نتائج البحث - "Mika Kosaka"

1

دورية أكاديمية

Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug‐Drug Interactions? Preclinical and Clinical Studies With 13‐cis‐Retinoic Acid

المؤلفون: Faith Stevison, Mika Kosaka, Jane R. Kenny, Susan Wong, Cathryn Hogarth, John K. Amory, Nina Isoherranen

المصدر: Clinical and Translational Science, Vol 12, Iss 4, Pp 350-360 (2019)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950, Public aspects of medicine, RA1-1270

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1752-8054; https://doaj.org/toc/1752-8062

URL الوصول: https://doaj.org/article/b5acde5239844f1d9420489cbb1d82fb

View record at Wiley

Find this article in full text from ProQuest

Full Text Finder

2

Isotretinoin and its Metabolites Alter mRNA of Multiple Enzyme and Transporter Genes In Vitro, but Downregulation of Organic Anion Transporting Polypeptide Does Not Translate to the Clinic

المؤلفون: Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory, Nina Isoherranen

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 50(7)

مصطلحات موضوعية: Pharmacology, Coproporphyrins, Pharmaceutical Science, Down-Regulation, Membrane Transport Proteins, Organic Anion Transporters, Cytochrome P-450 CYP2B6, Cytochrome P-450 Enzyme System, Cytochrome P-450 CYP1A2, Humans, Drug Interactions, RNA, Messenger, Isotretinoin, Biomarkers, Cytochrome P-450 CYP2C9

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ec1019807e64b2c80313286f3c89c4
https://pubmed.ncbi.nlm.nih.gov/35545255

3

Does In Vitro Cytochrome P450 Downregulation Translate to In Vivo Drug‐Drug Interactions? Preclinical and Clinical Studies With 13‐ cis ‐Retinoic Acid

المؤلفون: Cathryn A. Hogarth, John K. Amory, Susan Wong, Mika Kosaka, Faith Stevison, Nina Isoherranen, Jane R. Kenny

المصدر: Clinical and Translational Science, Vol 12, Iss 4, Pp 350-360 (2019)
Clinical and Translational Science

مصطلحات موضوعية: Male, 030213 general clinical medicine, Time Factors, Retinoic acid, Receptors, Cytoplasmic and Nuclear, Pharmacology, Dextromethorphan, 030226 pharmacology & pharmacy, Mice, chemistry.chemical_compound, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Drug Interactions, General Pharmacology, Toxicology and Pharmaceutics, Isotretinoin, Aged, 80 and over, biology, lcsh:Public aspects of medicine, General Neuroscience, Articles, General Medicine, Liver, Female, medicine.drug, Adult, CYP2D6, Down-Regulation, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Downregulation and upregulation, In vivo, medicine, Animals, Humans, Computer Simulation, RNA, Messenger, Dextrorphan, CYP3A4, Research, lcsh:RM1-950, Cytochrome P450, lcsh:RA1-1270, In vitro, lcsh:Therapeutics. Pharmacology, chemistry, Hepatocytes, biology.protein, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9789888ece45d86d225ef22ef114837b
https://doi.org/10.1111/cts.12616

View record at Wiley

Find this article in full text from ProQuest

4

NADPH-Independent Inactivation of CYP2B6 and NADPH-Dependent Inactivation of CYP3A4/5 by PBD: Potential Implication for Assessing Covalent Modulators for Time-Dependent Inhibition

المؤلفون: Simon Wong, Zhengyin Yan, Mika Kosaka, Donglu Zhang

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 48(8)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5d70790ecc75f51c55b63723061f18
https://pubmed.ncbi.nlm.nih.gov/32482757

5

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions

المؤلفون: Ning Liu, Mika Kosaka, Utkarsh Doshi, Jane R. Kenny, Albert P. Li, Peter Vuong, Suzanne Tay, Hoa Le, Susan Wong, Zhengyin Yan

المصدر: Drug Metabolism Letters. 12:3-13

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19a9d3d789b2df64d293be5faba52dc
https://doi.org/10.2174/1872312812666171213114422

6

NADPH-independent inactivation of CYP2B6 by pyrrolobenzodiazepine dimer and potential impact on time-dependent inhibition assay of covalent inhibitors

المؤلفون: Mika Kosaka, Donglu Zhang, Zhengyin Yan, Jing Wang, Simon Wong

المصدر: Drug Metabolism and Pharmacokinetics. 33:S52-S53

مصطلحات موضوعية: Pharmacology, Potential impact, CYP2B6, Covalent bond, Stereochemistry, Chemistry, Pharmaceutical Science, Pyrrolobenzodiazepine Dimer, Pharmacology (medical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7af586fd34523330ddc63f19dff8a7d8
https://doi.org/10.1016/j.dmpk.2017.11.180

View record from ScienceDirect

7

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

المؤلفون: Christopher Benner, Ronald M. Evans, Minna U. Kaikkonen, Michael T. Lam, Michael G. Rosenfeld, Sven Heinz, Cindy Y. Lee, Mika Kosaka, Hanna P. Lesch, Tamar R. Grossman, Aneeza Kim, Yumiko Tanaka-Oishi, Andrew T. Watt, David Gosselin, Han Cho, Christopher K. Glass

المصدر: Nature. 498:511-515

مصطلحات موضوعية: Genetics, 0303 health sciences, Multidisciplinary, Repressor, Enhancer RNAs, Promoter, Biology, body regions, 03 medical and health sciences, 0302 clinical medicine, Nuclear receptor, Transcription (biology), Gene expression, skin and connective tissue diseases, Enhancer, Psychological repression, 030217 neurology & neurosurgery, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::36e413a1ce5683345a01eb1e7b1728a8
https://doi.org/10.1038/nature12209

Find this article in full text from ProQuest

8

دورية أكاديمية

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

المؤلفون: Michael T. Y. Lam, Han Cho, Hanna P. Lesch, David Gosselin, Sven Heinz, Yumiko Tanaka-Oishi, Christopher Benner, Minna U. Kaikkonen, Aneeza S. Kim, Mika Kosaka, Cindy Y. Lee, Andy Watt, Ta

المصدر: Nature, Nature. 498(7455):511-515

الإتاحة: https://ideas.repec.org/a/nat/nature/v498y2013i7455d10.1038_nature12209.html

9

Targeted p21WAF1/CIP1 Activation by RNAa Inhibits Hepatocellular Carcinoma Cells

المؤلفون: Moo Rim Kang, Mika Kosaka, Glen Yang, Long-Cheng Li

المصدر: Nucleic Acid Therapeutics. 22:335-343

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2efcdfd2c4b3422d848e082cb119112
https://doi.org/10.1089/nat.2012.0354

Find this article in full text from ProQuest

10

Inducing gene expression by targeting promoter sequences using small activating RNAs

المؤلفون: Ji, Wang, Robert F, Place, Victoria, Portnoy, Vera, Huang, Moo Rim, Kang, Mika, Kosaka, Maurice Kwok Chung, Ho, Long-Cheng, Li

المصدر: Journal of Biological Methods, Vol 2, Iss 1, Pp e14-e14 (2015)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32de8ff8bb872408245a3ce008d300b1
http://www.jbmethods.org/jbm/article/view/39

تنقيح النتائج