke, Fen Wang, Sacha Ninkovic, Jeff Wang, Joe Zhongxiang Zhou, Pei-Pei Kung, Min-Jean Yin, Michael J. Hickey, Martin James Wythes, Jerry Meng, Buwen Huang, Ping Kang, John F. Braganza, Ketan S. Gajiwala, Tatlock John H, Pramod P. Mehta
المصدر: Journal of Medicinal Chemistry. 54:3368-3385
مصطلحات موضوعية: Pyrimidine, biology, Chemistry, Stereochemistry, medicine.drug_class, Carboxamide, Metabolic stability, Combinatorial chemistry, Hsp90, Bioavailability, chemistry.chemical_compound, Heat shock protein, Drug Discovery, Alkoxy group, biology.protein, medicine, Molecular Medicine, Potency
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3
المؤلفون: Pramod P. Mehta, Tod Smeal, Min-Jean Yin, Gerrit Los, Michael R. Gehring, Shinji Yamazaki, Marlena Walls, Leslie Nguyen, Andrea Shen, Pei-Pei Kung
المصدر: Cancer Letters. 300:30-39
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Cancer Research, Mutant, Antineoplastic Agents, Apoptosis, Protein degradation, Bioinformatics, Mice, In vivo, Cell Line, Tumor, Animals, Humans, Medicine, HSP90 Heat-Shock Proteins, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Melanoma, Protein kinase B, Cell Proliferation, biology, business.industry, medicine.disease, Hsp90, In vitro, Oncology, Mutation, biology.protein, Cancer research, Female, business, Proto-Oncogene Proteins c-akt, V600E
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4
المؤلفون: Shaoxian Sun, Zhihua Tao, John Barker, Michael R. Gehring, Stone D.-H. Shi
المصدر: Biochemistry. 49:8488-8498
مصطلحات موضوعية: Molecular Sequence Data, P70-S6 Kinase 1, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biology, Biochemistry, mTORC2, Cell Line, Substrate Specificity, Humans, Amino Acid Sequence, Enzyme Inhibitors, Phosphorylation, Protein kinase A, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, Sirolimus, mTOR Associated Protein, LST8 Homolog, TOR Serine-Threonine Kinases, Autophosphorylation, RPTOR, Intracellular Signaling Peptides and Proteins, Proteins, Regulatory-Associated Protein of mTOR, Recombinant Proteins, Up-Regulation, Kinetics, Rapamycin-Insensitive Companion of mTOR Protein, Protein kinase domain, Metals, Multiprotein Complexes, biological phenomena, cell phenomena, and immunity, Carrier Proteins
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5
المؤلفون: Pramod P, Mehta, Pei-Pei, Kung, Shinji, Yamazaki, Marlena, Walls, Andrea, Shen, Leslie, Nguyen, Michael R, Gehring, Gerrit, Los, Tod, Smeal, Min-Jean, Yin
المصدر: Cancer Letters. 422:132
مصطلحات موضوعية: Cancer Research, Oncology
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6
المؤلفون: Jennifer A. Digits, Jeff Elleraas, Gang Zhang, Ketan S. Gajiwala, Pei-Pei Kung, Michael J. Hickey, Min-Jean Yin, Michael Zientek, Buwen Huang, Caroline Rodgers, Shinji Yamazaki, Michael R. Gehring, Joe Zhongxiang Zhou, Jay F. Davies, Judith Skaptason, Jeff Wang, David Neul, Pramod P. Mehta
المصدر: Journal of Medicinal Chemistry. 53:499-503
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Molecular Conformation, Biological Availability, Carboxamide, Isoindoles, Crystallography, X-Ray, Chemical synthesis, Cell Line, Structure-Activity Relationship, Heat shock protein, Drug Discovery, medicine, Humans, Potency, HSP90 Heat-Shock Proteins, chemistry.chemical_classification, biology, Stereoisomerism, Amides, Hsp90, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Chaperone (protein), biology.protein, Molecular Medicine
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7
المؤلفون: Ping Kang, Pei-Pei Kung, Jeff Wang, Michael R. Gehring, Monica Jo Patten, Michael J. Hickey, Ketan S. Gajiwala, Buwen Huang, Sujin Cho-Schultz, Sutton Scott Channing, Pramod P. Mehta, Jeff Elleraas
المصدر: Journal of Combinatorial Chemistry. 11:860-874
مصطلحات موضوعية: biology, Protein Conformation, Chemistry, Hydrogen Bonding, General Chemistry, Crystallography, X-Ray, Hsp90, Solution phase, Combinatorial chemistry, Glucuronides, Heat shock protein, Chromatography, Gel, Hepatocytes, biology.protein, Combinatorial Chemistry Techniques, Humans, Organic chemistry, Pharmacokinetics, HSP90 Heat-Shock Proteins
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8
المصدر: Metabolic Engineering. 7:38-44
مصطلحات موضوعية: Affinity labeling, Chromatography, Chemistry, Ligand binding assay, Binding protein, Radioimmunoassay, Reproducibility of Results, Bioengineering, Ligand (biochemistry), Sensitivity and Specificity, Applied Microbiology and Biotechnology, Receptor–ligand kinetics, PPAR gamma, Scintillation proximity assay, Protein Interaction Mapping, Radioligand, Biophysics, Scintillation Counting, Binding site, Biotechnology
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9
المؤلفون: Michele Ann Mctigue, Michael R Gehring, Chris Pinko, J. Ernest Villafranca, Chen-Chen Kan, Camran V Parast, Krzysztof Appelt, Richard E. Showalter, Barbara Mroczkowski, John A Wickersham, Anna Tempczyk-Russell
المصدر: Structure. 7:319-330
مصطلحات موضوعية: Models, Molecular, Protein Folding, Protein Conformation, Recombinant Fusion Proteins, Molecular Sequence Data, Neovascularization, Physiologic, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, Protein Structure, Secondary, Receptor tyrosine kinase, Substrate Specificity, MAP2K7, angiogenesis, Structure-Activity Relationship, kinase insert domain, Adenosine Triphosphate, Structural Biology, Catalytic Domain, Humans, Receptors, Growth Factor, ASK1, Amino Acid Sequence, Kinase activity, Growth Substances, Molecular Biology, Binding Sites, Sequence Homology, Amino Acid, biology, MAP kinase kinase kinase, tyrosine kinase, Receptor Protein-Tyrosine Kinases, Protein-Tyrosine Kinases, Peptide Fragments, Cell biology, Kinetics, Receptors, Vascular Endothelial Growth Factor, Biochemistry, Multigene Family, Mutagenesis, Site-Directed, biology.protein, Cyclin-dependent kinase 9, X-ray structure, Sequence Alignment, signal transduction, Proto-oncogene tyrosine-protein kinase Src
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10
المؤلفون: Chen-Chen Kan, Ko Suzuki, Keith Brew, Hideaki Nagase, Wen Hung, Michael R. Gehring
المصدر: bchm. 379:185-192
مصطلحات موضوعية: Matrix Metalloproteinase 3, Recombinant Fusion Proteins, Clinical Biochemistry, Gene Expression, Matrix metalloproteinase, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Escherichia coli, medicine, Humans, Protease Inhibitors, Protein precursor, Molecular Biology, Sequence Deletion, chemistry.chemical_classification, Enzyme Precursors, Metalloproteinase, Tissue Inhibitor of Metalloproteinase-1, Tissue inhibitor of metalloproteinase, Cell biology, Amino acid, Enzyme Activation, EGTA, chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aacf20d3a95914e7bad543dbc902b31
https://doi.org/10.1515/bchm.1998.379.2.185