المؤلفون: Atsushi Nakamura, Hiroko Ono, Azusa Ando, Mikie Hinata, Kazuki Niidome, Shigeki Omachi, Gaku Sakaguchi, Shunji Shinohara

المصدر: Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 9-17 (2017)

مصطلحات موضوعية: Antinociception, Bone cancer pain, Extracellular regulated kinase, Opioid, Rewarding effect, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1347861316301608; https://doaj.org/toc/1347-8613

URL الوصول: https://doaj.org/article/46245ec94f2840988654d3441227fa84

المؤلفون: Narumi Horita, Daiki Nagamatsu, Yasuhide Morioka, Miki Tanimura, Gaku Sakaguchi, Azusa Nozu, Yasuyoshi Iso, Toshiyuki Kanemasa, Natsue Yamanada, Mikie Hinata, Toshiyuki Asaki, Masayuki Imai, Hidetoshi Matsuda, Kenji Takaya, Osamu Yoshida, Hiromi Nakai, Akira Yukimasa, Shinji Suzuki, Masahiko Soga, Naoki Tsuno, Tomoyuki Ogawa, Hiroki Yamaguchi, Miyuki Yamamoto, Satoko Funaki, Motohiro Fujiu

المصدر: Bioorganic & Medicinal Chemistry. 25:2177-2190

مصطلحات موضوعية: 0301 basic medicine, Analgesic effect, TRPV4, Spectrometry, Mass, Electrospray Ionization, Stereochemistry, Proton Magnetic Resonance Spectroscopy, Guinea Pigs, Clinical Biochemistry, TRPV Cation Channels, Pharmaceutical Science, Biochemistry, Guinea pig, Structure-Activity Relationship, 03 medical and health sciences, Mechanical Hyperalgesia, 0302 clinical medicine, Microsomes, Drug Discovery, Animals, Humans, Pain Management, Molecular Biology, Analgesics, Chemistry, Organic Chemistry, Antagonist, Complete adjuvant, Rats, Thiazoles, 030104 developmental biology, Molecular Medicine, Azabicyclo Compounds, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa29140063fa0c3811b33e5cee9b2d9e
https://doi.org/10.1016/j.bmc.2017.02.047

المؤلفون: Gaku Sakaguchi, Tetsuji Ito, Naoki Tsuno, Mikie Hinata, Akira Yukimasa, Yasuyoshi Iso, Satoko Funaki, Daiki Nagamatsu, Miki Tanimura, Miyuki Yamamoto, Tatsuhiko Ueno, Toshiyuki Kanemasa, Yoko Nishimura, Masahiko Soga, Natsue Yamanada, Yasuhide Morioka, Osamu Yoshida, Narumi Horita, Masayuki Imai, Takatsugu Inoue, Yusuke Ichihashi, Hiroki Yamaguchi, Hidetoshi Matsuda

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4930-4935

مصطلحات موضوعية: 0301 basic medicine, Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Administration, Oral, Biological Availability, TRPV Cation Channels, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, ADME, Analgesics, Drug discovery, Chemistry, Organic Chemistry, Antagonist, Bioavailability, 030104 developmental biology, Competitive antagonist, Molecular Medicine, Lead compound, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dfca53a6691693d86f5736a65ec6f2
https://doi.org/10.1016/j.bmcl.2016.09.013

المؤلفون: Masabumi Minami, Masayuki Imai, Minoru Hasegawa, Gaku Sakaguchi, Takeshi Yoshioka, Narumi Horita, Atsushi Morita, Junji Tsuchida, Yasuhide Morioka, Mikie Hinata, Kenichi Higashino, Shoji Yamane, Isao Fukuda, Masahiko Soga, Takao Sanaki, Minoru Ikeda, Toshiyuki Kanemasa, Miyuki Yamamoto, Sunao Imai

المصدر: Pain. 159(5)

مصطلحات موضوعية: 0301 basic medicine, TRPV4, Agonist, Male, medicine.medical_specialty, medicine.drug_class, Morpholines, Analgesic, Pain, TRPV Cation Channels, Osteoarthritis, Epoxyeicosatrienoic acid, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Dorsal root ganglion, Leucine, Internal medicine, Ganglia, Spinal, medicine, Animals, Pyrroles, Phosphorylation, Receptor, Pain Measurement, Neurons, Sulfonamides, Hand Strength, Antagonist, medicine.disease, Arthritis, Experimental, Iodoacetic Acid, Rats, Disease Models, Animal, 030104 developmental biology, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Endocrinology, Neurology, chemistry, Neurology (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd117c6492d9838952d160f17582672e
https://pubmed.ncbi.nlm.nih.gov/29438227

المؤلفون: Hiroko Ono, Shigeki Omachi, Atsushi Nakamura, Azusa Ando, Kazuki Niidome, Mikie Hinata, Gaku Sakaguchi, Shunji Shinohara

المصدر: Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 9-17 (2017)

مصطلحات موضوعية: 0301 basic medicine, Receptors, Opioid, mu, Opioid, Pharmacology, Antinociception, Mice, Radioligand Assay, 03 medical and health sciences, 0302 clinical medicine, Reward, Conditioning, Psychological, Nitriles, Butadienes, Animals, Medicine, Extracellular regulated kinase, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Bone cancer pain, Analgesics, Dose-Response Relationship, Drug, Morphine, business.industry, Kinase, MEK inhibitor, lcsh:RM1-950, Ventral Tegmental Area, Conditioned place preference, Up-Regulation, Ventral tegmental area, Disease Models, Animal, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, medicine.anatomical_structure, Nociception, Molecular Medicine, Rewarding effect, business, Oxycodone, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7016ec3665f0d022cebb9cbe2419d2d

المؤلفون: Mikie Hinata, Toshiyuki Asaki, Miyuki Yamamoto, Azusa Nozu, Osamu Yoshida, Masayuki Imai, Gaku Sakaguchi, Satoko Funaki, Kenji Takaya, Yasuyoshi Iso, Narumi Horita, Akira Yukimasa, Shinji Suzuki, Naoki Tsuno, Hidetoshi Matsuda, Masahiko Soga, Toshiyuki Kanemasa, Daiki Nagamatsu, Motohiro Fujiu, Hiromi Nakai, Yasuhide Morioka, Hiroki Yamaguchi, Yoko Nishimura, Tetsuji Ito, Tomoyuki Ogawa

المصدر: Bioorganicmedicinal chemistry letters. 26(20)

مصطلحات موضوعية: 0301 basic medicine, TRPV4, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, TRPV Cation Channels, Pharmacology, Biochemistry, Guinea pig, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Cricetinae, Drug Discovery, medicine, Structure–activity relationship, Animals, Thiazole, Molecular Biology, Chemistry, Drug discovery, Organic Chemistry, Bioavailability, Thiazoles, 030104 developmental biology, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07851f926e3ee62eead1648e33994ed6
https://pubmed.ncbi.nlm.nih.gov/27634196

المؤلفون: Mikie Hinata, Sunao Imai, Takao Sanaki, Junji Tsuchida, Takeshi Yoshioka, Kenichi Higashino, Miyuki Yamamoto, Masayuki Imai, Masahiko Soga, Narumi Horita, Isao Fukuda, Minoru Ikeda, Shoji Yamane, Atsushi Morita, Toshiyuki Kanemasa, Gaku Sakaguchi, Minoru Hasegawa, Masabumi Minami, Yasuhide Morioka, Hinata, Mikie

المصدر: PAIN; May2018, Vol. 159 Issue 5, p939-947, 9p