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المؤلفون: Rachel A. Matt, Daniel Hilger, Michael T. Lerch, Wayne L. Hubbell, Brian K. Kobilka, Matthieu Masureel, Matthias Elgeti, Kaavya Krishna Kumar, Bryon Foys
المصدر: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 50مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, conformational selection, Magnetic Resonance Spectroscopy, G protein, Protein Conformation, 1.1 Normal biological development and functioning, Population, beta(2) adrenergic receptor, beta-2, 03 medical and health sciences, Models, Underpinning research, Receptors, Pressure, Inverse agonist, education, Receptor, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, education.field_of_study, Multidisciplinary, Chemistry, 030302 biochemistry & molecular biology, alpha-Helical, Neurosciences, Molecular, Biological Sciences, double electron–electron resonance, β2 adrenergic receptor, basal activity, Transmembrane domain, high pressure, Förster resonance energy transfer, Membrane protein, Adrenergic, Biophysics, Thermodynamics, double electron-electron resonance, Generic health relevance, Receptors, Adrenergic, beta-2
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a637c454c11c427136437ad06c8bd4
https://europepmc.org/articles/PMC7749303/ -
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المؤلفون: Lise Giehm, Asuka Inoue, Michael T. Lerch, Hongli Hu, Evan S. O'Brien, Mie Fabricius Pedersen, Kaavya Krishna Kumar, Gozde Eskici, Brian K. Kobilka, Georgios Skiniotis, Christine Jennings, Daniel Hilger, Jesper Mosolff Mathiesen
المصدر: Hilger, D, Kumar, K K, Hu, H, Pedersen, M F, O'Brien, E S, Giehm, L, Jennings, C, Eskici, G, Inoue, A, Lerch, M, Mathiesen, J M, Skiniotis, G & Kobilka, B K 2020, ' Structural insights into differences in G protein activation by family A and family B GPCRs ', Science, vol. 369, no. 6503 . https://doi.org/10.1126/science.aba3373
مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, G protein, Chemistry, GTP-Binding Protein alpha Subunits, Cryoelectron Microscopy, Guanosine triphosphate, Protein Structure, Secondary, Cell biology, Enzyme Activation, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Protein structure, Guanosine diphosphate, Heterotrimeric G protein, GTP-Binding Protein alpha Subunits, Gs, Receptors, Glucagon, Humans, Receptors, Adrenergic, beta-2, Glucagon receptor, 030217 neurology & neurosurgery, G protein-coupled receptor
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b6bb82af914b1a42575b0409d28eeb
https://doi.org/10.1126/science.aba3373 -
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المؤلفون: Beth M, Stadtmueller, Michael D, Bridges, Kim-Marie, Dam, Michael T, Lerch, Kathryn E, Huey-Tubman, Wayne L, Hubbell, Pamela J, Bjorkman
المصدر: Immunity
مصطلحات موضوعية: viruses, conformational dynamics, Electron Spin Resonance Spectroscopy, env Gene Products, Human Immunodeficiency Virus, virus diseases, HIV-1 Envelope, bNAbs, HIV Antibodies, HIV Envelope Protein gp120, Antibodies, Neutralizing, HIV Envelope Protein gp41, Article, CD4, Cell Line, Epitopes, SOSIP, HEK293 Cells, electron paramagnetic resonance, double electron-electron resonance (DEER) spectroscopy, vaccine development, CD4 Antigens, Fluorescence Resonance Energy Transfer, HIV-1, Humans, Binding Sites, Antibody
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::0dbbe71ad12b34e3a2c0e0f3e765fbb2
https://pubmed.ncbi.nlm.nih.gov/30076100 -
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المؤلفون: Jeff Abramson, Wayne L. Hubbell, Lucie Bergdoll, Michael Grabe, John W. Patrick, Christian Altenbach, Kendrick Belardo, Arthur Laganowsky, Michael T. Lerch, Paola Bisignano
المصدر: Proceedings of the National Academy of Sciences. 115
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Voltage-dependent anion channel, Protein Conformation, Dimer, Mutant, Protonation, Mitochondrion, 010402 general chemistry, 01 natural sciences, Mice, 03 medical and health sciences, chemistry.chemical_compound, Glutamates, Animals, Alanine, Multidisciplinary, biology, Chemistry, Voltage-Dependent Anion Channel 1, Hydrogen-Ion Concentration, 0104 chemical sciences, Kinetics, Cytosol, 030104 developmental biology, PNAS Plus, Mutation, biology.protein, Biophysics, Protein Multimerization, Protons, VDAC1, Algorithms
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b182583ab31a7d7009630009132c12
https://doi.org/10.1073/pnas.1715464115 -
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المؤلفون: Daniel H. Arlow, Zhongyu Yang, Aashish Manglik, David W. Borhani, Ansgar Philippsen, Thomas J. Mildorf, Michael T. Lerch, Brian K. Kobilka, Daniel Hilger, Wayne L. Hubbell, Roger K. Sunahara, Ron O. Dror, David E. Shaw, Nicolas Villanueva
المصدر: Science. 348:1361-1365
مصطلحات موضوعية: Multidisciplinary, Protein structure, Biochemistry, G protein, GTP-Binding Protein alpha Subunits, Heterotrimeric G protein, Biophysics, Guanine nucleotide exchange factor, Protein engineering, Biology, Signal transduction, G protein-coupled receptor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7852d194960b30cbaad9f4b830f27dbe
https://doi.org/10.1126/science.aaa5264 -
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المؤلفون: Dean P. Staus, Matthias Elgeti, Michael T. Lerch, Naomi R. Latorraca, Brian K. Kobilka, Daniel Hilger, Laura M. Wingler, Wayne L. Hubbell, Robert J. Lefkowitz, Ron O. Dror
المصدر: Cell. 176:468-478.e11
مصطلحات موضوعية: Angiotensin receptor, Angiotensins, Arrestins, Protein Conformation, G protein, Spectroscopy, Electron Energy-Loss, Biology, Ligands, Receptor, Angiotensin, Type 1, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, Receptors, G-Protein-Coupled, Angiotensin Receptor Antagonists, 03 medical and health sciences, 0302 clinical medicine, Heterotrimeric G protein, Functional selectivity, Humans, Receptor, beta-Arrestins, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, Receptors, Angiotensin, Angiotensin II, Biophysics, Angiotensin II Type 1 Receptor Blockers, 030217 neurology & neurosurgery, Endogenous agonist, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58ff5b28a56db45ebab80b9274ea53e
https://doi.org/10.1016/j.cell.2018.12.005 -
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المصدر: Methods in enzymology. 564
مصطلحات موضوعية: Models, Molecular, Protein Folding, Protein Conformation, Electron Spin Resonance Spectroscopy, Pressure, Animals, Humans, Proteins, Thermodynamics, Spin Labels, Equipment Design
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8Saturation Recovery EPR and Nitroxide Spin Labeling for Exploring Structure and Dynamics in Proteins
المصدر: Methods in enzymology. 564
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Electron Spin Resonance Spectroscopy, Animals, Humans, Proteins, Spin Labels, Algorithms
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المؤلفون: H. Ewa Witkowska, Richard K. Niles, Miles N. Braten, Fred E. Regnier, Susan J. Fisher, Simon Allen, Haichuan Liu, Michael T. Lerch, Eric B. Johansen, Bensheng Li, Penelope M. Drake, Dylan J. Sorensen, Birgit Schilling, Bradford W. Gibson, Steven C. Hall
المصدر: Analytical Biochemistry. 408:71-85
مصطلحات موضوعية: chemistry.chemical_classification, Glycan, biology, Biophysics, Lectin, Cell Biology, biology.organism_classification, Biochemistry, Molecular biology, Aleuria aurantia, Sialic acid, chemistry.chemical_compound, Agglutinin, chemistry, C-type lectin, biology.protein, Glycoprotein, Molecular Biology, Fucosylation
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المؤلفون: Jeff Abramson, Michael Grabe, Lucie Bergdoll, John W. Patrick, Wayne L. Hubbell, Christian Altenbach, Arthur Laganowsky, Michael T. Lerch, Paola Bisignano
المصدر: Biophysical Journal. 114:378a
مصطلحات موضوعية: Chemistry, Stereochemistry, Association (object-oriented programming), Biophysics, Glutamate receptor, Protonation, State (functional analysis), VDAC1
