المؤلفون: Millard, CJ, Watson, PJ, Celardo, I, Gordiyenko, Y, Cowley, SM, Robinson, CV, Fairall, L, Schwabe, JW

المصدر: Molecular Cell

مصطلحات موضوعية: Models, Molecular, Protein Folding, Inositol Phosphates, Molecular Sequence Data, Histone Deacetylase 1, Cell Biology, Article, Histone Deacetylases, Protein Structure, Tertiary, Substrate Specificity, Repressor Proteins, HEK293 Cells, Trans-Activators, Humans, Amino Acid Sequence, Dimerization, Molecular Biology

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المؤلفون: Watson, PJ, Millard, CJ, Riley, A, Robertson, NS, Wright, LC, Godage, HY, Cowley, SM, Jamieson, AG, Potter, B, Schwabe, JWR

المصدر: Nature Communications. 7(11262)

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المؤلفون: Archibald LJ; School of Chemistry, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, U.K., Brown EA; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K., Millard CJ; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K., Watson PJ; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K., Robertson NS; Department of Chemistry, University of Cambridge, Cambridge CB2 1GA, U.K., Wang S; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K., Schwabe JWR; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K., Jamieson AG; School of Chemistry, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, U.K.

المصدر: ACS chemical biology [ACS Chem Biol] 2022 Sep 16; Vol. 17 (9), pp. 2572-2582. Date of Electronic Publication: 2022 Aug 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Hydroxamic Acids*/chemistry , Peptide Library*, Co-Repressor Proteins/metabolism ; Histone Deacetylase Inhibitors/chemistry ; Histone Deacetylases/metabolism ; Histones/metabolism ; Humans ; Lysine ; Peptides/chemistry

المؤلفون: Millard CJ; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK., Fairall L; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK., Ragan TJ; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK., Savva CG; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK., Schwabe JWR; The Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, UK.

المصدر: Nucleic acids research [Nucleic Acids Res] 2020 Dec 16; Vol. 48 (22), pp. 12972-12982.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Chromatin/*genetics , DNA-Binding Proteins/*genetics , Mi-2 Nucleosome Remodeling and Deacetylase Complex/*genetics , Repressor Proteins/*genetics , Retinoblastoma-Binding Protein 4/*genetics , Trans-Activators/*genetics, Amino Acid Sequence/genetics ; Cryoelectron Microscopy ; DNA-Binding Proteins/ultrastructure ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/ultrastructure ; Histone Deacetylases/genetics ; Histone Deacetylases/ultrastructure ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/ultrastructure ; Nucleosomes/genetics ; Nucleosomes/ultrastructure ; Protein Binding/genetics ; Protein Domains/genetics ; Repressor Proteins/ultrastructure ; Retinoblastoma-Binding Protein 4/ultrastructure ; Trans-Activators/ultrastructure

المؤلفون: Turnbull RE; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, UK.; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK., Fairall L; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, UK.; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK., Saleh A; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, UK.; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0HS, UK., Kelsall E; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK.; AstraZeneca, Milstein Building, Granta Park, Cambridge, CB21 6GH, UK., Morris KL; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK.; MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK., Ragan TJ; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, UK., Savva CG; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, UK., Chandru A; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK.; Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK., Millard CJ; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, UK.; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK., Makarova OV; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK., Smith CJ; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, UK., Roseman AM; Division of Molecular and Cellular Function, University of Manchester, Manchester, M13 9PL, UK., Fry AM; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK., Cowley SM; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK. smc57@leicester.ac.uk., Schwabe JWR; Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, LE1 7RH, UK. john.schwabe@leicester.ac.uk.; Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK. john.schwabe@leicester.ac.uk.

المصدر: Nature communications [Nat Commun] 2020 Jun 26; Vol. 11 (1), pp. 3252. Date of Electronic Publication: 2020 Jun 26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Embryonic Development*, Histone Deacetylases/*metabolism , Multiprotein Complexes/*metabolism, Amino Acid Sequence ; Animals ; Cell Line ; Chromatin/metabolism ; Chromosomes, Mammalian/metabolism ; Embryo, Mammalian/cytology ; Fibroblasts/metabolism ; Gene Regulatory Networks ; Heterozygote ; Homozygote ; Humans ; Mice, Inbred C57BL ; Mice, Knockout ; Mitosis ; Models, Molecular ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/ultrastructure ; Nuclear Proteins/metabolism ; Protein Domains ; Protein Multimerization

المؤلفون: Wang ZA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States., Millard CJ; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Lin CL; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Gurnett JE; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Wu M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States., Lee K; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States., Fairall L; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Schwabe JW; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom., Cole PA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, United States.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States.

المصدر: ELife [Elife] 2020 Jun 05; Vol. 9. Date of Electronic Publication: 2020 Jun 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Histone Deacetylases/*metabolism , Histones/*metabolism , Nucleosomes/*metabolism, Acetylation ; Co-Repressor Proteins/genetics ; Co-Repressor Proteins/metabolism ; Histone Deacetylases/genetics ; Histones/genetics ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Nucleosomes/genetics

المؤلفون: Smalley JP; Leicester Institute of Structural and Chemical Biology and Department of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK. JTHodgkinson@le.ac.uk., Adams GE; Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 9HN, UK. smc57@leicester.ac.uk., Millard CJ; Leicester Institute of Structural and Chemical Biology and Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 9HN, UK. john.schwabe@le.ac.uk., Song Y; Leicester Institute of Structural and Chemical Biology and Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 9HN, UK. john.schwabe@le.ac.uk., Norris JKS; Leicester Institute of Structural and Chemical Biology and Department of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK. JTHodgkinson@le.ac.uk., Schwabe JWR; Leicester Institute of Structural and Chemical Biology and Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 9HN, UK. john.schwabe@le.ac.uk., Cowley SM; Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 9HN, UK. smc57@leicester.ac.uk., Hodgkinson JT; Leicester Institute of Structural and Chemical Biology and Department of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK. JTHodgkinson@le.ac.uk.

المصدر: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Apr 21; Vol. 56 (32), pp. 4476-4479.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

مواضيع طبية MeSH: Co-Repressor Proteins*/metabolism , Histone Deacetylases*/metabolism, Animals ; Humans ; Mice ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Histone Deacetylase 1/antagonists & inhibitors ; Histone Deacetylase Inhibitors/chemistry ; Histone Deacetylase Inhibitors/pharmacology ; Histone Demethylases/antagonists & inhibitors ; Proteolysis

المؤلفون: Goos JAC; Departments of Plastic and Reconstructive Surgery and Hand Surgery.; Bioinformatics, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, The Netherlands., Vogel WK; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA., Mlcochova H; Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Millard CJ; Leicester Institute for Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK., Esfandiari E; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA., Selman WH; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA.; College of Veterinary Medicine, University of Al-Qadisiyah, Al Diwaniyah, Iraq., Calpena E; Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Koelling N; Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Carpenter EL; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA., Swagemakers SMA; Bioinformatics, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, The Netherlands.; Department of Pathology, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, The Netherlands., van der Spek PJ; Bioinformatics, Erasmus MC, University Medical Center Rotterdam, CA Rotterdam, The Netherlands., Filtz TM; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA., Schwabe JWR; Leicester Institute for Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK., Iwaniec UT; Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA., Mathijssen IMJ; Departments of Plastic and Reconstructive Surgery and Hand Surgery., Leid M; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA.; Department of Integrative Biosciences, Oregon Health & Science University, Portland, OR, USA., Twigg SRF; Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

المصدر: Human molecular genetics [Hum Mol Genet] 2019 Aug 01; Vol. 28 (15), pp. 2501-2513.

نوع المنشور: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Chromatin Assembly and Disassembly* , Mutation, Missense* , Osteogenesis*, Cranial Sutures/*growth & development , Craniosynostoses/*metabolism , Nucleosomes/*metabolism , Repressor Proteins/*genetics , Tumor Suppressor Proteins/*genetics, Animals ; Cranial Sutures/metabolism ; Craniosynostoses/genetics ; Craniosynostoses/physiopathology ; DNA Mutational Analysis ; Disease Models, Animal ; Humans ; Infant ; Male ; Mice ; Protein Binding ; Protein Conformation ; Repressor Proteins/metabolism ; Repressor Proteins/physiology ; Retinoblastoma-Binding Protein 4/metabolism ; Trans-Activators/metabolism ; Tumor Suppressor Proteins/metabolism ; Tumor Suppressor Proteins/physiology ; White People ; Whole Genome Sequencing

المؤلفون: Mahindra A; School of Chemistry , University of Glasgow , Joseph Black Building, University Avenue , Glasgow G12 8QQ , U.K., Millard CJ; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology , University of Leicester , Leicester LE1 7RH , U.K., Black I; School of Chemistry , University of Glasgow , Joseph Black Building, University Avenue , Glasgow G12 8QQ , U.K., Archibald LJ; School of Chemistry , University of Glasgow , Joseph Black Building, University Avenue , Glasgow G12 8QQ , U.K., Schwabe JWR; Leicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology , University of Leicester , Leicester LE1 7RH , U.K., Jamieson AG; School of Chemistry , University of Glasgow , Joseph Black Building, University Avenue , Glasgow G12 8QQ , U.K.

المصدر: Organic letters [Org Lett] 2019 May 03; Vol. 21 (9), pp. 3178-3182. Date of Electronic Publication: 2019 Apr 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett

مواضيع طبية MeSH: Amino Acids/*chemistry , Fluorenes/*chemistry , Histone Deacetylase Inhibitors/*chemical synthesis , Peptidomimetics/*chemical synthesis , Zinc/*chemistry, Chelating Agents/chemistry ; Coordination Complexes/chemistry ; Nickel/chemistry ; Solid-Phase Synthesis Techniques ; Stereoisomerism