-
1دورية أكاديمية
المؤلفون: Rebecca M. Klein, Mark E. Layton, Hillary Regan, Christopher P. Regan, Yuxing Li, Tracey Filzen, Matt Cato, Michelle K. Clements, Jixin Wang, Raul Sanoja, Thomas J. Greshock, Anthony J. Roecker, Joseph E. Pero, Ron Kim, Christopher Burgey, Christopher T. John, Ying-Hong Wang, Neetesh Bhandari, Arie Struyk, Richard L. Kraus, Darrell A. Henze, Andrea K. Houghton
المصدر: Channels, Vol 16, Iss 1, Pp 230-243 (2022)
مصطلحات موضوعية: Sodium channel inhibitor, respiration, selectivity, phrenic nerve, Therapeutics. Pharmacology, RM1-950, Physiology, QP1-981
وصف الملف: electronic resource
-
2
المؤلفون: Christopher Daley, Yuxing Li, Haiyan Sun, Xiu Wang, Fuqiang Zhao, Michelle K. Clements, Rebecca M. Klein, Aneta Jovanovska, Andrew Brunskill, Joseph E. Pero, Xuanjia Peng, Thomas J. Greshock, Christopher S. Burgey, Mark E. Layton, Jeanine E. Ballard, Deping Wang, Richard L. Kraus, Andrea K. Houghton, Anthony J. Roecker, Michael J. Kelly
المصدر: ACS Medicinal Chemistry Letters. 12:1038-1049
مصطلحات موضوعية: 010405 organic chemistry, business.industry, Organic Chemistry, Pharmacology, 01 natural sciences, Biochemistry, 0104 chemical sciences, Olfactory response, 010404 medicinal & biomolecular chemistry, IVIVC, Drug Discovery, NAV1, Potency, Medicine, business, Selectivity
-
3
المؤلفون: Richard L. Kraus, Ronald M. Kim, Jeanine E. Ballard, Thomas J. Greshock, Andrea K. Houghton, Michelle K. Clements, Marie A. Holahan, Andrew Danziger, Christopher S. Burgey, Yuxing Li, Mark E. Layton, Jordi Serra, Parul S. Pall, Rebecca M. Klein, Joshua D. Vardigan, Dan Zhou, Fuqiang Zhao, Christopher Daley, Darrell A. Henze
المصدر: Science Translational Medicine. 13
مصطلحات موضوعية: biology, business.industry, General Medicine, Olfaction, Microneurography, Pharmacology, biology.organism_classification, Olfactory bulb, Rhesus macaque, Electrophysiology, Nociception, In vivo, Nociceptor, Medicine, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2568b727c558da3b3a2a03b719a658df
https://doi.org/10.1126/scitranslmed.aay1050 -
4
المؤلفون: Andrea K. Houghton, Aneta Jovanovska, Tracey Filzen, Ying-Hong Wang, Jacqueline Panigel, Annie Liang, Michelle K. Clements, Rebecca M. Klein, Richard L. Kraus, John Majercak, Eleftheria N. Finger, Jixin Wang, Matthew J. Cato, Hannah D. G. F. Lehman, Christopher Daley, Yun Gregan, James Mulhearn, Yuxing Li, Michael A. Rossi, Darrell A. Henze, Mark O. Urban, Michael J. Kelly, Scott E. Wolkenberg, Mark E. Layton, Joseph E. Pero
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2683-2688
مصطلحات موضوعية: 0301 basic medicine, Ligand efficiency, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, In vivo, Oral administration, Drug Discovery, Molecular Medicine, Structure–activity relationship, Potency, Selectivity, Molecular Biology, Lead compound
-
5
المؤلفون: Mark E. Layton, Eleftheria N. Finger, Edward C. Sherer, Amy Jo Koser, Aneta Jovanovska, Robert Gomez, Xiu Wang, Deping Wang, Xuanjia Peng, John Majercak, Melissa Egbertson, Paul J. Coleman, Rebecca M. Klein, Kristen L.G. Jones, Richard L. Kraus, Jixin Wang, Tracey Filzen, Mark O. Urban, Yuxing Li, Anthony J. Roecker, Matthew J. Cato, Ying-Hong Wang, Michelle K. Clements, Jacqueline Panigel, Leo A. Joyce, Vincent P. Santarelli, Irene Gregan, Christopher Daley, Haiyan Sun, Andrea K. Houghton
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2087-2093
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Side effect, Chemistry, Sodium channel, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Bioavailability, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug Discovery, NAV1, Molecular Medicine, Potency, Molecular Biology, 030217 neurology & neurosurgery
-
6
المؤلفون: Richard L, Kraus, Fuqiang, Zhao, Parul S, Pall, Dan, Zhou, Joshua D, Vardigan, Andrew, Danziger, Yuxing, Li, Christopher, Daley, Jeanine E, Ballard, Michelle K, Clements, Rebecca M, Klein, Marie A, Holahan, Thomas J, Greshock, Ronald M, Kim, Mark E, Layton, Christopher S, Burgey, Jordi, Serra, Darrell A, Henze, Andrea K, Houghton
المصدر: Science translational medicine. 13(594)
مصطلحات موضوعية: Nociception, NAV1.7 Voltage-Gated Sodium Channel, Animals, Humans, Nociceptors, Pain, Macaca mulatta
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f9833016998efa2956e0258637677db9
https://pubmed.ncbi.nlm.nih.gov/34011626 -
7
المؤلفون: Joseph E, Pero, Michael A, Rossi, Hannah D G F, Lehman, Michael J, Kelly, James J, Mulhearn, Scott E, Wolkenberg, Matthew J, Cato, Michelle K, Clements, Christopher J, Daley, Tracey, Filzen, Eleftheria N, Finger, Yun, Gregan, Darrell A, Henze, Aneta, Jovanovska, Rebecca, Klein, Richard L, Kraus, Yuxing, Li, Annie, Liang, John M, Majercak, Jacqueline, Panigel, Mark O, Urban, Jixin, Wang, Ying-Hong, Wang, Andrea K, Houghton, Mark E, Layton
المصدر: Bioorganicmedicinal chemistry letters. 27(12)
مصطلحات موضوعية: Analgesics, Benzoxazoles, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Myocytes, Smooth Muscle, NAV1.7 Voltage-Gated Sodium Channel, Administration, Oral, Biological Availability, Pain, Rats, Disease Models, Animal, Mice, Structure-Activity Relationship, Formaldehyde, Animals, Humans
-
8
المؤلفون: Antonella Converso, Greg O’Donnell, Jixin Wang, Ming-Tain Lai, Kelli Solly, Wei Lemaire, Michael F.A. Finley, Mark E. Layton, Michelle K. Clements, Richard L. Kraus, Donnette D. Staas, Jason Cassaday, Tony Kreamer, Xinnian Li, Sean P. Cook, Chris Daley
المصدر: Journal of biomolecular screening. 21(5)
مصطلحات موضوعية: 0301 basic medicine, Pain, Nav1.5, Pharmacology, 01 natural sciences, Biochemistry, Analytical Chemistry, Membrane Potentials, NAV1.5 Voltage-Gated Sodium Channel, 03 medical and health sciences, Paroxysmal extreme pain disorder, medicine, Humans, Molecular Targeted Therapy, Membrane potential, Neurons, biology, Chemistry, Sodium channel, NAV1.7 Voltage-Gated Sodium Channel, Area under the curve, Rectum, medicine.disease, 0104 chemical sciences, High-Throughput Screening Assays, 010404 medicinal & biomolecular chemistry, Electrophysiology, Kinetics, 030104 developmental biology, NAV1, Neuropathic pain, biology.protein, Molecular Medicine, Neuralgia, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e333e0768a580b7c4fb09601f949b433
https://pubmed.ncbi.nlm.nih.gov/26861708 -
9
المؤلفون: Mark E. Duggan, Cyrille Sur, Marlene A. Jacobson, Craig W. Lindsley, Tsing-Bau Chen, David D. Wisnoski, Gene G. Kinney, Michelle K. Clements, Douglas J. Pettibone, Philip R. Tiller, Wei Lemaire, P. Jeffrey Conn, Maryann Burno, David L. Williams, Sheri Smith, Julie A. O'Brien, Denise J. Bickel
المصدر: Journal of Pharmacology and Experimental Therapeutics. 313:199-206
مصطلحات موضوعية: Reflex, Startle, Allosteric modulator, Receptor, Metabotropic Glutamate 5, animal diseases, Allosteric regulation, Phthalimides, CDPPB, CHO Cells, In Vitro Techniques, Motor Activity, Pharmacology, Biology, Receptors, Metabotropic Glutamate, Cell Line, Rats, Sprague-Dawley, Radioligand Assay, Dogs, Cricetinae, Image Interpretation, Computer-Assisted, mental disorders, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Amino Acids, Models, Statistical, Behavior, Animal, Metabotropic glutamate receptor 5, Glutamate receptor, Haplorhini, Rats, Amphetamine, Xanthenes, nervous system, Metabotropic glutamate receptor, Benzamides, Microsomes, Liver, Molecular Medicine, Metabotropic glutamate receptor 1, Central Nervous System Stimulants, Female, Metabotropic glutamate receptor 2, Excitatory Amino Acid Antagonists, Antipsychotic Agents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62906d66536c68f6fbed712a8f57cee
https://doi.org/10.1124/jpet.104.079244 -
10
المؤلفون: Gene G. Kinney, Anthony G. DiLella, P. Jeffrey Conn, Ornella Valenti, David L. Williams, J. Fred Hess, Terrence P. McDonald, Michael J. Marino, Michelle K. Clements, Ruiping Wang, Julie A. O'Brien
المصدر: Proceedings of the National Academy of Sciences. 100:13668-13673
مصطلحات موضوعية: Male, Agonist, Time Factors, Parkinson's disease, medicine.drug_class, Dopamine, Allosteric regulation, Biology, Pharmacology, Receptors, Metabotropic Glutamate, Models, Biological, Cell Line, Rats, Sprague-Dawley, chemistry.chemical_compound, AMN082, medicine, Animals, Humans, Benzopyrans, Multidisciplinary, Metabotropic glutamate receptor 4, Brain, Esters, Parkinson Disease, Long-term potentiation, Biological Sciences, Potentiator, medicine.disease, Rats, Electrophysiology, Models, Chemical, chemistry, Chromones, Synapses, Allosteric Site, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7dee85a6ed566f21bd820ae87d5c2b
https://doi.org/10.1073/pnas.1835724100