-
1
المؤلفون: Marieangela C. Wilson, Nathalie Guillen, Hannelore Held, Afsar Ali Mian, Paul S. Hole, Oliver G. Ottmann, Claudia Chiriches, Martin Ruthardt, Maria Wieske, Caroline Alvares, Dörte Becher, Andreas Otto, Carol Guy, Kate J. Heesom, Michal Jaroslaw Rokicki
مصطلحات موضوعية: ABL, Oncogene, Cancer research, Myeloid leukemia, Signal transduction, Biology, Proteomics, Protein kinase B, Transcription factor, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf55821ad18a69502c3763b2fb85382
https://doi.org/10.1101/464958 -
2
المؤلفون: Claudia Chiriches, Nathalie Guillen, Martin Ruthardt, Michal Jaroslaw Rokicki, Afsar Ali Mian, Oliver G. Ottmann, Carol Guy
المصدر: Blood. 132:3917-3917
مصطلحات موضوعية: ABL, biology, Oncogene, Immunology, Cell Biology, Hematology, medicine.disease, Biochemistry, Dasatinib, Leukemia, Imatinib mesylate, medicine, biology.protein, Cancer research, Protein kinase B, STAT5, PI3K/AKT/mTOR pathway, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8267f5fef07cc8245adc0b48595ed566
https://doi.org/10.1182/blood-2018-99-116631 -
3
المؤلفون: James R. Barnacle, Mathew James Rogers, David Glyn Kipling, Terence Davis, Michal Jaroslaw Rokicki, Hannah S. E. Tivey, Mark C. Bagley
المصدر: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
مصطلحات موضوعية: Senescence, Premature aging, p53, Aging, Telomerase, MAP Kinase Signaling System, Caveolin 1, Cell Cycle Proteins, Dwarfism, Ataxia Telangiectasia Mutated Proteins, Biology, Protein Serine-Threonine Kinases, p38 Mitogen-Activated Protein Kinases, Progeroid syndromes, RC0254, medicine, Humans, RNA, Small Interfering, Protein kinase A, Protein Kinase Inhibitors, Cells, Cultured, Cellular Senescence, Werner syndrome, Cell Proliferation, Chromosome instability, Replication stress, Facies, Fibroblasts, medicine.disease, Genes, p53, Actins, Cell biology, Seckel syndrome, Telomeres, ATR, Caveolin-1, Mutation, Cancer research, Microcephaly, Original Article, Fragile sites, Geriatrics and Gerontology, RB, Cell aging
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e0b6e673a5c7e177b86b1a26843e52
http://europepmc.org/articles/PMC3738025 -
4
المؤلفون: Michal Jaroslaw Rokicki, Amy Jayne Chedzoy Brook, Terence Davis, Hannah S. E. Tivey, David Glyn Kipling
المصدر: Biogerontology
مصطلحات موضوعية: p38 MAP kinase inhibitors, Senescence, Genome instability, Aging, Pyridines, DNA repair, RecQ helicase, Human telomerase, Biology, p38 Mitogen-Activated Protein Kinases, Genomic Instability, Progeroid syndromes, Ataxia Telangiectasia, Progeria, Stress, Physiological, Human ageing, medicine, Humans, F-actin stress fibres, QH426, Protein Kinase Inhibitors, Telomerase, Cells, Cultured, Cellular Senescence, Werner syndrome, Genetics, Imidazoles, Cellular morphology, Syndrome, Fibroblasts, SB203580, medicine.disease, R1, Cell biology, Ageing, Geriatrics and Gerontology, Gerontology, Cell aging, Research Article
وصف الملف: application/pdf
-
5
المؤلفون: Julia W. Grimstead, Amy Jayne Chedzoy Brook, Terence Davis, Hannah S. E. Tivey, Michal Jaroslaw Rokicki, David Glyn Kipling
المصدر: Age
مصطلحات موضوعية: Aging, Telomerase, Pyridines, medicine.disease_cause, p38 Mitogen-Activated Protein Kinases, 0302 clinical medicine, Stress-associated MAP kinases, Enzyme Inhibitors, Child, Rothmund–Thomson syndrome, Cells, Cultured, 0303 health sciences, Imidazoles, Rothmund-Thomson Syndrome, Gene Expression Regulation, Developmental, General Medicine, Cell biology, Phenotype, Child, Preschool, Senescence, Adolescent, Immunoblotting, Biology, Cellular senescence, Article, Young Adult, 03 medical and health sciences, medicine, Humans, QH426, Cell Proliferation, 030304 developmental biology, Cell growth, Fibroblasts, Tumour suppressor p53, medicine.disease, R1, Telomere, Enzyme Activation, Oxidative Stress, Ageing, Microscopy, Fluorescence, RNA, Ectopic expression, Progeroid syndrome, Geriatrics and Gerontology, 030217 neurology & neurosurgery, Oxidative stress
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd9e1219397b9af1b429e2dfb8d91f77
https://doi.org/10.1007/s11357-012-9476-9 -
6
المؤلفون: Terence Davis, David Glyn Kipling, Paola G. S. Murziani, Mark C. Bagley, Jessica E. Dwyer, Michal Jaroslaw Rokicki, Mohammed Baashen, Matthew C. Dix
مصطلحات موضوعية: 0301 basic medicine, RM, Ketone, p38 mitogen-activated protein kinases, 01 natural sciences, Biochemistry, p38 Mitogen-Activated Protein Kinases, Cell Line, Small Molecule Libraries, 03 medical and health sciences, Structure-Activity Relationship, medicine, Structure–activity relationship, Humans, QD, Physical and Theoretical Chemistry, Microwaves, Protein Kinase Inhibitors, Werner syndrome, Cell Proliferation, chemistry.chemical_classification, QD0415, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Cell growth, Organic Chemistry, Fibroblasts, Ketones, medicine.disease, R1, In vitro, 0104 chemical sciences, 030104 developmental biology, chemistry, Ageing, Cell culture, Cancer research, Pyrazoles, Werner Syndrome, QD0241
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798b72c49ce87d75fdf752614f7ca170
http://sro.sussex.ac.uk/id/eprint/59252/1/C5OB02229K.pdf -
7
المؤلفون: Matthew C. Dix, Mark C. Bagley, Paola G. S. Murziani, Michal Jaroslaw Rokicki, Terence Davis, David Glyn Kipling
المصدر: Future Medicinal Chemistry. 2:203-213
مصطلحات موضوعية: Ketone, Stereochemistry, p38 mitogen-activated protein kinases, p38 Mitogen-Activated Protein Kinases, Microwave assisted, Cell Line, Small Molecule Libraries, Cell Line, Tumor, Drug Discovery, Rapid access, medicine, Humans, Microwaves, Protein Kinase Inhibitors, Werner syndrome, Pharmacology, chemistry.chemical_classification, Chemistry, Kinase, medicine.disease, Pyrazoles, Molecular Medicine, Knoevenagel condensation, Werner Syndrome, Pharmacophore
وصف الملف: application/pdf
-
8
المؤلفون: Michal Jaroslaw Rokicki, Terence Davis, Vincenzo Fusillo, Mark C. Bagley, David Glyn Kipling, Morgane Pigeaux, Matthew C. Dix
المصدر: The Journal of Organic Chemistry. 74:8336-8342
مصطلحات موضوعية: chemistry.chemical_classification, Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, Ligand, Stereochemistry, Thiophenol, Aryl, Organic Chemistry, Iodide, chemistry.chemical_element, p38 Mitogen-Activated Protein Kinases, Combinatorial chemistry, Chemical synthesis, Ullmann reaction, Pyridazines, chemistry.chemical_compound, Pyrimidines, chemistry, Yield (chemistry), Protein Kinase Inhibitors, Palladium
-
9
المؤلفون: Paola G. S. Murziani, David Glyn Kipling, Marcus Aurelius Bachler, Terence Davis, Mark C. Bagley, Jameel M. Zayed, Matthew C. Dix, Caroline S. Widdowson, Michal Jaroslaw Rokicki
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:6832-6835
مصطلحات موضوعية: p38 mitogen-activated protein kinases, Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Biochemistry, Cell Line, Substrate Specificity, Mitogen-Activated Protein Kinase 14, In vivo, Drug Discovery, Humans, Phosphorylation, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Molecular Structure, biology, Chemistry, Cell growth, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Biological activity, Cell biology, Cell culture, Enzyme inhibitor, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Werner Syndrome
-
10
المؤلفون: Afsar Ali Mian, Dilawar Khan, Michal Jaroslaw Rokicki, Carol Guy, Nathalie Guillen, Claudia Chiriches, Oliver G. Ottmann, Martin Ruthardt
المصدر: Blood. 128:2746-2746
مصطلحات موضوعية: Immunology, Ponatinib, Cell Biology, Hematology, Biology, medicine.disease, Biochemistry, Transplantation, Dasatinib, Leukemia, chemistry.chemical_compound, chemistry, LYN, hemic and lymphatic diseases, Cancer research, medicine, Protein kinase B, PI3K/AKT/mTOR pathway, Proto-oncogene tyrosine-protein kinase Src, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::63e39f90ee4cd3bd75defb49d16fc617
https://doi.org/10.1182/blood.v128.22.2746.2746