المؤلفون: Charles S. Henry, Michael S. Scherman, Yosita Panraksa, James S. Terry, Zachary Call, Jeremy Link, Brian J. Geiss, David S. Dandy, Ilhoon Jang, Cody S. Carrell

مصطلحات موضوعية: Analyte, Coronavirus disease 2019 (COVID-19), medicine.diagnostic_test, business.industry, Computer science, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), World health, Serology, Immunoassay, False positive paradox, medicine, business, Sensitivity (electronics), Computer hardware

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5411b65ce2261a80a86a0889cdc5e4ae
https://doi.org/10.26434/chemrxiv-2021-c4bmd-v3

المؤلفون: Gregory T. Robertson, Pradeep B. Lukka, Chetan Rathi, Anne J. Lenaerts, Zaid H. Temrikar, Bernd Meibohm, Michael S. Scherman, Keyur Parmar, Santosh Wagh, Jiuyu Liu, Richard E. Lee

المصدر: Antimicrob Agents Chemother

مصطلحات موضوعية: Tuberculosis, Population, Antitubercular Agents, Microbial Sensitivity Tests, Pharmacology, Mycobacterium tuberculosis, Mice, Pharmacokinetics, In vivo, medicine, Animals, Pharmacology (medical), education, education.field_of_study, biology, business.industry, Dose fractionation, medicine.disease, biology.organism_classification, In vitro, Anti-Bacterial Agents, Disease Models, Animal, Infectious Diseases, Pharmacodynamics, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebe9d5488e98eb4793e78bb952f24af
https://pubmed.ncbi.nlm.nih.gov/34424046

المؤلفون: Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee

المصدر: PLoS ONE, Vol 9, Iss 2, p e87909 (2014)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3914891?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/5a17b56fb20942aa854494bae86ab371

المؤلفون: James S. Terry, Tony Schountz, Carley McAlister, Brian J. Geiss, Rushika Perera, Michael S. Scherman, Loran Br. Anderson

المصدر: bioRxiv
article-version (status) pre
article-version (number) 1
Virology

مصطلحات موضوعية: medicine.drug_class, viruses, Immunofluorescence, Immunoglobulin light chain, Monoclonal antibody, Antibodies, Viral, Virus, Article, law.invention, 03 medical and health sciences, Mice, Western blot, law, Virology, medicine, Escherichia coli, Animals, Coronavirus Nucleocapsid Proteins, Humans, Cloning, Molecular, skin and connective tissue diseases, 030304 developmental biology, 0303 health sciences, Mice, Inbred BALB C, medicine.diagnostic_test, biology, SARS-CoV-2, 030302 biochemistry & molecular biology, fungi, Antibodies, Monoclonal, COVID-19, Phosphoproteins, Recombinant Proteins, body regions, Epitope mapping, Viral replication, Recombinant DNA, biology.protein, Female, Antibody, Clone (B-cell biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fa5bd417e1ed439630d51c005ada18
http://europepmc.org/articles/PMC7480041

المؤلفون: Jason Halladay, Tanya Parish, Wai Choi, Vincent Hernandez, Anne J. Lenaerts, Anthony J. Smith, Matthew B. McNeil, Gregory T. Robertson, Victoria A. Ektnitphong, Michael S. Scherman, Pamela Berry, Weimin Mao, Aaron Korkegian, Devon Dennison, Yi Xia, Yasheen Zhou, David S. Carter, M. R. K. Alley

المصدر: Antimicrobial Agents and Chemotherapy

مصطلحات موضوعية: Boron Compounds, isoniazid, caseum, Tuberculosis, Hydrocarbons, Fluorinated, necrotic lesions, Antitubercular Agents, Microbial Sensitivity Tests, Microbiology, Mycobacterium tuberculosis, Mice, 03 medical and health sciences, Antibiotic resistance, Pharmacotherapy, Drug Development, Extracellular, Animals, Medicine, Inhibins, Experimental Therapeutics, Pharmacology (medical), antimicrobial resistance, C3HeB/FeJ mice, Lung, Tuberculosis, Pulmonary, 030304 developmental biology, Pharmacology, Aza Compounds, Mice, Inbred C3H, 0303 health sciences, biology, 030306 microbiology, business.industry, INHA, Isoniazid, Editor's Pick, biology.organism_classification, medicine.disease, Bacterial Load, Disease Models, Animal, Infectious Diseases, tuberculosis, Drug development, Female, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f207338121273b5a491c232cb556c368
https://doi.org/10.1128/aac.02071-18

المؤلفون: Pamela Berry, Yasheen Zhou, David S. Carter, Jason Halladay, Courtney Hastings, Vincent Hernandez, Bjorn Sunde, Weimin Mao, James C. Sacchettini, Aaron Korkegian, Wai Choi, Peter J. Tonge, Mrk Alley, Anne J. Lenaerts, Yi Xia, Gregory T. Robertson, Michael S. Scherman, Tanya Parish, Lisa K. Woolhiser, Veronica Gruppo, Lindsay Flint, Thomas R. Ioerger, Theresa O’Malley, Matthew B. McNeil

المصدر: Life Science Alliance

مصطلحات موضوعية: 0301 basic medicine, Drug, Tuberculosis, Health, Toxicology and Mutagenesis, media_common.quotation_subject, 030106 microbiology, Plant Science, Reductase, Biochemistry, Genetics and Molecular Biology (miscellaneous), Microbiology, Mycobacterium tuberculosis, 03 medical and health sciences, Medicine, Research Articles, media_common, chemistry.chemical_classification, Ecology, biology, business.industry, INHA, Isoniazid, medicine.disease, biology.organism_classification, In vitro, 3. Good health, 030104 developmental biology, Enzyme, chemistry, business, medicine.drug, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b771f3e73b484f275174c0822eeecdd9
http://europepmc.org/articles/PMC6238539

المؤلفون: Julian G. Hurdle, Rashid Akbergenov, Cristina Villellas, José A. Aínsa, Michael R. McNeil, Robin B. Lee, Jiuyu Liu, Dora B. Madhura, Erik C. Böttger, Rakesh, Zhong Zheng, Richard E. Lee, Bernd Meibohm, Pavan K. Vaddady, Jianjun Qi, Sourav Das, Samanthi L. Waidyarachchi, David F. Bruhn, Helena I. Boshoff, Michael S. Scherman, Dianqing Sun, Mercedes Gonzalez-Juarrero, Tanja Matt, Chetan Rathi, Anne J. Lenaerts, Ashit Trivedi

المساهمون: University of Zurich, Lee, Richard E

المصدر: Nature medicine

مصطلحات موضوعية: Models, Molecular, Spectinomycin, Tuberculosis, medicine.drug_class, Antibiotics, Antitubercular Agents, 610 Medicine & health, Drug resistance, Biology, Pharmacology, Antimycobacterial, Article, General Biochemistry, Genetics and Molecular Biology, Microbiology, Mice, Structure-Activity Relationship, 03 medical and health sciences, Bacterial Proteins, 1300 General Biochemistry, Genetics and Molecular Biology, Drug tolerance, Drug Resistance, Multiple, Bacterial, Tuberculosis, Multidrug-Resistant, medicine, Animals, 030304 developmental biology, 0303 health sciences, 10179 Institute of Medical Microbiology, 030306 microbiology, Drug discovery, Mycobacterium tuberculosis, General Medicine, medicine.disease, Amides, 3. Good health, Drug Design, 570 Life sciences, biology, ATP-Binding Cassette Transporters, Efflux, Ribosomes, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396f54db42daeebac88aa11700c39d12
https://doi.org/10.1038/nm.3458

المؤلفون: Victoria Jones, Mary Jackson, Marcus M. Maddox, Anna E. Grzegorzewicz, Christophe Morisseau, E. Jeffrey North, Michael R. McNeil, David F. Bruhn, Tamara Hess, Jerrod S. Scarborough, Richard E. Lee, Michael S. Scherman, Lei Yang

المصدر: Bioorganic & Medicinal Chemistry. 21:2587-2599

مصطلحات موضوعية: Epoxide hydrolase 2, Cell Survival, Stereochemistry, Clinical Biochemistry, Antitubercular Agents, Pharmaceutical Science, Oxadiazole, Microbial Sensitivity Tests, Pyrazole, Biochemistry, Article, Mycolic acid, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Chlorocebus aethiops, Drug Discovery, Animals, Humans, Tuberculosis, Urea, Structure–activity relationship, Enzyme Inhibitors, Isoxazole, Mycobacteriaceae, Vero Cells, Molecular Biology, Epoxide Hydrolases, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Enzyme, Solubility, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff5d124a69bf8a2f42fef4079b74623
https://doi.org/10.1016/j.bmc.2013.02.028

المؤلفون: Marko Maringer, Mary Gardiner, Wulf Oehlmann, Lisa Pirrie, Wassila Abdelli Boulkeroua, Ruth Brenk, Leah S. Torrie, Nicholas J. Westwood, Michael S. Scherman, Robert A. Field, Mahavir Singh, Aurijit Sarkar, Michael R. McNeil, James H. Naismith, David W. Gray, Magnus S. Alphey, Martin Rejzek

المصدر: ACS Chemical Biology
ACS Chemical Biology; Vol 8

مصطلحات موضوعية: Models, Molecular, Conformational change, Stereochemistry, In silico, Allosteric regulation, Cooperativity, 01 natural sciences, Biochemistry, Pyrophosphate, Binding, Competitive, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Structure–activity relationship, Transferase, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, biology, Molecular Structure, 010405 organic chemistry, Active site, General Medicine, Nucleotidyltransferases, 0104 chemical sciences, 3. Good health, High-Throughput Screening Assays, chemistry, Pseudomonas aeruginosa, biology.protein, Molecular Medicine, Allosteric Site, Thymine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c20f6ed0f58f102bfaec1f8823af09

المؤلفون: Ashit Trivedi, Bernd Meibohm, David F. Bruhn, Michael R. McNeil, Marcus M. Maddox, Michael S. Scherman, Rakesh, Dora B. Madhura, Lei Yang, Robin B. Lee, Anne J. Lenaerts, Richard E. Lee, Janet C. Gilliland, Veronica Gruppo

المصدر: Bioorganic & Medicinal Chemistry. 20:6063-6072

مصطلحات موضوعية: Cell Survival, Nitrofurans, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Antitubercular Agents, Pharmaceutical Science, Microbial Sensitivity Tests, Biochemistry, Article, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Microsomes, Morpholine, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Solubility, Molecular Biology, Nitrofuran, Organic Chemistry, Isoxazoles, Mycobacterium tuberculosis, Rats, Bioavailability, chemistry, Molecular Medicine, Piperidine, Caco-2 Cells, Lead compound, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774b8ff1cb144c294974a0c3a34bb7c9
https://doi.org/10.1016/j.bmc.2012.08.023